Urinary System Neoplasm — Genomics

Urinary System Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

49 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Bladder Cancer (MSK, Eur Urol 2014) blca_mskcc_solit_2014MSK

109 cases with simple somatic mutation data · 109 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Bladder Cancer (MSK, Eur Urol Open Sci 2025) blca_msk_2025MSK

308 cases with simple somatic mutation data · 308 cases total · 2026-01-20 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	190	308	61.7%	cbioportal
2	TP53	Ssm	154	308	50%	cbioportal
3	ARID1A	Ssm	81	308	26.3%	cbioportal
4	KDM6A	Ssm	70	308	22.7%	cbioportal
13	KMT2D	Ssm	24	107	22.4%	cbioportal
17	KMT2C	Ssm	20	107	18.7%	cbioportal
5	FGFR3	Ssm	52	308	16.9%	cbioportal
6	RB1	Ssm	46	308	14.9%	cbioportal
23	ELF3	Ssm	15	107	14%	cbioportal
7	ERBB2	Ssm	42	308	13.6%	cbioportal
8	PIK3CA	Ssm	42	308	13.6%	cbioportal
9	ATM	Ssm	35	308	11.4%	cbioportal
31	STAG2	Ssm	12	107	11.2%	cbioportal
10	TSC1	Ssm	33	308	10.7%	cbioportal
34	FAT1	Ssm	11	107	10.3%	cbioportal
33	CDKN1A	Ssm	11	107	10.3%	cbioportal
11	BRCA2	Ssm	28	308	9.1%	cbioportal
40	KMT2A	Ssm	9	107	8.4%	cbioportal
41	MGA	Ssm	9	107	8.4%	cbioportal
39	H3C7	Ssm	9	107	8.4%	cbioportal
12	SF3B1	Ssm	25	308	8.1%	cbioportal
47	NBN	Ssm	8	107	7.5%	cbioportal
14	BRCA1	Ssm	22	308	7.1%	cbioportal
15	ERBB3	Ssm	21	308	6.8%	cbioportal
54	ZFHX3	Ssm	7	107	6.5%	cbioportal
51	ANKRD11	Ssm	7	107	6.5%	cbioportal
53	NCOR1	Ssm	7	107	6.5%	cbioportal
16	CDKN2A	Ssm	20	308	6.5%	cbioportal
18	NF1	Ssm	20	308	6.5%	cbioportal
19	APC	Ssm	18	308	5.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-20

Bladder Cancer (MSK, J Clin Onco 2013) blca_mskcc_solit_2012MSK

97 cases with simple somatic mutation data · 97 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved11 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	31	97	32%	cbioportal
2	PIK3CA	Ssm	17	97	17.5%	cbioportal
3	FGFR3	Ssm	14	97	14.4%	cbioportal
4	RB1	Ssm	10	97	10.3%	cbioportal
5	TSC1	Ssm	6	97	6.2%	cbioportal
6	KRAS	Ssm	4	97	4.1%	cbioportal
7	AKT1	Ssm	2	97	2.1%	cbioportal
8	BRAF	Ssm	2	97	2.1%	cbioportal
9	CDKN2A	Ssm	2	97	2.1%	cbioportal
11	PTEN	Ssm	1	97	1%	cbioportal
10	AKT3	Ssm	1	97	1%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Cancer (MSK, Nat Genet 2016) blca_plasmacytoid_mskcc_2016MSK

34 cases with simple somatic mutation data · 34 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	CDH1	Ssm	27	34	79.4%	cbioportal
2	TP53	Ssm	20	34	58.8%	cbioportal
3	TERT	Ssm	12	34	35.3%	cbioportal
4	RB1	Ssm	9	34	26.5%	cbioportal
6	CDKN1A	Ssm	8	34	23.5%	cbioportal
5	ARID1A	Ssm	8	34	23.5%	cbioportal
7	PIK3R1	Ssm	7	34	20.6%	cbioportal
8	KMT2C	Ssm	6	34	17.6%	cbioportal
10	ERBB2	Ssm	5	34	14.7%	cbioportal
9	BAP1	Ssm	5	34	14.7%	cbioportal
11	ERBB3	Ssm	5	34	14.7%	cbioportal
12	ERCC2	Ssm	5	34	14.7%	cbioportal
13	KMT2A	Ssm	5	34	14.7%	cbioportal
14	KMT2D	Ssm	5	34	14.7%	cbioportal
15	PIK3CA	Ssm	5	34	14.7%	cbioportal
16	ATR	Ssm	4	34	11.8%	cbioportal
17	EPHB1	Ssm	4	34	11.8%	cbioportal
18	NOTCH4	Ssm	4	34	11.8%	cbioportal
19	SMARCA4	Ssm	4	34	11.8%	cbioportal
20	DICER1	Ssm	3	34	8.8%	cbioportal
31	TET1	Ssm	3	34	8.8%	cbioportal
27	NRAS	Ssm	3	34	8.8%	cbioportal
32	YAP1	Ssm	3	34	8.8%	cbioportal
28	PALB2	Ssm	3	34	8.8%	cbioportal
26	NOTCH2	Ssm	3	34	8.8%	cbioportal
25	NF1	Ssm	3	34	8.8%	cbioportal
24	MTOR	Ssm	3	34	8.8%	cbioportal
23	IRS2	Ssm	3	34	8.8%	cbioportal
22	FAT1	Ssm	3	34	8.8%	cbioportal
21	EP300	Ssm	3	34	8.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Cancer (MSK/TCGA, Eur Urol 2020) blca_msk_tcga_2020MSK/TCGA

474 cases with simple somatic mutation data · 476 cases total · 2026-01-27 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	245	474	51.7%	cbioportal
2	TTN	Ssm	155	474	32.7%	cbioportal
3	KMT2D	Ssm	139	474	29.3%	cbioportal
4	ARID1A	Ssm	127	474	26.8%	cbioportal
5	KDM6A	Ssm	124	474	26.2%	cbioportal
6	PIK3CA	Ssm	103	474	21.7%	cbioportal
8	TERT	Ssm	101	474	21.3%	cbioportal
7	MUC16	Ssm	101	474	21.3%	cbioportal
9	RB1	Ssm	100	474	21.1%	cbioportal
10	KMT2C	Ssm	80	474	16.9%	cbioportal
11	EP300	Ssm	70	474	14.8%	cbioportal
12	ERBB2	Ssm	70	474	14.8%	cbioportal
13	SYNE1	Ssm	66	474	13.9%	cbioportal
14	ERBB3	Ssm	65	474	13.7%	cbioportal
15	RYR2	Ssm	64	474	13.5%	cbioportal
16	FGFR3	Ssm	60	474	12.7%	cbioportal
18	FAT1	Ssm	58	474	12.2%	cbioportal
17	ATM	Ssm	58	474	12.2%	cbioportal
20	CREBBP	Ssm	56	474	11.8%	cbioportal
19	BIRC6	Ssm	56	474	11.8%	cbioportal
21	HMCN1	Ssm	55	474	11.6%	cbioportal
22	STAG2	Ssm	55	474	11.6%	cbioportal
23	MACF1	Ssm	54	474	11.4%	cbioportal
24	FLG	Ssm	53	474	11.2%	cbioportal
25	KMT2A	Ssm	53	474	11.2%	cbioportal
26	FAT4	Ssm	52	474	11%	cbioportal
27	ERCC2	Ssm	50	474	10.5%	cbioportal
29	ELF3	Ssm	48	474	10.1%	cbioportal
28	CSMD3	Ssm	48	474	10.1%	cbioportal
30	BRCA2	Ssm	47	474	9.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-27

Bladder Cancer (TCGA, Cell 2017) blca_tcga_pub_2017TCGA

412 cases with simple somatic mutation data · 413 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	198	412	48.1%	cbioportal
2	TTN	Ssm	198	412	48.1%	cbioportal
4	MUC16	Ssm	117	412	28.4%	cbioportal
3	KMT2D	Ssm	117	412	28.4%	cbioportal
5	KDM6A	Ssm	107	412	26%	cbioportal
6	ARID1A	Ssm	101	412	24.5%	cbioportal
7	PIK3CA	Ssm	91	412	22.1%	cbioportal
8	SYNE1	Ssm	84	412	20.4%	cbioportal
9	RYR2	Ssm	78	412	18.9%	cbioportal
10	KMT2C	Ssm	77	412	18.7%	cbioportal
11	HMCN1	Ssm	76	412	18.4%	cbioportal
12	RB1	Ssm	72	412	17.5%	cbioportal
13	FLG	Ssm	68	412	16.5%	cbioportal
14	MACF1	Ssm	66	412	16%	cbioportal
15	EP300	Ssm	63	412	15.3%	cbioportal
16	FAT4	Ssm	63	412	15.3%	cbioportal
17	FGFR3	Ssm	58	412	14.1%	cbioportal
19	CSMD3	Ssm	57	412	13.8%	cbioportal
20	STAG2	Ssm	57	412	13.8%	cbioportal
18	ATM	Ssm	57	412	13.8%	cbioportal
21	NEB	Ssm	56	412	13.6%	cbioportal
22	OBSCN	Ssm	56	412	13.6%	cbioportal
23	DNAH5	Ssm	54	412	13.1%	cbioportal
24	DNAH11	Ssm	53	412	12.9%	cbioportal
25	CUBN	Ssm	52	412	12.6%	cbioportal
26	SYNE2	Ssm	52	412	12.6%	cbioportal
27	BIRC6	Ssm	51	412	12.4%	cbioportal
28	FAT1	Ssm	51	412	12.4%	cbioportal
30	CREBBP	Ssm	50	412	12.1%	cbioportal
29	AHNAK2	Ssm	50	412	12.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma TCGA-BLCATCGA

412 cases with simple somatic mutation data · 412 cases total · Data Release 46.0 · mapped to Bladder Urothelial Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	294	412	71.4%	gdc
2	TTN	Ssm	281	412	68.2%	gdc
3	CDKN2A	Ssm	269	412	65.3%	gdc
4	CDKN2B	Ssm	267	412	64.8%	gdc
5	AL359922.1	Ssm	264	412	64.1%	gdc
6	CSMD1	Ssm	263	412	63.8%	gdc
7	MTAP	Ssm	261	412	63.3%	gdc
8	VPS13B	Ssm	260	412	63.1%	gdc
9	CSMD3	Ssm	260	412	63.1%	gdc
10	UBR5	Ssm	259	412	62.9%	gdc
11	GRHL2	Ssm	255	412	61.9%	gdc
12	DMRTA1	Ssm	255	412	61.9%	gdc
19	TEX15	Ssm	253	412	61.4%	gdc
17	TNFRSF10A	Ssm	253	412	61.4%	gdc
16	ZNF706	Ssm	253	412	61.4%	gdc
15	COL14A1	Ssm	253	412	61.4%	gdc
14	MYOM2	Ssm	253	412	61.4%	gdc
13	PABPC1	Ssm	253	412	61.4%	gdc
18	DNAH5	Ssm	253	412	61.4%	gdc
20	RIMS2	Ssm	252	412	61.2%	gdc
21	ADRA1A	Ssm	252	412	61.2%	gdc
28	PKHD1L1	Ssm	251	412	60.9%	gdc
26	NEFM	Ssm	251	412	60.9%	gdc
25	YWHAZ	Ssm	251	412	60.9%	gdc
24	CDCA2	Ssm	251	412	60.9%	gdc
23	RNF19A	Ssm	251	412	60.9%	gdc
22	SORBS3	Ssm	251	412	60.9%	gdc
27	FBXO43	Ssm	251	412	60.9%	gdc
29	RGS22	Ssm	250	412	60.7%	gdc
30	PRAG1	Ssm	250	412	60.7%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Bladder Urothelial Carcinoma (BGI, Nat Genet 2013) blca_bgiBGI

