Endocrine Neoplasm — Genomics

Endocrine Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

20 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Adrenocortical Carcinoma TCGA-ACCTCGA

92 cases with simple somatic mutation data · 92 cases total · Data Release 46.0 · mapped to Adrenal Cortical Carcinoma ALIAS

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	LRP1

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Adrenocortical Carcinoma (TCGA, Firehose Legacy) acc_tcgaTCGA

90 cases with simple somatic mutation data · 92 cases total · 2026-01-05 · mapped to Adrenal Cortical Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	ZFPM1	Ssm	47	90	52.2%	cbioportal
2	MUC5B	Ssm	35	90	38.9%	cbioportal
3	GARS1	Ssm	34	90	37.8%	cbioportal
4	ZNF517	Ssm	33	90	36.7%	cbioportal
5	LRIG1	Ssm	31	90	34.4%	cbioportal
6	MUC2	Ssm	28	90	31.1%	cbioportal
7	LACTB	Ssm	27	90	30%	cbioportal
8	OBSCN	Ssm	27	90	30%	cbioportal
9	CCDC102A	Ssm	26	90	28.9%	cbioportal
10	OPRD1	Ssm	26	90	28.9%	cbioportal
11	SOWAHA	Ssm	26	90	28.9%	cbioportal
13	USP42	Ssm	25	90	27.8%	cbioportal
12	TOR3A	Ssm	25	90	27.8%	cbioportal
14	CRIPAK	Ssm	24	90	26.7%	cbioportal
16	ZNF787	Ssm	24	90	26.7%	cbioportal
15	PODXL	Ssm	24	90	26.7%	cbioportal
17	TRIOBP	Ssm	23	90	25.6%	cbioportal
18	MAL2	Ssm	22	90	24.4%	cbioportal
19	MUC16	Ssm	22	90	24.4%	cbioportal
22	TPO	Ssm	21	90	23.3%	cbioportal
21	MUC4	Ssm	21	90	23.3%	cbioportal
20	IRX3	Ssm	21	90	23.3%	cbioportal
23	TMEM247	Ssm	20	90	22.2%	cbioportal
25	ERCC2	Ssm	19	90	21.1%	cbioportal
24	ASPDH	Ssm	19	90	21.1%	cbioportal
30	SALL3	Ssm	19	90	21.1%	cbioportal
29	RINL	Ssm	19	90	21.1%	cbioportal
28	OTOP1	Ssm	19	90	21.1%	cbioportal
27	KCNK17	Ssm	19	90	21.1%	cbioportal
26	GLTPD2	Ssm	19	90	21.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-05

Adrenocortical Carcinoma (TCGA GDC, 2025) acc_tcga_gdcTCGA GDC

90 cases with simple somatic mutation data · 92 cases total · 2026-02-04 · mapped to Adrenal Cortical Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	15	90	16.7%	cbioportal
2	MUC16	Ssm	14	90	15.6%	cbioportal
3	CTNNB1	Ssm	13	90	14.4%	cbioportal
4	TTN	Ssm	10	90	11.1%	cbioportal
8	PKHD1	Ssm	7	90	7.8%	cbioportal
7	PCDH15	Ssm	7	90	7.8%	cbioportal
6	CNTNAP5	Ssm	7	90	7.8%	cbioportal
5	ASXL3	Ssm	7	90	7.8%	cbioportal
10	HMCN1	Ssm	6	90	6.7%	cbioportal
9	DST	Ssm	6	90	6.7%	cbioportal
11	LRP1	Ssm	6	90	6.7%	cbioportal
13	SVEP1	Ssm	6	90	6.7%	cbioportal
12	NF1	Ssm	6	90	6.7%	cbioportal
25	TUT7	Ssm	5	90	5.6%	cbioportal
14	APOB	Ssm	5	90	5.6%	cbioportal
15	ATM	Ssm	5	90	5.6%	cbioportal
16	CMYA5	Ssm	5	90	5.6%	cbioportal
17	CSMD1	Ssm	5	90	5.6%	cbioportal
18	FAT4	Ssm	5	90	5.6%	cbioportal
19	FBN2	Ssm	5	90	5.6%	cbioportal
20	FRAS1	Ssm	5	90	5.6%	cbioportal
21	KMT2B	Ssm	5	90	5.6%	cbioportal
22	MEN1	Ssm	5	90	5.6%	cbioportal
23	PRKAR1A	Ssm	5	90	5.6%	cbioportal
24	TENM2	Ssm	5	90	5.6%	cbioportal
26	ADGRG4	Ssm	4	90	4.4%	cbioportal
27	AHNAK2	Ssm	4	90	4.4%	cbioportal
28	ANK2	Ssm	4	90	4.4%	cbioportal
29	ANK3	Ssm	4	90	4.4%	cbioportal
30	COL4A6	Ssm	4	90	4.4%	cbioportal

