Gene
FOXL2
forkhead box L2
Explore in graph →CI-GENE-00002166HGNC:1092 ENSG00000183770 NCBI 668 CIViC Cancer geneApproved
Curated evidence
Clinical evidence (4)
CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26033501
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| FOXL2 C134W4 | ||||||||
| (diagnostic) | Ovarian Sex Cord-Stromal TumorCURATED_BROADER | Diagnostic | A | Supports Positive | 5 | accepted | EID6034FOXL2 mutations were found in 94% of pathologically confirmed A-GCTs (95/101), in one of eight juvenile granulosa cell tumours (J-GCTs), and in two of 19 SLCTs. PMID 26033501 · Goulvent et al., 2016 · Open in CIViC | civic |
| 〃 | Adult-type Granulosa Cell Tumour Of The OvaryUNRESOLVED | Diagnostic | B | Supports Positive | 5 | submitted | EID13134Adult-type granulosa-cell tumour (GCT), the predominant malignant sex cord-stromal neoplasm of the ovary, has historically posed a diagnostic challenge because its morphology can overlap substantially… (full text at CIViC) PMID 19516027 · | |
Cohorts
Alteration frequency by cohort (37)
Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.
- Source
- cBioPortal for Cancer Genomics (public studies)
- Dataset
- cBioPortal mutated genes by study
- Version
- cbioportal-2026-09-01
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- cohort
- License
- ODC Open Database License (ODC-ODbL) unless otherwise noted per study; attribution to the original studies required
- PMID
- 36355783
- Run
- ING-CBIOPORTAL-20260908-000001
| Cohort | Mapped cancer | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Rank in cohort | Source |
|---|---|---|---|---|---|---|---|
| Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022 | Colorectal Adenocarcinoma | Ssm | 8 |
Literature
Linked publications (2)
25 per page, newest first.
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)