99 cases with simple somatic mutation data · 99 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KDM6A	Ssm	32	99	32.3%	cbioportal
2	TP53	Ssm	28	99	28.3%	cbioportal
3	PIK3CA	Ssm	24	99	24.2%	cbioportal
4	ZNF83	Ssm	18	99	18.2%	cbioportal
5	FGFR3	Ssm	16	99	16.2%	cbioportal
6	ARID1A	Ssm	15	99	15.2%	cbioportal
7	CREBBP	Ssm	15	99	15.2%	cbioportal
8	HRAS	Ssm	15	99	15.2%	cbioportal
9	EP300	Ssm	14	99	14.1%	cbioportal
11	STAG2	Ssm	13	99	13.1%	cbioportal
12	ZNF233	Ssm	13	99	13.1%	cbioportal
10	RB1	Ssm	13	99	13.1%	cbioportal
14	ERCC2	Ssm	10	99	10.1%	cbioportal
15	SYNE2	Ssm	10	99	10.1%	cbioportal
13	ERBB2	Ssm	10	99	10.1%	cbioportal
20	ZFP36L1	Ssm	9	99	9.1%	cbioportal
19	XIRP2	Ssm	9	99	9.1%	cbioportal
18	SYNE1	Ssm	9	99	9.1%	cbioportal
17	HMCN1	Ssm	9	99	9.1%	cbioportal
16	FGFRL1	Ssm	9	99	9.1%	cbioportal
21	CSMD3	Ssm	8	99	8.1%	cbioportal
22	KMT2A	Ssm	8	99	8.1%	cbioportal
25	AQP7	Ssm	7	99	7.1%	cbioportal
29	KRAS	Ssm	7	99	7.1%	cbioportal
28	GOLGB1	Ssm	7	99	7.1%	cbioportal
27	FMN2	Ssm	7	99	7.1%	cbioportal
30	LRP2	Ssm	7	99	7.1%	cbioportal
26	DNAH8	Ssm	7	99	7.1%	cbioportal
23	ACTB	Ssm	7	99	7.1%	cbioportal
24	ANK3	Ssm	7	99	7.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma (DFCI/MSK, Cancer Discov 2014) blca_dfarber_mskcc_2014DFCI/MSK

50 cases with simple somatic mutation data · 50 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	29	50	58%	cbioportal
2	TTN	Ssm	24	50	48%	cbioportal
3	MUC16	Ssm	19	50	38%	cbioportal
4	ERBB4	Ssm	17	50	34%	cbioportal
5	KMT2D	Ssm	15	50	30%	cbioportal
6	ZAN	Ssm	14	50	28%	cbioportal
7	ARID1A	Ssm	13	50	26%	cbioportal
8	ERBB3	Ssm	12	50	24%	cbioportal
9	KDM6A	Ssm	12	50	24%	cbioportal
10	RB1	Ssm	12	50	24%	cbioportal
11	ZNF721	Ssm	12	50	24%	cbioportal
15	PRG4	Ssm	10	50	20%	cbioportal
12	AHNAK2	Ssm	10	50	20%	cbioportal
13	MUC17	Ssm	10	50	20%	cbioportal
14	PIK3CA	Ssm	10	50	20%	cbioportal
16	SYNE1	Ssm	10	50	20%	cbioportal
17	AHNAK	Ssm	9	50	18%	cbioportal
23	SYNE2	Ssm	9	50	18%	cbioportal
22	RPTN	Ssm	9	50	18%	cbioportal
21	MAGEC1	Ssm	9	50	18%	cbioportal
20	FAT4	Ssm	9	50	18%	cbioportal
19	ERCC2	Ssm	9	50	18%	cbioportal
18	ANKRD30A	Ssm	9	50	18%	cbioportal
28	KMT2C	Ssm	8	50	16%	cbioportal
29	MDN1	Ssm	8	50	16%	cbioportal
30	MUC4	Ssm	8	50	16%	cbioportal
27	FLG	Ssm	8	50	16%	cbioportal
26	F5	Ssm	8	50	16%	cbioportal
25	BIRC6	Ssm	8	50	16%	cbioportal
24	ALMS1	Ssm	8	50	16%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma SWOG S1314 Trial (MSK, JCO Precis Oncol 2024) blca_msk_2024MSK

184 cases with simple somatic mutation data · 184 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	141	184	76.6%	cbioportal
2	TP53	Ssm	116	184	63%	cbioportal
3	KMT2D	Ssm	64	184	34.8%	cbioportal
4	KDM6A	Ssm	55	184	29.9%	cbioportal
5	ARID1A	Ssm	50	184	27.2%	cbioportal
6	RB1	Ssm	48	184	26.1%	cbioportal
7	PIK3CA	Ssm	42	184	22.8%	cbioportal
8	KMT2C	Ssm	35	184	19%	cbioportal
9	ATM	Ssm	31	184	16.8%	cbioportal
11	FAT1	Ssm	29	184	15.8%	cbioportal
10	ELF3	Ssm	29	184	15.8%	cbioportal
12	CREBBP	Ssm	27	184	14.7%	cbioportal
13	ERCC2	Ssm	27	184	14.7%	cbioportal
15	KMT2A	Ssm	26	184	14.1%	cbioportal
14	BRCA2	Ssm	26	184	14.1%	cbioportal
16	ERBB2	Ssm	25	184	13.6%	cbioportal
17	FGFR3	Ssm	25	184	13.6%	cbioportal
19	ERBB3	Ssm	24	184	13%	cbioportal
18	EP300	Ssm	24	184	13%	cbioportal
20	TSC1	Ssm	22	184	12%	cbioportal
21	FBXW7	Ssm	21	184	11.4%	cbioportal
22	CDKN1A	Ssm	20	184	10.9%	cbioportal
23	H3C7	Ssm	18	184	9.8%	cbioportal
24	NF1	Ssm	18	184	9.8%	cbioportal
25	STAG2	Ssm	18	184	9.8%	cbioportal
26	PTPRT	Ssm	17	184	9.2%	cbioportal
27	CDKN2A	Ssm	16	184	8.7%	cbioportal
28	KMT2B	Ssm	16	184	8.7%	cbioportal
29	NSD1	Ssm	16	184	8.7%	cbioportal
30	ARID1B	Ssm	15	184	8.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma (TCGA, Firehose Legacy) blca_tcgaTCGA

130 cases with simple somatic mutation data · 413 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	73	130	56.2%	cbioportal
2	TP53	Ssm	64	130	49.2%	cbioportal
3	MUC16	Ssm	43	130	33.1%	cbioportal
4	KMT2D	Ssm	36	130	27.7%	cbioportal
5	ARID1A	Ssm	34	130	26.2%	cbioportal
6	KDM6A	Ssm	31	130	23.8%	cbioportal
7	KMT2C	Ssm	27	130	20.8%	cbioportal
8	PIK3CA	Ssm	26	130	20%	cbioportal
9	HMCN1	Ssm	24	130	18.5%	cbioportal
10	SYNE1	Ssm	24	130	18.5%	cbioportal
11	FLG	Ssm	23	130	17.7%	cbioportal
12	EP300	Ssm	21	130	16.2%	cbioportal
13	RYR2	Ssm	20	130	15.4%	cbioportal
17	ZFHX4	Ssm	19	130	14.6%	cbioportal
15	PDE4DIP	Ssm	19	130	14.6%	cbioportal
14	MACF1	Ssm	19	130	14.6%	cbioportal
16	PKHD1L1	Ssm	19	130	14.6%	cbioportal
20	KMT2A	Ssm	18	130	13.8%	cbioportal
19	CDKN1A	Ssm	18	130	13.8%	cbioportal
18	AHNAK2	Ssm	18	130	13.8%	cbioportal
26	RB1	Ssm	17	130	13.1%	cbioportal
22	DNAH11	Ssm	17	130	13.1%	cbioportal
21	CREBBP	Ssm	17	130	13.1%	cbioportal
23	FAT4	Ssm	17	130	13.1%	cbioportal
24	LRP1B	Ssm	17	130	13.1%	cbioportal
25	MUC17	Ssm	17	130	13.1%	cbioportal
27	SYNE2	Ssm	17	130	13.1%	cbioportal
28	ADGRV1	Ssm	16	130	12.3%	cbioportal
29	ERCC2	Ssm	16	130	12.3%	cbioportal
30	FGFR3	Ssm	16	130	12.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma (TCGA GDC, 2025) blca_tcga_gdcTCGA GDC

408 cases with simple somatic mutation data · 413 cases total · 2026-01-19 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	202	408	49.5%	cbioportal
2	TTN	Ssm	176	408	43.1%	cbioportal
3	KMT2D	Ssm	109	408	26.7%	cbioportal
4	KDM6A	Ssm	104	408	25.5%	cbioportal
5	MUC16	Ssm	103	408	25.2%	cbioportal
6	ARID1A	Ssm	100	408	24.5%	cbioportal
7	PIK3CA	Ssm	86	408	21.1%	cbioportal
8	SYNE1	Ssm	80	408	19.6%	cbioportal
9	RB1	Ssm	72	408	17.6%	cbioportal
10	KMT2C	Ssm	69	408	16.9%	cbioportal
11	RYR2	Ssm	69	408	16.9%	cbioportal
12	HMCN1	Ssm	66	408	16.2%	cbioportal
15	MACF1	Ssm	60	408	14.7%	cbioportal
14	FAT4	Ssm	60	408	14.7%	cbioportal
13	EP300	Ssm	60	408	14.7%	cbioportal
16	FLG	Ssm	58	408	14.2%	cbioportal
18	STAG2	Ssm	56	408	13.7%	cbioportal
17	FGFR3	Ssm	56	408	13.7%	cbioportal
19	ELF3	Ssm	55	408	13.5%	cbioportal
20	CSMD3	Ssm	53	408	13%	cbioportal
21	ATM	Ssm	51	408	12.5%	cbioportal
22	OBSCN	Ssm	50	408	12.3%	cbioportal
23	NEB	Ssm	49	408	12%	cbioportal
24	CUBN	Ssm	48	408	11.8%	cbioportal
27	SYNE2	Ssm	47	408	11.5%	cbioportal
26	DNAH5	Ssm	47	408	11.5%	cbioportal
25	BIRC6	Ssm	47	408	11.5%	cbioportal
29	ERBB2	Ssm	46	408	11.3%	cbioportal
28	CREBBP	Ssm	46	408	11.3%	cbioportal
30	XIRP2	Ssm	46	408	11.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Bladder Urothelial Carcinoma (TCGA, Nature 2014) blca_tcga_pubTCGA

130 cases with simple somatic mutation data · 131 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	72	130	55.4%	cbioportal
2	TP53	Ssm	64	130	49.2%	cbioportal
3	MUC16	Ssm	43	130	33.1%	cbioportal
4	KMT2D	Ssm	35	130	26.9%	cbioportal
5	ARID1A	Ssm	33	130	25.4%	cbioportal
6	KDM6A	Ssm	31	130	23.8%	cbioportal
7	KMT2C	Ssm	28	130	21.5%	cbioportal
8	PIK3CA	Ssm	26	130	20%	cbioportal
9	FLG	Ssm	25	130	19.2%	cbioportal
10	HMCN1	Ssm	24	130	18.5%	cbioportal
11	SYNE1	Ssm	24	130	18.5%	cbioportal
12	EP300	Ssm	20	130	15.4%	cbioportal
13	RYR2	Ssm	20	130	15.4%	cbioportal
15	MACF1	Ssm	19	130	14.6%	cbioportal
17	PKHD1L1	Ssm	19	130	14.6%	cbioportal
18	ZFHX4	Ssm	19	130	14.6%	cbioportal
16	PDE4DIP	Ssm	19	130	14.6%	cbioportal
14	AHNAK2	Ssm	19	130	14.6%	cbioportal
20	KMT2A	Ssm	18	130	13.8%	cbioportal
22	SYNE2	Ssm	18	130	13.8%	cbioportal
21	LRP1B	Ssm	18	130	13.8%	cbioportal
19	CDKN1A	Ssm	18	130	13.8%	cbioportal
25	RB1	Ssm	17	130	13.1%	cbioportal
24	MUC17	Ssm	17	130	13.1%	cbioportal
23	LYST	Ssm	17	130	13.1%	cbioportal
30	DNAH3	Ssm	16	130	12.3%	cbioportal
27	CREBBP	Ssm	16	130	12.3%	cbioportal
26	ADGRV1	Ssm	16	130	12.3%	cbioportal
29	DNAH11	Ssm	16	130	12.3%	cbioportal
28	CSMD3	Ssm	16	130	12.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Bladder Urothelial Carcinoma (TCGA, PanCancer Atlas) blca_tcga_pan_can_atlas_2018TCGA

