Head and Neck Neoplasm — Genomics

Head and Neck Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

28 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Acinar Cell Carcinoma of the Pancreas (JHU, J Pathol 2014) paac_jhu_2014JHU

23 cases with simple somatic mutation data · 23 cases total · 2026-01-12 · mapped to Pancreatic Acinar Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SMAD4

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Adenoid Cystic Carcinoma (FMI, Am J Surg Pathl. 2014) acyc_fmi_2014FMI

28 cases with simple somatic mutation data · 28 cases total · 2026-01-05 · mapped to Adenoid Cystic Carcinoma EXACT_IDENTIFIER

cbioportalObserved15 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KDM6A	Ssm	5	28	17.9%	cbioportal
2	ARID1A	Ssm	4	28	14.3%	cbioportal
3	NOTCH1	Ssm	3	28	10.7%	cbioportal
4	RUNX1	Ssm	2	28	7.1%	cbioportal
8	CTNNB1	Ssm	1	28	3.6%	cbioportal
15	TP53	Ssm	1	28	3.6%	cbioportal
14	SPEN	Ssm	1	28	3.6%	cbioportal
13	RB1	Ssm	1	28	3.6%	cbioportal
12	PKHD1	Ssm	1	28	3.6%	cbioportal
11	PIK3CA	Ssm	1	28	3.6%	cbioportal
10	LTK	Ssm	1	28	3.6%	cbioportal
9	EGFR	Ssm	1	28	3.6%	cbioportal
7	BRCA2	Ssm	1	28	3.6%	cbioportal
6	BAP1	Ssm	1	28	3.6%	cbioportal
5	AKT1	Ssm	1	28	3.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Adenoid Cystic Carcinoma (JHU, Cancer Prev Res 2016) acyc_jhu_2016JHU

25 cases with simple somatic mutation data · 25 cases total · 2026-01-05 · mapped to Adenoid Cystic Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NOTCH1	Ssm	3	25	12%	cbioportal
2	ABCA4	Ssm	2	25	8%	cbioportal
3	EP300	Ssm	2	25	8%	cbioportal
4	KANK4	Ssm	2	25	8%	cbioportal
5	KDM6A	Ssm	2	25	8%	cbioportal
9	PRKD1	Ssm	2	25	8%	cbioportal
6	KMT2C	Ssm	2	25	8%	cbioportal
7	KMT2D	Ssm	2	25	8%	cbioportal
8	PLXNB1	Ssm	2	25	8%	cbioportal
14	ZNF292	Ssm	2	25	8%	cbioportal
13	TTN	Ssm	2	25	8%	cbioportal
12	SF3B1	Ssm	2	25	8%	cbioportal
11	RP1L1	Ssm	2	25	8%	cbioportal
10	RHOA	Ssm	2	25	8%	cbioportal
21	ADAMTS5	Ssm	1	25	4%	cbioportal
23	ADNP2	Ssm	1	25	4%	cbioportal
24	AEBP1	Ssm	1	25	4%	cbioportal
25	AFG3L2	Ssm	1	25	4%	cbioportal
26	AGMAT	Ssm	1	25	4%	cbioportal
27	AHNAK2	Ssm	1	25	4%	cbioportal
28	AIFM3	Ssm	1	25	4%	cbioportal
29	AJUBA	Ssm	1	25	4%	cbioportal
30	ALDH1A1	Ssm	1	25	4%	cbioportal
16	ACTB	Ssm	1	25	4%	cbioportal
17	ACTL6A	Ssm	1	25	4%	cbioportal
18	ACTN2	Ssm	1	25	4%	cbioportal
19	ADAM2	Ssm	1	25	4%	cbioportal
20	ADAMTS13	Ssm	1	25	4%	cbioportal
22	ADCY1	Ssm	1	25	4%	cbioportal
15	ABCC5	Ssm	1	25	4%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Adenoid Cystic Carcinoma (MDA, Clin Cancer Res 2015) acyc_mda_2015MDA

65 cases with simple somatic mutation data · 102 cases total · 2026-01-05 · mapped to Adenoid Cystic Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPEN	Ssm	5	65	7.7%	cbioportal
4	NOTCH1	Ssm	4	65	6.2%	cbioportal
3	MUC16	Ssm	4	65	6.2%	cbioportal
2	CREBBP	Ssm	4	65	6.2%	cbioportal
5	MUC12	Ssm	3	65	4.6%	cbioportal
6	TYW2	Ssm	3	65	4.6%	cbioportal
26	ZNF880	Ssm	2	65	3.1%	cbioportal
7	ABCA1	Ssm	2	65	3.1%	cbioportal
8	ATN1	Ssm	2	65	3.1%	cbioportal
9	C1ORF167	Ssm	2	65	3.1%	cbioportal
10	CARD14	Ssm	2	65	3.1%	cbioportal
11	CHST8	Ssm	2	65	3.1%	cbioportal
12	CUBN	Ssm	2	65	3.1%	cbioportal
13	IVL	Ssm	2	65	3.1%	cbioportal
14	MAP10	Ssm	2	65	3.1%	cbioportal
15	MBD3L1	Ssm	2	65	3.1%	cbioportal
16	MIR152	Ssm	2	65	3.1%	cbioportal
17	NMRK1	Ssm	2	65	3.1%	cbioportal
18	OTOF	Ssm	2	65	3.1%	cbioportal
19	RTN4R	Ssm	2	65	3.1%	cbioportal
20	SDK1	Ssm	2	65	3.1%	cbioportal
21	SMARCA2	Ssm	2	65	3.1%	cbioportal
22	TFAP4	Ssm	2	65	3.1%	cbioportal
23	USP34	Ssm	2	65	3.1%	cbioportal
24	VWA5B1	Ssm	2	65	3.1%	cbioportal
25	XKR7	Ssm	2	65	3.1%	cbioportal
30	ACCS	Ssm	1	65	1.5%	cbioportal
29	ABHD3	Ssm	1	65	1.5%	cbioportal
28	ABCD2	Ssm	1	65	1.5%	cbioportal
27	AAK1	Ssm	1	65	1.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Adenoid Cystic Carcinoma (MGH, Nat Gen 2016) acyc_mgh_2016MGH