Data updated 22 days agoSource updated 2026-02-04

Adrenocortical Carcinoma (TCGA, PanCancer Atlas) acc_tcga_pan_can_atlas_2018TCGA

91 cases with simple somatic mutation data · 92 cases total · 2026-06-05 · mapped to Adrenal Cortical Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	18	91	19.8%	cbioportal
2	CTNNB1	Ssm	14	91	15.4%	cbioportal
3	MUC16	Ssm	14	91	15.4%	cbioportal
4	TTN	Ssm	10	91	11%	cbioportal
5	HMCN1	Ssm	8	91	8.8%	cbioportal
7	PKHD1	Ssm	8	91	8.8%	cbioportal
6	PCDH15	Ssm	8	91	8.8%	cbioportal
11	FAT4	Ssm	7	91	7.7%	cbioportal
8	ASXL3	Ssm	7	91	7.7%	cbioportal
9	CNTNAP5	Ssm	7	91	7.7%	cbioportal
10	DST	Ssm	7	91	7.7%	cbioportal
12	MEN1	Ssm	7	91	7.7%	cbioportal
17	SVEP1	Ssm	6	91	6.6%	cbioportal
16	OBSCN	Ssm	6	91	6.6%	cbioportal
15	MUC4	Ssm	6	91	6.6%	cbioportal
14	KMT2B	Ssm	6	91	6.6%	cbioportal
13	HRNR	Ssm	6	91	6.6%	cbioportal
25	DNAH10	Ssm	5	91	5.5%	cbioportal
24	CSMD1	Ssm	5	91	5.5%	cbioportal
23	CMYA5	Ssm	5	91	5.5%	cbioportal
22	ATM	Ssm	5	91	5.5%	cbioportal
30	FRAS1	Ssm	5	91	5.5%	cbioportal
20	ANK2	Ssm	5	91	5.5%	cbioportal
19	AHNAK2	Ssm	5	91	5.5%	cbioportal
18	ADGRV1	Ssm	5	91	5.5%	cbioportal
21	APOB	Ssm	5	91	5.5%	cbioportal
29	FLG	Ssm	5	91	5.5%	cbioportal
28	FBN2	Ssm	5	91	5.5%	cbioportal
27	EYS	Ssm	5	91	5.5%	cbioportal
26	DNAH5	Ssm	5	91	5.5%	cbioportal

Data updated 22 days agoSource updated 2026-06-05

Comprehensive genomic characterization of radiation-related papillary thyroid cancer in the Ukraine REBC-THYRREBC

394 cases with simple somatic mutation data · 449 cases total · Data Release 46.0 · mapped to Thyroid Gland Papillary Carcinoma ALIAS

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	OR11H12	Ssm	104	394	26.4%	gdc
2	SMIM11B	Ssm	99	394	25.1%	gdc
3	KCNE1B	Ssm	99	394	25.1%	gdc
4	SMIM34B	Ssm	99	394	25.1%	gdc
5	FAM243B	Ssm	99	394	25.1%	gdc
6	OR11H1	Ssm	98	394	24.9%	gdc
7	POTEH	Ssm	96	394	24.4%	gdc
8	CNTNAP3C	Ssm	89	394	22.6%	gdc
9	SPATA31A7	Ssm

Data updated 22 days agoSource updated Data Release 46.0

Insulinoma (Shanghai, Nat Commun 2013) panet_shanghai_2013Shanghai

10 cases with simple somatic mutation data · 10 cases total · 2026-01-12 · mapped to Pancreatic Neuroendocrine Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	YY1	Ssm	3	10	30%	cbioportal
19	KPNA2	Ssm	1	10	10%	cbioportal
18	KLHL17	Ssm	1	10	10%	cbioportal
17	ITGAM	Ssm	1	10	10%	cbioportal
16	ITGA1	Ssm	1	10	10%	cbioportal
15	IRAG1	Ssm	1	10	10%	cbioportal
14	HSPA5	Ssm	1	10	10%	cbioportal
13	HNRNPK	Ssm	1	10	10%	cbioportal
12	HERC6	Ssm	1	10	10%	cbioportal
11	H3-3A	Ssm	1	10	10%	cbioportal
10	FPGS	Ssm	1	10	10%	cbioportal
9	CRYBB1	Ssm	1	10	10%	cbioportal
8	CPNE3	Ssm	1	10	10%	cbioportal
7	CLDN14	Ssm	1	10	10%	cbioportal
3	AMOTL1	Ssm	1	10	10%	cbioportal
5	CBLL2	Ssm	1	10	10%	cbioportal
4	BLTP2	Ssm	1	10	10%	cbioportal
29	NRXN1	Ssm	1	10	10%	cbioportal
28	NOTCH1	Ssm	1	10	10%	cbioportal
27	NLRC3	Ssm	1	10	10%	cbioportal
26	NELL2	Ssm	1	10	10%	cbioportal
25	MYOZ1	Ssm	1	10	10%	cbioportal
24	MTUS1	Ssm	1	10	10%	cbioportal
23	MTRF1	Ssm	1	10	10%	cbioportal
22	MICAL2	Ssm	1	10	10%	cbioportal
21	LMO2	Ssm	1	10	10%	cbioportal
20	KRTAP4-3	Ssm	1	10	10%	cbioportal
6	CKAP2L	Ssm	1	10	10%	cbioportal
38	SERPINA4	Ssm	1	10	10%	cbioportal
2	ABHD18	Ssm	1	10	10%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Metastatic Pancreatic Neuroendocrine Tumor (MSK, JCO Precis Oncol 2018) panet_msk_2018MSK

