KLF4

KLF transcription factor 4

Explore in graph →CI-GENE-00006998HGNC:6348 ENSG00000136826 NCBI 9314 CIViC Approved

Curated evidence

Clinical evidence (1)

CIViC items involving this gene, grouped by molecular profile and therapy, with native levels and directions. 50 items per page.

civicCuratedShowing 1–1 of 1 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Cancer	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
KLF4 K409Q1
(functional)	—UNRESOLVED	Functional	D	Supports Gain Of Function	2	submitted	EID9557 Transcriptomic analysis was performed on 17 meningiomas, 7 with K409Q mutation and 10 wild-type for KLF4. KLF4 K409Q tumors showed altered expression profiles with upregulation of the hypoxia and glyc… (full text at CIViC) PMID 32245394 · von Spreckelsen et al., 2020 · Open in CIViC	civic

Cohorts

Alteration frequency by cohort (40)

Frequency = cases affected / cases profiled within one cohort. Cohorts are never pooled.

cbioportalObserved40 cohort rows · frequency = affected / profiled, as published by each cohort; cohorts are not pooled. Hover a row badge for its release.

Cohort	Mapped cancer	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Rank in cohort	Source
Colorectal Cancer (MSK, Cancer Discovery 2022) coadread_mskresistance_2022	Colorectal Adenocarcinoma	Ssm	7

Literature

Linked publications (0)

Data not yet available

No publication linked to this gene yet.