10 cases with simple somatic mutation data · 10 cases total · 2026-01-05 · mapped to Adenoid Cystic Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
3	ZXDB	Ssm	4	10	40%	cbioportal
2	TTN	Ssm	4	10	40%	cbioportal
1	MUC12	Ssm	4	10	40%	cbioportal
12	LAMC2	Ssm	3	10	30%	cbioportal
9	GOLGA8M	Ssm	3	10	30%	cbioportal
10	HRNR	Ssm	3	10	30%	cbioportal
11	KDM6A	Ssm	3	10	30%	cbioportal
22	WASHC2A	Ssm	3	10	30%	cbioportal
21	TECPR1	Ssm	3	10	30%	cbioportal
20	RGPD4	Ssm	3	10	30%	cbioportal
19	POTEF	Ssm	3	10	30%	cbioportal
18	PLEC	Ssm	3	10	30%	cbioportal
17	OBSCN	Ssm	3	10	30%	cbioportal
16	NOTCH1	Ssm	3	10	30%	cbioportal
15	NANOGNB	Ssm	3	10	30%	cbioportal
14	MEGF6	Ssm	3	10	30%	cbioportal
13	LRP1B	Ssm	3	10	30%	cbioportal
4	ADGRV1	Ssm	3	10	30%	cbioportal
5	CREBBP	Ssm	3	10	30%	cbioportal
6	CUL9	Ssm	3	10	30%	cbioportal
7	DAGLA	Ssm	3	10	30%	cbioportal
8	FNDC1	Ssm	3	10	30%	cbioportal
23	ZFYVE28	Ssm	3	10	30%	cbioportal
24	AATK	Ssm	2	10	20%	cbioportal
29	AHDC1	Ssm	2	10	20%	cbioportal
177	VPS41	Ssm	2	10	20%	cbioportal
28	ADSS1	Ssm	2	10	20%	cbioportal
27	ADGRL3	Ssm	2	10	20%	cbioportal
26	ADGRL1	Ssm	2	10	20%	cbioportal
25	ABCA8	Ssm	2	10	20%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Adenoid Cystic Carcinoma (MSK, Nat Genet 2013) acyc_mskcc_2013MSK

60 cases with simple somatic mutation data · 60 cases total · 2026-01-05 · mapped to Adenoid Cystic Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	KDM6A	Ssm	4	60	6.7%	cbioportal
1	CREBBP	Ssm	4	60	6.7%	cbioportal
3	RYR3	Ssm	4	60	6.7%	cbioportal
8	TP53	Ssm	3	60	5%	cbioportal
7	SMARCA2	Ssm	3	60	5%	cbioportal
6	PIK3CA	Ssm	3	60	5%	cbioportal
5	NOTCH1	Ssm	3	60	5%	cbioportal
4	MUC16	Ssm	3	60	5%	cbioportal
19	HSPG2	Ssm	2	60	3.3%	cbioportal
28	NT5C3A	Ssm	2	60	3.3%	cbioportal
29	PLCZ1	Ssm	2	60	3.3%	cbioportal
30	REC8	Ssm	2	60	3.3%	cbioportal
9	ACTB	Ssm	2	60	3.3%	cbioportal
10	ADAM2	Ssm	2	60	3.3%	cbioportal
11	AFF2	Ssm	2	60	3.3%	cbioportal
12	BUB1B	Ssm	2	60	3.3%	cbioportal
13	CHST5	Ssm	2	60	3.3%	cbioportal
14	CMTR2	Ssm	2	60	3.3%	cbioportal
15	DYSF	Ssm	2	60	3.3%	cbioportal
16	ENC1	Ssm	2	60	3.3%	cbioportal
17	FAT4	Ssm	2	60	3.3%	cbioportal
18	FOXP2	Ssm	2	60	3.3%	cbioportal
20	INSRR	Ssm	2	60	3.3%	cbioportal
21	IRAK1	Ssm	2	60	3.3%	cbioportal
22	LAMA3	Ssm	2	60	3.3%	cbioportal
23	LPAR4	Ssm	2	60	3.3%	cbioportal
24	MGA	Ssm	2	60	3.3%	cbioportal
25	MUC4	Ssm	2	60	3.3%	cbioportal
26	NFIB	Ssm	2	60	3.3%	cbioportal
27	NR1H3	Ssm	2	60	3.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Adenoid Cystic Carcinoma of the Breast (MSK, J Pathol. 2015) acbc_mskcc_2015MSK

12 cases with simple somatic mutation data · 12 cases total · 2026-08-20 · mapped to Breast Adenoid Cystic Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4	Ssm	2	12	16.7%	cbioportal
2	MYB	Ssm	2	12	16.7%	cbioportal
3	TLN2	Ssm	2	12	16.7%	cbioportal
21	CAPZB	Ssm	1	12	8.3%	cbioportal
20	CACNA1G	Ssm	1	12	8.3%	cbioportal
19	C1QTNF9B	Ssm	1	12	8.3%	cbioportal
18	BRD1	Ssm	1	12	8.3%	cbioportal
17	BRAF	Ssm	1	12	8.3%	cbioportal
15	ATP1B2	Ssm	1	12	8.3%	cbioportal
13	ASB4	Ssm	1	12	8.3%	cbioportal
16	BMS1	Ssm	1	12	8.3%	cbioportal
14	ATP10D	Ssm	1	12	8.3%	cbioportal
4	ABCB7	Ssm	1	12	8.3%	cbioportal
5	ADAMTS14	Ssm	1	12	8.3%	cbioportal
6	ADGRF5	Ssm	1	12	8.3%	cbioportal
7	ALOX15	Ssm	1	12	8.3%	cbioportal
8	ANKRD29	Ssm	1	12	8.3%	cbioportal
9	AP1B1	Ssm	1	12	8.3%	cbioportal
10	ARAF	Ssm	1	12	8.3%	cbioportal
11	ARAP1	Ssm	1	12	8.3%	cbioportal
12	ARMCX4	Ssm	1	12	8.3%	cbioportal
30	CKAP2	Ssm	1	12	8.3%	cbioportal
29	CHAC1	Ssm	1	12	8.3%	cbioportal
28	CES1	Ssm	1	12	8.3%	cbioportal
27	CDK11A	Ssm	1	12	8.3%	cbioportal
26	CDH3	Ssm	1	12	8.3%	cbioportal
24	CDH1	Ssm	1	12	8.3%	cbioportal
25	CDH23	Ssm	1	12	8.3%	cbioportal
23	CCDC22	Ssm	1	12	8.3%	cbioportal
22	CASQ1	Ssm	1	12	8.3%	cbioportal

Data updated 22 days agoSource updated 2026-08-20

Adenoid Cystic Carcinoma Project (J Clin Invest 2019) acc_2019

1,049 cases with simple somatic mutation data · 1,049 cases total · 2026-01-05 · mapped to Adenoid Cystic Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NOTCH1	Ssm	232	1,049	22.1%	cbioportal
2	KDM6A	Ssm	138	1,049	13.2%	cbioportal
3	ARID1A	Ssm	120	1,049	11.4%	cbioportal
4	KMT2D	Ssm	111	1,049	10.6%	cbioportal
5	BCOR	Ssm	109	1,049	10.4%	cbioportal
6	KMT2C	Ssm	99	1,049	9.4%	cbioportal
7	CREBBP	Ssm	98	1,049	9.3%	cbioportal
8	ARID1B	Ssm	82	1,049	7.8%	cbioportal
9	TERT	Ssm	82	1,049	7.8%	cbioportal
10	TP53	Ssm	76	1,049	7.2%	cbioportal
11	EP300	Ssm	74	1,049	7.1%	cbioportal
12	RUNX1	Ssm	71	1,049	6.8%	cbioportal
13	SPEN	Ssm	67	1,049	6.4%	cbioportal
14	BRCA2	Ssm	64	1,049	6.1%	cbioportal
15	ATM	Ssm	59	1,049	5.6%	cbioportal
16	FAT1	Ssm	57	1,049	5.4%	cbioportal
17	PIK3CA	Ssm	54	1,049	5.1%	cbioportal
18	LRP1B	Ssm	52	1,049	5%	cbioportal
19	PIK3R1	Ssm	49	1,049	4.7%	cbioportal
21	NOTCH3	Ssm	44	1,049	4.2%	cbioportal
20	MED12	Ssm	44	1,049	4.2%	cbioportal
23	TSC2	Ssm	43	1,049	4.1%	cbioportal
22	IRS2	Ssm	43	1,049	4.1%	cbioportal
24	FAT3	Ssm	41	1,049	3.9%	cbioportal
25	NTRK1	Ssm	40	1,049	3.8%	cbioportal
26	NOTCH2	Ssm	36	1,049	3.4%	cbioportal
27	SPTA1	Ssm	36	1,049	3.4%	cbioportal
28	PARP4	Ssm	35	1,049	3.3%	cbioportal
29	FBXW7	Ssm	33	1,049	3.1%	cbioportal
30	AR	Ssm	32	1,049	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Adenoid Cystic Carcinoma (Sanger/MDA, JCI 2013) acyc_sanger_2013Sanger/MDA