410 cases with simple somatic mutation data · 411 cases total · 2026-08-20 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	202	410	49.3%	cbioportal
2	TTN	Ssm	192	410	46.8%	cbioportal
3	MUC16	Ssm	119	410	29%	cbioportal
4	KMT2D	Ssm	117	410	28.5%	cbioportal
5	KDM6A	Ssm	106	410	25.9%	cbioportal
6	ARID1A	Ssm	105	410	25.6%	cbioportal
7	PIK3CA	Ssm	90	410	22%	cbioportal
8	SYNE1	Ssm	87	410	21.2%	cbioportal
9	KMT2C	Ssm	81	410	19.8%	cbioportal
10	RB1	Ssm	78	410	19%	cbioportal
12	RYR2	Ssm	76	410	18.5%	cbioportal
11	MACF1	Ssm	76	410	18.5%	cbioportal
13	HMCN1	Ssm	75	410	18.3%	cbioportal
14	FLG	Ssm	68	410	16.6%	cbioportal
16	FAT4	Ssm	63	410	15.4%	cbioportal
15	EP300	Ssm	63	410	15.4%	cbioportal
17	FGFR3	Ssm	59	410	14.4%	cbioportal
18	CSMD3	Ssm	58	410	14.1%	cbioportal
19	STAG2	Ssm	57	410	13.9%	cbioportal
20	ATM	Ssm	55	410	13.4%	cbioportal
21	BIRC6	Ssm	54	410	13.2%	cbioportal
22	ELF3	Ssm	54	410	13.2%	cbioportal
23	OBSCN	Ssm	54	410	13.2%	cbioportal
25	NEB	Ssm	53	410	12.9%	cbioportal
24	CUBN	Ssm	53	410	12.9%	cbioportal
26	DNAH11	Ssm	52	410	12.7%	cbioportal
27	LRP1B	Ssm	52	410	12.7%	cbioportal
28	SYNE2	Ssm	52	410	12.7%	cbioportal
30	CREBBP	Ssm	51	410	12.4%	cbioportal
29	AHNAK2	Ssm	51	410	12.4%	cbioportal

Data updated 22 days agoSource updated 2026-08-20

Chromophobe Renal Cell Carcinoma (TCGA GDC, 2025) chrcc_tcga_gdcTCGA GDC

66 cases with simple somatic mutation data · 66 cases total · 2026-01-13 · mapped to Chromophobe Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	20	66	30.3%	cbioportal
2	PTEN	Ssm	6	66	9.1%	cbioportal
3	TTN	Ssm	4	66	6.1%	cbioportal
8	ZAN	Ssm	3	66	4.5%	cbioportal
7	MUC16	Ssm	3	66	4.5%	cbioportal
6	ICE1	Ssm	3	66	4.5%	cbioportal
4	CFAP47	Ssm	3	66	4.5%	cbioportal
5	CSF2RB	Ssm	3	66	4.5%	cbioportal
28	CACNA1C	Ssm	2	66	3%	cbioportal
87	TRRAP	Ssm	2	66	3%	cbioportal
9	ABCE1	Ssm	2	66	3%	cbioportal
10	ADAMTSL1	Ssm	2	66	3%	cbioportal
11	ADGRB1	Ssm	2	66	3%	cbioportal
12	AFF3	Ssm	2	66	3%	cbioportal
13	AGBL1	Ssm	2	66	3%	cbioportal
14	AICDA	Ssm	2	66	3%	cbioportal
15	ANKRD17	Ssm	2	66	3%	cbioportal
16	ARHGEF2	Ssm	2	66	3%	cbioportal
17	ATG2A	Ssm	2	66	3%	cbioportal
18	ATG2B	Ssm	2	66	3%	cbioportal
19	ATM	Ssm	2	66	3%	cbioportal
20	ATP10B	Ssm	2	66	3%	cbioportal
21	AXDND1	Ssm	2	66	3%	cbioportal
22	BIRC6	Ssm	2	66	3%	cbioportal
23	BLTP1	Ssm	2	66	3%	cbioportal
24	BPTF	Ssm	2	66	3%	cbioportal
25	BSN	Ssm	2	66	3%	cbioportal
26	C3ORF20	Ssm	2	66	3%	cbioportal
27	CACNA1A	Ssm	2	66	3%	cbioportal
29	CDKN1A	Ssm	2	66	3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Clear Cell Renal Cell Carcinoma (DFCI, Science 2019) ccrcc_dfci_2019DFCI

35 cases with simple somatic mutation data · 35 cases total · 2026-01-05 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	25	35	71.4%	cbioportal
2	PBRM1	Ssm	19	35	54.3%	cbioportal
3	SETD2	Ssm	15	35	42.9%	cbioportal
5	MACF1	Ssm	7	35	20%	cbioportal
4	KDM5C	Ssm	7	35	20%	cbioportal
7	TTN	Ssm	6	35	17.1%	cbioportal
6	CACNA1I	Ssm	6	35	17.1%	cbioportal
8	BAP1	Ssm	5	35	14.3%	cbioportal
14	ITCH	Ssm	4	35	11.4%	cbioportal
17	VPS13B	Ssm	4	35	11.4%	cbioportal
16	USP32	Ssm	4	35	11.4%	cbioportal
15	MTOR	Ssm	4	35	11.4%	cbioportal
13	HDAC9	Ssm	4	35	11.4%	cbioportal
12	DYNC1I1	Ssm	4	35	11.4%	cbioportal
11	DACH2	Ssm	4	35	11.4%	cbioportal
10	ATXN7L1	Ssm	4	35	11.4%	cbioportal
9	AK9	Ssm	4	35	11.4%	cbioportal
18	ADAMTS16	Ssm	3	35	8.6%	cbioportal
27	GUCY2C	Ssm	3	35	8.6%	cbioportal
28	HIF1A	Ssm	3	35	8.6%	cbioportal
29	HMCN1	Ssm	3	35	8.6%	cbioportal
25	EPB41	Ssm	3	35	8.6%	cbioportal
24	DNAH14	Ssm	3	35	8.6%	cbioportal
23	CTNNA2	Ssm	3	35	8.6%	cbioportal
22	CLCA4	Ssm	3	35	8.6%	cbioportal
21	CHD9	Ssm	3	35	8.6%	cbioportal
20	CD2AP	Ssm	3	35	8.6%	cbioportal
19	CABIN1	Ssm	3	35	8.6%	cbioportal
30	HUWE1	Ssm	3	35	8.6%	cbioportal
26	FIRRM	Ssm	3	35	8.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Kidney Chromophobe TCGA-KICHTCGA

86 cases with simple somatic mutation data · 113 cases total · Data Release 46.0 · mapped to Chromophobe Renal Cell Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	GPRIN2	Ssm	61	86	70.9%	gdc
5	TP53	Ssm	59	86	68.6%	gdc
10	ANXA8L1	Ssm	59	86	68.6%	gdc
6	ACAP3	Ssm	59	86	68.6%	gdc
7	GABRD	Ssm	59	86	68.6%	gdc
4	NBPF1	Ssm	59	86	68.6%	gdc
9	CROCC	Ssm	59	86	68.6%	gdc
2	SCNN1D	Ssm	59	86	68.6%	gdc
3	SYT15	Ssm	59	86	68.6%	gdc
8	FAM131C	Ssm	59	86	68.6%	gdc
14	TTC34	Ssm	58	86	67.4%	gdc
29	ATAD3C	Ssm	58	86	67.4%	gdc
28	MMP23B	Ssm	58	86	67.4%	gdc
27	DFFA	Ssm	58	86	67.4%	gdc
26	GNB1	Ssm	58	86	67.4%	gdc
25	TAS1R1	Ssm	58	86	67.4%	gdc
24	NADK	Ssm	58	86	67.4%	gdc
23	ATAD3A	Ssm	58	86	67.4%	gdc
22	TMEM52	Ssm	58	86	67.4%	gdc
21	MIB2	Ssm	58	86	67.4%	gdc
20	DUSP22	Ssm	58	86	67.4%	gdc
19	TMEM240	Ssm	58	86	67.4%	gdc
18	MRPL20	Ssm	58	86	67.4%	gdc
17	KCNAB2	Ssm	58	86	67.4%	gdc
16	PUSL1	Ssm	58	86	67.4%	gdc
15	SSU72	Ssm	58	86	67.4%	gdc
13	CDK11A	Ssm	58	86	67.4%	gdc
12	UBE2J2	Ssm	58	86	67.4%	gdc
11	INTS11	Ssm	58	86	67.4%	gdc
58	AGRN	Ssm	58	86	67.4%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Kidney Chromophobe (TCGA, Cancer Cell 2014) kich_tcga_pubTCGA

65 cases with simple somatic mutation data · 66 cases total · 2026-01-07 · mapped to Chromophobe Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	20	65	30.8%	cbioportal
2	PTEN	Ssm	6	65	9.2%	cbioportal
5	TTN	Ssm	3	65	4.6%	cbioportal
4	ICE1	Ssm	3	65	4.6%	cbioportal
3	CRACD	Ssm	3	65	4.6%	cbioportal
20	CSF2RB	Ssm	2	65	3.1%	cbioportal
21	CSMD1	Ssm	2	65	3.1%	cbioportal
22	DDX50	Ssm	2	65	3.1%	cbioportal
25	DSPP	Ssm	2	65	3.1%	cbioportal
26	DYNC2H1	Ssm	2	65	3.1%	cbioportal
27	ELAPOR1	Ssm	2	65	3.1%	cbioportal
28	ENTREP3	Ssm	2	65	3.1%	cbioportal
29	ESPL1	Ssm	2	65	3.1%	cbioportal
30	FLT4	Ssm	2	65	3.1%	cbioportal
23	DIDO1	Ssm	2	65	3.1%	cbioportal
16	CASP5	Ssm	2	65	3.1%	cbioportal
17	CDC27	Ssm	2	65	3.1%	cbioportal
18	CDKN1A	Ssm	2	65	3.1%	cbioportal
19	CLCN2	Ssm	2	65	3.1%	cbioportal
24	DSCAM	Ssm	2	65	3.1%	cbioportal
6	ADAMTS7	Ssm	2	65	3.1%	cbioportal
7	AFF3	Ssm	2	65	3.1%	cbioportal
8	AICDA	Ssm	2	65	3.1%	cbioportal
9	ARHGEF2	Ssm	2	65	3.1%	cbioportal
10	ATM	Ssm	2	65	3.1%	cbioportal
11	BAIAP2L2	Ssm	2	65	3.1%	cbioportal
12	BLTP1	Ssm	2	65	3.1%	cbioportal
13	C3ORF20	Ssm	2	65	3.1%	cbioportal
14	CACNA1A	Ssm	2	65	3.1%	cbioportal
15	CACNA1B	Ssm	2	65	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Kidney Chromophobe (TCGA, Firehose Legacy) kich_tcgaTCGA

66 cases with simple somatic mutation data · 113 cases total · 2026-01-07 · mapped to Chromophobe Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4	Ssm	46	66	69.7%	cbioportal
2	FRG1BP	Ssm	33	66	50%	cbioportal
3	MUC6	Ssm	22	66	33.3%	cbioportal
4	TP53	Ssm	22	66	33.3%	cbioportal
6	MUC2	Ssm	15	66	22.7%	cbioportal
5	MUC16	Ssm	15	66	22.7%	cbioportal
7	FRG1	Ssm	14	66	21.2%	cbioportal
8	MUC5B	Ssm	12	66	18.2%	cbioportal
9	NBPF10	Ssm	12	66	18.2%	cbioportal
10	CDC27	Ssm	11	66	16.7%	cbioportal
11	AHNAK2	Ssm	10	66	15.2%	cbioportal
12	KMT2C	Ssm	10	66	15.2%	cbioportal
15	PABPC3	Ssm	8	66	12.1%	cbioportal
14	PABPC1	Ssm	8	66	12.1%	cbioportal
13	DSPP	Ssm	8	66	12.1%	cbioportal
16	HLA-C	Ssm	7	66	10.6%	cbioportal
23	PRB2	Ssm	6	66	9.1%	cbioportal
24	PRSS3	Ssm	6	66	9.1%	cbioportal
26	RBMXL1	Ssm	6	66	9.1%	cbioportal
25	PTEN	Ssm	6	66	9.1%	cbioportal
22	PCDHA8	Ssm	6	66	9.1%	cbioportal
28	TAS2R43	Ssm	6	66	9.1%	cbioportal
29	ZNF469	Ssm	6	66	9.1%	cbioportal
17	DDX11	Ssm	6	66	9.1%	cbioportal
18	GOLGA6L6	Ssm	6	66	9.1%	cbioportal
19	HLA-A	Ssm	6	66	9.1%	cbioportal
20	MUC17	Ssm	6	66	9.1%	cbioportal
21	MUC21	Ssm	6	66	9.1%	cbioportal
27	SLC35G5	Ssm	6	66	9.1%	cbioportal
30	ADAMTS7	Ssm	5	66	7.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Kidney Chromophobe (TCGA, PanCancer Atlas) kich_tcga_pan_can_atlas_2018TCGA

