Gene

ABCB1

ATP binding cassette subfamily B member 1

Curated evidence

Clinical evidence (8)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–8 of 8 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ABCB1 I1145I2
(prognostic)	Malignant Breast Neoplasm	Prognostic	B	Supports Better Outcome	3	accepted	EID1076 A total of 57 women with HER2-positive metastatic breast cancer were analyzed after taxane plus trastuzumab chemotherapy. ABCB1 C3435T carriers had a longer progression-free survival (p = 0.039) along…

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved38 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
CPTAC-Brain, Head and Neck, Kidney, Lung, Pancreas, Uterus CPTAC-3	unmapped	Ssm

Literature

25 per page, newest first.

pubmedPublishedShowing 1–6 of 6 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

ABCB1 Overexpression2
Bafetinib + DasatinibSubstitutes	Chronic Myeloid Leukemia, BCR-ABL1 PositiveALIAS	Predictive	D	Supports Resistance	3	accepted	EID2681 The BCR-ABL1 expressing imatinib-resistant cell line K562/D1-9 overexpresses P-glycoprotein (ABCB1), a known drug membrane transporter. Bafetinib (INNO-406) and dasatinib showed drastically higher IC5… (full text at CIViC) PMID 18191450 · Deguchi et al., 2008 · Open in CIViC	civic
Paclitaxel	Lung Non-Small Cell CarcinomaCURATED_BROADER	Predictive	D	Supports Resistance	2	accepted	EID944 mRNA expression of ABCB1 in 17 NSCLC cell lines was associated with decreased response to paclitaxel (correlation of mRNA expression and paclitaxel IC50: r=0.5322, P=0.0279). PMID 21883677 · Meng et al., 2011 · Open in CIViC	civic

ABCB1 Overexpression + ALK FusionALK ABCB12
Alectinib + LorlatinibSubstitutes	Lung Adenocarcinoma	Predictive	D	Does Not Support Resistance	3	accepted	EID10016 EML4-ALK fusion positive lung adenocarcinoma cell lines with high expression of P-gp (ABCB1 gene) (H3122 and the newly established JFCR013-2) were found to be resistant to crizotinib and ceritinib. P-… (full text at CIViC) PMID 26870817 · Katayama et al., 2016 · Open in CIViC	civic
Ceritinib + CrizotinibSubstitutes	Lung Adenocarcinoma	Predictive	D	Supports Resistance	3	accepted	EID7869 EML4-ALK fusion positive lung adenocarcinoma cell lines (H3122 and the newly established JFCR013-2) with high expression of P-gp (ABCB1 gene) were found to be resistant to crizotinib and ceritinib. P… (full text at CIViC) PMID 26870817 · Katayama et al., 2016 · Open in CIViC	civic