96 cases with simple somatic mutation data · 96 cases total · 2026-01-12 · mapped to Pancreatic Neuroendocrine Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MEN1	Ssm	50	96	52.1%	cbioportal
2	DAXX	Ssm	41	96	42.7%	cbioportal
3	ATRX	Ssm	21	96	21.9%	cbioportal
4	TSC2	Ssm	18	96	18.8%	cbioportal
5	SETD2	Ssm	17	96	17.7%	cbioportal
6	TP53	Ssm	12	96	12.5%	cbioportal
8	PTEN	Ssm	11	96	11.5%	cbioportal
7	ARID1A	Ssm	11	96	11.5%	cbioportal
9	BRAF	Ssm	10	96	10.4%	cbioportal
118	PTP4A1	Ssm	2	21	9.5%	cbioportal
11	NOTCH3	Ssm	7	96	7.3%	cbioportal
10	KMT2C	Ssm	7	96	7.3%	cbioportal
14	MED12	Ssm	6	96	6.3%	cbioportal
12	ATM	Ssm	6	96	6.3%	cbioportal
13	KMT2D	Ssm	6	96	6.3%	cbioportal
16	TERT	Ssm	6	96	6.3%	cbioportal
15	NOTCH1	Ssm	6	96	6.3%	cbioportal
17	ARID2	Ssm	5	96	5.2%	cbioportal
19	CREBBP	Ssm	5	96	5.2%	cbioportal
20	FAT1	Ssm	5	96	5.2%	cbioportal
18	BRCA2	Ssm	5	96	5.2%	cbioportal
194	LYN	Ssm	1	21	4.8%	cbioportal
193	KMT2B	Ssm	1	21	4.8%	cbioportal
26	LATS2	Ssm	4	96	4.2%	cbioportal
25	KRAS	Ssm	4	96	4.2%	cbioportal
24	KMT2A	Ssm	4	96	4.2%	cbioportal
22	ERBB4	Ssm	4	96	4.2%	cbioportal
31	YAP1	Ssm	4	96	4.2%	cbioportal
30	VHL	Ssm	4	96	4.2%	cbioportal
29	TSC1	Ssm	4	96	4.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Neuroendocrine Tumors (Johns Hopkins University, Science 2011) panet_jhu_2011Johns Hopkins University

10 cases with simple somatic mutation data · 10 cases total · 2026-01-12 · mapped to Pancreatic Neuroendocrine Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MEN1	Ssm	5	10	50%	cbioportal
2	DAXX	Ssm	3	10	30%	cbioportal
3	PTEN	Ssm	2	10	20%	cbioportal
4	TSC2	Ssm	2	10	20%	cbioportal
23	CD1A	Ssm	1	10	10%	cbioportal
115	SULT2A1	Ssm	1	10	10%	cbioportal
5	ABCA7	Ssm	1	10	10%	cbioportal
6	ABCB4	Ssm	1	10	10%	cbioportal
7	ADAMTS8	Ssm	1	10	10%	cbioportal
8	ADGRG4	Ssm	1	10	10%	cbioportal
9	AFMID	Ssm	1	10	10%	cbioportal
10	AHNAK	Ssm	1	10	10%	cbioportal
11	AKAP6	Ssm	1	10	10%	cbioportal
12	ALK	Ssm	1	10	10%	cbioportal
13	ANXA8L1	Ssm	1	10	10%	cbioportal
14	ARMC5	Ssm	1	10	10%	cbioportal
15	ATP6V0A1	Ssm	1	10	10%	cbioportal
16	ATRX	Ssm	1	10	10%	cbioportal
17	BCL9L	Ssm	1	10	10%	cbioportal
18	BRD1	Ssm	1	10	10%	cbioportal
19	C21ORF58	Ssm	1	10	10%	cbioportal
20	CABIN1	Ssm	1	10	10%	cbioportal
21	CAMSAP2	Ssm	1	10	10%	cbioportal
22	CCDC158	Ssm	1	10	10%	cbioportal
24	CD1C	Ssm	1	10	10%	cbioportal
25	CEP135	Ssm	1	10	10%	cbioportal
26	CES1	Ssm	1	10	10%	cbioportal
27	CILP	Ssm	1	10	10%	cbioportal
28	COL1A1	Ssm	1	10	10%	cbioportal
29	CPNE8	Ssm	1	10	10%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Pancreatic Neuroendocrine Tumors (Multi-Institute, Nature 2017) panet_arcnet_2017Multi-Institute