24 cases with simple somatic mutation data · 24 cases total · 2026-01-05 · mapped to Adenoid Cystic Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPEN	Ssm	5	24	20.8%	cbioportal
2	SMARCA2	Ssm	3	24	12.5%	cbioportal
8	NOTCH1	Ssm	2	24	8.3%	cbioportal
7	KDM6A	Ssm	2	24	8.3%	cbioportal
6	FGFR2	Ssm	2	24	8.3%	cbioportal
9	SLC9C2	Ssm	2	24	8.3%	cbioportal
4	CREBBP	Ssm	2	24	8.3%	cbioportal
3	CNTNAP5	Ssm	2	24	8.3%	cbioportal
5	EP300	Ssm	2	24	8.3%	cbioportal
20	AKAP9	Ssm	1	24	4.2%	cbioportal
22	ANKS4B	Ssm	1	24	4.2%	cbioportal
23	APOA2	Ssm	1	24	4.2%	cbioportal
24	ARID1A	Ssm	1	24	4.2%	cbioportal
25	ARID1B	Ssm	1	24	4.2%	cbioportal
26	ARID5B	Ssm	1	24	4.2%	cbioportal
27	ASCC3	Ssm	1	24	4.2%	cbioportal
28	ATIC	Ssm	1	24	4.2%	cbioportal
29	ATM	Ssm	1	24	4.2%	cbioportal
30	ATN1	Ssm	1	24	4.2%	cbioportal
10	ABCA1	Ssm	1	24	4.2%	cbioportal
11	ACSL6	Ssm	1	24	4.2%	cbioportal
12	ACTB	Ssm	1	24	4.2%	cbioportal
13	ADAM20	Ssm	1	24	4.2%	cbioportal
14	ADAMTS10	Ssm	1	24	4.2%	cbioportal
15	ADAMTSL3	Ssm	1	24	4.2%	cbioportal
16	ADCYAP1	Ssm	1	24	4.2%	cbioportal
17	ADGRL4	Ssm	1	24	4.2%	cbioportal
18	AFDN	Ssm	1	24	4.2%	cbioportal
19	AGO2	Ssm	1	24	4.2%	cbioportal
21	ALOX15	Ssm	1	24	4.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Comprehensive genomic characterization of radiation-related papillary thyroid cancer in the Ukraine REBC-THYRREBC

394 cases with simple somatic mutation data · 449 cases total · Data Release 46.0 · mapped to Thyroid Gland Papillary Carcinoma ALIAS

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	OR11H12	Ssm	104	394	26.4%	gdc
5	FAM243B	Ssm	99	394	25.1%	gdc
4	SMIM34B	Ssm	99	394	25.1%	gdc
3	KCNE1B	Ssm	99	394	25.1%	gdc
2	SMIM11B	Ssm	99	394	25.1%	gdc
6	OR11H1	Ssm	98	394	24.9%	gdc
7	POTEH	Ssm	96	394	24.4%	gdc
8	CNTNAP3C	Ssm	89	394	22.6%	gdc
9	SPATA31A7	Ssm

Data updated 22 days agoSource updated Data Release 46.0

Head and Neck Squamous Cell Carcinoma TCGA-HNSCTCGA

528 cases with simple somatic mutation data · 528 cases total · Data Release 46.0 · mapped to Head and Neck Squamous Cell Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	392	528	74.2%	gdc
2	PIK3CA	Ssm	390	528	73.9%	gdc
3	CSMD3	Ssm	387	528	73.3%	gdc
4	CDKN2A	Ssm	384	528	72.7%	gdc
5	FAM135B	Ssm	383	528	72.5%	gdc
6	PLD1	Ssm	377	528	71.4%	gdc
7	COL22A1	Ssm	376	528	71.2%	gdc
8	CLDN16	Ssm	374	528	70.8%	gdc
12	SI	Ssm	373	528	70.6%	gdc
9	BCL6	Ssm	373	528	70.6%	gdc
13	TP63	Ssm	373	528	70.6%	gdc
14	IL1RAP	Ssm	373	528	70.6%	gdc
11	PKHD1L1	Ssm	373	528	70.6%	gdc
10	MB21D2	Ssm	373	528	70.6%	gdc
15	EIF4G1	Ssm	372	528	70.5%	gdc
20	OSTN	Ssm	372	528	70.5%	gdc
19	SPATA16	Ssm	372	528	70.5%	gdc
18	COL14A1	Ssm	372	528	70.5%	gdc
17	MUC4	Ssm	372	528	70.5%	gdc
16	RUBCN	Ssm	372	528	70.5%	gdc
25	LPP	Ssm	371	528	70.3%	gdc
21	ADCY8	Ssm	371	528	70.3%	gdc
30	PLEC	Ssm	371	528	70.3%	gdc
29	NLGN1	Ssm	371	528	70.3%	gdc
28	FER1L6	Ssm	371	528	70.3%	gdc
27	SLC7A14	Ssm	371	528	70.3%	gdc
26	CCDC50	Ssm	371	528	70.3%	gdc
24	MELTF	Ssm	371	528	70.3%	gdc
23	BDH1	Ssm	371	528	70.3%	gdc
22	FGF12	Ssm	371	528	70.3%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Head and Neck Squamous Cell Carcinoma (Broad, Science 2011) hnsc_broadBroad

