Gene

PTPRB

protein tyrosine phosphatase receptor type B

Explore in graph →CI-GENE-00022525HGNC:9665 ENSG00000127329 NCBI 5787 CIViC Cancer geneApproved

Curated evidence

Clinical evidence (4)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
PTPRB Loss-of-function2
(diagnostic)	Angiosarcoma	Diagnostic	B	Supports Positive	3	accepted	EID10079 A cohort of angiosarcomas (n=36) was sequenced and revealed to contain recurrent mutations in PTPRB (10/36) which were predominantly truncating or splice variants which impact the tyrosine phosphotase… (full text at CIViC) PMID 24633157 · Behjati et al., 2014 · Open in CIViC	civic
Sunitinib + VatalanibSubstitutes	Angiosarcoma	Predictive	D	Supports Sensitivity Response	3	accepted	EID1895 The endothelial phosphatase PTPRB, a negative regulator of vascular growth factor tyrosine kinases, harbored truncating mutations in 10 of 39 angiosarcomas (26%) which correlated with MYC amplificatio… (full text at CIViC) PMID 24633157 · Behjati et al., 2014 ·

Cohorts

Alteration frequency by cohort (36)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved36 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Desmoplastic Melanoma (Broad Institute, Nat Genet 2015) desm_broad_2015	Desmoplastic Melanoma	Ssm	7	20

Literature

Linked publications (1)

25 per page, newest first.

pubmedPublishedShowing 1–1 of 1 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Recurrent PTPRB and PLCG1 mutations in angiosarcoma.
· Nat Genet · 2014 · PMID 24633157 · validated civic_curation pubmed