Gene

KLF5

KLF transcription factor 5

Curated evidence

Clinical evidence (2)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–2 of 2 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
KLF5 E419K1
(functional)	—UNRESOLVED	Functional	D	Supports Neomorphic	2	accepted	EID11030 Wild-type and mutant (D418N, E419K, E419Q) KLF5 were infected into HEK293T cells and DNA binding specificity evaluated by ChIP-Seq. The binding motif for wild-type KLF5 has a C or T at the 5th nucleot… (full text at CIViC) PMID 28963353 · Zhang et al., 2018 · Open in CIViC	civic
KLF5 E419Q1
(functional)	—UNRESOLVED	Functional	D	Supports Neomorphic	2	accepted	EID11031 Wild-type and mutant (D418N, E419K, E419Q) KLF5 were infected into HEK293T cells and DNA binding specificity evaluated by ChIP-Seq. The binding motif for wild-type KLF5 has a C or T at the 5th nucleot…

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved10 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Sarcoma TCGA-SARC	Sarcoma	Ssm	139

Literature

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.