Connective and Soft Tissue Neoplasm — Genomics

Connective and Soft Tissue Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

24 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Count Me In (CMI): The Angiosarcoma (ASC) Project CMI-ASCCMI

36 cases with simple somatic mutation data · 36 cases total · Data Release 46.0 · mapped to Angiosarcoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Ewing Sarcoma (Institut Curie, Cancer Discov 2014) es_iocurie_2014Institut Curie

112 cases with simple somatic mutation data · 115 cases total · 2026-01-07 · mapped to Ewing Sarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	STAG2	Ssm	18	112	16.1%	cbioportal
2	TP53	Ssm	8	112	7.1%	cbioportal
3	CSMD1	Ssm	5	112	4.5%	cbioportal
4	TTN	Ssm	5	112	4.5%	cbioportal
5	EZH2	Ssm	3	112	2.7%	cbioportal
7	RYR2	Ssm	3	112	2.7%	cbioportal
6	MACF1	Ssm	3	112	2.7%	cbioportal
32	HTT	Ssm	2	112	1.8%	cbioportal
31	HSD3B2	Ssm	2	112	1.8%	cbioportal
30	HDC	Ssm	2	112	1.8%	cbioportal
29	HCN1	Ssm	2	112	1.8%	cbioportal
28	GRM4	Ssm	2	112	1.8%	cbioportal
27	GMPR	Ssm	2	112	1.8%	cbioportal
37	KMT2D	Ssm	2	112	1.8%	cbioportal
38	KRT38	Ssm	2	112	1.8%	cbioportal
46	OBSCN	Ssm	2	112	1.8%	cbioportal
48	OTOF	Ssm	2	112	1.8%	cbioportal
36	KMT2C	Ssm	2	112	1.8%	cbioportal
35	KCNG2	Ssm	2	112	1.8%	cbioportal
34	KCNC1	Ssm	2	112	1.8%	cbioportal
33	ISLR2	Ssm	2	112	1.8%	cbioportal
39	LCE1C	Ssm	2	112	1.8%	cbioportal
40	LRIT1	Ssm	2	112	1.8%	cbioportal
41	MROH5	Ssm	2	112	1.8%	cbioportal
42	MUC16	Ssm	2	112	1.8%	cbioportal
43	MYH15	Ssm	2	112	1.8%	cbioportal
44	NCAN	Ssm	2	112	1.8%	cbioportal
45	NUP155	Ssm	2	112	1.8%	cbioportal
47	OR4A16	Ssm	2	112	1.8%	cbioportal
49	PCDHB10	Ssm	2	112	1.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Ewing Sarcoma (MSK, Cancer Research 2024) es_dsrct_msk_2023MSK

290 cases with simple somatic mutation data · 290 cases total · 2026-02-14 · mapped to Ewing Sarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	21	290	7.2%	cbioportal
2	STAG2	Ssm	18	290	6.2%	cbioportal
3	TERT	Ssm	13	290	4.5%	cbioportal
4	ERF	Ssm	10	231	4.3%	cbioportal
6	EZH2	Ssm	9	290	3.1%	cbioportal
5	ARID1A	Ssm	9	290	3.1%	cbioportal
7	CREBBP	Ssm	7	290	2.4%	cbioportal
8	PTEN	Ssm	5	290	1.7%	cbioportal
9	BCOR	Ssm	4	290	1.4%	cbioportal
11	FAT1	Ssm	4	290	1.4%	cbioportal
12	RASA1	Ssm	4	290	1.4%	cbioportal
10	CDKN2A	Ssm	4	290	1.4%	cbioportal
13	SMARCA4	Ssm	4	290	1.4%	cbioportal
29	RAD21	Ssm	3	279	1.1%	cbioportal
30	ZFHX3	Ssm	3	279	1.1%	cbioportal
20	EP300	Ssm	3	290	1%	cbioportal
21	ERG	Ssm	3	290	1%	cbioportal
23	FGFR4	Ssm	3	290	1%	cbioportal
24	FLT1	Ssm	3	290	1%	cbioportal
25	IKZF1	Ssm	3	290	1%	cbioportal
26	KMT2D	Ssm	3	290	1%	cbioportal
27	KRAS	Ssm	3	290	1%	cbioportal
28	NOTCH1	Ssm	3	290	1%	cbioportal
19	DICER1	Ssm	3	290	1%	cbioportal
17	ATM	Ssm	3	290	1%	cbioportal
16	ASXL1	Ssm	3	290	1%	cbioportal
15	ARID2	Ssm	3	290	1%	cbioportal
14	ARID1B	Ssm	3	290	1%	cbioportal
22	FGFR1	Ssm	3	290	1%	cbioportal
18	COP1	Ssm	3	290	1%	cbioportal

Data updated 22 days agoSource updated 2026-02-14

Gastrointestinal Stromal Tumor (MSK 2025) gist_msk_2025

183 cases with simple somatic mutation data · 183 cases total · 2026-01-20 · mapped to Gastrointestinal Stromal Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KIT	Ssm	174	183	95.1%	cbioportal
2	CSDE1	Ssm	26	179	14.5%	cbioportal
3	SETD2	Ssm	21	183	11.5%	cbioportal
4	TP53	Ssm	20	183	10.9%	cbioportal
5	RB1	Ssm	18	183	9.8%	cbioportal
6	FAT1	Ssm	15	183	8.2%	cbioportal
9	ERCC2	Ssm	13	182	7.1%	cbioportal
8	ANKRD11	Ssm	13	182	7.1%	cbioportal
11	MLH1	Ssm	13	183	7.1%	cbioportal
12	PMS2	Ssm	13	183	7.1%	cbioportal
13	TSC1	Ssm	13	183	7.1%	cbioportal
10	FGFR4	Ssm	13	183	7.1%	cbioportal
7	AKT1	Ssm	13	183	7.1%	cbioportal
18	KMT2B	Ssm	12	180	6.7%	cbioportal
17	FUBP1	Ssm	12	182	6.6%	cbioportal
14	ARID1A	Ssm	12	183	6.6%	cbioportal
15	FGFR1	Ssm	12	183	6.6%	cbioportal
16	FOXL2	Ssm	12	183	6.6%	cbioportal
19	MYC	Ssm	11	183	6%	cbioportal
20	RUNX1	Ssm	11	183	6%	cbioportal
22	H3C3	Ssm	10	182	5.5%	cbioportal
23	KDM5A	Ssm	10	183	5.5%	cbioportal
24	MRE11	Ssm	10	183	5.5%	cbioportal
25	NCOR1	Ssm	10	183	5.5%	cbioportal
26	PIK3CG	Ssm	10	183	5.5%	cbioportal
27	TRAF2	Ssm	10	183	5.5%	cbioportal
21	BRCA2	Ssm	10	183	5.5%	cbioportal
28	BRCA1	Ssm	9	183	4.9%	cbioportal
29	MGA	Ssm	9	183	4.9%	cbioportal
30	NF1	Ssm	9	183	4.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-20