74 cases with simple somatic mutation data · 74 cases total · 2026-01-07 · mapped to Head and Neck Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	46	74	62.2%	cbioportal
2	TTN	Ssm	22	74	29.7%	cbioportal
3	SYNE1	Ssm	15	74	20.3%	cbioportal
4	MUC16	Ssm	14	74	18.9%	cbioportal
5	CSMD3	Ssm	12	74	16.2%	cbioportal
6	USH2A	Ssm	11	74	14.9%	cbioportal
7	RYR2	Ssm	10	74	13.5%	cbioportal
10	CUBN	Ssm	9	74	12.2%	cbioportal
9	COL22A1	Ssm	9	74	12.2%	cbioportal
8	CDKN2A	Ssm	9	74	12.2%	cbioportal
16	ZFHX4	Ssm	9	74	12.2%	cbioportal
15	PRDM9	Ssm	9	74	12.2%	cbioportal
14	NOTCH1	Ssm	9	74	12.2%	cbioportal
13	LRP1B	Ssm	9	74	12.2%	cbioportal
12	FAT3	Ssm	9	74	12.2%	cbioportal
11	FAT1	Ssm	9	74	12.2%	cbioportal
22	PCLO	Ssm	8	74	10.8%	cbioportal
21	NAV3	Ssm	8	74	10.8%	cbioportal
20	KMT2D	Ssm	8	74	10.8%	cbioportal
19	HMCN1	Ssm	8	74	10.8%	cbioportal
18	FAT4	Ssm	8	74	10.8%	cbioportal
17	FAT2	Ssm	8	74	10.8%	cbioportal
29	ZNF804B	Ssm	7	74	9.5%	cbioportal
27	SI	Ssm	7	74	9.5%	cbioportal
26	RIMS2	Ssm	7	74	9.5%	cbioportal
25	NSD1	Ssm	7	74	9.5%	cbioportal
24	FREM2	Ssm	7	74	9.5%	cbioportal
23	FLG	Ssm	7	74	9.5%	cbioportal
28	THSD7A	Ssm	7	74	9.5%	cbioportal
30	ADCY8	Ssm	6	74	8.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Head and Neck Squamous Cell Carcinoma (Johns Hopkins, Science 2011) hnsc_jhuJohns Hopkins

32 cases with simple somatic mutation data · 32 cases total · 2026-01-07 · mapped to Head and Neck Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	22	32	68.8%	cbioportal
2	NOTCH1	Ssm	4	32	12.5%	cbioportal
3	RELN	Ssm	4	32	12.5%	cbioportal
4	SYNE1	Ssm	4	32	12.5%	cbioportal
11	SI	Ssm	3	32	9.4%	cbioportal
5	EPHA7	Ssm	3	32	9.4%	cbioportal
6	FLG	Ssm	3	32	9.4%	cbioportal
7	HRAS	Ssm	3	32	9.4%	cbioportal
8	PIK3AP1	Ssm	3	32	9.4%	cbioportal
9	PIK3CA	Ssm	3	32	9.4%	cbioportal
10	RIMBP2	Ssm	3	32	9.4%	cbioportal
14	CACNA1D	Ssm	2	32	6.3%	cbioportal
15	CDKN2A	Ssm	2	32	6.3%	cbioportal
13	ABCD4	Ssm	2	32	6.3%	cbioportal
12	ABCA6	Ssm	2	32	6.3%	cbioportal
30	MMP16	Ssm	2	32	6.3%	cbioportal
29	MICAL2	Ssm	2	32	6.3%	cbioportal
28	MAMDC4	Ssm	2	32	6.3%	cbioportal
27	LRP1B	Ssm	2	32	6.3%	cbioportal
26	LAMA1	Ssm	2	32	6.3%	cbioportal
25	INSC	Ssm	2	32	6.3%	cbioportal
24	GRID1	Ssm	2	32	6.3%	cbioportal
23	GALNT14	Ssm	2	32	6.3%	cbioportal
22	FBXW7	Ssm	2	32	6.3%	cbioportal
21	FAT4	Ssm	2	32	6.3%	cbioportal
20	ENPP1	Ssm	2	32	6.3%	cbioportal
19	DNAI3	Ssm	2	32	6.3%	cbioportal
18	CSMD3	Ssm	2	32	6.3%	cbioportal
17	CR2	Ssm	2	32	6.3%	cbioportal
16	CELSR3	Ssm	2	32	6.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Head and Neck Squamous Cell Carcinoma (TCGA, Firehose Legacy) hnsc_tcgaTCGA

512 cases with simple somatic mutation data · 530 cases total · 2026-01-07 · mapped to Head and Neck Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	366	512	71.5%	cbioportal
2	TTN	Ssm	217	512	42.4%	cbioportal
3	FAT1	Ssm	115	512	22.5%	cbioportal
4	CDKN2A	Ssm	113	512	22.1%	cbioportal
5	FRG1BP	Ssm	106	512	20.7%	cbioportal
6	CSMD3	Ssm	105	512	20.5%	cbioportal
7	MUC16	Ssm	102	512	19.9%	cbioportal
8	PIK3CA	Ssm	94	512	18.4%	cbioportal
9	SYNE1	Ssm	92	512	18%	cbioportal
10	NOTCH1	Ssm	91	512	17.8%	cbioportal
11	LRP1B	Ssm	90	512	17.6%	cbioportal
12	KMT2D	Ssm	84	512	16.4%	cbioportal
13	PCLO	Ssm	82	512	16%	cbioportal
14	FLG	Ssm	76	512	14.8%	cbioportal
15	DNAH5	Ssm	70	512	13.7%	cbioportal
16	USH2A	Ssm	65	512	12.7%	cbioportal
17	NSD1	Ssm	62	512	12.1%	cbioportal
18	RYR2	Ssm	60	512	11.7%	cbioportal
19	PKHD1L1	Ssm	57	512	11.1%	cbioportal
20	XIRP2	Ssm	55	512	10.7%	cbioportal
21	CASP8	Ssm	54	512	10.5%	cbioportal
22	SI	Ssm	54	512	10.5%	cbioportal
23	AHNAK	Ssm	51	512	10%	cbioportal
24	DMD	Ssm	50	512	9.8%	cbioportal
25	FAM135B	Ssm	50	512	9.8%	cbioportal
26	COL11A1	Ssm	49	512	9.6%	cbioportal
27	HUWE1	Ssm	46	512	9%	cbioportal
29	PCDH15	Ssm	46	512	9%	cbioportal
28	PAPPA2	Ssm	46	512	9%	cbioportal
30	RELN	Ssm	46	512	9%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Head and Neck Squamous Cell Carcinoma (TCGA GDC, 2025) hnsc_tcga_gdcTCGA GDC

510 cases with simple somatic mutation data · 530 cases total · 2026-01-13 · mapped to Head and Neck Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	357	510	70%	cbioportal
2	TTN	Ssm	188	510	36.9%	cbioportal
3	FAT1	Ssm	108	510	21.2%	cbioportal
4	CDKN2A	Ssm	103	510	20.2%	cbioportal
5	CSMD3	Ssm	91	510	17.8%	cbioportal
6	MUC16	Ssm	90	510	17.6%	cbioportal
7	NOTCH1	Ssm	89	510	17.5%	cbioportal
8	PIK3CA	Ssm	85	510	16.7%	cbioportal
9	SYNE1	Ssm	83	510	16.3%	cbioportal
10	LRP1B	Ssm	79	510	15.5%	cbioportal
12	PCLO	Ssm	70	510	13.7%	cbioportal
11	KMT2D	Ssm	70	510	13.7%	cbioportal
13	DNAH5	Ssm	65	510	12.7%	cbioportal
14	FLG	Ssm	58	510	11.4%	cbioportal
15	USH2A	Ssm	58	510	11.4%	cbioportal
16	NSD1	Ssm	56	510	11%	cbioportal
17	CASP8	Ssm	53	510	10.4%	cbioportal
18	RYR2	Ssm	50	510	9.8%	cbioportal
19	XIRP2	Ssm	48	510	9.4%	cbioportal
21	PKHD1L1	Ssm	47	510	9.2%	cbioportal
20	FAM135B	Ssm	47	510	9.2%	cbioportal
22	AHNAK	Ssm	46	510	9%	cbioportal
25	HUWE1	Ssm	45	510	8.8%	cbioportal
23	DMD	Ssm	45	510	8.8%	cbioportal
24	DST	Ssm	45	510	8.8%	cbioportal
26	SI	Ssm	44	510	8.6%	cbioportal
27	PAPPA2	Ssm	43	510	8.4%	cbioportal
28	RELN	Ssm	43	510	8.4%	cbioportal
29	FAT3	Ssm	42	510	8.2%	cbioportal
30	COL11A1	Ssm	41	510	8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Head and Neck Squamous Cell Carcinoma (TCGA, Nature 2015) hnsc_tcga_pubTCGA

