Cancer Family
Connective and Soft Tissue Neoplasm
CI-CAN-00000010Explore in graph →
Non-malignant848 active trials17 approved drugs339 evidence items
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Cancer Family
CI-CAN-00000010Explore in graph →
Genomics
24 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
183 cases with simple somatic mutation data · 183 cases total · 2026-01-20 · mapped to Gastrointestinal Stromal Tumor EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | KIT | Ssm | 174 | 183 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 95.1% |
| cbioportal |
| 2 | CSDE1 | Ssm | 26 | 179 | 14.5% | cbioportal |
| 3 | SETD2 | Ssm | 21 | 183 | 11.5% | cbioportal |
| 4 | TP53 | Ssm | 20 | 183 | 10.9% | cbioportal |
| 5 | RB1 | Ssm | 18 | 183 | 9.8% | cbioportal |
| 6 | FAT1 | Ssm | 15 | 183 | 8.2% | cbioportal |
| 9 | ERCC2 | Ssm | 13 | 182 | 7.1% | cbioportal |
| 8 | ANKRD11 | Ssm | 13 | 182 | 7.1% | cbioportal |
| 13 | TSC1 | Ssm | 13 | 183 | 7.1% | cbioportal |
| 11 | MLH1 | Ssm | 13 | 183 | 7.1% | cbioportal |
| 12 | PMS2 | Ssm | 13 | 183 | 7.1% | cbioportal |
| 7 | AKT1 | Ssm | 13 | 183 | 7.1% | cbioportal |
| 10 | FGFR4 | Ssm | 13 | 183 | 7.1% | cbioportal |
| 18 | KMT2B | Ssm | 12 | 180 | 6.7% | cbioportal |
| 17 | FUBP1 | Ssm | 12 | 182 | 6.6% | cbioportal |
| 15 | FGFR1 | Ssm | 12 | 183 | 6.6% | cbioportal |
| 14 | ARID1A | Ssm | 12 | 183 | 6.6% | cbioportal |
| 16 | FOXL2 | Ssm | 12 | 183 | 6.6% | cbioportal |
| 20 | RUNX1 | Ssm | 11 | 183 | 6% | cbioportal |
| 19 | MYC | Ssm | 11 | 183 | 6% | cbioportal |
| 22 | H3C3 | Ssm | 10 | 182 | 5.5% | cbioportal |
| 24 | MRE11 | Ssm | 10 | 183 | 5.5% | cbioportal |
| 21 | BRCA2 | Ssm | 10 | 183 | 5.5% | cbioportal |
| 26 | PIK3CG | Ssm | 10 | 183 | 5.5% | cbioportal |
| 23 | KDM5A | Ssm | 10 | 183 | 5.5% | cbioportal |
| 27 | TRAF2 | Ssm | 10 | 183 | 5.5% | cbioportal |
| 25 | NCOR1 | Ssm | 10 | 183 | 5.5% | cbioportal |
| 30 | NF1 | Ssm | 9 | 183 | 4.9% | cbioportal |
| 28 | BRCA1 | Ssm | 9 | 183 | 4.9% | cbioportal |
| 29 | MGA | Ssm | 9 | 183 | 4.9% | cbioportal |
Data updated 21 days agoSource updated 2026-01-20