Gastrointestinal Stromal Tumor (MSK, NPJ Precis Oncol 2023) gist_msk_2022MSK

499 cases with simple somatic mutation data · 499 cases total · 2026-01-07 · mapped to Gastrointestinal Stromal Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KIT	Ssm	384	499	77%	cbioportal
2	PDGFRA	Ssm	49	499	9.8%	cbioportal
3	TP53	Ssm	21	499	4.2%	cbioportal
5	SETD2	Ssm	20	499	4%	cbioportal
4	NF1	Ssm	20	499	4%	cbioportal
6	MGA	Ssm	18	479	3.8%	cbioportal
7	MAX	Ssm	17	499	3.4%	cbioportal
10	CSDE1	Ssm	12	374	3.2%	cbioportal
8	RB1	Ssm	15	499	3%	cbioportal
11	KMT2B	Ssm	10	374	2.7%	cbioportal
9	PTEN	Ssm	13	499	2.6%	cbioportal
13	TSC1	Ssm	10	499	2%	cbioportal
12	SDHA	Ssm	10	499	2%	cbioportal
14	PIK3CA	Ssm	9	499	1.8%	cbioportal
100	ALB	Ssm	1	66	1.5%	cbioportal
123	CYP19A1	Ssm	1	66	1.5%	cbioportal
186	REST	Ssm	1	66	1.5%	cbioportal
16	ATM	Ssm	7	499	1.4%	cbioportal
15	ARID1A	Ssm	7	499	1.4%	cbioportal
18	KMT2C	Ssm	6	499	1.2%	cbioportal
17	CBL	Ssm	6	499	1.2%	cbioportal
19	MTOR	Ssm	6	499	1.2%	cbioportal
21	ROS1	Ssm	5	499	1%	cbioportal
20	CREBBP	Ssm	5	499	1%	cbioportal
22	ANKRD11	Ssm	4	479	0.8%	cbioportal
28	TGFBR2	Ssm	4	499	0.8%	cbioportal
24	DNMT3A	Ssm	4	499	0.8%	cbioportal
23	ATRX	Ssm	4	499	0.8%	cbioportal
26	IRS2	Ssm	4	499	0.8%	cbioportal
27	JAK1	Ssm	4	499	0.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Gastrointestinal Stromal Tumors (MSK, Clin Cancer Res 2023) gist_msk_2023MSK

469 cases with simple somatic mutation data · 469 cases total · 2026-01-07 · mapped to Gastrointestinal Stromal Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KIT	Ssm	353	469	75.3%	cbioportal
2	PDGFRA	Ssm	52	469	11.1%	cbioportal
4	TP53	Ssm	21	469	4.5%	cbioportal
3	NF1	Ssm	21	469	4.5%	cbioportal
5	SETD2	Ssm	19	469	4.1%	cbioportal
7	MGA	Ssm	18	447	4%	cbioportal
6	MAX	Ssm	18	469	3.8%	cbioportal
8	RB1	Ssm	17	469	3.6%	cbioportal
49	APLNR	Ssm	2	61	3.3%	cbioportal
9	CSDE1	Ssm	11	342	3.2%	cbioportal
10	PTEN	Ssm	10	469	2.1%	cbioportal
11	PIK3CA	Ssm	9	469	1.9%	cbioportal
12	SDHA	Ssm	9	469	1.9%	cbioportal
13	ARID1A	Ssm	8	469	1.7%	cbioportal
14	TSC1	Ssm	8	469	1.7%	cbioportal
175	REST	Ssm	1	61	1.6%	cbioportal
138	KBTBD4	Ssm	1	61	1.6%	cbioportal
113	CYP19A1	Ssm	1	61	1.6%	cbioportal
15	CREBBP	Ssm	7	469	1.5%	cbioportal
16	KMT2D	Ssm	7	469	1.5%	cbioportal
18	ROS1	Ssm	6	469	1.3%	cbioportal
17	MTOR	Ssm	6	469	1.3%	cbioportal
23	ZFHX3	Ssm	5	447	1.1%	cbioportal
22	KMT2C	Ssm	5	469	1.1%	cbioportal
21	KMT2A	Ssm	5	469	1.1%	cbioportal
20	CBL	Ssm	5	469	1.1%	cbioportal
19	ATM	Ssm	5	469	1.1%	cbioportal
38	KMT2B	Ssm	3	342	0.9%	cbioportal
29	PIK3C2G	Ssm	4	469	0.9%	cbioportal
30	PIK3R1	Ssm	4	469	0.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Liposarcoma (MSK, 2026) lipo_msk_2026MSK