65 cases with simple somatic mutation data · 65 cases total · 2026-06-23 · mapped to Chromophobe Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	21	65	32.3%	cbioportal
2	PTEN	Ssm	6	65	9.2%	cbioportal
3	ZAN	Ssm	5	65	7.7%	cbioportal
5	TTN	Ssm	4	65	6.2%	cbioportal
4	HERC2	Ssm	4	65	6.2%	cbioportal
14	KALRN	Ssm	3	65	4.6%	cbioportal
6	ATG2A	Ssm	3	65	4.6%	cbioportal
7	BIRC6	Ssm	3	65	4.6%	cbioportal
8	CFAP47	Ssm	3	65	4.6%	cbioportal
9	CSF2RB	Ssm	3	65	4.6%	cbioportal
10	DNAH1	Ssm	3	65	4.6%	cbioportal
11	FAT4	Ssm	3	65	4.6%	cbioportal
12	FLT4	Ssm	3	65	4.6%	cbioportal
13	ICE1	Ssm	3	65	4.6%	cbioportal
15	MUC16	Ssm	3	65	4.6%	cbioportal
16	PCLO	Ssm	3	65	4.6%	cbioportal
17	ZFHX4	Ssm	3	65	4.6%	cbioportal
23	AGBL1	Ssm	2	65	3.1%	cbioportal
26	AMPD2	Ssm	2	65	3.1%	cbioportal
24	AGRN	Ssm	2	65	3.1%	cbioportal
25	AICDA	Ssm	2	65	3.1%	cbioportal
27	ANKHD1	Ssm	2	65	3.1%	cbioportal
28	ANKRD17	Ssm	2	65	3.1%	cbioportal
29	ARFGAP3	Ssm	2	65	3.1%	cbioportal
18	ABCE1	Ssm	2	65	3.1%	cbioportal
19	ACAP3	Ssm	2	65	3.1%	cbioportal
20	ADAMTSL1	Ssm	2	65	3.1%	cbioportal
21	ADGRB1	Ssm	2	65	3.1%	cbioportal
22	AFF3	Ssm	2	65	3.1%	cbioportal
30	ARHGEF18	Ssm	2	65	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-06-23

Kidney Renal Clear Cell Carcinoma TCGA-KIRCTCGA

536 cases with simple somatic mutation data · 537 cases total · Data Release 46.0 · mapped to Clear Cell Renal Cell Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	463	536	86.4%	gdc
2	PBRM1	Ssm	456	536	85.1%	gdc
3	BAP1	Ssm	451	536	84.1%	gdc
4	PLXNB1	Ssm	450	536	84%	gdc
5	COL7A1	Ssm	450	536	84%	gdc
6	GLB1	Ssm	450	536	84%	gdc
26	IP6K2	Ssm	449	536	83.8%	gdc
27	TMEM89	Ssm	449	536	83.8%	gdc
17	CCDC51	Ssm	449	536	83.8%	gdc
7	TREX1	Ssm	449	536	83.8%	gdc
8	CDC25A	Ssm	449	536	83.8%	gdc
9	CELSR3	Ssm	449	536	83.8%	gdc
10	PRKAR2A	Ssm	449	536	83.8%	gdc
11	UQCRC1	Ssm	449	536	83.8%	gdc
12	PTH1R	Ssm	449	536	83.8%	gdc
13	SLC26A6	Ssm	449	536	83.8%	gdc
14	SETD2	Ssm	449	536	83.8%	gdc
15	UCN2	Ssm	449	536	83.8%	gdc
16	SHISA5	Ssm	449	536	83.8%	gdc
18	PFKFB4	Ssm	449	536	83.8%	gdc
19	FBXW12	Ssm	449	536	83.8%	gdc
20	SCN5A	Ssm	449	536	83.8%	gdc
21	NCKIPSD	Ssm	449	536	83.8%	gdc
22	HHATL	Ssm	449	536	83.8%	gdc
23	VIPR1	Ssm	449	536	83.8%	gdc
24	ATRIP	Ssm	449	536	83.8%	gdc
25	TMA7	Ssm	449	536	83.8%	gdc
28	SLC25A20	Ssm	448	536	83.6%	gdc
29	LAMB2	Ssm	448	536	83.6%	gdc
30	DCAF1	Ssm	448	536	83.6%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Kidney Renal Clear Cell Carcinoma (BGI, Nat Genet 2012) kirc_bgiBGI

98 cases with simple somatic mutation data · 98 cases total · 2026-01-07 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	25	98	25.5%	cbioportal
2	KDM5C	Ssm	9	98	9.2%	cbioportal
5	SYNE2	Ssm	7	98	7.1%	cbioportal
4	LRP1B	Ssm	7	98	7.1%	cbioportal
3	BAP1	Ssm	7	98	7.1%	cbioportal
6	TP53	Ssm	6	98	6.1%	cbioportal
7	AHNAK	Ssm	5	98	5.1%	cbioportal
9	CSMD3	Ssm	5	98	5.1%	cbioportal
10	RYR1	Ssm	5	98	5.1%	cbioportal
11	SPTBN4	Ssm	5	98	5.1%	cbioportal
8	AKAP13	Ssm	5	98	5.1%	cbioportal
15	SETD2	Ssm	4	98	4.1%	cbioportal
12	CARD11	Ssm	4	98	4.1%	cbioportal
13	FAM111B	Ssm	4	98	4.1%	cbioportal
16	ZNF804A	Ssm	4	98	4.1%	cbioportal
14	NAV3	Ssm	4	98	4.1%	cbioportal
18	CUL7	Ssm	3	98	3.1%	cbioportal
20	KMT2C	Ssm	3	98	3.1%	cbioportal
21	LRRK2	Ssm	3	98	3.1%	cbioportal
22	MTOR	Ssm	3	98	3.1%	cbioportal
25	TSC1	Ssm	3	98	3.1%	cbioportal
24	SHANK1	Ssm	3	98	3.1%	cbioportal
23	PZP	Ssm	3	98	3.1%	cbioportal
17	ATRNL1	Ssm	3	98	3.1%	cbioportal
19	FMN2	Ssm	3	98	3.1%	cbioportal
29	APC	Ssm	2	98	2%	cbioportal
30	BTRC	Ssm	2	98	2%	cbioportal
26	ADCY9	Ssm	2	98	2%	cbioportal
27	AFDN	Ssm	2	98	2%	cbioportal
28	AGXT	Ssm	2	98	2%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Kidney Renal Clear Cell Carcinoma (IRC, Nat Genet 2014) ccrcc_irc_2014IRC

78 cases with simple somatic mutation data · 79 cases total · 2026-01-05 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	62	78	79.5%	cbioportal
2	PBRM1	Ssm	29	78	37.2%	cbioportal
3	SETD2	Ssm	21	78	26.9%	cbioportal
4	BAP1	Ssm	19	78	24.4%	cbioportal
5	DOP1A	Ssm	17	78	21.8%	cbioportal
6	UGT2A1	Ssm	15	78	19.2%	cbioportal
7	DAPK1	Ssm	13	78	16.7%	cbioportal
8	ANO5	Ssm	12	78	15.4%	cbioportal
9	CENPF	Ssm	12	78	15.4%	cbioportal
10	MYH8	Ssm	12	78	15.4%	cbioportal
13	GLTPD2	Ssm	11	78	14.1%	cbioportal
14	ITGB3	Ssm	11	78	14.1%	cbioportal
15	MUC16	Ssm	11	78	14.1%	cbioportal
16	OR2A14	Ssm	11	78	14.1%	cbioportal
17	PPP6R1	Ssm	11	78	14.1%	cbioportal
12	EDC4	Ssm	11	78	14.1%	cbioportal
11	DUSP19	Ssm	11	78	14.1%	cbioportal
18	UNC80	Ssm	11	78	14.1%	cbioportal
27	EIF4G2	Ssm	10	78	12.8%	cbioportal
28	EXT1	Ssm	10	78	12.8%	cbioportal
29	FCAMR	Ssm	10	78	12.8%	cbioportal
30	GARRE1	Ssm	10	78	12.8%	cbioportal
19	ATP11B	Ssm	10	78	12.8%	cbioportal
20	ATXN1	Ssm	10	78	12.8%	cbioportal
21	BCAS2	Ssm	10	78	12.8%	cbioportal
22	C11ORF68	Ssm	10	78	12.8%	cbioportal
23	CCR6	Ssm	10	78	12.8%	cbioportal
24	CLCN2	Ssm	10	78	12.8%	cbioportal
25	CYP4F3	Ssm	10	78	12.8%	cbioportal
26	DDX52	Ssm	10	78	12.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Kidney Renal Clear Cell Carcinoma (TCGA, Firehose Legacy) kirc_tcgaTCGA

451 cases with simple somatic mutation data · 538 cases total · 2026-01-07 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	225	451	49.9%	cbioportal
2	PBRM1	Ssm	133	451	29.5%	cbioportal
3	MUC4	Ssm	77	451	17.1%	cbioportal
4	TTN	Ssm	71	451	15.7%	cbioportal
5	MUC16	Ssm	58	451	12.9%	cbioportal
6	SETD2	Ssm	51	451	11.3%	cbioportal
7	BAP1	Ssm	40	451	8.9%	cbioportal
8	MTOR	Ssm	32	451	7.1%	cbioportal
9	FBN2	Ssm	30	451	6.7%	cbioportal
10	XIRP2	Ssm	28	451	6.2%	cbioportal
11	DNAH3	Ssm	27	451	6%	cbioportal
12	KDM5C	Ssm	27	451	6%	cbioportal
13	HMCN1	Ssm	26	451	5.8%	cbioportal
16	TSHZ3	Ssm	25	451	5.5%	cbioportal
15	ARID1A	Ssm	25	451	5.5%	cbioportal
14	ARAP3	Ssm	25	451	5.5%	cbioportal
17	SSH2	Ssm	24	451	5.3%	cbioportal
21	VWF	Ssm	23	451	5.1%	cbioportal
20	SPEN	Ssm	23	451	5.1%	cbioportal
19	NAV3	Ssm	23	451	5.1%	cbioportal
18	AKAP9	Ssm	23	451	5.1%	cbioportal
23	CD4	Ssm	22	451	4.9%	cbioportal
26	PDZD2	Ssm	22	451	4.9%	cbioportal
25	MAP1B	Ssm	22	451	4.9%	cbioportal
24	GRIN2B	Ssm	22	451	4.9%	cbioportal
22	ABCA1	Ssm	22	451	4.9%	cbioportal
28	DCHS1	Ssm	21	451	4.7%	cbioportal
29	DDB1	Ssm	21	451	4.7%	cbioportal
30	DNMT1	Ssm	21	451	4.7%	cbioportal
27	ABCA6	Ssm	21	451	4.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Kidney Renal Clear Cell Carcinoma (TCGA, Nature 2013) kirc_tcga_pubTCGA

426 cases with simple somatic mutation data · 446 cases total · 2026-02-19 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	218	426	51.2%	cbioportal
2	PBRM1	Ssm	145	426	34%	cbioportal
3	MUC4	Ssm	90	426	21.1%	cbioportal
4	TTN	Ssm	63	426	14.8%	cbioportal
5	SETD2	Ssm	55	426	12.9%	cbioportal
6	BAP1	Ssm	42	426	9.9%	cbioportal
7	MUC16	Ssm	34	426	8%	cbioportal
8	KDM5C	Ssm	29	426	6.8%	cbioportal
9	MTOR	Ssm	23	426	5.4%	cbioportal
10	PABPC1	Ssm	19	426	4.5%	cbioportal
11	HMCN1	Ssm	18	426	4.2%	cbioportal
15	USH2A	Ssm	17	426	4%	cbioportal
12	AHNAK2	Ssm	17	426	4%	cbioportal
13	KMT2C	Ssm	17	426	4%	cbioportal
14	PTEN	Ssm	17	426	4%	cbioportal
17	MAGEC1	Ssm	16	426	3.8%	cbioportal
16	MACF1	Ssm	16	426	3.8%	cbioportal
21	PCLO	Ssm	15	426	3.5%	cbioportal
20	LRP1B	Ssm	15	426	3.5%	cbioportal
19	DNAH9	Ssm	15	426	3.5%	cbioportal
18	ADGRV1	Ssm	15	426	3.5%	cbioportal
22	SYNE1	Ssm	15	426	3.5%	cbioportal
25	DST	Ssm	14	426	3.3%	cbioportal
24	ATM	Ssm	14	426	3.3%	cbioportal
23	ARID1A	Ssm	14	426	3.3%	cbioportal
26	KMT2D	Ssm	14	426	3.3%	cbioportal
27	FBN2	Ssm	13	426	3.1%	cbioportal
30	MUC2	Ssm	13	426	3.1%	cbioportal
29	MUC17	Ssm	13	426	3.1%	cbioportal
28	FMN2	Ssm	13	426	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-02-19

