Ranking · Unmet Need

Research Gap Index

Burden percentile minus research-activity percentile (publications, last 5 years) within the same scope. Positive values flag cancers with high mortality burden but comparatively little literature. Caveat (Phase 1): literature counts are query-based per entity (query stored on each row); they are not aggregated over descendants.

Computedci-research-gap-v1unit: percentile pointshigher = worseAll metrics

Rank	Δ	Cancer	Research Gap Index (percentile points)	Percentile	Confidence	Sources	Why #n?
1	=	Malignant Central Nervous System Neoplasm	+70	100	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 17937 formula percentile(mortality_count) − percentile(publications_5y) activity 298 burdenPercentile 73.3 activityPercentile 3.3 ranking row 2606952
2	=	Malignant Uterine Corpus Neoplasm	+43.3	96.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 7751 formula percentile(mortality_count) − percentile(publications_5y) activity 105 burdenPercentile 43.3 activityPercentile 0 ranking row 2606953
3	=	Malignant Kidney Neoplasm	+20	93.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 14488 formula percentile(mortality_count) − percentile(publications_5y) activity 3700 burdenPercentile 63.3 activityPercentile 43.3 ranking row 2606955
3	▲1	Malignant Pancreatic Neoplasm	+20	93.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 48323 formula percentile(mortality_count) − percentile(publications_5y) activity 25767 burdenPercentile 96.7 activityPercentile 76.7 ranking row 2606954
5	=	Malignant Colon Neoplasm	+16.7	86.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 40431 formula percentile(mortality_count) − percentile(publications_5y) activity 18406 burdenPercentile 90 activityPercentile 73.3 ranking row 2606956
6	=	Malignant Liver Neoplasm	+16.6	83.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 28937 formula percentile(mortality_count) − percentile(publications_5y) activity 17939 burdenPercentile 83.3 activityPercentile 66.7 ranking row 2606957
7	=	Malignant Esophageal Neoplasm	+13.4	80	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 16014 formula percentile(mortality_count) − percentile(publications_5y) activity 10921 burdenPercentile 66.7 activityPercentile 53.3 ranking row 2606958
7	=	Non-Hodgkin Lymphoma	+13.4	80	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 19794 formula percentile(mortality_count) − percentile(publications_5y) activity 17190 burdenPercentile 76.7 activityPercentile 63.3 ranking row 2606959
9	=	Malignant Salivary Gland Neoplasm	+10	73.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1104 formula percentile(mortality_count) − percentile(publications_5y) activity 474 burdenPercentile 20 activityPercentile 10 ranking row 2606960
10	=	Malignant Vulvar Neoplasm	+6.6	70	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1550 formula percentile(mortality_count) − percentile(publications_5y) activity 870 burdenPercentile 23.3 activityPercentile 16.7 ranking row 2606961
11	▲1	Malignant Laryngeal Neoplasm	+3.4	66.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3933 formula percentile(mortality_count) − percentile(publications_5y) activity 2031 burdenPercentile 36.7 activityPercentile 33.3 ranking row 2606962
12	▲1	Malignant Lung Neoplasm	+3.3	63.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 131888 formula percentile(mortality_count) − percentile(publications_5y) activity 93034 burdenPercentile 100 activityPercentile 96.7 ranking row 2606963
12	▼1	Multiple Myeloma	+3.3	63.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12078 formula percentile(mortality_count) − percentile(publications_5y) activity 10244 burdenPercentile 53.3 activityPercentile 50 ranking row 2606964
14	=	Cutaneous Melanoma	0	56.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 8243 formula percentile(mortality_count) − percentile(publications_5y) activity 4407 burdenPercentile 46.7 activityPercentile 46.7 ranking row 2606965
14	▲2	Malignant Anal Neoplasm	0	56.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1600 formula percentile(mortality_count) − percentile(publications_5y) activity 1291 burdenPercentile 26.7 activityPercentile 26.7 ranking row 2606967
14	▲2	Malignant Bladder Neoplasm	0	56.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 17334 formula percentile(mortality_count) − percentile(publications_5y) activity 18250 burdenPercentile 70 activityPercentile 70 ranking row 2606966