277 cases with simple somatic mutation data · 277 cases total · 2026-08-21 · mapped to Liposarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	CRIPAK	Ssm	27	277	9.7%	cbioportal
2	ZFHX3	Ssm	20	277	7.2%	cbioportal
3	MDN1	Ssm	19	277	6.9%	cbioportal
5	NUP107	Ssm	17	277	6.1%	cbioportal
4	ATRX	Ssm	17	277	6.1%	cbioportal
6	NAV3	Ssm	15	277	5.4%	cbioportal
7	NOTCH3	Ssm	14	277	5.1%	cbioportal
8	WDR87	Ssm	14	277	5.1%	cbioportal
11	LAMA5	Ssm	12	277	4.3%	cbioportal
10	FRS2	Ssm	12	277	4.3%	cbioportal
9	FLG2	Ssm	12	277	4.3%	cbioportal
12	ADGRG4	Ssm	11	277	4%	cbioportal
14	RNF213	Ssm	11	277	4%	cbioportal
13	CSMD1	Ssm	11	277	4%	cbioportal
17	METTL1	Ssm	10	277	3.6%	cbioportal
16	FRAS1	Ssm	10	277	3.6%	cbioportal
15	DNAH1	Ssm	10	277	3.6%	cbioportal
20	PRRC2A	Ssm	10	277	3.6%	cbioportal
19	PCNT	Ssm	10	277	3.6%	cbioportal
18	NUP98	Ssm	10	277	3.6%	cbioportal
24	SPEG	Ssm	9	277	3.2%	cbioportal
22	MEGF6	Ssm	9	277	3.2%	cbioportal
21	DOCK4	Ssm	9	277	3.2%	cbioportal
25	TSC2	Ssm	9	277	3.2%	cbioportal
23	MGA	Ssm	9	277	3.2%	cbioportal
28	MALRD1	Ssm	8	277	2.9%	cbioportal
27	LMNB2	Ssm	8	277	2.9%	cbioportal
26	ERBB4	Ssm	8	277	2.9%	cbioportal
29	AKAP11	Ssm	7	277	2.5%	cbioportal
30	FLNA	Ssm	7	277	2.5%	cbioportal

Data updated 22 days agoSource updated 2026-08-21

Malignant Peripheral Nerve Sheath Tumor (MSK, Nat Genet 2014) mpnst_mskccMSK

15 cases with simple somatic mutation data · 15 cases total · 2026-01-08 · mapped to Malignant Peripheral Nerve Sheath Tumor EXACT_IDENTIFIER

cbioportalObserved19 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	EED	Ssm	5	15	33.3%	cbioportal
2	NF1	Ssm	4	15	26.7%	cbioportal
6	TP53	Ssm	2	15	13.3%	cbioportal
4	DAXX	Ssm	2	15	13.3%	cbioportal
5	HNF1A	Ssm	2	15	13.3%	cbioportal
3	BCL2L1	Ssm	2	15	13.3%	cbioportal
7	BRCA2	Ssm	1	15	6.7%	cbioportal
14	NCOR1	Ssm	1	15	6.7%	cbioportal
13	MUTYH	Ssm	1	15	6.7%	cbioportal
12	MTOR	Ssm	1	15	6.7%	cbioportal
11	IKZF1	Ssm	1	15	6.7%	cbioportal
10	IKBKE	Ssm	1	15	6.7%	cbioportal
9	HGF	Ssm	1	15	6.7%	cbioportal
19	SUFU	Ssm	1	15	6.7%	cbioportal
18	RB1	Ssm	1	15	6.7%	cbioportal
17	PTCH1	Ssm	1	15	6.7%	cbioportal
16	PIK3CA	Ssm	1	15	6.7%	cbioportal
15	PIK3C2G	Ssm	1	15	6.7%	cbioportal
8	FLT4	Ssm	1	15	6.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Meningioma (University of Toronto, Nature 2021) mng_utoronto_2021University of Toronto

115 cases with simple somatic mutation data · 121 cases total · 2026-01-08 · mapped to Meningioma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NF2	Ssm	64	115	55.7%	cbioportal
2	TTN	Ssm	23	115	20%	cbioportal
3	OBSCN	Ssm	12	115	10.4%	cbioportal
4	FLG	Ssm	10	115	8.7%	cbioportal
5	TRAF7	Ssm	8	115	7%	cbioportal
6	PLEC	Ssm	7	115	6.1%	cbioportal
11	NOTCH1	Ssm	6	115	5.2%	cbioportal
10	DNMT3A	Ssm	6	115	5.2%	cbioportal
9	DNAH3	Ssm	6	115	5.2%	cbioportal
13	SALL3	Ssm	6	115	5.2%	cbioportal
8	CREBBP	Ssm	6	115	5.2%	cbioportal
7	CMYA5	Ssm	6	115	5.2%	cbioportal
12	RYR2	Ssm	6	115	5.2%	cbioportal
14	SMARCB1	Ssm	6	115	5.2%	cbioportal
27	KMT2A	Ssm	5	115	4.3%	cbioportal
21	DMD	Ssm	5	115	4.3%	cbioportal
22	DNAH9	Ssm	5	115	4.3%	cbioportal
23	ESPNL	Ssm	5	115	4.3%	cbioportal
24	GON4L	Ssm	5	115	4.3%	cbioportal
25	KDM6A	Ssm	5	115	4.3%	cbioportal
26	KLF4	Ssm	5	115	4.3%	cbioportal
20	CHD2	Ssm	5	115	4.3%	cbioportal
28	MAP1B	Ssm	5	115	4.3%	cbioportal
29	PDPR	Ssm	5	115	4.3%	cbioportal
30	PTEN	Ssm	5	115	4.3%	cbioportal
15	AMBRA1	Ssm	5	115	4.3%	cbioportal
16	ARHGAP33	Ssm	5	115	4.3%	cbioportal
17	ARMC5	Ssm	5	115	4.3%	cbioportal
18	ATN1	Ssm	5	115	4.3%	cbioportal
19	BLTP1	Ssm	5	115	4.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Myoepithelial Carcinomas of Soft Tissue (WCM, CSH Molecular Case Studies 2022) stmyec_wcm_2022WCM