98 cases with simple somatic mutation data · 98 cases total · 2026-01-12 · mapped to Pancreatic Neuroendocrine Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MEN1	Ssm	36	98	36.7%	cbioportal
2	DAXX	Ssm	22	98	22.4%	cbioportal
3	ATRX	Ssm	10	98	10.2%	cbioportal
4	PTEN	Ssm	7	98	7.1%	cbioportal
5	SETD2	Ssm	5	98	5.1%	cbioportal
6	TTN	Ssm	5	98	5.1%	cbioportal
9	FREM3	Ssm	4	98	4.1%	cbioportal
10	MUC16	Ssm	4	98	4.1%	cbioportal
8	DYNC1I1	Ssm	4	98	4.1%	cbioportal
7	DNAH5	Ssm	4	98	4.1%	cbioportal
20	HERC1	Ssm	3	98	3.1%	cbioportal
11	A2M	Ssm	3	98	3.1%	cbioportal
19	GBP2	Ssm	3	98	3.1%	cbioportal
18	FLNC	Ssm	3	98	3.1%	cbioportal
17	FLG	Ssm	3	98	3.1%	cbioportal
16	EFTUD2	Ssm	3	98	3.1%	cbioportal
15	DST	Ssm	3	98	3.1%	cbioportal
27	NUMA1	Ssm	3	98	3.1%	cbioportal
13	CEP290	Ssm	3	98	3.1%	cbioportal
37	ZSCAN1	Ssm	3	98	3.1%	cbioportal
24	MED23	Ssm	3	98	3.1%	cbioportal
29	SLC12A8	Ssm	3	98	3.1%	cbioportal
28	RYR2	Ssm	3	98	3.1%	cbioportal
14	DNAH17	Ssm	3	98	3.1%	cbioportal
26	NLRP2	Ssm	3	98	3.1%	cbioportal
25	MTOR	Ssm	3	98	3.1%	cbioportal
12	ATM	Ssm	3	98	3.1%	cbioportal
23	LRP2	Ssm	3	98	3.1%	cbioportal
22	KMT2C	Ssm	3	98	3.1%	cbioportal
21	HSPG2	Ssm	3	98	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-12

Papillary Thyroid Cancer (TCGA GDC, 2025) thpa_tcga_gdcTCGA GDC

496 cases with simple somatic mutation data · 515 cases total · 2026-01-14 · mapped to Thyroid Gland Papillary Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BRAF	Ssm	293	496	59.1%	cbioportal
2	NRAS	Ssm	39	496	7.9%	cbioportal
3	TG	Ssm	19	496	3.8%	cbioportal
4	HRAS	Ssm	17	496	3.4%	cbioportal
5	TTN	Ssm	16	496	3.2%	cbioportal
6	EIF1AX	Ssm	7	496	1.4%	cbioportal
7	KMT2A	Ssm	7	496	1.4%	cbioportal
8	MUC16	Ssm	7	496	1.4%	cbioportal
9	SPTA1	Ssm	7	496	1.4%	cbioportal
10	ZFHX3	Ssm	7	496	1.4%	cbioportal
11	BDP1	Ssm	6	496	1.2%	cbioportal
12	USP9X	Ssm	6	496	1.2%	cbioportal
19	RYR1	Ssm	5	496	1%	cbioportal
18	PTPRZ1	Ssm	5	496	1%	cbioportal
17	PDZD2	Ssm	5	496	1%	cbioportal
16	PCDH11X	Ssm	5	496	1%	cbioportal
15	GBF1	Ssm	5	496	1%	cbioportal
14	ATM	Ssm	5	496	1%	cbioportal
13	AKT1	Ssm	5	496	1%	cbioportal
26	CSMD2	Ssm	4	496	0.8%	cbioportal
20	ABCB11	Ssm	4	496	0.8%	cbioportal
21	ARFGEF2	Ssm	4	496	0.8%	cbioportal
22	ARID2	Ssm	4	496	0.8%	cbioportal
23	BPTF	Ssm	4	496	0.8%	cbioportal
24	BSN	Ssm	4	496	0.8%	cbioportal
25	CHEK2	Ssm	4	496	0.8%	cbioportal
30	JMJD1C	Ssm	4	496	0.8%	cbioportal
29	ITPR2	Ssm	4	496	0.8%	cbioportal
28	HMCN1	Ssm	4	496	0.8%	cbioportal
27	GRIN2B	Ssm	4	496	0.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Papillary Thyroid Carcinoma (TCGA, Cell 2014) thca_tcga_pubTCGA

496 cases with simple somatic mutation data · 496 cases total · 2026-01-13 · mapped to Thyroid Gland Papillary Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BRAF	Ssm	240	496	48.4%	cbioportal
2	TERT	Ssm	37	496	7.5%	cbioportal
3	NRAS	Ssm	34	496	6.9%	cbioportal
4	HRAS	Ssm	14	496	2.8%	cbioportal
5	TTN	Ssm	13	496	2.6%	cbioportal
6	TG	Ssm	11	496	2.2%	cbioportal
7	MUC16	Ssm	10	496	2%	cbioportal
8	DNAH9	Ssm	9	496	1.8%	cbioportal
10	ZFHX3	Ssm	7	496	1.4%	cbioportal
9	KMT2A	Ssm	7	496	1.4%	cbioportal
12	SPTA1	Ssm	6	496	1.2%	cbioportal
11	EIF1AX	Ssm	6	496	1.2%	cbioportal
26	PPM1D	Ssm	5	496	1%	cbioportal
27	PRKDC	Ssm	5	496	1%	cbioportal
25	OTUD4	Ssm	5	496	1%	cbioportal
24	OBSCN	Ssm	5	496	1%	cbioportal
23	MUC5B	Ssm	5	496	1%	cbioportal
22	LRP1	Ssm	5	496	1%	cbioportal
21	ITPR2	Ssm	5	496	1%	cbioportal
20	COL5A3	Ssm	5	496	1%	cbioportal
19	CHEK2	Ssm	5	496	1%	cbioportal
18	CACNA1E	Ssm	5	496	1%	cbioportal
17	BDP1	Ssm	5	496	1%	cbioportal
16	ATM	Ssm	5	496	1%	cbioportal
15	ARID1B	Ssm	5	496	1%	cbioportal
14	APOB	Ssm	5	496	1%	cbioportal
13	ADGRV1	Ssm	5	496	1%	cbioportal
28	ARFGEF2	Ssm	4	496	0.8%	cbioportal
30	CDH8	Ssm	4	496	0.8%	cbioportal
29	CD163	Ssm	4	496	0.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Pheochromocytoma and Paraganglioma TCGA-PCPGTCGA

