NUP98 — gene · CancerIndex

Curated evidence

Clinical evidence (4)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
NUP98 Fusion4
(diagnostic)	Acute Myeloid Leukemia with NUP98 Rearrangement	Diagnostic	B	Supports Positive	4	accepted	EID12377 In this 2016 study the authors included 153 pediatric non-Down syndrome patients diagnosed with acute megakaryoblastic leukemia (AMKL) which is a rare subtype of acute myeloid leukemia. All patients w… (full text at CIViC) PMID 27114462 · de Rooij et al., 2016 · Open in CIViC	civic
〃	Acute Myeloid Leukemia with NUP98 Rearrangement	Diagnostic	B	Supports Positive	4	accepted	EID12378 In this 2011 study the authors included pediatric and adult cohorts of patients diagnosed with acute myeloid leukemia (AML). Initially, using RT-PCR, they detected the cytogenetically cryptic NUP98::N… (full text at CIViC) PMID 21813447 · Hollink et al., 2011 ·

Cohorts

Alteration frequency by cohort (6)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved6 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Urothelial Carcinoma (BCAN/HCRN, Nat Commun 2022) blca_bcan_hcrn_2022	Bladder Urothelial Carcinoma	Ssm	13

Literature

Linked publications (4)

25 per page, newest first.

pubmedPublishedShowing 1–4 of 4 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

NUP98/NSD1 characterizes a novel poor prognostic group in acute myeloid leukemia with a distinct HOX gene expression pattern.
· Blood · 2011 · PMID 21813447 · validated civic_curation pubmed
Recurrent abnormalities can be used for risk group stratification in pediatric AMKL: a retrospective intergroup study.
· Blood · 2016 · PMID 27114462 · validated civic_curation pubmed
NUP98/NSD1 and FLT3/ITD coexpression is more prevalent in younger AML patients and leads to induction failure: a COG and SWOG report.
· Blood · 2014 · PMID 25145343 · validated civic_curation pubmed
Comprehensive molecular and clinical characterization of NUP98 fusions in pediatric acute myeloid leukemia.
· Haematologica · 2023 · PMID 36815378 · validated