Kidney Renal Clear Cell Carcinoma (TCGA, PanCancer Atlas) kirc_tcga_pan_can_atlas_2018TCGA

402 cases with simple somatic mutation data · 512 cases total · 2026-06-05 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	166	402	41.3%	cbioportal
2	PBRM1	Ssm	145	402	36.1%	cbioportal
3	TTN	Ssm	69	402	17.2%	cbioportal
4	SETD2	Ssm	49	402	12.2%	cbioportal
5	BAP1	Ssm	38	402	9.5%	cbioportal
6	MTOR	Ssm	31	402	7.7%	cbioportal
7	MUC16	Ssm	30	402	7.5%	cbioportal
8	KDM5C	Ssm	20	402	5%	cbioportal
9	DNAH9	Ssm	18	402	4.5%	cbioportal
10	CSMD3	Ssm	17	402	4.2%	cbioportal
11	HMCN1	Ssm	17	402	4.2%	cbioportal
12	FBN2	Ssm	16	402	4%	cbioportal
13	KMT2C	Ssm	15	402	3.7%	cbioportal
14	LRP2	Ssm	15	402	3.7%	cbioportal
15	MACF1	Ssm	15	402	3.7%	cbioportal
16	PCLO	Ssm	15	402	3.7%	cbioportal
17	XIRP2	Ssm	15	402	3.7%	cbioportal
22	SPEN	Ssm	14	402	3.5%	cbioportal
18	AHNAK2	Ssm	14	402	3.5%	cbioportal
19	ARID1A	Ssm	14	402	3.5%	cbioportal
20	DST	Ssm	14	402	3.5%	cbioportal
21	FLG	Ssm	14	402	3.5%	cbioportal
26	LRP1B	Ssm	13	402	3.2%	cbioportal
28	NEB	Ssm	13	402	3.2%	cbioportal
29	PKHD1L1	Ssm	13	402	3.2%	cbioportal
23	ABCA13	Ssm	13	402	3.2%	cbioportal
24	ATM	Ssm	13	402	3.2%	cbioportal
25	DNAH2	Ssm	13	402	3.2%	cbioportal
27	MUC17	Ssm	13	402	3.2%	cbioportal
30	USH2A	Ssm	13	402	3.2%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Kidney Renal Papillary Cell Carcinoma TCGA-KIRPTCGA

291 cases with simple somatic mutation data · 291 cases total · Data Release 46.0 · mapped to Papillary Renal Cell Carcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
3	MED13	Ssm	187	291	64.3%	gdc
2	MRC2	Ssm	187	291	64.3%	gdc
4	RNF213	Ssm	187	291	64.3%	gdc
1	HELZ	Ssm	187	291	64.3%	gdc
8	CLTC	Ssm	186	291	63.9%	gdc
9	UBE2O	Ssm	186	291	63.9%	gdc
5	CCDC57	Ssm	186	291	63.9%	gdc
7	ACE	Ssm	186	291	63.9%	gdc
6	TEX2	Ssm	186	291	63.9%	gdc
11	BPTF	Ssm	186	291	63.9%	gdc
10	KCNH6	Ssm	186	291	63.9%	gdc
12	USP32	Ssm	186	291	63.9%	gdc
14	LRRC37A3	Ssm	185	291	63.6%	gdc
19	GNA13	Ssm	185	291	63.6%	gdc
20	UNC13D	Ssm	185	291	63.6%	gdc
15	QRICH2	Ssm	185	291	63.6%	gdc
21	TNRC6C	Ssm	185	291	63.6%	gdc
34	SMURF2	Ssm	185	291	63.6%	gdc
22	KIF19	Ssm	185	291	63.6%	gdc
13	EFCAB3	Ssm	185	291	63.6%	gdc
23	KCNJ16	Ssm	185	291	63.6%	gdc
24	NPTX1	Ssm	185	291	63.6%	gdc
25	AC127029.3	Ssm	185	291	63.6%	gdc
26	NOL11	Ssm	185	291	63.6%	gdc
27	TMC6	Ssm	185	291	63.6%	gdc
28	DCAF7	Ssm	185	291	63.6%	gdc
29	PPM1D	Ssm	185	291	63.6%	gdc
30	TBX4	Ssm	185	291	63.6%	gdc
31	SOX9	Ssm	185	291	63.6%	gdc
32	ABCA8	Ssm	185	291	63.6%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Kidney Renal Papillary Cell Carcinoma (TCGA, Firehose Legacy) kirp_tcgaTCGA

282 cases with simple somatic mutation data · 293 cases total · 2026-01-07 · mapped to Papillary Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	35	282	12.4%	cbioportal
2	MUC16	Ssm	24	282	8.5%	cbioportal
3	MET	Ssm	21	282	7.4%	cbioportal
4	KMT2C	Ssm	18	282	6.4%	cbioportal
5	BLTP1	Ssm	16	282	5.7%	cbioportal
6	KIF1A	Ssm	16	282	5.7%	cbioportal
7	SETD2	Ssm	16	282	5.7%	cbioportal
8	MUC4	Ssm	15	282	5.3%	cbioportal
10	KMT2D	Ssm	14	282	5%	cbioportal
9	BAP1	Ssm	14	282	5%	cbioportal
12	OBSCN	Ssm	13	282	4.6%	cbioportal
11	AR	Ssm	13	282	4.6%	cbioportal
13	PKHD1	Ssm	13	282	4.6%	cbioportal
14	CUBN	Ssm	12	282	4.3%	cbioportal
15	DNAH8	Ssm	12	282	4.3%	cbioportal
18	PCLO	Ssm	12	282	4.3%	cbioportal
19	WDFY3	Ssm	12	282	4.3%	cbioportal
17	NEFH	Ssm	12	282	4.3%	cbioportal
16	FAT1	Ssm	12	282	4.3%	cbioportal
24	SYNE1	Ssm	11	282	3.9%	cbioportal
20	LRP2	Ssm	11	282	3.9%	cbioportal
21	MUC2	Ssm	11	282	3.9%	cbioportal
22	PBRM1	Ssm	11	282	3.9%	cbioportal
23	PCF11	Ssm	11	282	3.9%	cbioportal
28	NF2	Ssm	10	282	3.5%	cbioportal
29	SMARCA4	Ssm	10	282	3.5%	cbioportal
25	CUL3	Ssm	10	282	3.5%	cbioportal
26	HELZ2	Ssm	10	282	3.5%	cbioportal
27	KDM6A	Ssm	10	282	3.5%	cbioportal
30	ADGRV1	Ssm	9	282	3.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Kidney Renal Papillary Cell Carcinoma (TCGA, PanCancer Atlas) kirp_tcga_pan_can_atlas_2018TCGA

276 cases with simple somatic mutation data · 283 cases total · 2026-06-05 · mapped to Papillary Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	51	276	18.5%	cbioportal
2	MUC16	Ssm	27	276	9.8%	cbioportal
3	MET	Ssm	22	276	8%	cbioportal
4	BLTP1	Ssm	19	276	6.9%	cbioportal
5	KMT2C	Ssm	19	276	6.9%	cbioportal
6	KMT2D	Ssm	18	276	6.5%	cbioportal
7	OBSCN	Ssm	18	276	6.5%	cbioportal
8	PKHD1	Ssm	18	276	6.5%	cbioportal
9	MACF1	Ssm	17	276	6.2%	cbioportal
10	SETD2	Ssm	17	276	6.2%	cbioportal
11	FAT1	Ssm	16	276	5.8%	cbioportal
12	USH2A	Ssm	15	276	5.4%	cbioportal
14	DNAH8	Ssm	14	276	5.1%	cbioportal
15	WDFY3	Ssm	14	276	5.1%	cbioportal
13	BAP1	Ssm	14	276	5.1%	cbioportal
16	CUBN	Ssm	13	276	4.7%	cbioportal
22	UBR4	Ssm	13	276	4.7%	cbioportal
21	SYNE1	Ssm	13	276	4.7%	cbioportal
20	SRRM2	Ssm	13	276	4.7%	cbioportal
19	HUWE1	Ssm	13	276	4.7%	cbioportal
18	HERC2	Ssm	13	276	4.7%	cbioportal
17	DNAH1	Ssm	13	276	4.7%	cbioportal
24	BIRC6	Ssm	12	276	4.3%	cbioportal
23	ARID1A	Ssm	12	276	4.3%	cbioportal
30	SYNE2	Ssm	12	276	4.3%	cbioportal
29	PBRM1	Ssm	12	276	4.3%	cbioportal
28	NEB	Ssm	12	276	4.3%	cbioportal
27	MDN1	Ssm	12	276	4.3%	cbioportal
26	DST	Ssm	12	276	4.3%	cbioportal
25	CENPF	Ssm	12	276	4.3%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Metastatic Bladder Urothelial Carcinoma (IMvigor210 Phase II Trial, ESMO Open. 2024) - iAtlas Harmonized blca_iatlas_imvigor210_2017

242 cases with simple somatic mutation data · 347 cases total · 2026-02-11 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	128	242	52.9%	cbioportal
2	TP53	Ssm	123	242	50.8%	cbioportal
3	MUC16	Ssm	80	242	33.1%	cbioportal
4	KMT2D	Ssm	70	242	28.9%	cbioportal
5	ARID1A	Ssm	64	242	26.4%	cbioportal
6	OBSCN	Ssm	61	242	25.2%	cbioportal
7	SYNE1	Ssm	55	242	22.7%	cbioportal
8	MACF1	Ssm	54	242	22.3%	cbioportal
9	KDM6A	Ssm	52	242	21.5%	cbioportal
11	PIK3CA	Ssm	46	242	19%	cbioportal
10	FAT1	Ssm	46	242	19%	cbioportal
12	RYR3	Ssm	45	242	18.6%	cbioportal
13	LRTM3	Ssm	44	242	18.2%	cbioportal
14	LRP1B	Ssm	43	242	17.8%	cbioportal
15	RNF213	Ssm	43	242	17.8%	cbioportal
16	FGFR3	Ssm	42	242	17.4%	cbioportal
17	ADGRV1	Ssm	41	242	16.9%	cbioportal
19	DST	Ssm	40	242	16.5%	cbioportal
18	CREBBP	Ssm	40	242	16.5%	cbioportal
21	PKHD1L1	Ssm	40	242	16.5%	cbioportal
20	FLG	Ssm	40	242	16.5%	cbioportal
25	HMCN1	Ssm	39	242	16.1%	cbioportal
26	MUC5AC	Ssm	39	242	16.1%	cbioportal
27	PCLO	Ssm	39	242	16.1%	cbioportal
22	AHNAK2	Ssm	39	242	16.1%	cbioportal
23	ELF3	Ssm	39	242	16.1%	cbioportal
24	FAT4	Ssm	39	242	16.1%	cbioportal
30	RYR2	Ssm	38	242	15.7%	cbioportal
28	KMT2C	Ssm	38	242	15.7%	cbioportal
29	MUC3A	Ssm	38	242	15.7%	cbioportal

Data updated 22 days agoSource updated 2026-02-11

Metastatic Renal Clear Cell Carcinoma (Phase 1 Biomarker Trial, Clin Cancer Res. 2016) - iAtlas Harmonized ccrcc_iatlas_choueiri_2016