279 cases with simple somatic mutation data · 279 cases total · 2026-01-07 · mapped to Head and Neck Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	207	279	74.2%	cbioportal
2	TTN	Ssm	127	279	45.5%	cbioportal
3	CSMD3	Ssm	66	279	23.7%	cbioportal
4	FAT1	Ssm	64	279	22.9%	cbioportal
5	CDKN2A	Ssm	63	279	22.6%	cbioportal
6	MUC16	Ssm	60	279	21.5%	cbioportal
7	PIK3CA	Ssm	58	279	20.8%	cbioportal
8	LRP1B	Ssm	57	279	20.4%	cbioportal
9	NOTCH1	Ssm	52	279	18.6%	cbioportal
10	KMT2D	Ssm	49	279	17.6%	cbioportal
11	SYNE1	Ssm	49	279	17.6%	cbioportal
12	FLG	Ssm	44	279	15.8%	cbioportal
13	DNAH5	Ssm	42	279	15.1%	cbioportal
14	PCLO	Ssm	42	279	15.1%	cbioportal
15	USH2A	Ssm	36	279	12.9%	cbioportal
16	PKHD1L1	Ssm	35	279	12.5%	cbioportal
17	SI	Ssm	32	279	11.5%	cbioportal
19	FRG1BP	Ssm	31	279	11.1%	cbioportal
18	DMD	Ssm	31	279	11.1%	cbioportal
20	RYR2	Ssm	31	279	11.1%	cbioportal
21	FAM135B	Ssm	30	279	10.8%	cbioportal
22	NSD1	Ssm	29	279	10.4%	cbioportal
23	RELN	Ssm	28	279	10%	cbioportal
24	COL11A1	Ssm	27	279	9.7%	cbioportal
25	LAMA2	Ssm	27	279	9.7%	cbioportal
26	CUBN	Ssm	26	279	9.3%	cbioportal
27	DNAH7	Ssm	26	279	9.3%	cbioportal
30	MUC17	Ssm	25	279	9%	cbioportal
28	ADGRV1	Ssm	25	279	9%	cbioportal
29	CSMD1	Ssm	25	279	9%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Head and Neck Squamous Cell Carcinoma (TCGA, PanCancer Atlas) hnsc_tcga_pan_can_atlas_2018TCGA

515 cases with simple somatic mutation data · 523 cases total · 2026-06-23 · mapped to Head and Neck Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	357	515	69.3%	cbioportal
2	TTN	Ssm	211	515	41%	cbioportal
3	FAT1	Ssm	111	515	21.6%	cbioportal
4	CDKN2A	Ssm	105	515	20.4%	cbioportal
5	MUC16	Ssm	101	515	19.6%	cbioportal
6	CSMD3	Ssm	97	515	18.8%	cbioportal
7	PIK3CA	Ssm	90	515	17.5%	cbioportal
8	NOTCH1	Ssm	88	515	17.1%	cbioportal
9	LRP1B

Data updated 22 days agoSource updated 2026-06-23

Hereditary SDHB-Mutant Pheochromocytomas and Paragangliomas (A5 Consortium, Nature Comm 2025) hnsc_a5consortium_2025A5 Consortium

94 cases with simple somatic mutation data · 94 cases total · 2026-01-07 · mapped to Head and Neck Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SDHB	Ssm	66	94	70.2%	cbioportal
2	TERT	Ssm	18	94	19.1%	cbioportal
3	MUC17	Ssm	13	94	13.8%	cbioportal
4	GTF2I	Ssm	11	94	11.7%	cbioportal
5	TEX13C	Ssm	11	94	11.7%	cbioportal
6	ATRX	Ssm	9	94	9.6%	cbioportal
8	TCHH	Ssm	6	94	6.4%	cbioportal
7	MDC1	Ssm	6	94	6.4%	cbioportal
11	FLG2	Ssm	5	94	5.3%	cbioportal
9	BLOC1S5-TXNDC5	Ssm	5	94	5.3%	cbioportal
10	FAM47C	Ssm	5	94	5.3%	cbioportal
12	OBSCN	Ssm	5	94	5.3%	cbioportal
22	NBPF11	Ssm	4	94	4.3%	cbioportal
27	TTN	Ssm	4	94	4.3%	cbioportal
26	SECISBP2L	Ssm	4	94	4.3%	cbioportal
25	PRR5-ARHGAP8	Ssm	4	94	4.3%	cbioportal
24	PCNT	Ssm	4	94	4.3%	cbioportal
23	NOX5	Ssm	4	94	4.3%	cbioportal
21	MUC5AC	Ssm	4	94	4.3%	cbioportal
20	MED12	Ssm	4	94	4.3%	cbioportal
19	LINC01618	Ssm	4	94	4.3%	cbioportal
18	DST	Ssm	4	94	4.3%	cbioportal
17	CACNA1E	Ssm	4	94	4.3%	cbioportal
16	CACNA1A	Ssm	4	94	4.3%	cbioportal
15	BCR	Ssm	4	94	4.3%	cbioportal
14	BCOR	Ssm	4	94	4.3%	cbioportal
13	ADAMTS2	Ssm	4	94	4.3%	cbioportal
28	AHNAK	Ssm	3	94	3.2%	cbioportal
30	ANKRD30B	Ssm	3	94	3.2%	cbioportal
29	AMOTL2	Ssm	3	94	3.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Nasopharyngeal Carcinoma (Singapore, Nat Genet 2014) npc_nusingaporeSingapore