179 cases with simple somatic mutation data · 179 cases total · Data Release 46.0 · mapped to Paraganglioma CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
3	AMY1A	Ssm	128	179	71.5%	gdc
2	AMY2A	Ssm	128	179	71.5%	gdc
1	AMY1B	Ssm	128	179	71.5%	gdc
8	SH3GLB1	Ssm	127	179	70.9%	gdc
9	GSTM3	Ssm	127	179	70.9%	gdc
29	SELENOF	Ssm	127	179	70.9%	gdc
30	GSTM5	Ssm	127	179	70.9%	gdc
28	STRIP1	Ssm	127	179	70.9%	gdc
27	CSF1	Ssm	127	179	70.9%	gdc
26	PLPPR4	Ssm	127	179	70.9%	gdc
25	AMY2B	Ssm	127	179	70.9%	gdc
24	EPS8L3	Ssm	127	179	70.9%	gdc
23	STXBP3	Ssm	127	179	70.9%	gdc
22	GPR61	Ssm	127	179	70.9%	gdc
21	FNDC7	Ssm	127	179	70.9%	gdc
20	AHCYL1	Ssm	127	179	70.9%	gdc
5	SLC6A17	Ssm	127	179	70.9%	gdc
4	LMO4	Ssm	127	179	70.9%	gdc
19	AMPD2	Ssm	127	179	70.9%	gdc
16	COL24A1	Ssm	127	179	70.9%	gdc
17	GNAT2	Ssm	127	179	70.9%	gdc
18	UBL4B	Ssm	127	179	70.9%	gdc
11	HS2ST1	Ssm	127	179	70.9%	gdc
6	CLCA2	Ssm	127	179	70.9%	gdc
10	GSTM2	Ssm	127	179	70.9%	gdc
15	ODF2L	Ssm	127	179	70.9%	gdc
12	GNAI3	Ssm	127	179	70.9%	gdc
14	TGFBR3	Ssm	127	179	70.9%	gdc
13	RBM15	Ssm	127	179	70.9%	gdc
7	AC093155.3	Ssm	127	179	70.9%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Pituitary Adenoma (MSK, 2026) ptad_msk_2026MSK

62 cases with simple somatic mutation data · 62 cases total · 2026-08-24 · mapped to Pituitary Neuroendocrine Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
106	MYO10	Ssm	2	2	100%	cbioportal
112	OR51I2	Ssm	2	2	100%	cbioportal
118	PPP1R12B	Ssm	2	2	100%	cbioportal
73	COL16A1	Ssm	2	2	100%	cbioportal
113	OR5A2	Ssm	2	2	100%	cbioportal
148	ZNF235	Ssm	2	2	100%	cbioportal
146	UAP1	Ssm	2	2	100%	cbioportal
144	TRMT6	Ssm	2	2	100%	cbioportal
134	SNUPN	Ssm	2	2	100%	cbioportal
131	SH3TC1	Ssm	2	2	100%	cbioportal
125	RAX2	Ssm	2	2	100%	cbioportal
176	CLVS2	Ssm	1	2	50%	cbioportal
150	ADK	Ssm	1	2	50%	cbioportal
149	ABI3BP	Ssm	1	2	50%	cbioportal
182	CTSC	Ssm	1	2	50%	cbioportal
1	TP53	Ssm	22	62	35.5%	cbioportal
2	ATRX	Ssm	10	62	16.1%	cbioportal
8	USP8	Ssm	5	41	12.2%	cbioportal
3	KMT2C	Ssm	7	62	11.3%	cbioportal
4	DAXX	Ssm	6	62	9.7%	cbioportal
7	SPEN	Ssm	5	62	8.1%	cbioportal
5	APC	Ssm	5	62	8.1%	cbioportal
6	MSH6	Ssm	5	62	8.1%	cbioportal
18	TBX3	Ssm	4	62	6.5%	cbioportal
13	KDM6A	Ssm	4	62	6.5%	cbioportal
12	JAK1	Ssm	4	62	6.5%	cbioportal
17	PIK3CD	Ssm	4	62	6.5%	cbioportal
10	ARID2	Ssm	4	62	6.5%	cbioportal
9	ANKRD11	Ssm	4	62	6.5%	cbioportal
11	EPHB1	Ssm	4	62	6.5%	cbioportal

