Breast Neoplasm — Genomics

Breast Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

33 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Adenoid Cystic Carcinoma of the Breast (MSK, J Pathol. 2015) acbc_mskcc_2015MSK

12 cases with simple somatic mutation data · 12 cases total · 2026-08-20 · mapped to Breast Adenoid Cystic Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Breast Cancer (HTAN, 2022) brca_hta9_htan_2022HTAN

5 cases with simple somatic mutation data · 5 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	BNC2	Ssm	5	5	100%	cbioportal
29	ZNF648	Ssm	5	5	100%	cbioportal
28	ZC3H12C	Ssm	5	5	100%	cbioportal
27	THOP1	Ssm	5	5	100%	cbioportal
26	TBC1D5	Ssm	5	5	100%	cbioportal
25	SLITRK3	Ssm	5	5	100%	cbioportal
24	SLC35B3	Ssm	5	5	100%	cbioportal
23	SH2B1	Ssm	5	5	100%	cbioportal
22	SBNO2	Ssm	5	5	100%	cbioportal
21	PREX1	Ssm	5	5	100%	cbioportal
20	PLEKHM1	Ssm	5	5	100%	cbioportal
19	PKHD1L1	Ssm	5	5	100%	cbioportal
18	PEX5L	Ssm	5	5	100%	cbioportal
17	PCNT	Ssm	5	5	100%	cbioportal
16	MYO15A	Ssm	5	5	100%	cbioportal
15	IPO13	Ssm	5	5	100%	cbioportal
14	HSF5	Ssm	5	5	100%	cbioportal
13	GPM6B	Ssm	5	5	100%	cbioportal
12	GDPD2	Ssm	5	5	100%	cbioportal
11	GCA	Ssm	5	5	100%	cbioportal
10	FLG	Ssm	5	5	100%	cbioportal
9	ENTHD1	Ssm	5	5	100%	cbioportal
8	DPM1	Ssm	5	5	100%	cbioportal
7	DNAH6	Ssm	5	5	100%	cbioportal
6	CRTAM	Ssm	5	5	100%	cbioportal
5	CEP55	Ssm	5	5	100%	cbioportal
4	CDK9	Ssm	5	5	100%	cbioportal
3	CCDC158	Ssm	5	5	100%	cbioportal
1	ATP2B2	Ssm	5	5	100%	cbioportal
30	CFAP65	Ssm	4	5	80%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Cancer (METABRIC, Nature 2012 & Nat Commun 2016) brca_metabricMETABRIC

2,433 cases with simple somatic mutation data · 2,509 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	975	2,433	40.1%	cbioportal
2	TP53	Ssm	864	2,433	35.5%	cbioportal
3	MUC16	Ssm	409	2,433	16.8%	cbioportal
4	AHNAK2	Ssm	395	2,433	16.2%	cbioportal
5	SYNE1	Ssm	294	2,433	12.1%	cbioportal
6	KMT2C	Ssm	280	2,433	11.5%	cbioportal
7	GATA3	Ssm	269	2,433	11.1%	cbioportal
8	CDH1	Ssm	236	2,433	9.7%	cbioportal
9	MAP3K1	Ssm	236	2,433	9.7%	cbioportal
10	DNAH11	Ssm	226	2,433	9.3%	cbioportal
11	AHNAK	Ssm	220	2,433	9%	cbioportal
12	DNAH2	Ssm	186	2,433	7.6%	cbioportal
13	KMT2D	Ssm	176	2,433	7.2%	cbioportal
14	USH2A	Ssm	170	2,433	7%	cbioportal
15	DNAH5	Ssm	167	2,433	6.9%	cbioportal
17	RYR2	Ssm	161	2,433	6.6%	cbioportal
16	HERC2	Ssm	161	2,433	6.6%	cbioportal
18	PDE4DIP	Ssm	146	2,433	6%	cbioportal
19	AKAP9	Ssm	143	2,433	5.9%	cbioportal
20	TG	Ssm	137	2,433	5.6%	cbioportal
21	BIRC6	Ssm	128	2,433	5.3%	cbioportal
22	UTRN	Ssm	124	2,433	5.1%	cbioportal
23	TBX3	Ssm	123	2,433	5.1%	cbioportal
24	COL6A3	Ssm	119	2,433	4.9%	cbioportal
25	LAMA2	Ssm	117	2,433	4.8%	cbioportal
26	NOTCH1	Ssm	116	2,433	4.8%	cbioportal
27	ARID1A	Ssm	114	2,433	4.7%	cbioportal
28	CBFB	Ssm	112	2,433	4.6%	cbioportal
29	COL12A1	Ssm	103	2,433	4.2%	cbioportal
30	NCOR2	Ssm	102	2,433	4.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Cancer (MSK, Clinical Cancer Res 2020) brca_pareja_msk_2020MSK

60 cases with simple somatic mutation data · 60 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	29	60	48.3%	cbioportal
2	PIK3CA	Ssm	22	60	36.7%	cbioportal
3	GATA3	Ssm	15	60	25%	cbioportal
4	MUC16	Ssm	9	60	15%	cbioportal
5	AGGF1	Ssm	8	60	13.3%	cbioportal
8	KIF5A	Ssm	7	60	11.7%	cbioportal
6	CCAR1	Ssm	7	60	11.7%	cbioportal
7	CDC27	Ssm	7	60	11.7%	cbioportal
9	TTN	Ssm	7	60	11.7%	cbioportal
13	PKHD1	Ssm	6	60	10%	cbioportal
12	KMT2A	Ssm	6	60	10%	cbioportal
11	DNAH1	Ssm	6	60	10%	cbioportal
10	ARHGAP22	Ssm	6	60	10%	cbioportal
16	RP1	Ssm	6	60	10%	cbioportal
15	PTEN	Ssm	6	60	10%	cbioportal
14	PPL	Ssm	6	60	10%	cbioportal
22	IFT122	Ssm	5	60	8.3%	cbioportal
28	USP8	Ssm	5	60	8.3%	cbioportal
27	SPEN	Ssm	5	60	8.3%	cbioportal
26	SCN4A	Ssm	5	60	8.3%	cbioportal
25	NPAT	Ssm	5	60	8.3%	cbioportal
24	MLXIP	Ssm	5	60	8.3%	cbioportal
21	CBFB	Ssm	5	60	8.3%	cbioportal
23	L3MBTL1	Ssm	5	60	8.3%	cbioportal
17	ADAMTS14	Ssm	5	60	8.3%	cbioportal
18	APOBR	Ssm	5	60	8.3%	cbioportal
19	ARHGEF18	Ssm	5	60	8.3%	cbioportal
20	ATR	Ssm	5	60	8.3%	cbioportal
29	ABCB11	Ssm	4	60	6.7%	cbioportal
30	ABCC5	Ssm	4	60	6.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Cancer (MSK, Nat Genet 2025) breast_msk_2025MSK

3,879 cases with simple somatic mutation data · 3,879 cases total · 2026-01-20 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	1,707	3,879	44%	cbioportal
2	PIK3CA	Ssm	1,401	3,879	36.1%	cbioportal
3	GATA3	Ssm	582	3,879	15%	cbioportal
4	CDH1	Ssm	566	3,879	14.6%	cbioportal
5	ESR1	Ssm	388	3,879	10%	cbioportal
6	KMT2C	Ssm	357	3,879	9.2%	cbioportal
7	MAP3K1	Ssm	314	3,879	8.1%	cbioportal
8	PTEN	Ssm	303	3,879	7.8%	cbioportal
9	ARID1A	Ssm	279	3,879	7.2%	cbioportal
10	TBX3	Ssm	237	3,879	6.1%	cbioportal
11	AKT1	Ssm	220	3,879	5.7%	cbioportal
12	NF1	Ssm	217	3,879	5.6%	cbioportal
13	FOXA1	Ssm	194	3,879	5%	cbioportal
14	KMT2D	Ssm	188	3,879	4.8%	cbioportal
15	ERBB2	Ssm	182	3,879	4.7%	cbioportal
16	MAP2K4	Ssm	169	3,879	4.4%	cbioportal
17	RB1	Ssm	169	3,879	4.4%	cbioportal
18	NCOR1	Ssm	163	3,879	4.2%	cbioportal
19	SPEN	Ssm	157	3,879	4%	cbioportal
20	CBFB	Ssm	153	3,879	3.9%	cbioportal
21	BRCA2	Ssm	152	3,879	3.9%	cbioportal
22	FAT1	Ssm	149	3,879	3.8%	cbioportal
23	RUNX1	Ssm	143	3,879	3.7%	cbioportal
24	ATM	Ssm	126	3,879	3.2%	cbioportal
25	KMT2A	Ssm	122	3,879	3.1%	cbioportal
26	ZFHX3	Ssm	110	3,508	3.1%	cbioportal
52	PREX2	Ssm	76	2,602	2.9%	cbioportal
32	MGA	Ssm	99	3,508	2.8%	cbioportal
27	PIK3R1	Ssm	106	3,879	2.7%	cbioportal
59	KMT2B	Ssm	70	2,602	2.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-20