16 cases with simple somatic mutation data · 16 cases total · 2026-02-16 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SETD2	Ssm	10	16	62.5%	cbioportal
2	VHL	Ssm	8	16	50%	cbioportal
3	PBRM1	Ssm	6	16	37.5%	cbioportal
5	FBXL13	Ssm	4	16	25%	cbioportal
6	ZFC3H1	Ssm	4	16	25%	cbioportal
4	BTG4	Ssm	4	16	25%	cbioportal
10	FNDC1	Ssm	3	16	18.8%	cbioportal
9	DMXL2	Ssm	3	16	18.8%	cbioportal
8	CENPB	Ssm	3	16	18.8%	cbioportal
7	ARHGAP39	Ssm	3	16	18.8%	cbioportal
21	TTN	Ssm	3	16	18.8%	cbioportal
23	VCPIP1	Ssm	3	16	18.8%	cbioportal
20	SYNE1	Ssm	3	16	18.8%	cbioportal
24	WDR47	Ssm	3	16	18.8%	cbioportal
19	SRPK1	Ssm	3	16	18.8%	cbioportal
22	UBR4	Ssm	3	16	18.8%	cbioportal
18	SPEF2	Ssm	3	16	18.8%	cbioportal
17	SLC9A9	Ssm	3	16	18.8%	cbioportal
16	SCUBE2	Ssm	3	16	18.8%	cbioportal
15	PRKDC	Ssm	3	16	18.8%	cbioportal
14	MYO10	Ssm	3	16	18.8%	cbioportal
13	LRP2	Ssm	3	16	18.8%	cbioportal
12	HUWE1	Ssm	3	16	18.8%	cbioportal
11	HEATR1	Ssm	3	16	18.8%	cbioportal
26	ABCC2	Ssm	2	16	12.5%	cbioportal
25	ABCA5	Ssm	2	16	12.5%	cbioportal
27	ADAMTS20	Ssm	2	16	12.5%	cbioportal
28	ADAMTSL3	Ssm	2	16	12.5%	cbioportal
29	ADAR	Ssm	2	16	12.5%	cbioportal
30	AGBL2	Ssm	2	16	12.5%	cbioportal

Data updated 22 days agoSource updated 2026-02-16

Nonmuscle Invasive Bladder Cancer (MSK Eur Urol 2017) blca_nmibc_2017

105 cases with simple somatic mutation data · 105 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	77	105	73.3%	cbioportal
2	KDM6A	Ssm	50	105	47.6%	cbioportal
3	FGFR3	Ssm	47	105	44.8%	cbioportal
4	ARID1A	Ssm	30	105	28.6%	cbioportal
5	PIK3CA	Ssm	29	105	27.6%	cbioportal
6	KMT2D	Ssm	25	105	23.8%	cbioportal
7	CREBBP	Ssm	22	105	21%	cbioportal
9	TP53	Ssm	22	105	21%	cbioportal
8	STAG2	Ssm	22	105	21%	cbioportal
10	ERBB2	Ssm	19	105	18.1%	cbioportal
11	ERCC2	Ssm	18	105	17.1%	cbioportal
12	ARID1B	Ssm	17	105	16.2%	cbioportal
13	FAT1	Ssm	17	105	16.2%	cbioportal
14	ATM	Ssm	16	105	15.2%	cbioportal
15	EP300	Ssm	15	105	14.3%	cbioportal
16	FBXW7	Ssm	15	105	14.3%	cbioportal
17	PBRM1	Ssm	15	105	14.3%	cbioportal
18	RBM10	Ssm	15	105	14.3%	cbioportal
19	MGA	Ssm	14	103	13.6%	cbioportal
20	BAP1	Ssm	13	105	12.4%	cbioportal
22	ERBB3	Ssm	12	105	11.4%	cbioportal
21	CDKN1A	Ssm	12	105	11.4%	cbioportal
23	KMT2C	Ssm	12	105	11.4%	cbioportal
24	NF1	Ssm	12	105	11.4%	cbioportal
25	BRCA2	Ssm	11	105	10.5%	cbioportal
26	SMARCA4	Ssm	11	105	10.5%	cbioportal
27	SPEN	Ssm	11	105	10.5%	cbioportal
28	TSC1	Ssm	11	105	10.5%	cbioportal
30	NCOR1	Ssm	10	105	9.5%	cbioportal
29	ATR	Ssm	10	105	9.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Papillary Renal Cell Carcinoma (TCGA GDC, 2025) prcc_tcga_gdcTCGA GDC

279 cases with simple somatic mutation data · 292 cases total · 2026-01-13 · mapped to Papillary Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	40	279	14.3%	cbioportal
2	MUC16	Ssm	22	279	7.9%	cbioportal
3	MET	Ssm	20	279	7.2%	cbioportal
4	KMT2C	Ssm	18	279	6.5%	cbioportal
5	BLTP1	Ssm	15	279	5.4%	cbioportal
7	SETD2	Ssm	15	279	5.4%	cbioportal
6	PKHD1	Ssm	15	279	5.4%	cbioportal
8	BAP1	Ssm	14	279	5%	cbioportal
10	FAT1	Ssm	14	279	5%	cbioportal
9	CUBN	Ssm	14	279	5%	cbioportal
13	USH2A	Ssm	13	279	4.7%	cbioportal
12	SYNE1	Ssm	13	279	4.7%	cbioportal
11	KMT2D	Ssm	13	279	4.7%	cbioportal
17	WDFY3	Ssm	12	279	4.3%	cbioportal
16	SYNE2	Ssm	12	279	4.3%	cbioportal
15	HERC2	Ssm	12	279	4.3%	cbioportal
14	DNAH8	Ssm	12	279	4.3%	cbioportal
21	PBRM1	Ssm	11	279	3.9%	cbioportal
19	LRP2	Ssm	11	279	3.9%	cbioportal
18	ARID1A	Ssm	11	279	3.9%	cbioportal
22	PCF11	Ssm	11	279	3.9%	cbioportal
20	OBSCN	Ssm	11	279	3.9%	cbioportal
24	KDM6A	Ssm	10	279	3.6%	cbioportal
26	SRRM2	Ssm	10	279	3.6%	cbioportal
25	MACF1	Ssm	10	279	3.6%	cbioportal
23	CUL3	Ssm	10	279	3.6%	cbioportal
27	ADGRV1	Ssm	9	279	3.2%	cbioportal
28	ANK3	Ssm	9	279	3.2%	cbioportal
29	BIRC6	Ssm	9	279	3.2%	cbioportal
30	HERC1	Ssm	9	279	3.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Renal Cell Carcinoma (CPTAC GDC, 2025) rcc_cptac_gdcCPTAC GDC

352 cases with simple somatic mutation data · 354 cases total · 2026-01-14 · mapped to Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	237	352	67.3%	cbioportal
2	PBRM1	Ssm	114	352	32.4%	cbioportal
3	BAP1	Ssm	48	352	13.6%	cbioportal
4	TTN	Ssm	44	352	12.5%	cbioportal
5	KDM5C	Ssm	43	352	12.2%	cbioportal
6	SETD2	Ssm	39	352	11.1%	cbioportal
7	CSMD3	Ssm	34	352	9.7%	cbioportal
8	MTOR	Ssm	23	352	6.5%	cbioportal
9	LRP2	Ssm	20	352	5.7%	cbioportal
10	MUC16	Ssm	20	352	5.7%	cbioportal
12	USH2A	Ssm	19	352	5.4%	cbioportal
11	RYR2	Ssm	19	352	5.4%	cbioportal
13	CUBN	Ssm	18	352	5.1%	cbioportal
15	YLPM1	Ssm	17	352	4.8%	cbioportal
14	MUC17	Ssm	17	352	4.8%	cbioportal
18	SYNE2	Ssm	16	352	4.5%	cbioportal
17	SYNE1	Ssm	16	352	4.5%	cbioportal
16	HMCN1	Ssm	16	352	4.5%	cbioportal
19	ZNF292	Ssm	16	352	4.5%	cbioportal
22	MACF1	Ssm	15	352	4.3%	cbioportal
20	DST	Ssm	15	352	4.3%	cbioportal
21	FSIP2	Ssm	15	352	4.3%	cbioportal
23	SI	Ssm	15	352	4.3%	cbioportal
26	DNAH5	Ssm	14	352	4%	cbioportal
24	APOB	Ssm	14	352	4%	cbioportal
25	BIRC6	Ssm	14	352	4%	cbioportal
27	PKD1	Ssm	14	352	4%	cbioportal
30	MAP1A	Ssm	13	352	3.7%	cbioportal
28	GOLGB1	Ssm	13	352	3.7%	cbioportal
29	LRTM3	Ssm	13	352	3.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Renal Cell Carcinoma (IMmotion150 Clinical Trial, Nat Med. 2018) - iAtlas Harmonized rcc_iatlas_immotion150_2018

158 cases with simple somatic mutation data · 263 cases total · 2026-02-11 · mapped to Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	106	158	67.1%	cbioportal
2	PBRM1	Ssm	79	158	50%	cbioportal
3	TTN	Ssm	67	158	42.4%	cbioportal
4	MUC16	Ssm	60	158	38%	cbioportal
5	AHNAK2	Ssm	56	158	35.4%	cbioportal
6	SETD2	Ssm	52	158	32.9%	cbioportal
7	OBSCN	Ssm	51	158	32.3%	cbioportal
8	HSPG2	Ssm	48	158	30.4%	cbioportal
9	KMT2D	Ssm	46	158	29.1%	cbioportal
10	LRP1	Ssm	45	158	28.5%	cbioportal
11	BSN	Ssm	44	158	27.8%	cbioportal
12	MUC5B	Ssm	44	158	27.8%	cbioportal
13	ZNF469	Ssm	41	158	25.9%	cbioportal
14	ZNF594	Ssm	40	158	25.3%	cbioportal
16	LAMA5	Ssm	39	158	24.7%	cbioportal
15	COL7A1	Ssm	39	158	24.7%	cbioportal
17	AHNAK	Ssm	38	158	24.1%	cbioportal
18	FLNA	Ssm	38	158	24.1%	cbioportal
19	MUC5AC	Ssm	38	158	24.1%	cbioportal
20	OTOG	Ssm	38	158	24.1%	cbioportal
21	PLEC	Ssm	38	158	24.1%	cbioportal
22	DNAH1	Ssm	37	158	23.4%	cbioportal
23	RYR1	Ssm	37	158	23.4%	cbioportal
24	SYNE1	Ssm	37	158	23.4%	cbioportal
25	IRF2BPL	Ssm	36	158	22.8%	cbioportal
26	KIF1A	Ssm	36	158	22.8%	cbioportal
27	PLXNB3	Ssm	36	158	22.8%	cbioportal
28	SPEG	Ssm	35	158	22.2%	cbioportal
29	ADGRV1	Ssm	34	158	21.5%	cbioportal
30	CACNA1H	Ssm	34	158	21.5%	cbioportal

Data updated 22 days agoSource updated 2026-02-11

Renal Cell Carcinoma (St. James, Clin Cancer Res 2023) ccrcc_sjuh_2023St. James

943 cases with simple somatic mutation data · 943 cases total · 2026-03-09 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved12 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	642	943	68.1%	cbioportal
2	PBRM1	Ssm	325	943	34.5%	cbioportal
3	SETD2	Ssm	151	943	16%	cbioportal
4	BAP1	Ssm	119	943	12.6%	cbioportal
5	KDM5C	Ssm	67	943	7.1%	cbioportal
6	ATM	Ssm	31	943	3.3%	cbioportal
8	TP53	Ssm	29	943	3.1%	cbioportal
7	DMD	Ssm	29	943	3.1%	cbioportal
9	COL11A1	Ssm	21	943	2.2%	cbioportal
10	TRRAP	Ssm	12	943	1.3%	cbioportal
11	PTK7	Ssm	6	943	0.6%	cbioportal
12	ATP9B	Ssm	5	943	0.5%	cbioportal

Data updated 22 days agoSource updated 2026-03-09

Renal Clear Cell Carcinoma (TCGA GDC, 2025) ccrcc_tcga_gdcTCGA GDC

375 cases with simple somatic mutation data · 537 cases total · 2026-01-13 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	172	375	45.9%	cbioportal
2	PBRM1	Ssm	147	375	39.2%	cbioportal
3	TTN	Ssm	63	375	16.8%	cbioportal
4	SETD2	Ssm	46	375	12.3%	cbioportal
5	BAP1	Ssm	40	375	10.7%	cbioportal
6	MUC16	Ssm	29	375	7.7%	cbioportal
7	MTOR	Ssm	27	375	7.2%	cbioportal
8	KDM5C	Ssm	20	375	5.3%	cbioportal
10	DST	Ssm	19	375	5.1%	cbioportal
9	DNAH9	Ssm	19	375	5.1%	cbioportal
11	ATM	Ssm	17	375	4.5%	cbioportal
12	CSMD3	Ssm	17	375	4.5%	cbioportal
13	FBN2	Ssm	16	375	4.3%	cbioportal
14	HMCN1	Ssm	16	375	4.3%	cbioportal
15	KMT2C	Ssm	16	375	4.3%	cbioportal
16	LRP2	Ssm	16	375	4.3%	cbioportal
17	AHNAK2	Ssm	15	375	4%	cbioportal
18	ANK3	Ssm	14	375	3.7%	cbioportal
21	USH2A	Ssm	14	375	3.7%	cbioportal
20	SYNE1	Ssm	14	375	3.7%	cbioportal
19	SPEN	Ssm	14	375	3.7%	cbioportal
23	MUC17	Ssm	13	375	3.5%	cbioportal
22	DNAH2	Ssm	13	375	3.5%	cbioportal
25	PTEN	Ssm	13	375	3.5%	cbioportal
24	PCLO	Ssm	13	375	3.5%	cbioportal
30	XIRP2	Ssm	12	375	3.2%	cbioportal
27	FLG	Ssm	12	375	3.2%	cbioportal
26	ARID1A	Ssm	12	375	3.2%	cbioportal
29	PKHD1L1	Ssm	12	375	3.2%	cbioportal
28	LRP1B	Ssm	12	375	3.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Renal Clear Cell Carcinoma (UTokyo, Nat Genet 2013) ccrcc_utokyo_2013UTokyo