12 cases with simple somatic mutation data · 12 cases total · 2026-01-13 · mapped to Malignant Myoepithelioma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	CORO2A	Ssm	6	12	50%	cbioportal
3	KCNJ10	Ssm	5	12	41.7%	cbioportal
4	OXA1L	Ssm	5	12	41.7%	cbioportal
5	SPECC1	Ssm	5	12	41.7%	cbioportal
6	STON1	Ssm	5	12	41.7%	cbioportal
7	SYT7	Ssm	5	12	41.7%	cbioportal
2	COL4A2	Ssm	5	12	41.7%	cbioportal
14	RBM14-RBM4	Ssm	4	12	33.3%	cbioportal
8	CDCP1	Ssm	4	12	33.3%	cbioportal
9	DCHS1	Ssm	4	12	33.3%	cbioportal
10	EPPK1	Ssm	4	12	33.3%	cbioportal
11	FRAS1	Ssm	4	12	33.3%	cbioportal
12	ITGB4	Ssm	4	12	33.3%	cbioportal
13	NUP50	Ssm	4	12	33.3%	cbioportal
16	PTGFR	Ssm	3	12	25%	cbioportal
15	POLE	Ssm	3	12	25%	cbioportal
17	SCNN1G	Ssm	3	12	25%	cbioportal
18	CELF4	Ssm	2	12	16.7%	cbioportal
23	TMEM121	Ssm	2	12	16.7%	cbioportal
22	TGFBR1	Ssm	2	12	16.7%	cbioportal
21	PTPN21	Ssm	2	12	16.7%	cbioportal
20	PRSS1	Ssm	2	12	16.7%	cbioportal
19	LRP10	Ssm	2	12	16.7%	cbioportal
29	BRAF	Ssm	1	12	8.3%	cbioportal
28	ASMTL	Ssm	1	12	8.3%	cbioportal
24	AMPD3	Ssm	1	12	8.3%	cbioportal
43	GABRB3	Ssm	1	12	8.3%	cbioportal
25	ARHGEF2	Ssm	1	12	8.3%	cbioportal
26	ARHGEF40	Ssm	1	12	8.3%	cbioportal
27	ARIH2	Ssm	1	12	8.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Osteosarcoma TARGET-OSTARGET

145 cases with simple somatic mutation data · 383 cases total · Data Release 46.0 · mapped to Osteosarcoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	70	145	48.3%	gdc
3	FOXO3B	Ssm	68	145	46.9%	gdc
2	TBC1D28	Ssm	68	145	46.9%	gdc
4	TRIM16L	Ssm	68	145	46.9%	gdc
13	AC005324.2	Ssm	67	145	46.2%	gdc
15	TVP23C-CDRT4	Ssm	67	145	46.2%	gdc
14	MIEF2	Ssm	67	145	46.2%	gdc
11	SLC5A10	Ssm	67	145	46.2%	gdc
10	FLII	Ssm	67	145	46.2%	gdc
9	PRPSAP2	Ssm	67	145	46.2%	gdc
17	SMCR8	Ssm	67	145	46.2%	gdc
16	TOP3A	Ssm	67	145	46.2%	gdc
8	TVP23B	Ssm	67	145	46.2%	gdc
6	FBXW10	Ssm	67	145	46.2%	gdc
5	EVPLL	Ssm	67	145	46.2%	gdc
21	FAM83G	Ssm	67	145	46.2%	gdc
20	SHMT1	Ssm	67	145	46.2%	gdc
19	GRAP	Ssm	67	145	46.2%	gdc
12	TVP23C	Ssm	67	145	46.2%	gdc
7	CDRT4	Ssm	67	145	46.2%	gdc
18	LGALS9C	Ssm	67	145	46.2%	gdc
44	LLGL1	Ssm	66	145	45.5%	gdc
22	ZNF286A	Ssm	66	145	45.5%	gdc
49	ALDH3A1	Ssm	66	145	45.5%	gdc
48	MTSS1	Ssm	66	145	45.5%	gdc
47	CDRT1	Ssm	66	145	45.5%	gdc
46	B9D1	Ssm	66	145	45.5%	gdc
45	LGALS9B	Ssm	66	145	45.5%	gdc
43	TRIM16	Ssm	66	145	45.5%	gdc
42	DRG2	Ssm	66	145	45.5%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Osteosarcoma (TARGET GDC, 2025) os_target_gdcTARGET GDC

143 cases with simple somatic mutation data · 159 cases total · 2026-01-14 · mapped to Osteosarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	32	143	22.4%	cbioportal
2	MUC16	Ssm	16	143	11.2%	cbioportal
3	TTN	Ssm	16	143	11.2%	cbioportal
4	ATRX	Ssm	11	143	7.7%	cbioportal
5	DNAH9	Ssm	10	143	7%	cbioportal
6	RB1	Ssm	8	143	5.6%	cbioportal
8	DMD	Ssm	7	143	4.9%	cbioportal
7	CNTNAP5	Ssm	7	143	4.9%	cbioportal
10	PCLO	Ssm	7	143	4.9%	cbioportal
9	MUC4	Ssm	7	143	4.9%	cbioportal
11	CSMD3	Ssm	6	143	4.2%	cbioportal
14	RYR2	Ssm	5	143	3.5%	cbioportal
12	ADGRV1	Ssm	5	143	3.5%	cbioportal
13	DNAH3	Ssm	5	143	3.5%	cbioportal
21	HECTD4	Ssm	4	143	2.8%	cbioportal
17	CSMD1	Ssm	4	143	2.8%	cbioportal
18	CSMD2	Ssm	4	143	2.8%	cbioportal
19	DNAI4	Ssm	4	143	2.8%	cbioportal
20	GRM5	Ssm	4	143	2.8%	cbioportal
22	LAMA1	Ssm	4	143	2.8%	cbioportal
23	LAMA2	Ssm	4	143	2.8%	cbioportal
24	PKHD1L1	Ssm	4	143	2.8%	cbioportal
25	RYR1	Ssm	4	143	2.8%	cbioportal
15	ALMS1	Ssm	4	143	2.8%	cbioportal
26	ZFHX3	Ssm	4	143	2.8%	cbioportal
16	CMYA5	Ssm	4	143	2.8%	cbioportal
43	MICAL3	Ssm	3	143	2.1%	cbioportal
47	PKD1	Ssm	3	143	2.1%	cbioportal
46	PCDH15	Ssm	3	143	2.1%	cbioportal
45	NNT	Ssm	3	143	2.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Pediatric Ewing Sarcoma (DFCI, Cancer Discov 2014) es_dfarber_broad_2014DFCI

