Ranking · Unmet Need

Research Gap Index

Burden percentile minus research-activity percentile (publications, last 5 years) within the same scope. Positive values flag cancers with high mortality burden but comparatively little literature. Caveat (Phase 1): literature counts are query-based per entity (query stored on each row); they are not aggregated over descendants.

Computedci-research-gap-v1unit: percentile pointshigher = worseAll metrics

Rank	Δ	Cancer	Research Gap Index (percentile points)	Percentile	Confidence	Sources	Why #n?
1	=	Malignant Central Nervous System Neoplasm	+64	100	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 9510 formula percentile(mortality_count) − percentile(publications_5y) activity 298 burdenPercentile 64 activityPercentile 0 ranking row 2601962
2	=	Malignant Esophageal Neoplasm	+24	96	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12317 formula percentile(mortality_count) − percentile(publications_5y) activity 10921 burdenPercentile 76 activityPercentile 52 ranking row 2601963
2	=	Malignant Salivary Gland Neoplasm	+24	96	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 653 formula percentile(mortality_count) − percentile(publications_5y) activity 474 burdenPercentile 28 activityPercentile 4 ranking row 2601964
4	=	Malignant Kidney Neoplasm	+20	88	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 8996 formula percentile(mortality_count) − percentile(publications_5y) activity 3700 burdenPercentile 60 activityPercentile 40 ranking row 2601965
5	=	Malignant Liver Neoplasm	+16	84	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 17843 formula percentile(mortality_count) − percentile(publications_5y) activity 17939 burdenPercentile 84 activityPercentile 68 ranking row 2601966
6	=	Malignant Colon Neoplasm	+12	80	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 21568 formula percentile(mortality_count) − percentile(publications_5y) activity 18406 burdenPercentile 88 activityPercentile 76 ranking row 2601969
6	=	Malignant Laryngeal Neoplasm	+12	80	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3048 formula percentile(mortality_count) − percentile(publications_5y) activity 2031 burdenPercentile 40 activityPercentile 28 ranking row 2601968
6	=	Malignant Pancreatic Neoplasm	+12	80	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 21899 formula percentile(mortality_count) − percentile(publications_5y) activity 25767 burdenPercentile 92 activityPercentile 80 ranking row 2601967
9	=	Malignant Nasopharyngeal Neoplasm	+8	68	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 510 formula percentile(mortality_count) − percentile(publications_5y) activity 952 burdenPercentile 20 activityPercentile 12 ranking row 2601970
10	=	Malignant Lung Neoplasm	+4	64	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 80775 formula percentile(mortality_count) − percentile(publications_5y) activity 93034 burdenPercentile 100 activityPercentile 96 ranking row 2601972
10	=	Malignant Mesothelioma	+4	64	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1972 formula percentile(mortality_count) − percentile(publications_5y) activity 2145 burdenPercentile 36 activityPercentile 32 ranking row 2601971
10	=	Malignant Prostate Neoplasm	+4	64	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 30370 formula percentile(mortality_count) − percentile(publications_5y) activity 52116 burdenPercentile 96 activityPercentile 92 ranking row 2601975
10	=	Multiple Myeloma	+4	64	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 6734 formula percentile(mortality_count) − percentile(publications_5y) activity 10244 burdenPercentile 52 activityPercentile 48 ranking row 2601973
10	=	Non-Hodgkin Lymphoma	+4	64	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 11300 formula percentile(mortality_count) − percentile(publications_5y) activity 17190 burdenPercentile 68 activityPercentile 64 ranking row 2601974
15	=	Cutaneous Melanoma	0	44	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 5425 formula percentile(mortality_count) − percentile(publications_5y) activity 4407 burdenPercentile 44 activityPercentile 44 ranking row 2601976
15	=	Malignant Bladder Neoplasm	0	44	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 11941 formula percentile(mortality_count) − percentile(publications_5y) activity 18250 burdenPercentile 72 activityPercentile 72 ranking row 2601977
17	=	Leukemia	-4	36	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 13360 formula percentile(mortality_count) − percentile(publications_5y) activity 31893 burdenPercentile 80 activityPercentile 84 ranking row 2601978
17	=	Malignant Hypopharyngeal Neoplasm	-4	36	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 322 formula percentile(mortality_count) − percentile(publications_5y) activity 581 burdenPercentile 4 activityPercentile 8 ranking row 2601979
19	=	Malignant Rectal Neoplasm	-8	28	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 6074 formula percentile(mortality_count) − percentile(publications_5y) activity 12506 burdenPercentile 48 activityPercentile 56 ranking row 2601980
20	=	Hodgkin Lymphoma	-12	24	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 579 formula percentile(mortality_count) − percentile(publications_5y) activity 2178 burdenPercentile 24 activityPercentile 36 ranking row 2601981
20	=	Malignant Anal Neoplasm	-12	24	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 427 formula percentile(mortality_count) − percentile(publications_5y) activity 1291 burdenPercentile 8 activityPercentile 20 ranking row 2601983
20	=	Malignant Testicular Neoplasm	-12	24	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 431 formula percentile(mortality_count) − percentile(publications_5y) activity 1806 burdenPercentile 12 activityPercentile 24 ranking row 2601982
23	=	Malignant Penile Neoplasm	-16	12	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 317 formula percentile(mortality_count) − percentile(publications_5y) activity 1025 burdenPercentile 0 activityPercentile 16 ranking row 2601984
24	=	Malignant Thyroid Gland Neoplasm	-28	8	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 926 formula percentile(mortality_count) − percentile(publications_5y) activity 13792 burdenPercentile 32 activityPercentile 60 ranking row 2601985
25	=	Malignant Gastric Neoplasm	-32	4	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 6845 formula percentile(mortality_count) − percentile(publications_5y) activity 34783 burdenPercentile 56 activityPercentile 88 ranking row 2601986
26	=	Malignant Breast Neoplasm	-84	0	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 464 formula percentile(mortality_count) − percentile(publications_5y) activity 133010 burdenPercentile 16 activityPercentile 100 ranking row 2601987

Data updated 16 hours agoSource updated unknown26 eligible entities · inputs hash 22ae052f9ceb5893047527e8

Methodology

How this table was built

Formula: percentile(mortality_count) − percentile(publications_5y)
Version: ci-research-gap-v1
Scope: USA · Male · all ages · 2016 · top-level cancers
Scope key: geo=USA|sex=male|age=all|year=2016|level=top
Eligible entities: 26
Generated: Sep 29, 2026, 06:30 AM UTC
Inputs hash: 22ae052f9ceb5893047527e8
Sources: U.S. Cancer Statistics (USCS) — NPCR/SEER incidence and NVSS mortality pubmed cdc-wonder seer iarc-globocan
Aggregation: none

Eligibility

requires: mortality_count
publications_5y
entityLevel: top

Full methodology · ties share a rank (1, 2, 2, 4) · previous rank refers to the last snapshot of the same scope.

Download CSV (with attribution)

Burden and lethality metrics depend on registry definitions (site groups, standard population, estimate type). Compare only within one table.