Breast Cancer (MSK, NPJ Breast Cancer 2019) brca_mskcc_2019MSK

70 cases with simple somatic mutation data · 70 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	35	70	50%	cbioportal
2	TP53	Ssm	19	70	27.1%	cbioportal
3	CDH1	Ssm	15	70	21.4%	cbioportal
4	GATA3	Ssm	12	70	17.1%	cbioportal
5	MAP3K1	Ssm	12	70	17.1%	cbioportal
6	KMT2C	Ssm	10	70	14.3%	cbioportal
7	ERBB2	Ssm	8	70	11.4%	cbioportal
8	MDC1	Ssm	8	70	11.4%	cbioportal
9	BRCA2	Ssm	7	70	10%	cbioportal
11	PTEN	Ssm	7	70	10%	cbioportal
10	MED12	Ssm	7	70	10%	cbioportal
12	ALK	Ssm	6	70	8.6%	cbioportal
14	RUNX1	Ssm	6	70	8.6%	cbioportal
13	ATM	Ssm	6	70	8.6%	cbioportal
15	TSC2	Ssm	6	70	8.6%	cbioportal
16	BRCA1	Ssm	5	70	7.1%	cbioportal
17	EGFR	Ssm	5	70	7.1%	cbioportal
18	ESR1	Ssm	5	70	7.1%	cbioportal
19	NCOR1	Ssm	5	70	7.1%	cbioportal
20	POLE	Ssm	5	70	7.1%	cbioportal
21	PTPRD	Ssm	5	70	7.1%	cbioportal
22	TGFBR2	Ssm	5	70	7.1%	cbioportal
25	FANCA	Ssm	4	70	5.7%	cbioportal
23	ATR	Ssm	4	70	5.7%	cbioportal
24	ERBB3	Ssm	4	70	5.7%	cbioportal
26	FAT1	Ssm	4	70	5.7%	cbioportal
27	MAP2K4	Ssm	4	70	5.7%	cbioportal
28	NOTCH2	Ssm	4	70	5.7%	cbioportal
29	SF3B1	Ssm	4	70	5.7%	cbioportal
30	SPEN	Ssm	4	70	5.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Cancer (SMC 2018) brca_smc_2018

186 cases with simple somatic mutation data · 187 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	89	186	47.8%	cbioportal
2	PIK3CA	Ssm	53	186	28.5%	cbioportal
3	GATA3	Ssm	23	186	12.4%	cbioportal
4	TTN	Ssm	23	186	12.4%	cbioportal
5	MUC16	Ssm	12	186	6.5%	cbioportal
6	CSMD3	Ssm	9	186	4.8%	cbioportal
7	MAP3K1	Ssm	9	186	4.8%	cbioportal
8	MAML3	Ssm	8	186	4.3%	cbioportal
14	NF1	Ssm	7	186	3.8%	cbioportal
10	ARID1A	Ssm	7	186	3.8%	cbioportal
11	KMT2C	Ssm	7	186	3.8%	cbioportal
9	APOB	Ssm	7	186	3.8%	cbioportal
16	UBR4	Ssm	7	186	3.8%	cbioportal
15	SYNE1	Ssm	7	186	3.8%	cbioportal
12	MUC4	Ssm	7	186	3.8%	cbioportal
13	NEB	Ssm	7	186	3.8%	cbioportal
22	ZNF536	Ssm	6	186	3.2%	cbioportal
17	LRP1B	Ssm	6	186	3.2%	cbioportal
18	NEFH	Ssm	6	186	3.2%	cbioportal
19	PKHD1	Ssm	6	186	3.2%	cbioportal
20	PTEN	Ssm	6	186	3.2%	cbioportal
21	USH2A	Ssm	6	186	3.2%	cbioportal
24	AKT1	Ssm	5	186	2.7%	cbioportal
30	COL4A6	Ssm	5	186	2.7%	cbioportal
29	CDH23	Ssm	5	186	2.7%	cbioportal
28	CBFB	Ssm	5	186	2.7%	cbioportal
25	ANK3	Ssm	5	186	2.7%	cbioportal
23	ABCA13	Ssm	5	186	2.7%	cbioportal
27	BIRC6	Ssm	5	186	2.7%	cbioportal
26	ATXN1	Ssm	5	186	2.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Cancer Xenografts (British Columbia, Nature 2015) brca_bccrc_xenograft_2014British Columbia

116 cases with simple somatic mutation data · 117 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	41	116	35.3%	cbioportal
3	SHOC2	Ssm	24	116	20.7%	cbioportal
2	ABCD4	Ssm	24	116	20.7%	cbioportal
5	KALRN	Ssm	22	116	19%	cbioportal
4	FAM47C	Ssm	22	116	19%	cbioportal
6	PLEC	Ssm	21	116	18.1%	cbioportal
9	ZNF415	Ssm	20	116	17.2%	cbioportal
7	NOTCH1	Ssm	20	116	17.2%	cbioportal
8	TTN	Ssm	20	116	17.2%	cbioportal
10	CCER1	Ssm	19	116	16.4%	cbioportal
11	HPS3	Ssm	17	116	14.7%	cbioportal
22	EXOC3L4	Ssm	16	116	13.8%	cbioportal
21	DUSP16	Ssm	16	116	13.8%	cbioportal
20	CAPN9	Ssm	16	116	13.8%	cbioportal
12	ANKRD61	Ssm	16	116	13.8%	cbioportal
13	APOA5	Ssm	16	116	13.8%	cbioportal
14	ARMC12	Ssm	16	116	13.8%	cbioportal
15	ASIC5	Ssm	16	116	13.8%	cbioportal
16	ATXN7L3	Ssm	16	116	13.8%	cbioportal
17	BTNL3	Ssm	16	116	13.8%	cbioportal
18	C2ORF78	Ssm	16	116	13.8%	cbioportal
19	CABLES2	Ssm	16	116	13.8%	cbioportal
30	NPR2	Ssm	16	116	13.8%	cbioportal
29	NOTCH3	Ssm	16	116	13.8%	cbioportal
28	MYT1	Ssm	16	116	13.8%	cbioportal
27	MUC4	Ssm	16	116	13.8%	cbioportal
26	MMP16	Ssm	16	116	13.8%	cbioportal
25	IFNGR2	Ssm	16	116	13.8%	cbioportal
24	GRM1	Ssm	16	116	13.8%	cbioportal
23	GABRQ	Ssm	16	116	13.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Carcinoma (MSK, NPJ Precis Oncol 2025) brca_msk_2025MSK

527 cases with simple somatic mutation data · 527 cases total · 2026-01-20 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	316	527	60%	cbioportal
2	TP53	Ssm	288	527	54.6%	cbioportal
3	CDH1	Ssm	173	527	32.8%	cbioportal
4	KMT2C	Ssm	147	527	27.9%	cbioportal
5	KMT2D	Ssm	108	527	20.5%	cbioportal
6	NF1	Ssm	103	527	19.5%	cbioportal
7	ARID1A	Ssm	92	527	17.5%	cbioportal
8	FAT1	Ssm	89	527	16.9%	cbioportal
9	SPEN	Ssm	88	527	16.7%	cbioportal
10	MAP3K1	Ssm	87	527	16.5%	cbioportal
12	ZFHX3	Ssm	73	488	15%	cbioportal
11	PTEN	Ssm	77	527	14.6%	cbioportal
25	KMT2B	Ssm	57	407	14%	cbioportal
13	FOXA1	Ssm	72	527	13.7%	cbioportal
21	MGA	Ssm	66	488	13.5%	cbioportal
14	NCOR1	Ssm	71	527	13.5%	cbioportal
15	BRCA2	Ssm	70	527	13.3%	cbioportal
16	ATM	Ssm	69	527	13.1%	cbioportal
18	GATA3	Ssm	69	527	13.1%	cbioportal
17	ESR1	Ssm	69	527	13.1%	cbioportal
19	KMT2A	Ssm	68	527	12.9%	cbioportal
20	TBX3	Ssm	67	527	12.7%	cbioportal
22	ATRX	Ssm	61	527	11.6%	cbioportal
23	APC	Ssm	60	527	11.4%	cbioportal
24	ATR	Ssm	59	527	11.2%	cbioportal
28	SETD2	Ssm	54	527	10.2%	cbioportal
27	ROS1	Ssm	54	527	10.2%	cbioportal
26	RB1	Ssm	54	527	10.2%	cbioportal
30	NOTCH4	Ssm	53	527	10.1%	cbioportal
29	ARID1B	Ssm	53	527	10.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-20