107 cases with simple somatic mutation data · 107 cases total · 2026-01-07 · mapped to Ewing Sarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	30	107	28%	cbioportal
2	TP53	Ssm	13	107	12.1%	cbioportal
4	MUC6	Ssm	12	107	11.2%	cbioportal
3	KMT2D	Ssm	12	107	11.2%	cbioportal
5	ADGRV1	Ssm	11	107	10.3%	cbioportal
6	STAG2	Ssm	11	107	10.3%	cbioportal
7	EPPK1	Ssm	10	107	9.3%	cbioportal
9	DNAH1	Ssm	9	107	8.4%	cbioportal
8	AHNAK2	Ssm	9	107	8.4%	cbioportal
15	THBS4	Ssm	8	107	7.5%	cbioportal
16	ZFHX3	Ssm	8	107	7.5%	cbioportal
12	NPHP4	Ssm	8	107	7.5%	cbioportal
14	PCDH15	Ssm	8	107	7.5%	cbioportal
11	BSN	Ssm	8	107	7.5%	cbioportal
10	AHNAK	Ssm	8	107	7.5%	cbioportal
13	OBSCN	Ssm	8	107	7.5%	cbioportal
21	HRNR	Ssm	7	107	6.5%	cbioportal
18	CR1	Ssm	7	107	6.5%	cbioportal
17	ATP7B	Ssm	7	107	6.5%	cbioportal
26	SYNE1	Ssm	7	107	6.5%	cbioportal
25	SPTA1	Ssm	7	107	6.5%	cbioportal
24	SPEN	Ssm	7	107	6.5%	cbioportal
23	RPTN	Ssm	7	107	6.5%	cbioportal
22	NEB	Ssm	7	107	6.5%	cbioportal
20	FLG	Ssm	7	107	6.5%	cbioportal
19	DSP	Ssm	7	107	6.5%	cbioportal
29	COL18A1	Ssm	6	107	5.6%	cbioportal
28	ANK3	Ssm	6	107	5.6%	cbioportal
27	ABCA13	Ssm	6	107	5.6%	cbioportal
31	DNAH8	Ssm	6	107	5.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Pediatric Rhabdomyosarcomas (MSK, JCO Precis Oncol 2023) rms_msk_2023MSK

24 cases with simple somatic mutation data · 24 cases total · 2026-01-16 · mapped to Rhabdomyosarcoma EXACT_IDENTIFIER

cbioportalObserved20 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MED12	Ssm	3	24	12.5%	cbioportal
2	MYOD1	Ssm	2	24	8.3%	cbioportal
10	KMT2B	Ssm	1	19	5.3%	cbioportal
18	TP53BP1	Ssm	1	19	5.3%	cbioportal
20	ZFHX3	Ssm	1	22	4.5%	cbioportal
17	PTPRS	Ssm	1	24	4.2%	cbioportal
19	XPO1	Ssm	1	24	4.2%	cbioportal
3	APC	Ssm	1	24	4.2%	cbioportal
4	ARID5B	Ssm	1	24	4.2%	cbioportal
5	BCOR	Ssm	1	24	4.2%	cbioportal
6	DNMT3B	Ssm	1	24	4.2%	cbioportal
12	NOTCH1	Ssm	1	24	4.2%	cbioportal
11	NF1	Ssm	1	24	4.2%	cbioportal
7	GRIN2A	Ssm	1	24	4.2%	cbioportal
8	HRAS	Ssm	1	24	4.2%	cbioportal
9	KDM6A	Ssm	1	24	4.2%	cbioportal
13	NOTCH4	Ssm	1	24	4.2%	cbioportal
14	PIK3CA	Ssm	1	24	4.2%	cbioportal
15	PTEN	Ssm	1	24	4.2%	cbioportal
16	PTPRD	Ssm	1	24	4.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Rhabdomyosarcoma (NIH, Cancer Discov 2014) rms_nih_2014NIH

43 cases with simple somatic mutation data · 43 cases total · 2026-01-13 · mapped to Rhabdomyosarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	NRAS	Ssm	4	43	9.3%	cbioportal
4	FGFR4	Ssm	3	43	7%	cbioportal
10	SLC6A17	Ssm	3	43	7%	cbioportal
9	PIK3CA	Ssm	3	43	7%	cbioportal
8	OR52N1	Ssm	3	43	7%	cbioportal
6	NF1	Ssm	3	43	7%	cbioportal
5	KRAS	Ssm	3	43	7%	cbioportal
3	FBXW7	Ssm	3	43	7%	cbioportal
2	BCOR	Ssm	3	43	7%	cbioportal
7	NPHS1	Ssm	3	43	7%	cbioportal
11	C1GALT1C1	Ssm	2	43	4.7%	cbioportal
12	CACNA1A	Ssm	2	43	4.7%	cbioportal
13	CDK12	Ssm	2	43	4.7%	cbioportal
14	CELSR3	Ssm	2	43	4.7%	cbioportal
15	CFAP44	Ssm	2	43	4.7%	cbioportal
16	CHST5	Ssm	2	43	4.7%	cbioportal
17	COL12A1	Ssm	2	43	4.7%	cbioportal
18	DGKQ	Ssm	2	43	4.7%	cbioportal
19	DYSF	Ssm	2	43	4.7%	cbioportal
20	HRAS	Ssm	2	43	4.7%	cbioportal
21	LGI1	Ssm	2	43	4.7%	cbioportal
22	LRP1B	Ssm	2	43	4.7%	cbioportal
23	PDGFRA	Ssm	2	43	4.7%	cbioportal
24	PER3	Ssm	2	43	4.7%	cbioportal
25	PIP5K1A	Ssm	2	43	4.7%	cbioportal
26	PKN1	Ssm	2	43	4.7%	cbioportal
27	SASH1	Ssm	2	43	4.7%	cbioportal
28	SEC14L5	Ssm	2	43	4.7%	cbioportal
29	SNUPN	Ssm	2	43	4.7%	cbioportal
30	TTN	Ssm	2	43	4.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Rhabdomyosarcomas (MSK, NPJ Precis Oncol 2023) soft_tissue_msk_2023MSK

