Cancer Family
Breast Neoplasm
CI-CAN-00000007Explore in graph →
Non-malignant2,893 active trials43 approved drugs310 evidence items
- NCIt
- C2910
- OncoTree
- BNNOS
- MeSH
- D000069584
- MeSH
- D001943
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Cancer Family
CI-CAN-00000007Explore in graph →
Genomics
33 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
971 cases with simple somatic mutation data · 1,102 cases total · 2026-01-13 · mapped to Invasive Breast Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 | Ssm |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 334 |
| 971 |
| 34.4% |
| cbioportal |
| 2 | PIK3CA | Ssm | 331 | 971 | 34.1% | cbioportal |
| 3 | TTN | Ssm | 166 | 971 | 17.1% | cbioportal |
| 4 | CDH1 | Ssm | 130 | 971 | 13.4% | cbioportal |
| 5 | GATA3 | Ssm | 124 | 971 | 12.8% | cbioportal |
| 6 | MUC16 | Ssm | 98 | 971 | 10.1% | cbioportal |
| 7 | KMT2C | Ssm | 86 | 971 | 8.9% | cbioportal |
| 8 | MAP3K1 | Ssm | 82 | 971 | 8.4% | cbioportal |
| 9 | HMCN1 | Ssm | 58 | 971 | 6% | cbioportal |
| 11 | RYR2 | Ssm | 56 | 971 | 5.8% | cbioportal |
| 10 | FLG | Ssm | 56 | 971 | 5.8% | cbioportal |
| 12 | SYNE1 | Ssm | 53 | 971 | 5.5% | cbioportal |
| 14 | USH2A | Ssm | 52 | 971 | 5.4% | cbioportal |
| 13 | PTEN | Ssm | 52 | 971 | 5.4% | cbioportal |
| 15 | NCOR1 | Ssm | 49 | 971 | 5% | cbioportal |
| 16 | SPTA1 | Ssm | 47 | 971 | 4.8% | cbioportal |
| 17 | ZFHX4 | Ssm | 47 | 971 | 4.8% | cbioportal |
| 18 | DMD | Ssm | 45 | 971 | 4.6% | cbioportal |
| 19 | MUC17 | Ssm | 43 | 971 | 4.4% | cbioportal |
| 20 | NEB | Ssm | 42 | 971 | 4.3% | cbioportal |
| 21 | LRP2 | Ssm | 40 | 971 | 4.1% | cbioportal |
| 22 | FAT3 | Ssm | 39 | 971 | 4% | cbioportal |
| 23 | NF1 | Ssm | 39 | 971 | 4% | cbioportal |
| 24 | CSMD3 | Ssm | 38 | 971 | 3.9% | cbioportal |
| 25 | DST | Ssm | 38 | 971 | 3.9% | cbioportal |
| 26 | MAP2K4 | Ssm | 38 | 971 | 3.9% | cbioportal |
| 27 | SYNE2 | Ssm | 38 | 971 | 3.9% | cbioportal |
| 29 | RYR3 | Ssm | 37 | 971 | 3.8% | cbioportal |
| 28 | RUNX1 | Ssm | 37 | 971 | 3.8% | cbioportal |
| 32 | HUWE1 | Ssm | 36 | 971 | 3.7% | cbioportal |
Data updated 21 days agoSource updated 2026-01-13