Data updated 22 days agoSource updated 2026-08-24

Pituitary Adenoma (MSK, Acta Neuropathologica 2024) ptad_msk_2024MSK

104 cases with simple somatic mutation data · 104 cases total · 2026-01-16 · mapped to Pituitary Neuroendocrine Tumor EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	15	104	14.4%	cbioportal
114	SMARCA2	Ssm	2	15	13.3%	cbioportal
125	USP8	Ssm	2	15	13.3%	cbioportal
155	CTR9	Ssm	1	15	6.7%	cbioportal
128	ARHGAP35	Ssm	1	15	6.7%	cbioportal
197	KLF5	Ssm	1	15	6.7%	cbioportal
2	KMT2C	Ssm	6	104	5.8%	cbioportal
5	DAXX	Ssm	5	104	4.8%	cbioportal
4	ATRX	Ssm	5	104	4.8%	cbioportal
3	ANKRD11	Ssm	5	104	4.8%	cbioportal
7	KMT2D	Ssm	5	104	4.8%	cbioportal
8	SPEN	Ssm	5	104	4.8%	cbioportal
6	GNAS	Ssm	5	104	4.8%	cbioportal
14	MEN1	Ssm	4	104	3.8%	cbioportal
13	KDM6A	Ssm	4	104	3.8%	cbioportal
12	JAK1	Ssm	4	104	3.8%	cbioportal
11	EPHB1	Ssm	4	104	3.8%	cbioportal
10	ASXL1	Ssm	4	104	3.8%	cbioportal
20	TSC2	Ssm	4	104	3.8%	cbioportal
9	APC	Ssm	4	104	3.8%	cbioportal
19	TBX3	Ssm	4	104	3.8%	cbioportal
18	PIK3CD	Ssm	4	104	3.8%	cbioportal
17	NSD1	Ssm	4	104	3.8%	cbioportal
16	MSH6	Ssm	4	104	3.8%	cbioportal
15	MGA	Ssm	4	104	3.8%	cbioportal
42	WWTR1	Ssm	3	101	3%	cbioportal
41	TP53BP1	Ssm	3	101	3%	cbioportal
39	PRKD1	Ssm	3	101	3%	cbioportal
28	CSDE1	Ssm	3	101	3%	cbioportal
30	INPPL1	Ssm	3	101	3%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Small Cell Lung Cancer (CLCGP, Nat Genet 2012) sclc_clcgpCLCGP

29 cases with simple somatic mutation data · 29 cases total · 2026-01-13 · mapped to Lung Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	26	29	89.7%	cbioportal
2	RB1	Ssm	19	29	65.5%	cbioportal
4	USH2A	Ssm	13	29	44.8%	cbioportal
3	LRP1B	Ssm	13	29	44.8%	cbioportal
5	TTN	Ssm	11	29	37.9%	cbioportal
7	PKHD1	Ssm	10	29	34.5%	cbioportal
6	CSMD3	Ssm	10	29	34.5%	cbioportal
9	MUC17	Ssm	9	29	31%	cbioportal
8	COL11A1	Ssm	9	29	31%	cbioportal
10	PRDM9	Ssm	9	29	31%	cbioportal
13	SYNE1	Ssm	8	29	27.6%	cbioportal
12	SPHKAP	Ssm	8	29	27.6%	cbioportal
11	DMD	Ssm	8	29	27.6%	cbioportal
15	ZNF536	Ssm	8	29	27.6%	cbioportal
14	ZNF521	Ssm	8	29	27.6%	cbioportal
22	ZNF804A	Ssm	7	29	24.1%	cbioportal
20	TMEM132D	Ssm	7	29	24.1%	cbioportal
21	TNN	Ssm	7	29	24.1%	cbioportal
19	TKTL2	Ssm	7	29	24.1%	cbioportal
18	SI	Ssm	7	29	24.1%	cbioportal
17	FLG	Ssm	7	29	24.1%	cbioportal
16	CSMD2	Ssm	7	29	24.1%	cbioportal
28	ERICH3	Ssm	6	29	20.7%	cbioportal
23	ANKRD30A	Ssm	6	29	20.7%	cbioportal
24	CDH10	Ssm	6	29	20.7%	cbioportal
25	COL22A1	Ssm	6	29	20.7%	cbioportal
26	DNAH9	Ssm	6	29	20.7%	cbioportal
27	ERBB4	Ssm	6	29	20.7%	cbioportal
29	FAT4	Ssm	6	29	20.7%	cbioportal
30	HCN1	Ssm	6	29	20.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Small Cell Lung Cancer (Johns Hopkins, Nat Genet 2012) sclc_jhuJohns Hopkins

