Gene

ABCC10

ATP binding cassette subfamily C member 10

Explore in graph →CI-GENE-00000084HGNC:52 ENSG00000124574 NCBI 89845 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ABCC10 Overexpression1
Paclitaxel	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	D	Supports Resistance	3	accepted	EID952 Increased expression of ABCC10 in 17 NSCLC cell lines was inversely correlated with paclitaxel sensitivity (r = 0.574; P < 0.05). PMID 18445659 · Oguri et al., 2008 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (13)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved13 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Breast Cancer Xenografts (British Columbia, Nature 2015) brca_bccrc_xenograft_2014	Invasive Breast Carcinoma	Ssm	14

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

MRP7/ABCC10 expression is a predictive biomarker for the resistance to paclitaxel in non-small cell lung cancer.
· Mol Cancer Ther · 2008 · PMID 18445659 · validated civic_curation pubmed