Breast Fibroepithelial Tumors (Duke-NUS, Nat Genet 2015) bfn_duke_nus_2015Duke-NUS

22 cases with simple somatic mutation data · 22 cases total · 2026-01-05 · mapped to Breast Fibroepithelial Neoplasm EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MED12	Ssm	10	22	45.5%	cbioportal
3	SETD2	Ssm	5	22	22.7%	cbioportal
2	RARA	Ssm	5	22	22.7%	cbioportal
4	FLNA	Ssm	4	22	18.2%	cbioportal
7	TP53	Ssm	2	22	9.1%	cbioportal
5	BCOR	Ssm	2	22	9.1%	cbioportal
6	KMT2D	Ssm	2	22	9.1%	cbioportal
8	A2M	Ssm	1	22	4.5%	cbioportal
22	ADCY4	Ssm	1	22	4.5%	cbioportal
23	ADGRE2	Ssm	1	22	4.5%	cbioportal
24	ADIPOQ	Ssm	1	22	4.5%	cbioportal
25	AFTPH	Ssm	1	22	4.5%	cbioportal
26	AHDC1	Ssm	1	22	4.5%	cbioportal
27	AHR	Ssm	1	22	4.5%	cbioportal
28	AIFM3	Ssm	1	22	4.5%	cbioportal
29	AKAP11	Ssm	1	22	4.5%	cbioportal
30	ALOX15	Ssm	1	22	4.5%	cbioportal
9	ABCA3	Ssm	1	22	4.5%	cbioportal
10	ABCB1	Ssm	1	22	4.5%	cbioportal
11	ABCB4	Ssm	1	22	4.5%	cbioportal
12	ABCB9	Ssm	1	22	4.5%	cbioportal
13	ABCC9	Ssm	1	22	4.5%	cbioportal
14	ABR	Ssm	1	22	4.5%	cbioportal
15	ACSF3	Ssm	1	22	4.5%	cbioportal
16	ACSM3	Ssm	1	22	4.5%	cbioportal
17	ACTN1	Ssm	1	22	4.5%	cbioportal
18	ACVR1	Ssm	1	22	4.5%	cbioportal
19	ADAM32	Ssm	1	22	4.5%	cbioportal
20	ADAMTS18	Ssm	1	22	4.5%	cbioportal
21	ADAMTS8	Ssm	1	22	4.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Invasive Carcinoma TCGA-BRCATCGA

1,098 cases with simple somatic mutation data · 1,098 cases total · Data Release 46.0 · mapped to Breast Invasive Carcinoma, NOS ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	OBSCN	Ssm	806	1,098	73.4%	gdc
2	PIK3C2B	Ssm	804	1,098	73.2%	gdc
3	NID1	Ssm	803	1,098	73.1%	gdc
4	NFASC	Ssm	803	1,098	73.1%	gdc
6	MDM4	Ssm	803	1,098	73.1%	gdc
7	LRRN2	Ssm	803	1,098	73.1%	gdc
5	USH2A	Ssm	803	1,098	73.1%	gdc
8	PLEKHA6	Ssm	802	1,098	73%	gdc
9	PPP1R15B	Ssm	801	1,098	73%	gdc
10	CDK18	Ssm	800	1,098	72.9%	gdc
12	RYR2	Ssm	800	1,098	72.9%	gdc
11	ASPM	Ssm	800	1,098	72.9%	gdc
17	TMEM81	Ssm	799	1,098	72.8%	gdc
16	SLC35F3	Ssm	799	1,098	72.8%	gdc
15	LYST	Ssm	799	1,098	72.8%	gdc
14	CHI3L1	Ssm	799	1,098	72.8%	gdc
13	EXOC8	Ssm	799	1,098	72.8%	gdc
20	DSTYK	Ssm	799	1,098	72.8%	gdc
19	CNTN2	Ssm	799	1,098	72.8%	gdc
18	TMCC2	Ssm	799	1,098	72.8%	gdc
30	NUAK2	Ssm	798	1,098	72.7%	gdc
28	LEMD1	Ssm	798	1,098	72.7%	gdc
27	ATP2B4	Ssm	798	1,098	72.7%	gdc
26	KISS1	Ssm	798	1,098	72.7%	gdc
25	ZC3H11A	Ssm	798	1,098	72.7%	gdc
24	BLACAT1	Ssm	798	1,098	72.7%	gdc
23	GOLT1A	Ssm	798	1,098	72.7%	gdc
22	GNPAT	Ssm	798	1,098	72.7%	gdc
21	RBBP5	Ssm	798	1,098	72.7%	gdc
29	RAB29	Ssm	798	1,098	72.7%	gdc

Data updated 23 days agoSource updated Data Release 46.0

Breast Invasive Carcinoma (British Columbia, Nature 2012) brca_bccrcBritish Columbia

65 cases with simple somatic mutation data · 65 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	35	65	53.8%	cbioportal
2	PIK3CA	Ssm	7	65	10.8%	cbioportal
3	MYO3A	Ssm	6	65	9.2%	cbioportal
4	USH2A	Ssm	6	65	9.2%	cbioportal
5	PTEN	Ssm	5	65	7.7%	cbioportal
12	SYNE1	Ssm	4	65	6.2%	cbioportal
13	TTN	Ssm	4	65	6.2%	cbioportal
14	UBR5	Ssm	4	65	6.2%	cbioportal
15	ZNF142	Ssm	4	65	6.2%	cbioportal
9	LRP2	Ssm	4	65	6.2%	cbioportal
8	COL6A3	Ssm	4	65	6.2%	cbioportal
7	ATR	Ssm	4	65	6.2%	cbioportal
6	ADGRG4	Ssm	4	65	6.2%	cbioportal
10	MDN1	Ssm	4	65	6.2%	cbioportal
11	RB1	Ssm	4	65	6.2%	cbioportal
28	KATNIP	Ssm	3	65	4.6%	cbioportal
29	LAMA2	Ssm	3	65	4.6%	cbioportal
30	MUC17	Ssm	3	65	4.6%	cbioportal
24	FMN2	Ssm	3	65	4.6%	cbioportal
23	EMSY	Ssm	3	65	4.6%	cbioportal
22	DNAH5	Ssm	3	65	4.6%	cbioportal
21	DLG5	Ssm	3	65	4.6%	cbioportal
20	CEP192	Ssm	3	65	4.6%	cbioportal
19	CELSR1	Ssm	3	65	4.6%	cbioportal
18	BRCA2	Ssm	3	65	4.6%	cbioportal
17	ARHGAP5	Ssm	3	65	4.6%	cbioportal
16	ADGRL2	Ssm	3	65	4.6%	cbioportal
25	GH1	Ssm	3	65	4.6%	cbioportal
26	HECW1	Ssm	3	65	4.6%	cbioportal
27	HRNR	Ssm	3	65	4.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Invasive Carcinoma (Broad, Nature 2012) brca_broadBroad