56 cases with simple somatic mutation data · 56 cases total · 2026-01-08 · mapped to Nasopharyngeal Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	7	56	12.5%	cbioportal
2	TTN	Ssm	5	56	8.9%	cbioportal
4	SYNE1	Ssm	4	56	7.1%	cbioportal
3	MUC17	Ssm	4	56	7.1%	cbioportal
11	KMT2D	Ssm	3	56	5.4%	cbioportal
15	TET2	Ssm	3	56	5.4%	cbioportal
14	SRCAP	Ssm	3	56	5.4%	cbioportal
13	RYR2	Ssm	3	56	5.4%	cbioportal
12	PTPRS	Ssm	3	56	5.4%	cbioportal
9	FRY	Ssm	3	56	5.4%	cbioportal
10	IGFN1	Ssm	3	56	5.4%	cbioportal
5	AQP7	Ssm	3	56	5.4%	cbioportal
6	BAP1	Ssm	3	56	5.4%	cbioportal
7	CSMD1	Ssm	3	56	5.4%	cbioportal
8	FAT2	Ssm	3	56	5.4%	cbioportal
17	ZNF462	Ssm	3	56	5.4%	cbioportal
16	TFAP2D	Ssm	3	56	5.4%	cbioportal
27	ATG13	Ssm	2	56	3.6%	cbioportal
21	ADGRL2	Ssm	2	56	3.6%	cbioportal
20	ADGRD1	Ssm	2	56	3.6%	cbioportal
19	ADAMTSL1	Ssm	2	56	3.6%	cbioportal
18	ABCC10	Ssm	2	56	3.6%	cbioportal
26	ATAD2	Ssm	2	56	3.6%	cbioportal
25	ARID1A	Ssm	2	56	3.6%	cbioportal
24	ARFGEF3	Ssm	2	56	3.6%	cbioportal
22	AHCTF1	Ssm	2	56	3.6%	cbioportal
23	APOA5	Ssm	2	56	3.6%	cbioportal
30	CCDC27	Ssm	2	56	3.6%	cbioportal
29	CACNA1A	Ssm	2	56	3.6%	cbioportal
28	ATG7	Ssm	2	56	3.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Oral Squamous Cell Carcinoma (MD Anderson, Cancer Discov 2013) hnsc_mdanderson_2013MD Anderson

40 cases with simple somatic mutation data · 40 cases total · 2026-01-07 · mapped to Head and Neck Squamous Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	19	40	47.5%	cbioportal
2	TTN	Ssm	5	40	12.5%	cbioportal
3	FAT1	Ssm	4	40	10%	cbioportal
4	OR2T35	Ssm	4	40	10%	cbioportal
6	EPHA7	Ssm	3	40	7.5%	cbioportal
5	ARHGAP29	Ssm	3	40	7.5%	cbioportal
8	RYR2	Ssm	3	40	7.5%	cbioportal
7	GPRIN2	Ssm	3	40	7.5%	cbioportal
9	ABCA6	Ssm	2	40	5%	cbioportal
29	HCRTR2	Ssm	2	40	5%	cbioportal
28	GDF2	Ssm	2	40	5%	cbioportal
27	GALNT14	Ssm	2	40	5%	cbioportal
26	ERICH3	Ssm	2	40	5%	cbioportal
25	EPG5	Ssm	2	40	5%	cbioportal
24	EGFR	Ssm	2	40	5%	cbioportal
23	DSC1	Ssm	2	40	5%	cbioportal
22	DMKN	Ssm	2	40	5%	cbioportal
21	DCC	Ssm	2	40	5%	cbioportal
20	CSMD3	Ssm	2	40	5%	cbioportal
19	CRABP2	Ssm	2	40	5%	cbioportal
18	COL11A1	Ssm	2	40	5%	cbioportal
17	CASP8	Ssm	2	40	5%	cbioportal
16	CACNA1D	Ssm	2	40	5%	cbioportal
15	BBS9	Ssm	2	40	5%	cbioportal
14	ALPI	Ssm	2	40	5%	cbioportal
13	AKAP12	Ssm	2	40	5%	cbioportal
12	AHNAK2	Ssm	2	40	5%	cbioportal
11	ACSF3	Ssm	2	40	5%	cbioportal
10	ABR	Ssm	2	40	5%	cbioportal
30	HLA-B	Ssm	2	40	5%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Pancreatic Acinar Cell Carcinoma (MSK, JCO 2023) paac_msk_jco_2023MSK

47 cases with simple somatic mutation data · 47 cases total · 2026-01-12 · mapped to Pancreatic Acinar Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SMAD4	Ssm	8	47	17%	cbioportal
2	AXIN1	Ssm	6	47	12.8%	cbioportal
3	CTNNB1	Ssm	6	47	12.8%	cbioportal
4	NF1	Ssm	5	47	10.6%	cbioportal
6	RB1	Ssm	5	47	10.6%	cbioportal
5	PRKAR1A	Ssm	5	47	10.6%	cbioportal
7	CREBBP	Ssm	4	47	8.5%	cbioportal
9	PTEN	Ssm	4	47	8.5%	cbioportal
8	PBRM1	Ssm	4	47	8.5%	cbioportal
155	SLFN11	Ssm	1	13	7.7%	cbioportal
93	GNB1	Ssm	1	13	7.7%	cbioportal
154	SETDB1	Ssm	1	13	7.7%	cbioportal
172	ZNRF3	Ssm	1	13	7.7%	cbioportal
19	MGA	Ssm	3	46	6.5%	cbioportal
12	ATM	Ssm	3	47	6.4%	cbioportal
13	BRAF	Ssm	3	47	6.4%	cbioportal
14	BRCA2	Ssm	3	47	6.4%	cbioportal
15	CDKN2A	Ssm	3	47	6.4%	cbioportal
16	IKBKE	Ssm	3	47	6.4%	cbioportal
17	KMT2D	Ssm	3	47	6.4%	cbioportal
18	MEN1	Ssm	3	47	6.4%	cbioportal
21	PIK3CG	Ssm	3	47	6.4%	cbioportal
22	POLE	Ssm	3	47	6.4%	cbioportal
23	RARA	Ssm	3	47	6.4%	cbioportal
24	SETD2	Ssm	3	47	6.4%	cbioportal
25	TP53	Ssm	3	47	6.4%	cbioportal
26	TSC2	Ssm	3	47	6.4%	cbioportal
20	NRAS	Ssm	3	47	6.4%	cbioportal
10	ARID1A	Ssm	3	47	6.4%	cbioportal
11	ASXL1	Ssm	3	47	6.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Papillary Thyroid Cancer (TCGA GDC, 2025) thpa_tcga_gdcTCGA GDC

496 cases with simple somatic mutation data · 515 cases total · 2026-01-14 · mapped to Thyroid Gland Papillary Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BRAF	Ssm	293	496	59.1%	cbioportal
2	NRAS	Ssm	39	496	7.9%	cbioportal
3	TG	Ssm	19	496	3.8%	cbioportal
4	HRAS	Ssm	17	496	3.4%	cbioportal
5	TTN	Ssm	16	496	3.2%	cbioportal
6	EIF1AX	Ssm	7	496	1.4%	cbioportal
7	KMT2A	Ssm	7	496	1.4%	cbioportal
8	MUC16	Ssm	7	496	1.4%	cbioportal
9	SPTA1	Ssm	7	496	1.4%	cbioportal
10	ZFHX3	Ssm	7	496	1.4%	cbioportal
12	USP9X	Ssm	6	496	1.2%	cbioportal
11	BDP1	Ssm	6	496	1.2%	cbioportal
18	PTPRZ1	Ssm	5	496	1%	cbioportal
19	RYR1	Ssm	5	496	1%	cbioportal
16	PCDH11X	Ssm	5	496	1%	cbioportal
14	ATM	Ssm	5	496	1%	cbioportal
13	AKT1	Ssm	5	496	1%	cbioportal
15	GBF1	Ssm	5	496	1%	cbioportal
17	PDZD2	Ssm	5	496	1%	cbioportal
21	ARFGEF2	Ssm	4	496	0.8%	cbioportal
29	ITPR2	Ssm	4	496	0.8%	cbioportal
28	HMCN1	Ssm	4	496	0.8%	cbioportal
27	GRIN2B	Ssm	4	496	0.8%	cbioportal
26	CSMD2	Ssm	4	496	0.8%	cbioportal
25	CHEK2	Ssm	4	496	0.8%	cbioportal
24	BSN	Ssm	4	496	0.8%	cbioportal
23	BPTF	Ssm	4	496	0.8%	cbioportal
22	ARID2	Ssm	4	496	0.8%	cbioportal
30	JMJD1C	Ssm	4	496	0.8%	cbioportal
20	ABCB11	Ssm	4	496	0.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Papillary Thyroid Carcinoma (TCGA, Cell 2014) thca_tcga_pubTCGA

