Gene

ATP7B

ATPase copper transporting beta

Curated evidence

Clinical evidence (4)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
ATP7B Expression4
Amphotericin B	Malignant Ovarian Neoplasm	Predictive	D	Supports Sensitivity Response	3	submitted	EID12305 A high-throughput screening (HTS) strategy based on synthetic lethality was used to identify drugs that reduce cisplatin resistance in IGROV-CP20 cells, assessed via an MTT colorimetric assay. Various… (full text at CIViC) PMID 32155756 · Mariniello et al., 2020 · Open in CIViC	civic
Cisplatin	Malignant Ovarian Neoplasm	Predictive	D	Supports Resistance	3	submitted	EID12304 To investigate the role of ATP7B in cisplatin resistance, the IGROV-CP20 ovarian cancer cell line was compared to its parental cisplatin-sensitive IGROV line. IGROV-CP20 cells exhibited significantly … (full text at CIViC) PMID 32155756 · Mariniello et al., 2020 · Open in CIViC

Cohorts

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

gdcObserved14 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Sarcoma TCGA-SARC	Sarcoma	Ssm	138

Literature

Data not yet available

No publication linked to this gene yet.