EWSR1 — gene · CancerIndex

Curated evidence

Clinical evidence (6)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–6 of 6 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
EWSR1 Fusion1
(diagnostic)	Myoepithelial TumorALIAS	Diagnostic	A	Supports Positive	4	rejected	EID12932 Drawing on previously published large case series and molecular studies, in this 2015 review the authors summarized clinicopathologic, immunophenotypic, and genetic features of myoepithelial neoplasms… (full text at CIViC) PMID 25804378 · Jo et al., 2015 · Open in CIViC	civic
EWSR1 mutation1
(oncogenic)	Mantle Cell Lymphoma	Oncogenic	E	Supports Oncogenicity	3	submitted	EID11846 Somewhat rare but recurrent mutations have been described PMID 32160292 · Pararajalingam et al., 2020 ·

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved8 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Thyroid Carcinoma TCGA-THCA	Thyroid Gland CarcinomaALIAS

Literature

25 per page, newest first.

pubmedPublishedShowing 1–4 of 4 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

EWSR1 Fusion4
(diagnostic)	Myoepithelial TumorALIAS	Diagnostic	B	Supports Positive	3	accepted	EID12926 The authors performed retrospective analysis of 66 myoepithelial (ME) tumors arising outside the salivary glands, including soft tissue, bone, and visceral lesions. The cohort included 36 females and … (full text at CIViC) PMID 20815032 · Antonescu et al., 2010 · Open in CIViC	civic
〃	Myoepithelial TumorALIAS	Diagnostic	B	Supports Positive	3	accepted	EID12927 In this 2024 study, the authors analyzed 40 myoepithelial tumors of soft tissue and bone arising in patients ≤21 years of age. The cohort included 22 females and 18 males, with ages ranging from 3 mon… (full text at CIViC) PMID 38782103 · Logan et al., 2024 · Open in CIViC	civic
〃	Myoepithelial TumorALIAS	Diagnostic	B	Supports Positive	3	accepted	EID12929 In this 2011 study the authors analyzed 18 cutaneous myoepithelial tumors arising in 7 female and 11 male patients, with a median age of 56 years (range 34–86 years). Tumors included 9 mixed tumors, 8… (full text at CIViC) PMID 21725291 · Flucke et al., 2011 · Open in CIViC	civic
〃	Myoepithelial TumorALIAS	Diagnostic	C	Supports Positive	3	accepted	EID12931 In this report the authors described a 9-year-old boy with a myoepithelioma arising in the right posterior mediastinum. The tumor’s deep location is exceptionally rare, with only four well-documented … (full text at CIViC) PMID 36190002 · Du et al., 2022 · Open in CIViC	civic