496 cases with simple somatic mutation data · 496 cases total · 2026-01-13 · mapped to Thyroid Gland Papillary Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BRAF	Ssm	240	496	48.4%	cbioportal
2	TERT	Ssm	37	496	7.5%	cbioportal
3	NRAS	Ssm	34	496	6.9%	cbioportal
4	HRAS	Ssm	14	496	2.8%	cbioportal
5	TTN	Ssm	13	496	2.6%	cbioportal
6	TG	Ssm	11	496	2.2%	cbioportal
7	MUC16	Ssm	10	496	2%	cbioportal
8	DNAH9	Ssm	9	496	1.8%	cbioportal
9	KMT2A	Ssm	7	496	1.4%	cbioportal
10	ZFHX3	Ssm	7	496	1.4%	cbioportal
12	SPTA1	Ssm	6	496	1.2%	cbioportal
11	EIF1AX	Ssm	6	496	1.2%	cbioportal
18	CACNA1E	Ssm	5	496	1%	cbioportal
13	ADGRV1	Ssm	5	496	1%	cbioportal
14	APOB	Ssm	5	496	1%	cbioportal
15	ARID1B	Ssm	5	496	1%	cbioportal
16	ATM	Ssm	5	496	1%	cbioportal
17	BDP1	Ssm	5	496	1%	cbioportal
19	CHEK2	Ssm	5	496	1%	cbioportal
20	COL5A3	Ssm	5	496	1%	cbioportal
21	ITPR2	Ssm	5	496	1%	cbioportal
22	LRP1	Ssm	5	496	1%	cbioportal
23	MUC5B	Ssm	5	496	1%	cbioportal
24	OBSCN	Ssm	5	496	1%	cbioportal
25	OTUD4	Ssm	5	496	1%	cbioportal
26	PPM1D	Ssm	5	496	1%	cbioportal
27	PRKDC	Ssm	5	496	1%	cbioportal
30	CDH8	Ssm	4	496	0.8%	cbioportal
28	ARFGEF2	Ssm	4	496	0.8%	cbioportal
29	CD163	Ssm	4	496	0.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Pituitary Adenoma (MSK, 2026) ptad_msk_2026MSK

62 cases with simple somatic mutation data · 62 cases total · 2026-08-24 · mapped to Pituitary Neuroendocrine Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
118	PPP1R12B	Ssm	2	2	100%	cbioportal
106	MYO10	Ssm	2	2	100%	cbioportal
131	SH3TC1	Ssm	2	2	100%	cbioportal
148	ZNF235	Ssm	2	2	100%	cbioportal
113	OR5A2	Ssm	2	2	100%	cbioportal
144	TRMT6	Ssm	2	2	100%	cbioportal
73	COL16A1	Ssm	2	2	100%	cbioportal
125	RAX2	Ssm	2	2	100%	cbioportal
112	OR51I2	Ssm	2	2	100%	cbioportal
134	SNUPN	Ssm	2	2	100%	cbioportal
146	UAP1	Ssm	2	2	100%	cbioportal
176	CLVS2	Ssm	1	2	50%	cbioportal
182	CTSC	Ssm	1	2	50%	cbioportal
150	ADK	Ssm	1	2	50%	cbioportal
149	ABI3BP	Ssm	1	2	50%	cbioportal
1	TP53	Ssm	22	62	35.5%	cbioportal
2	ATRX	Ssm	10	62	16.1%	cbioportal
8	USP8	Ssm	5	41	12.2%	cbioportal
3	KMT2C	Ssm	7	62	11.3%	cbioportal
4	DAXX	Ssm	6	62	9.7%	cbioportal
7	SPEN	Ssm	5	62	8.1%	cbioportal
5	APC	Ssm	5	62	8.1%	cbioportal
6	MSH6	Ssm	5	62	8.1%	cbioportal
10	ARID2	Ssm	4	62	6.5%	cbioportal
14	LATS2	Ssm	4	62	6.5%	cbioportal
15	MEN1	Ssm	4	62	6.5%	cbioportal
9	ANKRD11	Ssm	4	62	6.5%	cbioportal
12	JAK1	Ssm	4	62	6.5%	cbioportal
13	KDM6A	Ssm	4	62	6.5%	cbioportal
11	EPHB1	Ssm	4	62	6.5%	cbioportal

Data updated 22 days agoSource updated 2026-08-24

Pituitary Adenoma (MSK, Acta Neuropathologica 2024) ptad_msk_2024MSK

104 cases with simple somatic mutation data · 104 cases total · 2026-01-16 · mapped to Pituitary Neuroendocrine Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	15	104	14.4%	cbioportal
125	USP8	Ssm	2	15	13.3%	cbioportal
114	SMARCA2	Ssm	2	15	13.3%	cbioportal
128	ARHGAP35	Ssm	1	15	6.7%	cbioportal
197	KLF5	Ssm	1	15	6.7%	cbioportal
155	CTR9	Ssm	1	15	6.7%	cbioportal
2	KMT2C	Ssm	6	104	5.8%	cbioportal
8	SPEN	Ssm	5	104	4.8%	cbioportal
6	GNAS	Ssm	5	104	4.8%	cbioportal
5	DAXX	Ssm	5	104	4.8%	cbioportal
4	ATRX	Ssm	5	104	4.8%	cbioportal
7	KMT2D	Ssm	5	104	4.8%	cbioportal
3	ANKRD11	Ssm	5	104	4.8%	cbioportal
9	APC	Ssm	4	104	3.8%	cbioportal
18	PIK3CD	Ssm	4	104	3.8%	cbioportal
19	TBX3	Ssm	4	104	3.8%	cbioportal
20	TSC2	Ssm	4	104	3.8%	cbioportal
14	MEN1	Ssm	4	104	3.8%	cbioportal
13	KDM6A	Ssm	4	104	3.8%	cbioportal
12	JAK1	Ssm	4	104	3.8%	cbioportal
10	ASXL1	Ssm	4	104	3.8%	cbioportal
11	EPHB1	Ssm	4	104	3.8%	cbioportal
15	MGA	Ssm	4	104	3.8%	cbioportal
16	MSH6	Ssm	4	104	3.8%	cbioportal
17	NSD1	Ssm	4	104	3.8%	cbioportal
39	PRKD1	Ssm	3	101	3%	cbioportal
28	CSDE1	Ssm	3	101	3%	cbioportal
41	TP53BP1	Ssm	3	101	3%	cbioportal
42	WWTR1	Ssm	3	101	3%	cbioportal
30	INPPL1	Ssm	3	101	3%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Thyroid Carcinoma TCGA-THCATCGA

