Gene

ACTL6A

actin like 6A

Curated evidence

Clinical evidence (3)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ACTL6A Overexpression3
Cisplatin	Lung Adenocarcinoma	Predictive	D	Supports Resistance	4	submitted	EID8977 High expression of ACTL6A has been shown to be associated with resistance to cisplatin in multiple cancer types. In vitro experiments using A549 and H1299 lung cancer cell lines showed that overexpres… (full text at CIViC) PMID 33408251 · Xiao et al., 2021 · Open in CIViC	civic
〃	Malignant Ovarian Neoplasm	Predictive	D	Supports Resistance	3	submitted	EID8983 High expression of ACTL6A has been shown to be associated with resistance to cisplatin in multiple cancer types. In vitro experiments using A2780cis ovarian cancer cell line showed that overexpression… (full text at CIViC) PMID 33408251 · Xiao et al., 2021 · Open in CIViC

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved7 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Lung Squamous Cell Carcinoma TCGA-LUSC	Lung Squamous Cell Carcinoma	Ssm

Literature

Data not yet available

No publication linked to this gene yet.