103 cases with simple somatic mutation data · 103 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	TP53	Ssm	28	103	27.2%	cbioportal
1	PIK3CA	Ssm	28	103	27.2%	cbioportal
3	TTN	Ssm	12	103	11.7%	cbioportal
4	KMT2C	Ssm	7	103	6.8%	cbioportal
5	AKT1	Ssm	6	103	5.8%	cbioportal
7	MUC16	Ssm	6	103	5.8%	cbioportal
6	FLG	Ssm	6	103	5.8%	cbioportal
8	MUC2	Ssm	6	103	5.8%	cbioportal
9	DMD	Ssm	5	103	4.9%	cbioportal
24	SI	Ssm	4	103	3.9%	cbioportal
23	SCN3A	Ssm	4	103	3.9%	cbioportal
22	RYR3	Ssm	4	103	3.9%	cbioportal
21	RYR2	Ssm	4	103	3.9%	cbioportal
20	LRP1B	Ssm	4	103	3.9%	cbioportal
19	HMCN1	Ssm	4	103	3.9%	cbioportal
18	GATA3	Ssm	4	103	3.9%	cbioportal
17	DST	Ssm	4	103	3.9%	cbioportal
16	DNAH8	Ssm	4	103	3.9%	cbioportal
15	CSMD3	Ssm	4	103	3.9%	cbioportal
14	CBFB	Ssm	4	103	3.9%	cbioportal
13	CACNA1E	Ssm	4	103	3.9%	cbioportal
12	ATM	Ssm	4	103	3.9%	cbioportal
11	AGRN	Ssm	4	103	3.9%	cbioportal
10	ADAMTS7	Ssm	4	103	3.9%	cbioportal
26	SYNE1	Ssm	4	103	3.9%	cbioportal
25	SRRM2	Ssm	4	103	3.9%	cbioportal
28	ADAMTS20	Ssm	3	103	2.9%	cbioportal
30	AHNAK	Ssm	3	103	2.9%	cbioportal
29	ADGRG4	Ssm	3	103	2.9%	cbioportal
27	ACE	Ssm	3	103	2.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Invasive Carcinoma (Sanger, Nature 2012) brca_sangerSanger

100 cases with simple somatic mutation data · 100 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	37	100	37%	cbioportal
2	PIK3CA	Ssm	30	100	30%	cbioportal
3	TTN	Ssm	26	100	26%	cbioportal
4	GATA3	Ssm	15	100	15%	cbioportal
5	KMT2C	Ssm	11	100	11%	cbioportal
6	MUC16	Ssm	10	100	10%	cbioportal
7	CDH1	Ssm	8	100	8%	cbioportal
8	BIRC6	Ssm	7	100	7%	cbioportal
9	FSIP2	Ssm	7	100	7%	cbioportal
10	SYNE1	Ssm	7	100	7%	cbioportal
14	MAP3K1	Ssm	6	100	6%	cbioportal
11	CSMD1	Ssm	6	100	6%	cbioportal
17	VPS13C	Ssm	6	100	6%	cbioportal
16	STAB2	Ssm	6	100	6%	cbioportal
13	DST	Ssm	6	100	6%	cbioportal
15	NCOR1	Ssm	6	100	6%	cbioportal
12	DNAH11	Ssm	6	100	6%	cbioportal
19	AKT1	Ssm	5	100	5%	cbioportal
29	TENM1	Ssm	5	100	5%	cbioportal
28	PRRC2B	Ssm	5	100	5%	cbioportal
27	NBAS	Ssm	5	100	5%	cbioportal
26	MAP2K4	Ssm	5	100	5%	cbioportal
25	LRP2	Ssm	5	100	5%	cbioportal
24	HYDIN2	Ssm	5	100	5%	cbioportal
23	HERC1	Ssm	5	100	5%	cbioportal
22	DIDO1	Ssm	5	100	5%	cbioportal
21	BRCA2	Ssm	5	100	5%	cbioportal
20	ARID1B	Ssm	5	100	5%	cbioportal
18	ADGRG4	Ssm	5	100	5%	cbioportal
30	AHNAK	Ssm	4	100	4%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Invasive Carcinoma (TCGA, Cell 2015) brca_tcga_pub2015TCGA

817 cases with simple somatic mutation data · 818 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	282	817	34.5%	cbioportal
2	TP53	Ssm	280	817	34.3%	cbioportal
3	TTN	Ssm	135	817	16.5%	cbioportal
4	CDH1	Ssm	107	817	13.1%	cbioportal
5	GATA3	Ssm	96	817	11.8%	cbioportal
6	MUC16	Ssm	71	817	8.7%	cbioportal
7	MAP3K1	Ssm	69	817	8.4%	cbioportal
8	KMT2C	Ssm	62	817	7.6%	cbioportal
9	MUC4	Ssm	50	817	6.1%	cbioportal
10	MUC12	Ssm	47	817	5.8%	cbioportal
11	PTEN	Ssm	42	817	5.1%	cbioportal
12	FLG	Ssm	41	817	5%	cbioportal
14	SYNE1	Ssm	41	817	5%	cbioportal
13	NCOA3	Ssm	41	817	5%	cbioportal
16	USH2A	Ssm	38	817	4.7%	cbioportal
15	NCOR1	Ssm	38	817	4.7%	cbioportal
17	NEB	Ssm	37	817	4.5%	cbioportal
18	RYR2	Ssm	36	817	4.4%	cbioportal
21	RYR3	Ssm	33	817	4%	cbioportal
19	ARID1A	Ssm	33	817	4%	cbioportal
20	DMD	Ssm	33	817	4%	cbioportal
23	SPEN	Ssm	32	817	3.9%	cbioportal
22	MUC5B	Ssm	32	817	3.9%	cbioportal
24	RUNX1	Ssm	31	817	3.8%	cbioportal
29	MAP2K4	Ssm	30	817	3.7%	cbioportal
28	LRP2	Ssm	30	817	3.7%	cbioportal
27	HMCN1	Ssm	30	817	3.7%	cbioportal
26	FOXA1	Ssm	30	817	3.7%	cbioportal
25	FAT3	Ssm	30	817	3.7%	cbioportal
30	SPTA1	Ssm	30	817	3.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Invasive Carcinoma (TCGA, Firehose Legacy) brca_tcgaTCGA

982 cases with simple somatic mutation data · 1,108 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	319	982	32.5%	cbioportal
2	TP53	Ssm	301	982	30.7%	cbioportal
3	TTN	Ssm	161	982	16.4%	cbioportal
4	CDH1	Ssm	112	982	11.4%	cbioportal
5	GATA3	Ssm	97	982	9.9%	cbioportal
6	MUC16	Ssm	74	982	7.5%	cbioportal
7	MAP3K1	Ssm	71	982	7.2%	cbioportal
8	KMT2C	Ssm	70	982	7.1%	cbioportal
9	MUC12	Ssm	54	982	5.5%	cbioportal
10	MUC4	Ssm	53	982	5.4%	cbioportal
12	USH2A	Ssm	45	982	4.6%	cbioportal
11	FLG	Ssm	45	982	4.6%	cbioportal
13	SYNE1	Ssm	43	982	4.4%	cbioportal
14	RYR2	Ssm	42	982	4.3%	cbioportal
15	NCOR1	Ssm	40	982	4.1%	cbioportal
16	DMD	Ssm	39	982	4%	cbioportal
17	HMCN1	Ssm	37	982	3.8%	cbioportal
20	SYNE2	Ssm	37	982	3.8%	cbioportal
19	RYR3	Ssm	37	982	3.8%	cbioportal
18	NEB	Ssm	37	982	3.8%	cbioportal
21	MUC5B	Ssm	36	982	3.7%	cbioportal
22	FAT3	Ssm	35	982	3.6%	cbioportal
23	HUWE1	Ssm	35	982	3.6%	cbioportal
24	PTEN	Ssm	35	982	3.6%	cbioportal
26	LRP2	Ssm	34	982	3.5%	cbioportal
25	HRNR	Ssm	34	982	3.5%	cbioportal
27	OBSCN	Ssm	33	982	3.4%	cbioportal
29	SPTA1	Ssm	33	982	3.4%	cbioportal
30	ZFHX4	Ssm	33	982	3.4%	cbioportal
28	SPEN	Ssm	33	982	3.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Invasive Carcinoma (TCGA, Nature 2012) brca_tcga_pubTCGA