507 cases with simple somatic mutation data · 507 cases total · Data Release 46.0 · mapped to Thyroid Gland Carcinoma ALIAS

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BRAF	Ssm	302	507	59.6%	gdc
3	THOC5	Ssm	71	507	14%	gdc
2	TCN2	Ssm	71	507	14%	gdc
11	TNRC6B	Ssm	70	507	13.8%	gdc
4	SFI1	Ssm	70	507	13.8%	gdc
5	ZNRF3	Ssm	70	507	13.8%	gdc
6	EIF4ENIF1	Ssm	70	507	13.8%	gdc
7	SEC14L2	Ssm	70	507	13.8%	gdc
8	SEC14L4	Ssm	70	507	13.8%	gdc
9	PISD	Ssm	70	507	13.8%	gdc
10	PLA2G3	Ssm	70	507	13.8%	gdc
12	RFPL1	Ssm	70	507	13.8%	gdc
13	CELSR1	Ssm	70	507	13.8%	gdc
14	DEPDC5	Ssm	70	507	13.8%	gdc
15	SF3A1	Ssm	70	507	13.8%	gdc
17	PATZ1	Ssm	69	507	13.6%	gdc
26	LIMK2	Ssm	69	507	13.6%	gdc
25	SMTN	Ssm	69	507	13.6%	gdc
24	FBXO7	Ssm	69	507	13.6%	gdc
23	PIK3IP1	Ssm	69	507	13.6%	gdc
22	EWSR1	Ssm	69	507	13.6%	gdc
21	TUG1	Ssm	69	507	13.6%	gdc
20	SLC35E4	Ssm	69	507	13.6%	gdc
19	NEFH	Ssm	69	507	13.6%	gdc
18	SLC5A1	Ssm	69	507	13.6%	gdc
30	PES1	Ssm	69	507	13.6%	gdc
29	DRG1	Ssm	69	507	13.6%	gdc
28	CCDC157	Ssm	69	507	13.6%	gdc
16	MORC2	Ssm	69	507	13.6%	gdc
27	MPPED1	Ssm	69	507	13.6%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Thyroid Carcinoma (TCGA, Firehose Legacy) thca_tcgaTCGA

405 cases with simple somatic mutation data · 516 cases total · 2026-01-13 · mapped to Thyroid Gland Papillary Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BRAF	Ssm	242	405	59.8%	cbioportal
2	NRAS	Ssm	34	405	8.4%	cbioportal
3	HRAS	Ssm	14	405	3.5%	cbioportal
4	TTN	Ssm	13	405	3.2%	cbioportal
5	TG	Ssm	11	405	2.7%	cbioportal
6	MUC16	Ssm	10	405	2.5%	cbioportal
7	DNAH9	Ssm	9	405	2.2%	cbioportal
9	ZFHX3	Ssm	7	405	1.7%	cbioportal
8	KMT2A	Ssm	7	405	1.7%	cbioportal
10	EIF1AX	Ssm	6	405	1.5%	cbioportal
11	SPTA1	Ssm	6	405	1.5%	cbioportal
24	OTUD4	Ssm	5	405	1.2%	cbioportal
25	PCDHAC2	Ssm	5	405	1.2%	cbioportal
26	PCDHGC5	Ssm	5	405	1.2%	cbioportal
27	PPM1D	Ssm	5	405	1.2%	cbioportal
28	PRKDC	Ssm	5	405	1.2%	cbioportal
21	LRP1	Ssm	5	405	1.2%	cbioportal
20	ITPR2	Ssm	5	405	1.2%	cbioportal
19	COL5A3	Ssm	5	405	1.2%	cbioportal
18	CHEK2	Ssm	5	405	1.2%	cbioportal
17	CACNA1E	Ssm	5	405	1.2%	cbioportal
16	BDP1	Ssm	5	405	1.2%	cbioportal
23	OBSCN	Ssm	5	405	1.2%	cbioportal
22	MUC5B	Ssm	5	405	1.2%	cbioportal
15	ATM	Ssm	5	405	1.2%	cbioportal
14	ARID1B	Ssm	5	405	1.2%	cbioportal
13	APOB	Ssm	5	405	1.2%	cbioportal
12	ADGRV1	Ssm	5	405	1.2%	cbioportal
30	CD163	Ssm	4	405	1%	cbioportal
29	ARFGEF2	Ssm	4	405	1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Thyroid Carcinoma (TCGA, PanCancer Atlas) thca_tcga_pan_can_atlas_2018TCGA

490 cases with simple somatic mutation data · 500 cases total · 2026-06-04 · mapped to Thyroid Gland Papillary Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BRAF	Ssm	287	490	58.6%	cbioportal
2	NRAS	Ssm	39	490	8%	cbioportal
3	TTN	Ssm	21	490	4.3%	cbioportal
4	TG	Ssm	19	490	3.9%	cbioportal
5	HRAS	Ssm	16	490	3.3%	cbioportal
6	MUC16	Ssm	13	490	2.7%	cbioportal
8	ZFHX3	Ssm	10	490	2%	cbioportal
7	DNAH9	Ssm	10	490	2%	cbioportal
9	SPTA1	Ssm	8	490	1.6%	cbioportal
16	PLEC	Ssm	7	490	1.4%	cbioportal
14	KMT2A	Ssm	7	490	1.4%	cbioportal
13	ITPR2	Ssm	7	490	1.4%	cbioportal
12	EIF1AX	Ssm	7	490	1.4%	cbioportal
15	MACF1	Ssm	7	490	1.4%	cbioportal
11	DNAH2	Ssm	7	490	1.4%	cbioportal
10	COL5A3	Ssm	7	490	1.4%	cbioportal
17	RYR1	Ssm	7	490	1.4%	cbioportal
18	ADGRV1	Ssm	6	490	1.2%	cbioportal
24	PIK3R5	Ssm	6	490	1.2%	cbioportal
23	MUC5B	Ssm	6	490	1.2%	cbioportal
22	KMT2C	Ssm	6	490	1.2%	cbioportal
21	HMCN1	Ssm	6	490	1.2%	cbioportal
20	FAT3	Ssm	6	490	1.2%	cbioportal
19	ATM	Ssm	6	490	1.2%	cbioportal
30	CSMD1	Ssm	5	490	1%	cbioportal
25	AKT1	Ssm	5	490	1%	cbioportal
26	ALPK3	Ssm	5	490	1%	cbioportal
27	BDP1	Ssm	5	490	1%	cbioportal
28	BPTF	Ssm	5	490	1%	cbioportal
29	COL7A1	Ssm	5	490	1%	cbioportal

Data updated 22 days agoSource updated 2026-06-04