80 cases with simple somatic mutation data · 80 cases total · 2026-01-13 · mapped to Lung Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	36	80	45%	cbioportal
2	RB1	Ssm	19	80	23.8%	cbioportal
3	CSMD3	Ssm	17	80	21.3%	cbioportal
4	TTN	Ssm	16	80	20%	cbioportal
5	LRP1B	Ssm	15	80	18.8%	cbioportal
6	MUC17	Ssm	12	80	15%	cbioportal
8	USH2A	Ssm	11	80	13.8%	cbioportal
7	HCN1	Ssm	11	80	13.8%	cbioportal
9	DNAH7	Ssm	10	80	12.5%	cbioportal
12	SYNE1	Ssm	9	80	11.3%	cbioportal
10	COL11A1	Ssm	9	80	11.3%	cbioportal
11	COL22A1	Ssm	9	80	11.3%	cbioportal
14	GRIN2B	Ssm	8	80	10%	cbioportal
13	BRINP3	Ssm	8	80	10%	cbioportal
23	NAV3	Ssm	7	80	8.8%	cbioportal
25	RYR2	Ssm	7	80	8.8%	cbioportal
15	ANK2	Ssm	7	80	8.8%	cbioportal
16	DNAH5	Ssm	7	80	8.8%	cbioportal
17	ERICH3	Ssm	7	80	8.8%	cbioportal
18	FAM135B	Ssm	7	80	8.8%	cbioportal
19	FSIP2	Ssm	7	80	8.8%	cbioportal
20	KIF21A	Ssm	7	80	8.8%	cbioportal
21	MORC1	Ssm	7	80	8.8%	cbioportal
22	MYH2	Ssm	7	80	8.8%	cbioportal
24	PKHD1	Ssm	7	80	8.8%	cbioportal
29	DCC	Ssm	6	80	7.5%	cbioportal
28	COL4A2	Ssm	6	80	7.5%	cbioportal
27	CNTNAP2	Ssm	6	80	7.5%	cbioportal
26	ADGRG4	Ssm	6	80	7.5%	cbioportal
30	DIP2C	Ssm	6	80	7.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Small-Cell Lung Cancer (Multi-Institute, Cancer Cell 2017) sclc_cancercell_gardner_2017Multi-Institute

20 cases with simple somatic mutation data · 20 cases total · 2026-01-13 · mapped to Lung Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	POLE	Ssm	20	20	100%	cbioportal
2	CUBN	Ssm	19	20	95%	cbioportal
3	GRIN2C	Ssm	19	20	95%	cbioportal
7	FSIP2	Ssm	18	20	90%	cbioportal
10	OR10Q1	Ssm	18	20	90%	cbioportal
9	MUC16	Ssm	18	20	90%	cbioportal
4	CATSPERT	Ssm	18	20	90%	cbioportal
5	DBN1	Ssm	18	20	90%	cbioportal
6	DGKG	Ssm	18	20	90%	cbioportal
8	GART	Ssm	18	20	90%	cbioportal
13	PIKFYVE	Ssm	17	20	85%	cbioportal
12	OBSCN	Ssm	17	20	85%	cbioportal
11	IGLV1-47	Ssm	17	20	85%	cbioportal
165	STK31	Ssm	16	20	80%	cbioportal
150	RTTN	Ssm	16	20	80%	cbioportal
151	SCN10A	Ssm	16	20	80%	cbioportal
152	SCO2	Ssm	16	20	80%	cbioportal
153	SHCBP1	Ssm	16	20	80%	cbioportal
154	SIGLEC12	Ssm	16	20	80%	cbioportal
155	SIRPB2	Ssm	16	20	80%	cbioportal
156	SIX5	Ssm	16	20	80%	cbioportal
157	SLC26A2	Ssm	16	20	80%	cbioportal
158	SLC41A3	Ssm	16	20	80%	cbioportal
159	SLU7	Ssm	16	20	80%	cbioportal
160	SON	Ssm	16	20	80%	cbioportal
161	SOWAHA	Ssm	16	20	80%	cbioportal
162	SPECC1L	Ssm	16	20	80%	cbioportal
163	SPEN	Ssm	16	20	80%	cbioportal
164	SSH3	Ssm	16	20	80%	cbioportal
166	SVOPL	Ssm	16	20	80%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Small Cell Lung Cancer (U Cologne, Nature 2015) sclc_ucologne_2015U Cologne

120 cases with simple somatic mutation data · 120 cases total · 2026-01-13 · mapped to Lung Small Cell Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	103	120	85.8%	cbioportal
2	RB1	Ssm	87	120	72.5%	cbioportal
3	TTN	Ssm	77	120	64.2%	cbioportal
4	RYR2	Ssm	54	120	45%	cbioportal
5	LRP1B	Ssm	51	120	42.5%	cbioportal
6	MUC16	Ssm	49	120	40.8%	cbioportal
7	ZFHX4	Ssm	46	120	38.3%	cbioportal
8	USH2A	Ssm	44	120	36.7%	cbioportal
9	CSMD3	Ssm	42	120	35%	cbioportal
10	NAV3	Ssm	35	120	29.2%	cbioportal
11	PCDH15	Ssm	32	120	26.7%	cbioportal
12	COL11A1	Ssm	31	120	25.8%	cbioportal
13	CSMD1	Ssm	28	120	23.3%	cbioportal
16	SYNE1	Ssm	27	120	22.5%	cbioportal
14	EYS	Ssm	27	120	22.5%	cbioportal
15	MUC17	Ssm	27	120	22.5%	cbioportal
18	FAM135B	Ssm	26	120	21.7%	cbioportal
17	ANKRD30B	Ssm	26	120	21.7%	cbioportal
19	FSIP2	Ssm	25	120	20.8%	cbioportal
20	TMEM132D	Ssm	25	120	20.8%	cbioportal
22	PKHD1	Ssm	24	120	20%	cbioportal
23	SI	Ssm	24	120	20%	cbioportal
21	ERICH3	Ssm	24	120	20%	cbioportal
26	SPTA1	Ssm	23	120	19.2%	cbioportal
28	XIRP2	Ssm	23	120	19.2%	cbioportal
27	TENM1	Ssm	23	120	19.2%	cbioportal
24	PKHD1L1	Ssm	23	120	19.2%	cbioportal
25	RYR1	Ssm	23	120	19.2%	cbioportal
30	FAT3	Ssm	22	120	18.3%	cbioportal
29	ADGB	Ssm	22	120	18.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Thyroid Carcinoma (TCGA, Firehose Legacy) thca_tcgaTCGA