507 cases with simple somatic mutation data · 825 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	190	507	37.5%	cbioportal
2	PIK3CA	Ssm	179	507	35.3%	cbioportal
3	TTN	Ssm	75	507	14.8%	cbioportal
4	GATA3	Ssm	54	507	10.7%	cbioportal
5	MAP3K1	Ssm	39	507	7.7%	cbioportal
7	MUC16	Ssm	38	507	7.5%	cbioportal
6	KMT2C	Ssm	38	507	7.5%	cbioportal
8	CDH1	Ssm	34	507	6.7%	cbioportal
9	USH2A	Ssm	27	507	5.3%	cbioportal
10	BRCA2	Ssm	24	507	4.7%	cbioportal
11	RYR2	Ssm	23	507	4.5%	cbioportal
12	FLG	Ssm	22	507	4.3%	cbioportal
13	MAP2K4	Ssm	21	507	4.1%	cbioportal
15	FAT3	Ssm	20	507	3.9%	cbioportal
14	ATM	Ssm	20	507	3.9%	cbioportal
17	NEB	Ssm	19	507	3.7%	cbioportal
16	HMCN1	Ssm	19	507	3.7%	cbioportal
18	OBSCN	Ssm	19	507	3.7%	cbioportal
19	BRCA1	Ssm	18	507	3.6%	cbioportal
22	RUNX1	Ssm	18	507	3.6%	cbioportal
21	PTEN	Ssm	18	507	3.6%	cbioportal
20	MUC17	Ssm	18	507	3.6%	cbioportal
23	LRP2	Ssm	17	507	3.4%	cbioportal
26	SYNE1	Ssm	17	507	3.4%	cbioportal
25	NCOR1	Ssm	17	507	3.4%	cbioportal
24	MUC4	Ssm	17	507	3.4%	cbioportal
27	CSMD1	Ssm	16	507	3.2%	cbioportal
29	ZFHX4	Ssm	16	507	3.2%	cbioportal
28	SYNE2	Ssm	16	507	3.2%	cbioportal
30	APOB	Ssm	15	507	3%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Breast Invasive Carcinoma (TCGA, PanCancer Atlas) brca_tcga_pan_can_atlas_2018TCGA

1,066 cases with simple somatic mutation data · 1,084 cases total · 2026-06-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	TP53	Ssm	347	1,066	32.6%	cbioportal
1	PIK3CA	Ssm	347	1,066	32.6%	cbioportal
3	TTN	Ssm	187	1,066	17.5%	cbioportal
4	CDH1	Ssm	130	1,066	12.2%	cbioportal
5	GATA3	Ssm	127	1,066	11.9%	cbioportal
6	MUC16	Ssm	109	1,066	10.2%	cbioportal
7	KMT2C	Ssm	99	1,066	9.3%	cbioportal
8	MAP3K1	Ssm	89	1,066	8.3%	cbioportal
9	FLG	Ssm	66	1,066	6.2%	cbioportal
10	RYR2	Ssm	66	1,066	6.2%	cbioportal
11	SYNE1	Ssm	63	1,066	5.9%	cbioportal
12	USH2A	Ssm	62	1,066	5.8%	cbioportal
13	HMCN1	Ssm	61	1,066	5.7%	cbioportal
14	PTEN	Ssm	58	1,066	5.4%	cbioportal
15	SPTA1	Ssm	54	1,066	5.1%	cbioportal
16	ZFHX4	Ssm	53	1,066	5%	cbioportal
17	NEB	Ssm	52	1,066	4.9%	cbioportal
18	DMD	Ssm	51	1,066	4.8%	cbioportal
19	NCOR1	Ssm	50	1,066	4.7%	cbioportal
21	SYNE2	Ssm	46	1,066	4.3%	cbioportal
20	MUC4	Ssm	46	1,066	4.3%	cbioportal
22	MUC17	Ssm	45	1,066	4.2%	cbioportal
23	CSMD3	Ssm	44	1,066	4.1%	cbioportal
24	OBSCN	Ssm	44	1,066	4.1%	cbioportal
25	RYR3	Ssm	44	1,066	4.1%	cbioportal
26	FAT3	Ssm	43	1,066	4%	cbioportal
28	MAP2K4	Ssm	42	1,066	3.9%	cbioportal
27	CSMD1	Ssm	42	1,066	3.9%	cbioportal
30	PKHD1L1	Ssm	41	1,066	3.8%	cbioportal
29	MACF1	Ssm	41	1,066	3.8%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Count Me In (CMI): The Metastatic Breast Cancer (MBC) Project CMI-MBCCMI

174 cases with simple somatic mutation data · 200 cases total · Data Release 46.0 · mapped to Malignant Breast Neoplasm CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	58	174	33.3%	gdc
2	PIK3CA	Ssm	52	174	29.9%	gdc
3	TTN	Ssm	28	174	16.1%	gdc
4	CDH1	Ssm	22	174	12.6%	gdc
5	GATA3	Ssm	20	174	11.5%	gdc
6	HMCN1	Ssm	16	174	9.2%	gdc
7	MUC16	Ssm	13	174	7.5%	gdc
8	PTEN	Ssm	12	174	6.9%	gdc
10	RYR1	Ssm	11	174	6.3%	gdc
9	TENM2	Ssm	11	174	6.3%	gdc
17	RYR2	Ssm	10	174	5.7%	gdc
13	USH2A	Ssm	10	174	5.7%	gdc
12	RIMS2	Ssm	10	174	5.7%	gdc
14	MUC5B	Ssm	10	174	5.7%	gdc
11	DYNC1H1	Ssm	10	174	5.7%	gdc
15	RELN	Ssm	10	174	5.7%	gdc
16	NF1	Ssm	10	174	5.7%	gdc
18	CUBN	Ssm	9	174	5.2%	gdc
20	ASTN1	Ssm	9	174	5.2%	gdc
21	ARID1A	Ssm	9	174	5.2%	gdc
19	MAP2K4	Ssm	9	174	5.2%	gdc
33	PLEC	Ssm	8	174	4.6%	gdc
29	KMT2C	Ssm	8	174	4.6%	gdc
28	KIAA1109	Ssm	8	174	4.6%	gdc
23	CACNA1H	Ssm	8	174	4.6%	gdc
30	HERC2	Ssm	8	174	4.6%	gdc
22	DST	Ssm	8	174	4.6%	gdc
32	FLNA	Ssm	8	174	4.6%	gdc
31	DNAH5	Ssm	8	174	4.6%	gdc
24	GVINP1	Ssm	8	174	4.6%	gdc

Data updated 23 days agoSource updated Data Release 46.0

Invasive Breast Carcinoma (TCGA GDC, 2025) brca_tcga_gdcTCGA GDC

971 cases with simple somatic mutation data · 1,102 cases total · 2026-01-13 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	334	971	34.4%	cbioportal
2	PIK3CA	Ssm	331	971	34.1%	cbioportal
3	TTN	Ssm	166	971	17.1%	cbioportal
4	CDH1	Ssm	130	971	13.4%	cbioportal
5	GATA3	Ssm	124	971	12.8%	cbioportal
6	MUC16	Ssm	98	971	10.1%	cbioportal
7	KMT2C	Ssm	86	971	8.9%	cbioportal
8	MAP3K1	Ssm	82	971	8.4%	cbioportal
9	HMCN1	Ssm	58	971	6%	cbioportal
10	FLG	Ssm	56	971	5.8%	cbioportal
11	RYR2	Ssm	56	971	5.8%	cbioportal
12	SYNE1	Ssm	53	971	5.5%	cbioportal
13	PTEN	Ssm	52	971	5.4%	cbioportal
14	USH2A	Ssm	52	971	5.4%	cbioportal
15	NCOR1	Ssm	49	971	5%	cbioportal
17	ZFHX4	Ssm	47	971	4.8%	cbioportal
16	SPTA1	Ssm	47	971	4.8%	cbioportal
18	DMD	Ssm	45	971	4.6%	cbioportal
19	MUC17	Ssm	43	971	4.4%	cbioportal
20	NEB	Ssm	42	971	4.3%	cbioportal
21	LRP2	Ssm	40	971	4.1%	cbioportal
23	NF1	Ssm	39	971	4%	cbioportal
22	FAT3	Ssm	39	971	4%	cbioportal
27	SYNE2	Ssm	38	971	3.9%	cbioportal
24	CSMD3	Ssm	38	971	3.9%	cbioportal
25	DST	Ssm	38	971	3.9%	cbioportal
26	MAP2K4	Ssm	38	971	3.9%	cbioportal
29	RYR3	Ssm	37	971	3.8%	cbioportal
28	RUNX1	Ssm	37	971	3.8%	cbioportal
30	APOB	Ssm	36	971	3.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Juvenile Papillomatosis and Breast Cancer (MSK,J Pathol. 2015) brca_jup_msk_2020MSK