106 cases with simple somatic mutation data · 106 cases total · 2026-01-05 · mapped to Clear Cell Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	VHL	Ssm	43	106	40.6%	cbioportal
2	PBRM1	Ssm	31	106	29.2%	cbioportal
3	TTN	Ssm	21	106	19.8%	cbioportal
4	MUC16	Ssm	15	106	14.2%	cbioportal
5	SETD2	Ssm	12	106	11.3%	cbioportal
6	BAP1	Ssm	9	106	8.5%	cbioportal
7	CSMD3	Ssm	8	106	7.5%	cbioportal
8	AHNAK2	Ssm	7	106	6.6%	cbioportal
12	MTOR	Ssm	6	106	5.7%	cbioportal
14	TET2	Ssm	6	106	5.7%	cbioportal
13	MUC4	Ssm	6	106	5.7%	cbioportal
9	FRYL	Ssm	6	106	5.7%	cbioportal
10	HMCN1	Ssm	6	106	5.7%	cbioportal
11	KMT2C	Ssm	6	106	5.7%	cbioportal
19	PKHD1	Ssm	5	106	4.7%	cbioportal
15	ELOC	Ssm	5	106	4.7%	cbioportal
16	KCNMA1	Ssm	5	106	4.7%	cbioportal
17	KEAP1	Ssm	5	106	4.7%	cbioportal
18	PIK3CA	Ssm	5	106	4.7%	cbioportal
20	ZNF536	Ssm	5	106	4.7%	cbioportal
30	IQGAP2	Ssm	4	106	3.8%	cbioportal
21	ARHGEF28	Ssm	4	106	3.8%	cbioportal
22	BCL11A	Ssm	4	106	3.8%	cbioportal
23	CACNA1G	Ssm	4	106	3.8%	cbioportal
24	CUBN	Ssm	4	106	3.8%	cbioportal
25	DNAH11	Ssm	4	106	3.8%	cbioportal
26	DNAH3	Ssm	4	106	3.8%	cbioportal
27	EP300	Ssm	4	106	3.8%	cbioportal
28	GRB7	Ssm	4	106	3.8%	cbioportal
29	HYDIN	Ssm	4	106	3.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Renal Non-Clear Cell Carcinoma (Genentech, Nat Genet 2014) nccrcc_genentech_2014Genentech

146 cases with simple somatic mutation data · 146 cases total · 2026-01-08 · mapped to Renal Non-Clear Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	17	146	11.6%	cbioportal
2	TP53	Ssm	11	146	7.5%	cbioportal
3	MET	Ssm	10	146	6.8%	cbioportal
4	MUC4	Ssm	9	146	6.2%	cbioportal
5	MACF1	Ssm	7	146	4.8%	cbioportal
6	PCLO	Ssm	7	146	4.8%	cbioportal
7	ARID1A	Ssm	6	146	4.1%	cbioportal
8	LRP2	Ssm	6	146	4.1%	cbioportal
9	SPEN	Ssm	6	146	4.1%	cbioportal
10	FREM2	Ssm	5	146	3.4%	cbioportal
11	KMT2C	Ssm	5	146	3.4%	cbioportal
12	MUC16	Ssm	5	146	3.4%	cbioportal
13	MUC6	Ssm	5	146	3.4%	cbioportal
14	OBSCN	Ssm	5	146	3.4%	cbioportal
15	PTEN	Ssm	5	146	3.4%	cbioportal
16	SETD2	Ssm	5	146	3.4%	cbioportal
17	STARD9	Ssm	5	146	3.4%	cbioportal
18	ADGRV1	Ssm	4	146	2.7%	cbioportal
19	AHNAK	Ssm	4	146	2.7%	cbioportal
20	ANK3	Ssm	4	146	2.7%	cbioportal
21	APC	Ssm	4	146	2.7%	cbioportal
22	ARID1B	Ssm	4	146	2.7%	cbioportal
23	BIRC6	Ssm	4	146	2.7%	cbioportal
24	BLTP1	Ssm	4	146	2.7%	cbioportal
25	CACNA1C	Ssm	4	146	2.7%	cbioportal
26	CEP295	Ssm	4	146	2.7%	cbioportal
27	CUBN	Ssm	4	146	2.7%	cbioportal
28	DNAH5	Ssm	4	146	2.7%	cbioportal
29	ERCC2	Ssm	4	146	2.7%	cbioportal
30	FAT2	Ssm	4	146	2.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Unclassified Renal Cell Carcinoma (MSK, Nature 2016) urcc_mskcc_2016MSK

62 cases with simple somatic mutation data · 62 cases total · 2026-01-16 · mapped to Unclassified Renal Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
2	SETD2	Ssm	11	62	17.7%	cbioportal
1	NF2	Ssm	11	62	17.7%	cbioportal
3	BAP1	Ssm	8	62	12.9%	cbioportal
4	KMT2C	Ssm	6	62	9.7%	cbioportal
5	MTOR	Ssm	5	62	8.1%	cbioportal
6	ATRX	Ssm	4	62	6.5%	cbioportal
7	PTEN	Ssm	4	62	6.5%	cbioportal
8	TSC1	Ssm	4	62	6.5%	cbioportal
12	KMT2D	Ssm	3	62	4.8%	cbioportal
11	KLF6	Ssm	3	62	4.8%	cbioportal
10	FH	Ssm	3	62	4.8%	cbioportal
16	TSC2	Ssm	3	62	4.8%	cbioportal
9	DNMT3A	Ssm	3	62	4.8%	cbioportal
15	TP53	Ssm	3	62	4.8%	cbioportal
14	SMARCB1	Ssm	3	62	4.8%	cbioportal
13	NOTCH2	Ssm	3	62	4.8%	cbioportal
26	RICTOR	Ssm	2	62	3.2%	cbioportal
17	CHEK2	Ssm	2	62	3.2%	cbioportal
18	EPHA6	Ssm	2	62	3.2%	cbioportal
19	GNAS	Ssm	2	62	3.2%	cbioportal
28	SUFU	Ssm	2	62	3.2%	cbioportal
20	IRS1	Ssm	2	62	3.2%	cbioportal
25	PRKN	Ssm	2	62	3.2%	cbioportal
22	KMT2A	Ssm	2	62	3.2%	cbioportal
21	KDM6A	Ssm	2	62	3.2%	cbioportal
23	MLST8	Ssm	2	62	3.2%	cbioportal
24	PBRM1	Ssm	2	62	3.2%	cbioportal
27	RPTOR	Ssm	2	62	3.2%	cbioportal
49	EPHA5	Ssm	1	62	1.6%	cbioportal
48	EP300	Ssm	1	62	1.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Upper Tract Urothelial Cancer (MSK, Eur Urol 2015) utuc_mskcc_2015MSK

85 cases with simple somatic mutation data · 85 cases total · 2026-01-16 · mapped to Renal Pelvis and Ureter Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FGFR3	Ssm	41	85	48.2%	cbioportal
2	KMT2D	Ssm	30	85	35.3%	cbioportal
3	KDM6A	Ssm	29	85	34.1%	cbioportal
4	KMT2C	Ssm	22	85	25.9%	cbioportal
5	STAG2	Ssm	19	85	22.4%	cbioportal
7	TP53	Ssm	15	85	17.6%	cbioportal
6	CREBBP	Ssm	15	85	17.6%	cbioportal
8	TSC1	Ssm	14	85	16.5%	cbioportal
9	PIK3CA	Ssm	13	85	15.3%	cbioportal
10	ARID1A	Ssm	11	85	12.9%	cbioportal
12	TERT	Ssm	10	85	11.8%	cbioportal
11	ATM	Ssm	10	85	11.8%	cbioportal
13	HRAS	Ssm	9	85	10.6%	cbioportal
14	SMARCA4	Ssm	9	85	10.6%	cbioportal
16	FAT1	Ssm	8	85	9.4%	cbioportal
15	EP300	Ssm	8	85	9.4%	cbioportal
17	ARID2	Ssm	7	85	8.2%	cbioportal
18	EPHA5	Ssm	7	85	8.2%	cbioportal
22	PBRM1	Ssm	6	85	7.1%	cbioportal
20	FBXW7	Ssm	6	85	7.1%	cbioportal
19	ERBB2	Ssm	6	85	7.1%	cbioportal
21	NF1	Ssm	6	85	7.1%	cbioportal
25	CDKN2A	Ssm	5	85	5.9%	cbioportal
23	ARID1B	Ssm	5	85	5.9%	cbioportal
24	CDKN1A	Ssm	5	85	5.9%	cbioportal
26	GRIN2A	Ssm	5	85	5.9%	cbioportal
27	INPP4A	Ssm	5	85	5.9%	cbioportal
28	MET	Ssm	5	85	5.9%	cbioportal
29	MTOR	Ssm	5	85	5.9%	cbioportal
30	NOTCH1	Ssm	5	85	5.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Upper Tract Urothelial Carcinoma (Cornell/Baylor/MDACC, Nat Commun 2019) utuc_cornell_baylor_mdacc_2019Cornell/Baylor/MDACC

37 cases with simple somatic mutation data · 47 cases total · 2026-01-19 · mapped to Renal Pelvis and Ureter Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KMT2D	Ssm	13	37	35.1%	cbioportal
2	TP53	Ssm	12	37	32.4%	cbioportal
3	FGFR3	Ssm	11	37	29.7%	cbioportal
4	PIK3CA	Ssm	8	37	21.6%	cbioportal
5	ATM	Ssm	7	37	18.9%	cbioportal
6	ADGRV1	Ssm	5	37	13.5%	cbioportal
7	CDKN1A	Ssm	5	37	13.5%	cbioportal
8	EYS	Ssm	5	37	13.5%	cbioportal
9	OBSCN	Ssm	5	37	13.5%	cbioportal
10	AFF1	Ssm	4	37	10.8%	cbioportal
11	ARID1A	Ssm	4	37	10.8%	cbioportal
12	KDM6A	Ssm	4	37	10.8%	cbioportal
13	MACF1	Ssm	4	37	10.8%	cbioportal
14	MUC17	Ssm	4	37	10.8%	cbioportal
15	PLXNA2	Ssm	4	37	10.8%	cbioportal
16	RNF213	Ssm	4	37	10.8%	cbioportal
17	SPTAN1	Ssm	4	37	10.8%	cbioportal
18	TTN	Ssm	4	37	10.8%	cbioportal
19	UTRN	Ssm	4	37	10.8%	cbioportal
20	ZFHX4	Ssm	4	37	10.8%	cbioportal
27	ATR	Ssm	3	37	8.1%	cbioportal
34	CARMIL1	Ssm	3	37	8.1%	cbioportal
21	ABCC1	Ssm	3	37	8.1%	cbioportal
22	AHCTF1	Ssm	3	37	8.1%	cbioportal
23	AHNAK	Ssm	3	37	8.1%	cbioportal
24	ARK2N	Ssm	3	37	8.1%	cbioportal
25	ATG2A	Ssm	3	37	8.1%	cbioportal
26	ATP2B2	Ssm	3	37	8.1%	cbioportal
28	BAP1	Ssm	3	37	8.1%	cbioportal
29	BICD2	Ssm	3	37	8.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Upper Tract Urothelial Carcinoma (IGBMC, Genome Biology 2021) utuc_igbmc_2021IGBMC