405 cases with simple somatic mutation data · 516 cases total · 2026-01-13 · mapped to Thyroid Gland Papillary Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BRAF	Ssm	242	405	59.8%	cbioportal
2	NRAS	Ssm	34	405	8.4%	cbioportal
3	HRAS	Ssm	14	405	3.5%	cbioportal
4	TTN	Ssm	13	405	3.2%	cbioportal
5	TG	Ssm	11	405	2.7%	cbioportal
6	MUC16	Ssm	10	405	2.5%	cbioportal
7	DNAH9	Ssm	9	405	2.2%	cbioportal
8	KMT2A	Ssm	7	405	1.7%	cbioportal
9	ZFHX3	Ssm	7	405	1.7%	cbioportal
10	EIF1AX	Ssm	6	405	1.5%	cbioportal
11	SPTA1	Ssm	6	405	1.5%	cbioportal
17	CACNA1E	Ssm	5	405	1.2%	cbioportal
28	PRKDC	Ssm	5	405	1.2%	cbioportal
27	PPM1D	Ssm	5	405	1.2%	cbioportal
26	PCDHGC5	Ssm	5	405	1.2%	cbioportal
25	PCDHAC2	Ssm	5	405	1.2%	cbioportal
24	OTUD4	Ssm	5	405	1.2%	cbioportal
23	OBSCN	Ssm	5	405	1.2%	cbioportal
22	MUC5B	Ssm	5	405	1.2%	cbioportal
21	LRP1	Ssm	5	405	1.2%	cbioportal
20	ITPR2	Ssm	5	405	1.2%	cbioportal
19	COL5A3	Ssm	5	405	1.2%	cbioportal
18	CHEK2	Ssm	5	405	1.2%	cbioportal
16	BDP1	Ssm	5	405	1.2%	cbioportal
15	ATM	Ssm	5	405	1.2%	cbioportal
14	ARID1B	Ssm	5	405	1.2%	cbioportal
13	APOB	Ssm	5	405	1.2%	cbioportal
12	ADGRV1	Ssm	5	405	1.2%	cbioportal
30	CD163	Ssm	4	405	1%	cbioportal
29	ARFGEF2	Ssm	4	405	1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Thyroid Carcinoma (TCGA, PanCancer Atlas) thca_tcga_pan_can_atlas_2018TCGA

490 cases with simple somatic mutation data · 500 cases total · 2026-06-04 · mapped to Thyroid Gland Papillary Carcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	BRAF	Ssm	287	490	58.6%	cbioportal
2	NRAS	Ssm	39	490	8%	cbioportal
3	TTN	Ssm	21	490	4.3%	cbioportal
4	TG	Ssm	19	490	3.9%	cbioportal
5	HRAS	Ssm	16	490	3.3%	cbioportal
6	MUC16	Ssm	13	490	2.7%	cbioportal
8	ZFHX3	Ssm	10	490	2%	cbioportal
7	DNAH9	Ssm	10	490	2%	cbioportal
9	SPTA1	Ssm	8	490	1.6%	cbioportal
10	COL5A3	Ssm	7	490	1.4%	cbioportal
11	DNAH2	Ssm	7	490	1.4%	cbioportal
12	EIF1AX	Ssm	7	490	1.4%	cbioportal
13	ITPR2	Ssm	7	490	1.4%	cbioportal
16	PLEC	Ssm	7	490	1.4%	cbioportal
17	RYR1	Ssm	7	490	1.4%	cbioportal
15	MACF1	Ssm	7	490	1.4%	cbioportal
14	KMT2A	Ssm	7	490	1.4%	cbioportal
19	ATM	Ssm	6	490	1.2%	cbioportal
21	HMCN1	Ssm	6	490	1.2%	cbioportal
24	PIK3R5	Ssm	6	490	1.2%	cbioportal
23	MUC5B	Ssm	6	490	1.2%	cbioportal
22	KMT2C	Ssm	6	490	1.2%	cbioportal
18	ADGRV1	Ssm	6	490	1.2%	cbioportal
20	FAT3	Ssm	6	490	1.2%	cbioportal
27	BDP1	Ssm	5	490	1%	cbioportal
28	BPTF	Ssm	5	490	1%	cbioportal
29	COL7A1	Ssm	5	490	1%	cbioportal
30	CSMD1	Ssm	5	490	1%	cbioportal
25	AKT1	Ssm	5	490	1%	cbioportal
26	ALPK3	Ssm	5	490	1%	cbioportal

Data updated 22 days agoSource updated 2026-06-04