42 cases with simple somatic mutation data · 42 cases total · 2026-01-13 · mapped to Rhabdomyosarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	9	42	21.4%	cbioportal
9	ETAA1	Ssm	2	22	9.1%	cbioportal
2	BCOR	Ssm	3	42	7.1%	cbioportal
3	CTNNB1	Ssm	3	42	7.1%	cbioportal
19	TP53BP1	Ssm	2	41	4.9%	cbioportal
13	NOTCH1	Ssm	2	42	4.8%	cbioportal
14	NOTCH3	Ssm	2	42	4.8%	cbioportal
15	NRAS	Ssm	2	42	4.8%	cbioportal
16	PAX5	Ssm	2	42	4.8%	cbioportal
17	SUFU	Ssm	2	42	4.8%	cbioportal
18	TET2	Ssm	2	42	4.8%	cbioportal
20	WT1	Ssm	2	42	4.8%	cbioportal
6	ATM	Ssm	2	42	4.8%	cbioportal
8	DICER1	Ssm	2	42	4.8%	cbioportal
10	FGF3	Ssm	2	42	4.8%	cbioportal
11	GRIN2A	Ssm	2	42	4.8%	cbioportal
12	HRAS	Ssm	2	42	4.8%	cbioportal
4	APC	Ssm	2	42	4.8%	cbioportal
5	ARID5B	Ssm	2	42	4.8%	cbioportal
7	DDR2	Ssm	2	42	4.8%	cbioportal
21	YES1	Ssm	2	42	4.8%	cbioportal
42	SMARCA2	Ssm	1	22	4.5%	cbioportal
43	SOS1	Ssm	1	41	2.4%	cbioportal
34	KMT2B	Ssm	1	41	2.4%	cbioportal
22	ALK	Ssm	1	42	2.4%	cbioportal
36	MED12	Ssm	1	42	2.4%	cbioportal
23	ARID1A	Ssm	1	42	2.4%	cbioportal
24	ASXL1	Ssm	1	42	2.4%	cbioportal
25	BRD4	Ssm	1	42	2.4%	cbioportal
26	CXCR4	Ssm	1	42	2.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Sarcoma TCGA-SARCTCGA

261 cases with simple somatic mutation data · 261 cases total · Data Release 46.0 · mapped to Sarcoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	167	261	64%	gdc
2	RB1	Ssm	165	261	63.2%	gdc
3	ITM2B	Ssm	154	261	59%	gdc
4	RCBTB2	Ssm	154	261	59%	gdc
5	LPAR6	Ssm	154	261	59%	gdc
6	CAB39L	Ssm	153	261	58.6%	gdc
10	MLNR	Ssm	152	261	58.2%	gdc
11	CDADC1	Ssm	152	261	58.2%	gdc
7	CYSLTR2	Ssm	152	261	58.2%	gdc
8	FNDC3A	Ssm	152	261	58.2%	gdc
9	SETDB2	Ssm	152	261	58.2%	gdc
12	RCBTB1	Ssm	151	261	57.9%	gdc
16	MED4	Ssm	151	261	57.9%	gdc
15	NUDT15	Ssm	151	261	57.9%	gdc
14	SUCLA2	Ssm	151	261	57.9%	gdc
13	PHF11	Ssm	151	261	57.9%	gdc
17	ARL11	Ssm	150	261	57.5%	gdc
18	KCNRG	Ssm	150	261	57.5%	gdc
19	KPNA3	Ssm	149	261	57.1%	gdc
20	TRIM13	Ssm	149	261	57.1%	gdc
21	EBPL	Ssm	149	261	57.1%	gdc
22	SPRYD7	Ssm	148	261	56.7%	gdc
23	HTR2A	Ssm	147	261	56.3%	gdc
24	DLEU7	Ssm	146	261	55.9%	gdc
26	ESD	Ssm	146	261	55.9%	gdc
25	LRCH1	Ssm	146	261	55.9%	gdc
29	LCP1	Ssm	145	261	55.6%	gdc
28	SIAH3	Ssm	145	261	55.6%	gdc
27	RUBCNL	Ssm	145	261	55.6%	gdc
30	CPB2	Ssm	144	261	55.2%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Soft Tissue Sarcoma MYOD1 (MSK, Sci Adv 2026) soft_tissue_myod1_msk_2025MSK

20 cases with simple somatic mutation data · 20 cases total · 2026-03-05 · mapped to Rhabdomyosarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MYOD1	Ssm	20	20	100%	cbioportal
2	PIK3CA	Ssm	5	20	25%	cbioportal
7	NOTCH4	Ssm	2	20	10%	cbioportal
9	SMARCB1	Ssm	2	20	10%	cbioportal
3	ARID1B	Ssm	2	20	10%	cbioportal
4	CHEK2	Ssm	2	20	10%	cbioportal
5	FGFR4	Ssm	2	20	10%	cbioportal
8	NRAS	Ssm	2	20	10%	cbioportal
6	MAP3K1	Ssm	2	20	10%	cbioportal
38	ZFHX3	Ssm	1	17	5.9%	cbioportal
22	H3C10	Ssm	1	17	5.9%	cbioportal
36	STAT5A	Ssm	1	17	5.9%	cbioportal
21	H3-3A	Ssm	1	17	5.9%	cbioportal
28	MGA	Ssm	1	17	5.9%	cbioportal
23	HLA-A	Ssm	1	17	5.9%	cbioportal
26	INHBA	Ssm	1	17	5.9%	cbioportal
31	PLCG2	Ssm	1	17	5.9%	cbioportal
30	PIK3R3	Ssm	1	20	5%	cbioportal
32	POLE	Ssm	1	20	5%	cbioportal
25	IL7R	Ssm	1	20	5%	cbioportal
27	KMT2D	Ssm	1	20	5%	cbioportal
29	NOTCH1	Ssm	1	20	5%	cbioportal
37	TMEM127	Ssm	1	20	5%	cbioportal
35	SPEN	Ssm	1	20	5%	cbioportal
34	ROS1	Ssm	1	20	5%	cbioportal
33	PTEN	Ssm	1	20	5%	cbioportal
18	FBXW7	Ssm	1	20	5%	cbioportal
19	FGFR1	Ssm	1	20	5%	cbioportal
20	GATA2	Ssm	1	20	5%	cbioportal
24	IKBKE	Ssm	1	20	5%	cbioportal

