Gene

WWTR1

WW domain containing transcription regulator 1

Explore in graph →CI-GENE-00038935HGNC:24042 ENSG00000018408 NCBI 25937 Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
WWTR1 Fusion1
(diagnostic)	Pseudomyogenic Hemangioendothelioma	Diagnostic	C	Supports Positive	4	accepted	EID12752 In this study, the authors investigated a case of pseudomyogenic hemangioendothelioma in a 33-year-old woman presenting with multifocal lytic bone lesions. Previous studies had demonstrated recurrent … (full text at CIViC) PMID 31243110 · Panagopoulos et al., 2019 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (8)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved8 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm	8

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Fusion of the Genes WWTR1 and FOSB in Pseudomyogenic Hemangioendothelioma.
· Cancer Genomics Proteomics · 2019 · PMID 31243110 · validated civic_curation pubmed