30 cases with simple somatic mutation data · 30 cases total · 2026-01-19 · mapped to Renal Pelvis and Ureter Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FGFR3	Ssm	15	30	50%	cbioportal
2	TTN	Ssm	9	30	30%	cbioportal
3	KDM6A	Ssm	8	30	26.7%	cbioportal
4	KMT2D	Ssm	8	30	26.7%	cbioportal
6	MUC4	Ssm	7	30	23.3%	cbioportal
5	KMT2C	Ssm	7	30	23.3%	cbioportal
7	HYDIN	Ssm	6	30	20%	cbioportal
8	ZFP36L1	Ssm	6	30	20%	cbioportal
10	CELSR1	Ssm	5	30	16.7%	cbioportal
11	STAG2	Ssm	5	30	16.7%	cbioportal
12	TP53	Ssm	5	30	16.7%	cbioportal
9	ARID1A	Ssm	5	30	16.7%	cbioportal
18	MUC16	Ssm	4	30	13.3%	cbioportal
15	EP300	Ssm	4	30	13.3%	cbioportal
14	CRIPAK	Ssm	4	30	13.3%	cbioportal
16	GANAB	Ssm	4	30	13.3%	cbioportal
13	ACACA	Ssm	4	30	13.3%	cbioportal
19	ZNF469	Ssm	4	30	13.3%	cbioportal
17	HECTD4	Ssm	4	30	13.3%	cbioportal
26	COG2	Ssm	3	30	10%	cbioportal
35	GLYR1	Ssm	3	30	10%	cbioportal
34	GABRA5	Ssm	3	30	10%	cbioportal
33	FLG	Ssm	3	30	10%	cbioportal
32	FAT3	Ssm	3	30	10%	cbioportal
31	EPHA5	Ssm	3	30	10%	cbioportal
30	DOCK4	Ssm	3	30	10%	cbioportal
29	DNAH17	Ssm	3	30	10%	cbioportal
28	DNAH11	Ssm	3	30	10%	cbioportal
27	CSMD3	Ssm	3	30	10%	cbioportal
25	CNTNAP4	Ssm	3	30	10%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Upper Tract Urothelial Carcinoma (MSK, Nat Commun 2020) utuc_msk_2019MSK

119 cases with simple somatic mutation data · 119 cases total · 2026-01-16 · mapped to Renal Pelvis and Ureter Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FGFR3	Ssm	55	119	46.2%	cbioportal
2	KMT2D	Ssm	41	119	34.5%	cbioportal
3	KDM6A	Ssm	39	119	32.8%	cbioportal
4	TERT	Ssm	32	119	26.9%	cbioportal
5	KMT2C	Ssm	27	119	22.7%	cbioportal
6	ARID1A	Ssm	26	119	21.8%	cbioportal
7	TP53	Ssm	26	119	21.8%	cbioportal
8	STAG2	Ssm	24	119	20.2%	cbioportal
9	CREBBP	Ssm	21	119	17.6%	cbioportal
11	PIK3CA	Ssm	19	119	16%	cbioportal
10	ATM	Ssm	19	119	16%	cbioportal
12	TSC1	Ssm	16	119	13.4%	cbioportal
13	HRAS	Ssm	14	119	11.8%	cbioportal
45	ZFHX3	Ssm	7	60	11.7%	cbioportal
14	SMARCA4	Ssm	13	119	10.9%	cbioportal
17	ERBB2	Ssm	11	119	9.2%	cbioportal
16	EP300	Ssm	11	119	9.2%	cbioportal
18	FAT1	Ssm	11	119	9.2%	cbioportal
15	ARID1B	Ssm	11	119	9.2%	cbioportal
19	FBXW7	Ssm	11	119	9.2%	cbioportal
21	PBRM1	Ssm	10	119	8.4%	cbioportal
20	NF1	Ssm	10	119	8.4%	cbioportal
81	SPEN	Ssm	5	61	8.2%	cbioportal
22	CDKN1A	Ssm	9	119	7.6%	cbioportal
25	MTOR	Ssm	9	119	7.6%	cbioportal
23	EPHA5	Ssm	9	119	7.6%	cbioportal
24	MET	Ssm	9	119	7.6%	cbioportal
29	KRAS	Ssm	8	119	6.7%	cbioportal
28	CTCF	Ssm	8	119	6.7%	cbioportal
30	MED12	Ssm	8	119	6.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Upper Tract Urothelial Carcinoma PDX (MSK, Nat Commun 2020) utuc_pdx_msk_2019MSK

78 cases with simple somatic mutation data · 78 cases total · 2026-01-16 · mapped to Renal Pelvis and Ureter Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	37	78	47.4%	cbioportal
2	ARID1A	Ssm	29	78	37.2%	cbioportal
3	FGFR3	Ssm	28	78	35.9%	cbioportal
4	TP53	Ssm	27	78	34.6%	cbioportal
5	KMT2D	Ssm	25	78	32.1%	cbioportal
6	KDM6A	Ssm	24	78	30.8%	cbioportal
7	ATM	Ssm	19	78	24.4%	cbioportal
8	CREBBP	Ssm	17	78	21.8%	cbioportal
9	ZFHX3	Ssm	15	70	21.4%	cbioportal
10	SMARCA4	Ssm	14	78	17.9%	cbioportal
13	MDC1	Ssm	13	76	17.1%	cbioportal
12	EP300	Ssm	13	78	16.7%	cbioportal
99	MSH3	Ssm	5	30	16.7%	cbioportal
11	ASXL1	Ssm	13	78	16.7%	cbioportal
15	MSH2	Ssm	12	78	15.4%	cbioportal
16	PIK3CA	Ssm	12	78	15.4%	cbioportal
17	SETD2	Ssm	12	78	15.4%	cbioportal
14	BRCA1	Ssm	12	78	15.4%	cbioportal
18	NOTCH2	Ssm	11	78	14.1%	cbioportal
29	RECQL4	Ssm	10	76	13.2%	cbioportal
25	FAT1	Ssm	10	78	12.8%	cbioportal
26	HRAS	Ssm	10	78	12.8%	cbioportal
24	DNMT3A	Ssm	10	78	12.8%	cbioportal
23	DNMT1	Ssm	10	78	12.8%	cbioportal
22	CTCF	Ssm	10	78	12.8%	cbioportal
21	CDKN1A	Ssm	10	78	12.8%	cbioportal
20	BCOR	Ssm	10	78	12.8%	cbioportal
19	ARID1B	Ssm	10	78	12.8%	cbioportal
28	PIK3CB	Ssm	10	78	12.8%	cbioportal
27	MET	Ssm	10	78	12.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Urothelial Cancer Patient Derived Organoids (MSK, 2025) blca_pdx_msk_2025MSK

90 cases with simple somatic mutation data · 90 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TERT	Ssm	71	90	78.9%	cbioportal
3	KDM6A	Ssm	35	90	38.9%	cbioportal
2	FGFR3	Ssm	35	90	38.9%	cbioportal
4	TP53	Ssm	34	90	37.8%	cbioportal
24	USP8	Ssm	12	34	35.3%	cbioportal
5	KMT2D	Ssm	31	90	34.4%	cbioportal
28	HLA-B	Ssm	11	46	23.9%	cbioportal
58	SERPINB3	Ssm	8	34	23.5%	cbioportal
6	MDC1	Ssm	21	90	23.3%	cbioportal
7	ARID1A	Ssm	20	90	22.2%	cbioportal
8	KMT2C	Ssm	19	90	21.1%	cbioportal
10	PIK3CA	Ssm	18	90	20%	cbioportal
11	TSC1	Ssm	18	90	20%	cbioportal
9	CREBBP	Ssm	18	90	20%	cbioportal
12	ZFHX3	Ssm	17	88	19.3%	cbioportal
13	ATM	Ssm	16	90	17.8%	cbioportal
102	SERPINB4	Ssm	6	34	17.6%	cbioportal
74	ATXN7	Ssm	6	34	17.6%	cbioportal
14	BRCA2	Ssm	15	90	16.7%	cbioportal
15	ATR	Ssm	14	90	15.6%	cbioportal
16	SPEN	Ssm	14	90	15.6%	cbioportal
71	PREX2	Ssm	7	46	15.2%	cbioportal
112	HLA-C	Ssm	5	34	14.7%	cbioportal
126	SMARCA2	Ssm	5	34	14.7%	cbioportal
17	STAG2	Ssm	13	90	14.4%	cbioportal
22	PALB2	Ssm	12	90	13.3%	cbioportal
21	NOTCH3	Ssm	12	90	13.3%	cbioportal
23	ROS1	Ssm	12	90	13.3%	cbioportal
19	FAT1	Ssm	12	90	13.3%	cbioportal
18	ERBB2	Ssm	12	90	13.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Urothelial Carcinoma (BCAN/HCRN, Nat Commun 2022) blca_bcan_hcrn_2022BCAN/HCRN

192 cases with simple somatic mutation data · 192 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	108	192	56.3%	cbioportal
2	KMT2D	Ssm	62	192	32.3%	cbioportal
3	ARID1A	Ssm	55	192	28.6%	cbioportal
4	RNF213	Ssm	54	192	28.1%	cbioportal
5	KDM6A	Ssm	48	192	25%	cbioportal
6	LRP1B	Ssm	47	192	24.5%	cbioportal
7	AKAP9	Ssm	39	192	20.3%	cbioportal
8	SPEN	Ssm	38	192	19.8%	cbioportal
9	BRCA2	Ssm	37	192	19.3%	cbioportal
10	KMT2C	Ssm	35	192	18.2%	cbioportal
12	FGFR3	Ssm	34	192	17.7%	cbioportal
11	EP300	Ssm	34	192	17.7%	cbioportal
13	RB1	Ssm	32	192	16.7%	cbioportal
14	ATM	Ssm	31	192	16.1%	cbioportal
15	PRKDC	Ssm	31	192	16.1%	cbioportal
16	KMT2A	Ssm	30	192	15.6%	cbioportal
17	CREBBP	Ssm	29	192	15.1%	cbioportal
18	PDE4DIP	Ssm	29	192	15.1%	cbioportal
19	PIK3CA	Ssm	29	192	15.1%	cbioportal
21	PCM1	Ssm	26	192	13.5%	cbioportal
20	KIAA1549	Ssm	26	192	13.5%	cbioportal
25	NOTCH1	Ssm	25	192	13%	cbioportal
26	RECQL4	Ssm	25	192	13%	cbioportal
24	MYH9	Ssm	25	192	13%	cbioportal
23	KNL1	Ssm	25	192	13%	cbioportal
22	FANCA	Ssm	25	192	13%	cbioportal
27	ERBB3	Ssm	24	192	12.5%	cbioportal
28	ERCC2	Ssm	23	192	12%	cbioportal
30	TRIP11	Ssm	22	192	11.5%	cbioportal
29	CNTRL	Ssm	22	192	11.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Urothelial Carcinoma (Cornell/Trento, Nat Gen 2016) blca_cornell_2016Cornell/Trento

72 cases with simple somatic mutation data · 72 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	41	72	56.9%	cbioportal
2	TTN	Ssm	26	72	36.1%	cbioportal
3	MUC16	Ssm	19	72	26.4%	cbioportal
4	RYR2	Ssm	19	72	26.4%	cbioportal
6	MDC1	Ssm	17	72	23.6%	cbioportal
7	MYLK	Ssm	17	72	23.6%	cbioportal
8	ZNF729	Ssm	17	72	23.6%	cbioportal
5	KMT2D	Ssm	17	72	23.6%	cbioportal
12	NIN	Ssm	16	72	22.2%	cbioportal
13	PEAK1	Ssm	16	72	22.2%	cbioportal
10	MBD4	Ssm	16	72	22.2%	cbioportal
9	DLG2	Ssm	16	72	22.2%	cbioportal
11	MTCL2	Ssm	16	72	22.2%	cbioportal
17	PCF11	Ssm	15	72	20.8%	cbioportal
18	TCHH	Ssm	15	72	20.8%	cbioportal
19	USP48	Ssm	15	72	20.8%	cbioportal
14	CTCF	Ssm	15	72	20.8%	cbioportal
15	DYNC1H1	Ssm	15	72	20.8%	cbioportal
16	NOM1	Ssm	15	72	20.8%	cbioportal
22	LATS1	Ssm	14	72	19.4%	cbioportal
29	SYNE2	Ssm	14	72	19.4%	cbioportal
23	LRWD1	Ssm	14	72	19.4%	cbioportal
24	MLXIPL	Ssm	14	72	19.4%	cbioportal
25	NCOA3	Ssm	14	72	19.4%	cbioportal
26	PDCL	Ssm	14	72	19.4%	cbioportal
27	PXDN	Ssm	14	72	19.4%	cbioportal
28	SPTAN1	Ssm	14	72	19.4%	cbioportal
20	BICRA	Ssm	14	72	19.4%	cbioportal
21	IFIH1	Ssm	14	72	19.4%	cbioportal
30	ACE	Ssm	13	72	18.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-05