5 cases with simple somatic mutation data · 5 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	4	5	80%	cbioportal
2	CES1	Ssm	3	5	60%	cbioportal
3	SMG1	Ssm	3	5	60%	cbioportal
12	KLF2	Ssm	2	5	40%	cbioportal
24	VPS41	Ssm	2	5	40%	cbioportal
23	TLN1	Ssm	2	5	40%	cbioportal
22	TINAG	Ssm	2	5	40%	cbioportal
20	PPP6R3	Ssm	2	5	40%	cbioportal
19	PIK3CB	Ssm	2	5	40%	cbioportal
18	PIK3C2A	Ssm	2	5	40%	cbioportal
17	NUTM2F	Ssm	2	5	40%	cbioportal
16	NUP93	Ssm	2	5	40%	cbioportal
15	MED13	Ssm	2	5	40%	cbioportal
14	MARCHF11	Ssm	2	5	40%	cbioportal
13	KMT2C	Ssm	2	5	40%	cbioportal
11	KEAP1	Ssm	2	5	40%	cbioportal
10	FAM83G	Ssm	2	5	40%	cbioportal
9	ENOX1	Ssm	2	5	40%	cbioportal
8	CTSW	Ssm	2	5	40%	cbioportal
7	CLEC12B	Ssm	2	5	40%	cbioportal
6	CKAP2L	Ssm	2	5	40%	cbioportal
5	ARID1A	Ssm	2	5	40%	cbioportal
4	AKAP12	Ssm	2	5	40%	cbioportal
21	SLC24A4	Ssm	2	5	40%	cbioportal
45	GMIP	Ssm	1	5	20%	cbioportal
31	CLRN1	Ssm	1	5	20%	cbioportal
30	CEP170	Ssm	1	5	20%	cbioportal
29	CD33	Ssm	1	5	20%	cbioportal
28	BTBD17	Ssm	1	5	20%	cbioportal
27	BRWD1	Ssm	1	5	20%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

MAPK on resistance to anti-HER2 therapy for breast cancer (MSK, Nat Commun. 2022) brca_mapk_hp_msk_2021MSK

145 cases with simple somatic mutation data · 145 cases total · 2026-04-07 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	88	145	60.7%	cbioportal
2	PIK3CA	Ssm	42	145	29%	cbioportal
3	GATA3	Ssm	17	145	11.7%	cbioportal
4	CDH1	Ssm	12	145	8.3%	cbioportal
5	ERBB2	Ssm	11	145	7.6%	cbioportal
6	NF1	Ssm	10	145	6.9%	cbioportal
8	TBX3	Ssm	9	145	6.2%	cbioportal
7	KMT2C	Ssm	9	145	6.2%	cbioportal
9	ARID2	Ssm	8	145	5.5%	cbioportal
14	RARA	Ssm	7	145	4.8%	cbioportal
11	ATM	Ssm	7	145	4.8%	cbioportal
13	PTPRD	Ssm	7	145	4.8%	cbioportal
10	ARID1A	Ssm	7	145	4.8%	cbioportal
12	ERBB3	Ssm	7	145	4.8%	cbioportal
15	KMT2D	Ssm	6	145	4.1%	cbioportal
23	ZFHX3	Ssm	5	122	4.1%	cbioportal
20	RECQL4	Ssm	5	145	3.4%	cbioportal
19	PTEN	Ssm	5	145	3.4%	cbioportal
18	PIK3R1	Ssm	5	145	3.4%	cbioportal
16	ALK	Ssm	5	145	3.4%	cbioportal
17	FAT1	Ssm	5	145	3.4%	cbioportal
21	RUNX1	Ssm	5	145	3.4%	cbioportal
22	TET1	Ssm	5	145	3.4%	cbioportal
27	KMT2A	Ssm	4	145	2.8%	cbioportal
28	NCOR1	Ssm	4	145	2.8%	cbioportal
29	NOTCH4	Ssm	4	145	2.8%	cbioportal
26	ESR1	Ssm	4	145	2.8%	cbioportal
30	PTPRS	Ssm	4	145	2.8%	cbioportal
25	EPHA5	Ssm	4	145	2.8%	cbioportal
24	BRD4	Ssm	4	145	2.8%	cbioportal

Data updated 22 days agoSource updated 2026-04-07

Metaplastic Breast Cancer (MSK,NPJ Breast Cancer 2021) mbc_msk_2021MSK

19 cases with simple somatic mutation data · 19 cases total · 2026-01-16 · mapped to Breast Metaplastic Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	16	19	84.2%	cbioportal
4	ZFHX4	Ssm	3	5	60%	cbioportal
6	DPYD	Ssm	2	5	40%	cbioportal
8	KIF26A	Ssm	2	5	40%	cbioportal
14	VPS9D1	Ssm	2	5	40%	cbioportal
5	APOBR	Ssm	2	5	40%	cbioportal
10	MUC22	Ssm	2	5	40%	cbioportal
13	RYR2	Ssm	2	5	40%	cbioportal
2	PIK3CA	Ssm	5	19	26.3%	cbioportal
200	IFT88	Ssm	1	5	20%	cbioportal
175	GAL3ST3	Ssm	1	5	20%	cbioportal
176	GATAD1	Ssm	1	5	20%	cbioportal
177	GATB	Ssm	1	5	20%	cbioportal
178	GDI2	Ssm	1	5	20%	cbioportal
179	GGPS1	Ssm	1	5	20%	cbioportal
180	GGT7	Ssm	1	5	20%	cbioportal
181	GIMAP5	Ssm	1	5	20%	cbioportal
182	GLI2	Ssm	1	5	20%	cbioportal
183	GOLGA7B	Ssm	1	5	20%	cbioportal
184	GPR162	Ssm	1	5	20%	cbioportal
185	GPR183	Ssm	1	5	20%	cbioportal
186	GRM2	Ssm	1	5	20%	cbioportal
187	GRM8	Ssm	1	5	20%	cbioportal
188	GTF3C4	Ssm	1	5	20%	cbioportal
190	HAP1	Ssm	1	5	20%	cbioportal
191	HCST	Ssm	1	5	20%	cbioportal
192	HDAC4	Ssm	1	5	20%	cbioportal
193	HHIPL1	Ssm	1	5	20%	cbioportal
194	HNRNPF	Ssm	1	5	20%	cbioportal
196	ICAM5	Ssm	1	5	20%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Metastatic Breast Cancer (AURORA US Network, Nat Cancer 2023) brca_aurora_2023AURORA US Network

134 cases with simple somatic mutation data · 155 cases total · 2026-01-29 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	58	134	43.3%	cbioportal
2	TTN	Ssm	51	134	38.1%	cbioportal
3	SYNE1	Ssm	41	134	30.6%	cbioportal
4	MUC16	Ssm	40	134	29.9%	cbioportal
6	VPS13B	Ssm	30	134	22.4%	cbioportal
5	RYR2	Ssm	30	134	22.4%	cbioportal
7	USH2A	Ssm	29	134	21.6%	cbioportal
8	SYNE2	Ssm	27	134	20.1%	cbioportal
11	NEB	Ssm	26	134	19.4%	cbioportal
9	HUWE1	Ssm	26	134	19.4%	cbioportal
10	MUC19	Ssm	26	134	19.4%	cbioportal
14	OBSCN	Ssm	25	134	18.7%	cbioportal
12	DST	Ssm	25	134	18.7%	cbioportal
13	LRTM3	Ssm	25	134	18.7%	cbioportal
16	DYNC1H1	Ssm	24	134	17.9%	cbioportal
15	ASPM	Ssm	24	134	17.9%	cbioportal
19	RUNX1T1	Ssm	24	134	17.9%	cbioportal
18	PLEC	Ssm	24	134	17.9%	cbioportal
17	HMCN1	Ssm	24	134	17.9%	cbioportal
20	BLTP1	Ssm	23	134	17.2%	cbioportal
21	MYH15	Ssm	23	134	17.2%	cbioportal
23	CSMD3	Ssm	22	134	16.4%	cbioportal
22	ABCA13	Ssm	22	134	16.4%	cbioportal
28	VPS13D	Ssm	22	134	16.4%	cbioportal
27	TCHH	Ssm	22	134	16.4%	cbioportal
25	RYR3	Ssm	22	134	16.4%	cbioportal
26	SPEN	Ssm	22	134	16.4%	cbioportal
24	KMT2A	Ssm	22	134	16.4%	cbioportal
30	FAM186A	Ssm	21	134	15.7%	cbioportal
29	DNAH5	Ssm	21	134	15.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-29

