Cancer Family
Connective and Soft Tissue Neoplasm
CI-CAN-00000010Explore in graph →
Non-malignant848 active trials17 approved drugs339 evidence items
Loading cancer entity…
Cancer Family
CI-CAN-00000010Explore in graph →
Genomics
24 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
143 cases with simple somatic mutation data · 159 cases total · 2026-01-14 · mapped to Osteosarcoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TP53 | Ssm | 32 | 143 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 22.4% |
| cbioportal |
| 2 | MUC16 | Ssm | 16 | 143 | 11.2% | cbioportal |
| 3 | TTN | Ssm | 16 | 143 | 11.2% | cbioportal |
| 4 | ATRX | Ssm | 11 | 143 | 7.7% | cbioportal |
| 5 | DNAH9 | Ssm | 10 | 143 | 7% | cbioportal |
| 6 | RB1 | Ssm | 8 | 143 | 5.6% | cbioportal |
| 7 | CNTNAP5 | Ssm | 7 | 143 | 4.9% | cbioportal |
| 8 | DMD | Ssm | 7 | 143 | 4.9% | cbioportal |
| 10 | PCLO | Ssm | 7 | 143 | 4.9% | cbioportal |
| 9 | MUC4 | Ssm | 7 | 143 | 4.9% | cbioportal |
| 11 | CSMD3 | Ssm | 6 | 143 | 4.2% | cbioportal |
| 12 | ADGRV1 | Ssm | 5 | 143 | 3.5% | cbioportal |
| 14 | RYR2 | Ssm | 5 | 143 | 3.5% | cbioportal |
| 13 | DNAH3 | Ssm | 5 | 143 | 3.5% | cbioportal |
| 26 | ZFHX3 | Ssm | 4 | 143 | 2.8% | cbioportal |
| 15 | ALMS1 | Ssm | 4 | 143 | 2.8% | cbioportal |
| 16 | CMYA5 | Ssm | 4 | 143 | 2.8% | cbioportal |
| 17 | CSMD1 | Ssm | 4 | 143 | 2.8% | cbioportal |
| 18 | CSMD2 | Ssm | 4 | 143 | 2.8% | cbioportal |
| 19 | DNAI4 | Ssm | 4 | 143 | 2.8% | cbioportal |
| 20 | GRM5 | Ssm | 4 | 143 | 2.8% | cbioportal |
| 22 | LAMA1 | Ssm | 4 | 143 | 2.8% | cbioportal |
| 23 | LAMA2 | Ssm | 4 | 143 | 2.8% | cbioportal |
| 21 | HECTD4 | Ssm | 4 | 143 | 2.8% | cbioportal |
| 24 | PKHD1L1 | Ssm | 4 | 143 | 2.8% | cbioportal |
| 25 | RYR1 | Ssm | 4 | 143 | 2.8% | cbioportal |
| 28 | CARMIL1 | Ssm | 3 | 143 | 2.1% | cbioportal |
| 42 | MAPRE3 | Ssm | 3 | 143 | 2.1% | cbioportal |
| 38 | HELZ2 | Ssm | 3 | 143 | 2.1% | cbioportal |
| 58 | UNC79 | Ssm | 3 | 143 | 2.1% | cbioportal |
Data updated 21 days agoSource updated 2026-01-14