Data updated 22 days agoSource updated 2026-03-05

The Angiosarcoma Project - Count Me In (Nature Medicine, 2020) angs_project_painter_2018Nature Medicine

48 cases with simple somatic mutation data · 48 cases total · 2026-01-05 · mapped to Angiosarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	14	48	29.2%	cbioportal
2	KDR	Ssm	10	48	20.8%	cbioportal
3	PIK3CA	Ssm	10	48	20.8%	cbioportal
4	LRP2	Ssm	9	48	18.8%	cbioportal
6	TTN	Ssm	9	48	18.8%	cbioportal
5	RYR2	Ssm	9	48	18.8%	cbioportal
7	ABCA13	Ssm	8	48	16.7%	cbioportal
8	ASXL3	Ssm	8	48	16.7%	cbioportal
9	PKHD1	Ssm	8	48	16.7%	cbioportal
10	PLCG1	Ssm	8	48	16.7%	cbioportal
11	POT1	Ssm	8	48	16.7%	cbioportal
12	RYR1	Ssm	8	48	16.7%	cbioportal
13	CSMD2	Ssm	7	48	14.6%	cbioportal
19	SI	Ssm	7	48	14.6%	cbioportal
18	MYH14	Ssm	7	48	14.6%	cbioportal
17	MUC16	Ssm	7	48	14.6%	cbioportal
16	LRRK2	Ssm	7	48	14.6%	cbioportal
15	HRNR	Ssm	7	48	14.6%	cbioportal
14	FLG	Ssm	7	48	14.6%	cbioportal
24	COL19A1	Ssm	6	48	12.5%	cbioportal
25	COL22A1	Ssm	6	48	12.5%	cbioportal
26	EPB41L3	Ssm	6	48	12.5%	cbioportal
27	FAT1	Ssm	6	48	12.5%	cbioportal
28	FLT4	Ssm	6	48	12.5%	cbioportal
29	FREM2	Ssm	6	48	12.5%	cbioportal
30	GRIK2	Ssm	6	48	12.5%	cbioportal
23	COL11A1	Ssm	6	48	12.5%	cbioportal
22	CCDC178	Ssm	6	48	12.5%	cbioportal
21	CACNA1I	Ssm	6	48	12.5%	cbioportal
20	ADGRV1	Ssm	6	48	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

The Angiosarcoma Project - Count Me In (Provisional, April 2025) angs_painter_2025Provisional

129 cases with simple somatic mutation data · 328 cases total · 2026-02-16 · mapped to Angiosarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	23	129	17.8%	cbioportal
4	PKHD1	Ssm	15	129	11.6%	cbioportal
3	MUC16	Ssm	15	129	11.6%	cbioportal
2	KDR	Ssm	15	129	11.6%	cbioportal
5	PLCG1	Ssm	14	129	10.9%	cbioportal
7	RYR2	Ssm	13	129	10.1%	cbioportal
6	POT1	Ssm	13	129	10.1%	cbioportal
8	TTN	Ssm	13	129	10.1%	cbioportal
9	SI	Ssm	12	129	9.3%	cbioportal
12	SPTA1	Ssm	11	129	8.5%	cbioportal
11	LRP1B	Ssm	11	129	8.5%	cbioportal
10	DNAH5	Ssm	11	129	8.5%	cbioportal
16	USH2A	Ssm	10	129	7.8%	cbioportal
14	PTPRB	Ssm	10	129	7.8%	cbioportal
13	LRP2	Ssm	10	129	7.8%	cbioportal
15	TDRD15	Ssm	10	129	7.8%	cbioportal
22	LRRK2	Ssm	9	129	7%	cbioportal
17	COL11A1	Ssm	9	129	7%	cbioportal
18	COL22A1	Ssm	9	129	7%	cbioportal
19	DMD	Ssm	9	129	7%	cbioportal
20	GLI3	Ssm	9	129	7%	cbioportal
21	KMT2D	Ssm	9	129	7%	cbioportal
23	NCKAP5	Ssm	9	129	7%	cbioportal
24	TPO	Ssm	9	129	7%	cbioportal
25	ABCA13	Ssm	8	129	6.2%	cbioportal
30	DNAH11	Ssm	8	129	6.2%	cbioportal
29	CNTN5	Ssm	8	129	6.2%	cbioportal
28	CARMIL3	Ssm	8	129	6.2%	cbioportal
27	ASXL1	Ssm	8	129	6.2%	cbioportal
26	ANK3	Ssm	8	129	6.2%	cbioportal

