Gene
PATZ1
POZ/BTB and AT hook containing zinc finger 1
Explore in graph →CI-GENE-00018949HGNC:13071 ENSG00000100105 NCBI 23598 Cancer geneApproved
Curated evidence
Clinical evidence (4)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 31189996
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| PATZ1 Fusion4 | ||||||||
| (diagnostic) | Round Cell Sarcoma with EWSR1-non-ETS Fusion | Diagnostic | C | Supports Positive | 3 | accepted | EID12735This case series study reported 11 neoplasms harboring the EWSR1::PATZ1 gene fusion with 7 in the soft tissue and 4 in the brain. Paired-end sequencing identified a somatic intra-chromosomal paracentr… (full text at CIViC) PMID 31189996 · Bridge et al., 2019 · Open in CIViC | civic |
| 〃 | Round Cell Sarcoma with EWSR1-non-ETS Fusion | Diagnostic | C | Supports Positive | 3 | accepted | EID12738This case series study presented clinical, histopathological, and molecular findings of 9 EWSR1::PATZ1-rearranged sarcomas, including one previously reported case. The cohort included 4 males and 5 fe… (full text at CIViC) PMID 33012788 · Michal et al., 2021 · Open in CIViC | |
Cohorts
Alteration frequency by cohort (2)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 25589618
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Cutaneous Squamous Cell Carcinoma (DFCI, Clin Cancer Res 2015) cscc_dfarber_2015 | Skin Squamous Cell Carcinoma | Ssm | 4 |
Literature
Linked publications (3)
25 per page, newest first.
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)