14	▲7	Malignant Rectal Neoplasm	0	56.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12536 formula percentile(mortality_count) − percentile(publications_5y) activity 12506 burdenPercentile 56.7 activityPercentile 56.7 ranking row 2606968
18	▼2	Malignant Vaginal Neoplasm	-3.4	43.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 434 formula percentile(mortality_count) − percentile(publications_5y) activity 373 burdenPercentile 3.3 activityPercentile 6.7 ranking row 2606969
19	▲2	Malignant Mesothelioma	-3.4	40	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 2236 formula percentile(mortality_count) − percentile(publications_5y) activity 2145 burdenPercentile 33.3 activityPercentile 36.7 ranking row 2606970
20	▲6	Malignant Prostate Neoplasm	-6.6	36.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 33363 formula percentile(mortality_count) − percentile(publications_5y) activity 52116 burdenPercentile 86.7 activityPercentile 93.3 ranking row 2606971
21	▼1	Malignant Hypopharyngeal Neoplasm	-6.6	33.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 490 formula percentile(mortality_count) − percentile(publications_5y) activity 581 burdenPercentile 6.7 activityPercentile 13.3 ranking row 2606972
22	▲3	Malignant Nasopharyngeal Neoplasm	-6.7	30	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 686 formula percentile(mortality_count) − percentile(publications_5y) activity 952 burdenPercentile 13.3 activityPercentile 20 ranking row 2606973
23	=	Leukemia	-6.7	26.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 23496 formula percentile(mortality_count) − percentile(publications_5y) activity 31893 burdenPercentile 80 activityPercentile 86.7 ranking row 2606974
23	▲3	Malignant Breast Neoplasm	-6.7	26.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 42672 formula percentile(mortality_count) − percentile(publications_5y) activity 133010 burdenPercentile 93.3 activityPercentile 100 ranking row 2606975
25	▲5	Malignant Ovarian Neoplasm	-20	20	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 13214 formula percentile(mortality_count) − percentile(publications_5y) activity 25793 burdenPercentile 60 activityPercentile 80 ranking row 2606976
25	▲5	Malignant Testicular Neoplasm	-20	20	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 510 formula percentile(mortality_count) − percentile(publications_5y) activity 1806 burdenPercentile 10 activityPercentile 30 ranking row 2606977
27	▲5	Hodgkin Lymphoma	-23.3	13.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1056 formula percentile(mortality_count) − percentile(publications_5y) activity 2178 burdenPercentile 16.7 activityPercentile 40 ranking row 2606978
27	▲5	Malignant Penile Neoplasm	-23.3	13.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 361 formula percentile(mortality_count) − percentile(publications_5y) activity 1025 burdenPercentile 0 activityPercentile 23.3 ranking row 2606979
29	▲6	Malignant Thyroid Gland Neoplasm	-30	6.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 2204 formula percentile(mortality_count) − percentile(publications_5y) activity 13792 burdenPercentile 30 activityPercentile 60 ranking row 2606980
30	▲4	Malignant Gastric Neoplasm	-40	3.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 10852 formula percentile(mortality_count) − percentile(publications_5y) activity 34783 burdenPercentile 50 activityPercentile 90 ranking row 2606981
31	▲5	Malignant Cervical Neoplasm	-43.3	0	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 4051 formula percentile(mortality_count) − percentile(publications_5y) activity 26673 burdenPercentile 40 activityPercentile 83.3 ranking row 2606982

Data updated 16 hours agoSource updated unknown31 eligible entities · inputs hash 6479d73d7b11d2aef5f35013

Methodology

How this table was built

Formula: percentile(mortality_count) − percentile(publications_5y)
Version: ci-research-gap-v1
Scope: USA · both sexes · all ages · 2022 · top-level cancers
Scope key: geo=USA|sex=all|age=all|year=2022|level=top
Eligible entities: 31
Generated: Sep 29, 2026, 06:30 AM UTC
Inputs hash: 6479d73d7b11d2aef5f35013
Sources: U.S. Cancer Statistics (USCS) — NPCR/SEER incidence and NVSS mortality pubmed cdc-wonder seer iarc-globocan
Aggregation: none

Eligibility

requires: mortality_count
publications_5y
entityLevel: top

Full methodology · ties share a rank (1, 2, 2, 4) · previous rank refers to the last snapshot of the same scope.

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Burden and lethality metrics depend on registry definitions (site groups, standard population, estimate type). Compare only within one table.