Data updated 22 days agoSource updated 2026-02-16

The Angiosarcoma Project (Provisional, July 2020) angs_painter_2020Provisional

83 cases with simple somatic mutation data · 83 cases total · 2026-01-05 · mapped to Angiosarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	20	83	24.1%	cbioportal
2	MUC16	Ssm	17	83	20.5%	cbioportal
3	RYR2	Ssm	17	83	20.5%	cbioportal
4	TTN	Ssm	17	83	20.5%	cbioportal
7	XIST	Ssm	15	83	18.1%	cbioportal
5	PKHD1	Ssm	15	83	18.1%	cbioportal
6	POT1	Ssm	15	83	18.1%	cbioportal
8	ZNF208	Ssm	15	83	18.1%	cbioportal
9	LRP2	Ssm	14	83	16.9%	cbioportal
11	KDR	Ssm	13	83	15.7%	cbioportal
10	FLG	Ssm	13	83	15.7%	cbioportal
13	PTPRB	Ssm	13	83	15.7%	cbioportal
12	LRP1B	Ssm	13	83	15.7%	cbioportal
14	CHD9	Ssm	12	83	14.5%	cbioportal
15	COL11A1	Ssm	12	83	14.5%	cbioportal
16	FAT1	Ssm	12	83	14.5%	cbioportal
17	LRRK2	Ssm	12	83	14.5%	cbioportal
18	SI	Ssm	12	83	14.5%	cbioportal
25	NEB	Ssm	11	83	13.3%	cbioportal
19	ADGRV1	Ssm	11	83	13.3%	cbioportal
20	ANK3	Ssm	11	83	13.3%	cbioportal
21	CMYA5	Ssm	11	83	13.3%	cbioportal
22	DNAH5	Ssm	11	83	13.3%	cbioportal
23	DNAH7	Ssm	11	83	13.3%	cbioportal
24	NCKAP5	Ssm	11	83	13.3%	cbioportal
30	GRIN2A	Ssm	10	83	12%	cbioportal
26	ABCA13	Ssm	10	83	12%	cbioportal
27	ASXL3	Ssm	10	83	12%	cbioportal
28	FAT3	Ssm	10	83	12%	cbioportal
29	GLI3	Ssm	10	83	12%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Uterine Sarcoma/Mesenchymal (MSK, Clin Cancer Res 2020) usarc_msk_2020MSK

108 cases with simple somatic mutation data · 108 cases total · 2026-01-19 · mapped to Uterine Corpus Sarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	40	108	37%	cbioportal
2	ATRX	Ssm	25	108	23.1%	cbioportal
3	RB1	Ssm	12	108	11.1%	cbioportal
4	MED12	Ssm	11	108	10.2%	cbioportal
5	BRCA2	Ssm	7	108	6.5%	cbioportal
7	PTEN	Ssm	6	108	5.6%	cbioportal
6	FAT1	Ssm	6	108	5.6%	cbioportal
57	AGO2	Ssm	1	20	5%	cbioportal
145	TEK	Ssm	1	20	5%	cbioportal
130	PPARG	Ssm	1	20	5%	cbioportal
8	AR	Ssm	5	108	4.6%	cbioportal
9	ROS1	Ssm	5	108	4.6%	cbioportal
12	NSD1	Ssm	4	108	3.7%	cbioportal
11	KDR	Ssm	4	108	3.7%	cbioportal
10	ARID2	Ssm	4	108	3.7%	cbioportal
14	PIK3CA	Ssm	4	108	3.7%	cbioportal
13	PDGFRB	Ssm	4	108	3.7%	cbioportal
16	ASXL1	Ssm	3	108	2.8%	cbioportal
15	ARID1A	Ssm	3	108	2.8%	cbioportal
17	BRD4	Ssm	3	108	2.8%	cbioportal
24	TERT	Ssm	3	108	2.8%	cbioportal
22	MET	Ssm	3	108	2.8%	cbioportal
23	NF1	Ssm	3	108	2.8%	cbioportal
21	KMT2A	Ssm	3	108	2.8%	cbioportal
20	ERBB4	Ssm	3	108	2.8%	cbioportal
19	DAXX	Ssm	3	108	2.8%	cbioportal
18	CARD11	Ssm	3	108	2.8%	cbioportal
55	TOP1	Ssm	2	108	1.9%	cbioportal
50	POLE	Ssm	2	108	1.9%	cbioportal
49	PIK3CG	Ssm	2	108	1.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Well-Differentiated and Dedifferentiated Liposarcoma Histologic Subvariants (MSK, 2024) lipo_msk_2024MSK

140 cases with simple somatic mutation data · 140 cases total · 2026-01-20 · mapped to Liposarcoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ATRX	Ssm	8	140	5.7%	cbioportal
2	PIK3CG	Ssm	4	140	2.9%	cbioportal
4	ROS1	Ssm	3	140	2.1%	cbioportal
3	ERBB4	Ssm	3	140	2.1%	cbioportal
5	TP53	Ssm	3	140	2.1%	cbioportal
12	KMT2B	Ssm	2	133	1.5%	cbioportal
21	UPF1	Ssm	2	133	1.5%	cbioportal
15	MGA	Ssm	2	138	1.4%	cbioportal
16	MST1R	Ssm	2	138	1.4%	cbioportal
8	CARD11	Ssm	2	140	1.4%	cbioportal
9	DAXX	Ssm	2	140	1.4%	cbioportal
10	EED	Ssm	2	140	1.4%	cbioportal
11	IKZF1	Ssm	2	140	1.4%	cbioportal
13	KMT2D	Ssm	2	140	1.4%	cbioportal
14	MED12	Ssm	2	140	1.4%	cbioportal
18	SETD2	Ssm	2	140	1.4%	cbioportal
19	SMARCA4	Ssm	2	140	1.4%	cbioportal
20	TSC2	Ssm	2	140	1.4%	cbioportal
25	ATXN7	Ssm	1	70	1.4%	cbioportal
89	SETDB1	Ssm	1	70	1.4%	cbioportal
62	MLLT1	Ssm	1	70	1.4%	cbioportal
77	POT1	Ssm	1	70	1.4%	cbioportal
17	RB1	Ssm	2	140	1.4%	cbioportal
6	ALK	Ssm	2	140	1.4%	cbioportal
7	BRD4	Ssm	2	140	1.4%	cbioportal
36	CYLD	Ssm	1	133	0.8%	cbioportal
90	SLX4	Ssm	1	133	0.8%	cbioportal
67	NSD3	Ssm	1	133	0.8%	cbioportal
84	RECQL	Ssm	1	133	0.8%	cbioportal
79	PTP4A1	Ssm	1	133	0.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-20