Metastatic Breast Cancer (DFCI, Cancer Discov 2020) brca_dfci_2020DFCI

59 cases with simple somatic mutation data · 59 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PIK3CA	Ssm	26	59	44.1%	cbioportal
2	TP53	Ssm	21	59	35.6%	cbioportal
3	TTN	Ssm	18	59	30.5%	cbioportal
4	ESR1	Ssm	17	59	28.8%	cbioportal
5	GATA3	Ssm	11	59	18.6%	cbioportal
6	MUC16	Ssm	10	59	16.9%	cbioportal
10	MYO9B	Ssm	8	59	13.6%	cbioportal
11	NEB	Ssm	8	59	13.6%	cbioportal
8	FLG	Ssm	8	59	13.6%	cbioportal
13	TBX3	Ssm	8	59	13.6%	cbioportal
7	CDH1	Ssm	8	59	13.6%	cbioportal
12	OBSCN	Ssm	8	59	13.6%	cbioportal
9	KMT2C	Ssm	8	59	13.6%	cbioportal
15	ARID1A	Ssm	7	59	11.9%	cbioportal
19	PLEC	Ssm	7	59	11.9%	cbioportal
18	MAP2K4	Ssm	7	59	11.9%	cbioportal
17	ATAD5	Ssm	7	59	11.9%	cbioportal
16	ARID2	Ssm	7	59	11.9%	cbioportal
14	AHNAK	Ssm	7	59	11.9%	cbioportal
27	ZFHX4	Ssm	6	59	10.2%	cbioportal
20	ADGRV1	Ssm	6	59	10.2%	cbioportal
21	DCC	Ssm	6	59	10.2%	cbioportal
22	DCHS2	Ssm	6	59	10.2%	cbioportal
23	MED23	Ssm	6	59	10.2%	cbioportal
24	PKHD1	Ssm	6	59	10.2%	cbioportal
25	RIMS2	Ssm	6	59	10.2%	cbioportal
26	TCHH	Ssm	6	59	10.2%	cbioportal
29	AKT1	Ssm	5	59	8.5%	cbioportal
28	ABCA13	Ssm	5	59	8.5%	cbioportal
30	APOB	Ssm	5	59	8.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Metastatic Breast Cancer (INSERM, PLoS Med 2016) brca_igr_2015INSERM

216 cases with simple somatic mutation data · 216 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	84	216	38.9%	cbioportal
2	PIK3CA	Ssm	66	216	30.6%	cbioportal
3	TTN	Ssm	40	216	18.5%	cbioportal
4	GATA3	Ssm	26	216	12%	cbioportal
5	ESR1	Ssm	22	216	10.2%	cbioportal
6	RYR2	Ssm	20	216	9.3%	cbioportal
7	MAP3K1	Ssm	18	216	8.3%	cbioportal
9	FSIP2	Ssm	16	216	7.4%	cbioportal
8	CDH1	Ssm	16	216	7.4%	cbioportal
10	FRAS1	Ssm	15	216	6.9%	cbioportal
13	USH2A	Ssm	15	216	6.9%	cbioportal
12	OBSCN	Ssm	15	216	6.9%	cbioportal
11	HMCN1	Ssm	15	216	6.9%	cbioportal
17	SYNE1	Ssm	14	216	6.5%	cbioportal
15	MUC16	Ssm	14	216	6.5%	cbioportal
14	KMT2C	Ssm	14	216	6.5%	cbioportal
16	RYR3	Ssm	14	216	6.5%	cbioportal
23	PKHD1L1	Ssm	13	216	6%	cbioportal
21	FLG	Ssm	13	216	6%	cbioportal
20	DNAH9	Ssm	13	216	6%	cbioportal
19	DNAH6	Ssm	13	216	6%	cbioportal
18	DMD	Ssm	13	216	6%	cbioportal
22	NEB	Ssm	13	216	6%	cbioportal
25	CACNA1E	Ssm	12	216	5.6%	cbioportal
24	ANK3	Ssm	12	216	5.6%	cbioportal
26	NF1	Ssm	12	216	5.6%	cbioportal
27	PCLO	Ssm	12	216	5.6%	cbioportal
28	RYR1	Ssm	12	216	5.6%	cbioportal
29	TENM3	Ssm	12	216	5.6%	cbioportal
30	XIRP2	Ssm	12	216	5.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Metastatic Triple Negative Breast Cancer (UNC Phase II Trial, J Immunother Cancer 2022) - iAtlas Harmonized brca_iatlas_anders_2022

25 cases with simple somatic mutation data · 31 cases total · 2026-02-11 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	18	25	72%	cbioportal
2	TTN	Ssm	7	25	28%	cbioportal
4	FAT1	Ssm	6	25	24%	cbioportal
3	DST	Ssm	6	25	24%	cbioportal
6	OBSCN	Ssm	6	25	24%	cbioportal
5	LAMA5	Ssm	6	25	24%	cbioportal
7	RYR2	Ssm	6	25	24%	cbioportal
8	SPTA1	Ssm	6	25	24%	cbioportal
14	RYR1	Ssm	5	25	20%	cbioportal
16	SYNE1	Ssm	5	25	20%	cbioportal
9	AEBP1	Ssm	5	25	20%	cbioportal
10	FASN	Ssm	5	25	20%	cbioportal
11	PAPPA2	Ssm	5	25	20%	cbioportal
12	PKHD1L1	Ssm	5	25	20%	cbioportal
13	PLEC	Ssm	5	25	20%	cbioportal
15	SRCAP	Ssm	5	25	20%	cbioportal
24	DNAH9	Ssm	4	25	16%	cbioportal
23	CUX2	Ssm	4	25	16%	cbioportal
22	CEMIP2	Ssm	4	25	16%	cbioportal
21	CARD10	Ssm	4	25	16%	cbioportal
20	CACNA1A	Ssm	4	25	16%	cbioportal
19	ATP2B1	Ssm	4	25	16%	cbioportal
18	ARHGAP32	Ssm	4	25	16%	cbioportal
17	ADGRG5	Ssm	4	25	16%	cbioportal
26	FAT4	Ssm	4	25	16%	cbioportal
27	FGFR3	Ssm	4	25	16%	cbioportal
28	GOLGA2	Ssm	4	25	16%	cbioportal
29	KMT2A	Ssm	4	25	16%	cbioportal
30	KMT2B	Ssm	4	25	16%	cbioportal
25	ERICH3	Ssm	4	25	16%	cbioportal

Data updated 22 days agoSource updated 2026-02-11

Proteogenomic landscape of breast cancer (CPTAC, Cell 2020) brca_cptac_2020CPTAC

122 cases with simple somatic mutation data · 122 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	51	122	41.8%	cbioportal
2	PIK3CA	Ssm	40	122	32.8%	cbioportal
3	TTN	Ssm	33	122	27%	cbioportal
4	MUC16	Ssm	15	122	12.3%	cbioportal
7	HMCN1	Ssm	13	122	10.7%	cbioportal
8	OBSCN	Ssm	13	122	10.7%	cbioportal
5	ABCA13	Ssm	13	122	10.7%	cbioportal
6	AHNAK	Ssm	13	122	10.7%	cbioportal
9	FLG	Ssm	12	122	9.8%	cbioportal
12	RYR1	Ssm	11	122	9%	cbioportal
11	MAP3K1	Ssm	11	122	9%	cbioportal
10	HERC1	Ssm	11	122	9%	cbioportal
15	XIRP2	Ssm	10	122	8.2%	cbioportal
13	KMT2C	Ssm	10	122	8.2%	cbioportal
14	MUC5B	Ssm	10	122	8.2%	cbioportal
16	ADGRV1	Ssm	9	122	7.4%	cbioportal
29	ZFHX4	Ssm	9	122	7.4%	cbioportal
28	TENM4	Ssm	9	122	7.4%	cbioportal
27	SPTA1	Ssm	9	122	7.4%	cbioportal
26	RYR2	Ssm	9	122	7.4%	cbioportal
25	PTEN	Ssm	9	122	7.4%	cbioportal
24	PCLO	Ssm	9	122	7.4%	cbioportal
23	NEB	Ssm	9	122	7.4%	cbioportal
22	FSIP2	Ssm	9	122	7.4%	cbioportal
21	DNAH9	Ssm	9	122	7.4%	cbioportal
20	DNAH11	Ssm	9	122	7.4%	cbioportal
19	CDH1	Ssm	9	122	7.4%	cbioportal
18	BLTP1	Ssm	9	122	7.4%	cbioportal
17	AHNAK2	Ssm	9	122	7.4%	cbioportal
30	ADGRB1	Ssm	8	122	6.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

The Metastatic Breast Cancer Project (Archived, 2020) brca_mbcproject_wagle_2017Archived

