NUDT15

nudix hydrolase 15

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NUDT15 Inactivating Mutation1
Azathioprine + Mercaptopurine + ThioguanineSubstitutes	Childhood Acute Lymphoblastic LeukemiaALIAS	Predictive	B	Supports Adverse Response	4	submitted	EID7794 Patients from three (Guatemala, Singapore and Japan) separate cohorts harboring NUDT15 loss of function mutations displayed intolerance to Thiopurine treatment (p=0.021, 2.1e-5, & 0.0054). Patients wi… (full text at CIViC) PMID 26878724 · Moriyama et al., 2016 · Open in CIViC	civic

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved1 cohort row · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Sarcoma TCGA-SARC	Sarcoma	Ssm	151

Literature

Data not yet available

No publication linked to this gene yet.