237 cases with simple somatic mutation data · 237 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	TP53	Ssm	76	237	32.1%	cbioportal
1	PIK3CA	Ssm	76	237	32.1%	cbioportal
3	TTN	Ssm	51	237	21.5%	cbioportal
4	CDH1	Ssm	34	237	14.3%	cbioportal
5	HMCN1	Ssm	24	237	10.1%	cbioportal
6	GATA3	Ssm	23	237	9.7%	cbioportal
7	MUC16	Ssm	21	237	8.9%	cbioportal
8	PTEN	Ssm	19	237	8%	cbioportal
9	KMT2C	Ssm	17	237	7.2%	cbioportal
10	CSMD3	Ssm	16	237	6.8%	cbioportal
11	DMD	Ssm	16	237	6.8%	cbioportal
12	DNAH5	Ssm	15	237	6.3%	cbioportal
13	USH2A	Ssm	15	237	6.3%	cbioportal
15	HUWE1	Ssm	14	237	5.9%	cbioportal
17	TENM2	Ssm	14	237	5.9%	cbioportal
16	STAB2	Ssm	14	237	5.9%	cbioportal
14	CSMD1	Ssm	14	237	5.9%	cbioportal
18	BLTP1	Ssm	13	237	5.5%	cbioportal
19	MUC5B	Ssm	13	237	5.5%	cbioportal
20	ARID1A	Ssm	12	237	5.1%	cbioportal
21	DST	Ssm	12	237	5.1%	cbioportal
22	FMN2	Ssm	12	237	5.1%	cbioportal
24	SYNE1	Ssm	12	237	5.1%	cbioportal
23	SPTA1	Ssm	12	237	5.1%	cbioportal
25	TBX3	Ssm	12	237	5.1%	cbioportal
28	KDM6B	Ssm	11	237	4.6%	cbioportal
26	CSMD2	Ssm	11	237	4.6%	cbioportal
27	ESR1	Ssm	11	237	4.6%	cbioportal
29	MYT1L	Ssm	11	237	4.6%	cbioportal
30	PKD1	Ssm	11	237	4.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

The Metastatic Breast Cancer Project (Provisional, December 2021) brca_mbcproject_2022Provisional

379 cases with simple somatic mutation data · 379 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	113	379	29.8%	cbioportal
2	TTN	Ssm	82	379	21.6%	cbioportal
3	PIK3CA	Ssm	76	379	20.1%	cbioportal
4	CDH1	Ssm	55	379	14.5%	cbioportal
5	IGDCC4	Ssm	50	379	13.2%	cbioportal
7	MUC16	Ssm	43	379	11.3%	cbioportal
6	ESR1	Ssm	43	379	11.3%	cbioportal
8	HMCN1	Ssm	38	379	10%	cbioportal
9	ZKSCAN1	Ssm	37	379	9.8%	cbioportal
10	GIMAP6	Ssm	36	379	9.5%	cbioportal
11	SYNE1	Ssm	32	379	8.4%	cbioportal
12	RYR2	Ssm	31	379	8.2%	cbioportal
13	GATA3	Ssm	30	379	7.9%	cbioportal
14	RYR1	Ssm	29	379	7.7%	cbioportal
15	ZNF208	Ssm	28	379	7.4%	cbioportal
18	OBSCN	Ssm	27	379	7.1%	cbioportal
17	KMT2C	Ssm	27	379	7.1%	cbioportal
16	CSMD3	Ssm	27	379	7.1%	cbioportal
19	PTEN	Ssm	24	379	6.3%	cbioportal
20	ANK2	Ssm	23	379	6.1%	cbioportal
24	SPTBN4	Ssm	23	379	6.1%	cbioportal
23	RGPD4	Ssm	23	379	6.1%	cbioportal
21	DNAH5	Ssm	23	379	6.1%	cbioportal
22	LPIN1	Ssm	23	379	6.1%	cbioportal
25	ABCA13	Ssm	22	379	5.8%	cbioportal
30	ZNF195	Ssm	22	379	5.8%	cbioportal
26	ANO6	Ssm	22	379	5.8%	cbioportal
27	CHD9	Ssm	22	379	5.8%	cbioportal
28	LCN9	Ssm	22	379	5.8%	cbioportal
29	PKD1	Ssm	22	379	5.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Triple Negative Breast Cancer (DLDCCC, Cancer Discov 2022) brca_dldccc_2022DLDCCC

75 cases with simple somatic mutation data · 75 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	53	75	70.7%	cbioportal
2	TTN	Ssm	19	75	25.3%	cbioportal
3	MUC16	Ssm	14	75	18.7%	cbioportal
4	DNAH8	Ssm	13	75	17.3%	cbioportal
5	OBSCN	Ssm	13	75	17.3%	cbioportal
7	TNXB	Ssm	12	75	16%	cbioportal
6	FLG	Ssm	12	75	16%	cbioportal
10	FBN3	Ssm	11	75	14.7%	cbioportal
8	ADCY10	Ssm	11	75	14.7%	cbioportal
9	DNAH11	Ssm	11	75	14.7%	cbioportal
11	LORICRIN	Ssm	11	75	14.7%	cbioportal
14	FCGBP	Ssm	10	75	13.3%	cbioportal
15	HEATR1	Ssm	10	75	13.3%	cbioportal
16	LAMA5	Ssm	10	75	13.3%	cbioportal
17	MYO15A	Ssm	10	75	13.3%	cbioportal
18	TG	Ssm	10	75	13.3%	cbioportal
12	CACNA1H	Ssm	10	75	13.3%	cbioportal
13	FAM83H	Ssm	10	75	13.3%	cbioportal
30	MKI67	Ssm	9	75	12%	cbioportal
19	ABCA13	Ssm	9	75	12%	cbioportal
20	AHNAK2	Ssm	9	75	12%	cbioportal
21	COL18A1	Ssm	9	75	12%	cbioportal
22	DNAH10	Ssm	9	75	12%	cbioportal
23	DNAH3	Ssm	9	75	12%	cbioportal
24	EPPK1	Ssm	9	75	12%	cbioportal
25	F5	Ssm	9	75	12%	cbioportal
26	GPRIN2	Ssm	9	75	12%	cbioportal
27	GREB1	Ssm	9	75	12%	cbioportal
28	LAMA1	Ssm	9	75	12%	cbioportal
29	LAMC3	Ssm	9	75	12%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Triple-Negative Breast Cancer (FUSCC, Cell Research 2020) brca_fuscc_2020FUSCC

69 cases with simple somatic mutation data · 69 cases total · 2026-01-05 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	48	69	69.6%	cbioportal
2	PIK3CA	Ssm	12	69	17.4%	cbioportal
3	PKD1	Ssm	8	69	11.6%	cbioportal
4	PTEN	Ssm	7	69	10.1%	cbioportal
7	TSC2	Ssm	6	69	8.7%	cbioportal
8	USH2A	Ssm	6	69	8.7%	cbioportal
6	PTPRD	Ssm	6	69	8.7%	cbioportal
5	KMT2D	Ssm	6	69	8.7%	cbioportal
12	FAM47C	Ssm	5	69	7.2%	cbioportal
13	KMT2C	Ssm	5	69	7.2%	cbioportal
14	PLCG1	Ssm	5	69	7.2%	cbioportal
11	EHMT2	Ssm	5	69	7.2%	cbioportal
10	CREBBP	Ssm	5	69	7.2%	cbioportal
9	ARID1B	Ssm	5	69	7.2%	cbioportal
17	ANKRD11	Ssm	4	69	5.8%	cbioportal
18	ARID1A	Ssm	4	69	5.8%	cbioportal
27	ITGB4	Ssm	4	69	5.8%	cbioportal
20	COL2A1	Ssm	4	69	5.8%	cbioportal
21	ERBB2	Ssm	4	69	5.8%	cbioportal
22	ERBB3	Ssm	4	69	5.8%	cbioportal
23	ERCC4	Ssm	4	69	5.8%	cbioportal
24	FASN	Ssm	4	69	5.8%	cbioportal
25	FGFR2	Ssm	4	69	5.8%	cbioportal
26	INSR	Ssm	4	69	5.8%	cbioportal
19	CDH1	Ssm	4	69	5.8%	cbioportal
28	KCNB2	Ssm	4	69	5.8%	cbioportal
30	PIK3R1	Ssm	4	69	5.8%	cbioportal
29	MAP3K1	Ssm	4	69	5.8%	cbioportal
15	AFF2	Ssm	4	69	5.8%	cbioportal
16	AKT1	Ssm	4	69	5.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-05