Ranking · Unmet Need

Research Gap Index

Burden percentile minus research-activity percentile (publications, last 5 years) within the same scope. Positive values flag cancers with high mortality burden but comparatively little literature. Caveat (Phase 1): literature counts are query-based per entity (query stored on each row); they are not aggregated over descendants.

Computedci-research-gap-v1unit: percentile pointshigher = worseAll metrics

Rank	Δ	Cancer	Research Gap Index (percentile points)	Percentile	Confidence	Sources	Why #n?
1	=	Malignant Central Nervous System Neoplasm	+63.4	100	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 13724 formula percentile(mortality_count) − percentile(publications_5y) activity 298 burdenPercentile 66.7 activityPercentile 3.3 ranking row 2596895
2	=	Malignant Uterine Corpus Neoplasm	+36.7	96.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3436 formula percentile(mortality_count) − percentile(publications_5y) activity 105 burdenPercentile 36.7 activityPercentile 0 ranking row 2596896
3	=	Malignant Colon Neoplasm	+23.4	93.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 43650 formula percentile(mortality_count) − percentile(publications_5y) activity 18406 burdenPercentile 96.7 activityPercentile 73.3 ranking row 2596897
4	=	Malignant Kidney Neoplasm	+16.7	90	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12895 formula percentile(mortality_count) − percentile(publications_5y) activity 3700 burdenPercentile 60 activityPercentile 43.3 ranking row 2596899
4	=	Non-Hodgkin Lymphoma	+16.7	90	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 20368 formula percentile(mortality_count) − percentile(publications_5y) activity 17190 burdenPercentile 80 activityPercentile 63.3 ranking row 2596898
6	=	Malignant Pancreatic Neoplasm	+13.3	83.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 35234 formula percentile(mortality_count) − percentile(publications_5y) activity 25767 burdenPercentile 90 activityPercentile 76.7 ranking row 2596900
7	=	Malignant Esophageal Neoplasm	+10	80	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 13714 formula percentile(mortality_count) − percentile(publications_5y) activity 10921 burdenPercentile 63.3 activityPercentile 53.3 ranking row 2596901
7	=	Malignant Liver Neoplasm	+10	80	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 18213 formula percentile(mortality_count) − percentile(publications_5y) activity 17939 burdenPercentile 76.7 activityPercentile 66.7 ranking row 2596903
7	=	Malignant Salivary Gland Neoplasm	+10	80	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 718 formula percentile(mortality_count) − percentile(publications_5y) activity 474 burdenPercentile 20 activityPercentile 10 ranking row 2596902
10	=	Malignant Laryngeal Neoplasm	+6.7	70	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3760 formula percentile(mortality_count) − percentile(publications_5y) activity 2031 burdenPercentile 40 activityPercentile 33.3 ranking row 2596904
11	=	Malignant Vulvar Neoplasm	+6.6	66.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 921 formula percentile(mortality_count) − percentile(publications_5y) activity 870 burdenPercentile 23.3 activityPercentile 16.7 ranking row 2596905
12	=	Malignant Vaginal Neoplasm	+3.3	63.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 417 formula percentile(mortality_count) − percentile(publications_5y) activity 373 burdenPercentile 10 activityPercentile 6.7 ranking row 2596906
13	=	Malignant Lung Neoplasm	+3.3	60	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 158592 formula percentile(mortality_count) − percentile(publications_5y) activity 93034 burdenPercentile 100 activityPercentile 96.7 ranking row 2596907
13	=	Multiple Myeloma	+3.3	60	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 10606 formula percentile(mortality_count) − percentile(publications_5y) activity 10244 burdenPercentile 53.3 activityPercentile 50 ranking row 2596908
15	=	Cutaneous Melanoma	0	53.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 8623 formula percentile(mortality_count) − percentile(publications_5y) activity 4407 burdenPercentile 46.7 activityPercentile 46.7 ranking row 2596909
15	=	Malignant Bladder Neoplasm	0	53.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 14036 formula percentile(mortality_count) − percentile(publications_5y) activity 18250 burdenPercentile 70 activityPercentile 70 ranking row 2596910
17	=	Leukemia	-3.4	46.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 22431 formula percentile(mortality_count) − percentile(publications_5y) activity 31893 burdenPercentile 83.3 activityPercentile 86.7 ranking row 2596911
17	=	Malignant Mesothelioma	-3.4	46.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 2538 formula percentile(mortality_count) − percentile(publications_5y) activity 2145 burdenPercentile 33.3 activityPercentile 36.7 ranking row 2596912
19	=	Malignant Prostate Neoplasm	-6.6	40	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 28471 formula percentile(mortality_count) − percentile(publications_5y) activity 52116 burdenPercentile 86.7 activityPercentile 93.3 ranking row 2596913
20	=	Malignant Anal Neoplasm	-6.7	36.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 718 formula percentile(mortality_count) − percentile(publications_5y) activity 1291 burdenPercentile 20 activityPercentile 26.7 ranking row 2596915
20	=	Malignant Nasopharyngeal Neoplasm	-6.7	36.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 645 formula percentile(mortality_count) − percentile(publications_5y) activity 952 burdenPercentile 13.3 activityPercentile 20 ranking row 2596914
22	=	Malignant Breast Neoplasm	-6.7	30	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 41026 formula percentile(mortality_count) − percentile(publications_5y) activity 133010 burdenPercentile 93.3 activityPercentile 100 ranking row 2596916
22	=	Malignant Ovarian Neoplasm	-6.7	30	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 14362 formula percentile(mortality_count) − percentile(publications_5y) activity 25793 burdenPercentile 73.3 activityPercentile 80 ranking row 2596917
22	=	Malignant Rectal Neoplasm	-6.7	30	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 9207 formula percentile(mortality_count) − percentile(publications_5y) activity 12506 burdenPercentile 50 activityPercentile 56.7 ranking row 2596918
25	=	Malignant Hypopharyngeal Neoplasm	-10	20	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 294 formula percentile(mortality_count) − percentile(publications_5y) activity 581 burdenPercentile 3.3 activityPercentile 13.3 ranking row 2596919
26	=	Hodgkin Lymphoma	-13.3	16.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1171 formula percentile(mortality_count) − percentile(publications_5y) activity 2178 burdenPercentile 26.7 activityPercentile 40 ranking row 2596920
27	=	Malignant Penile Neoplasm	-23.3	13.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 246 formula percentile(mortality_count) − percentile(publications_5y) activity 1025 burdenPercentile 0 activityPercentile 23.3 ranking row 2596921
27	=	Malignant Testicular Neoplasm	-23.3	13.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 358 formula percentile(mortality_count) − percentile(publications_5y) activity 1806 burdenPercentile 6.7 activityPercentile 30 ranking row 2596922
29	=	Malignant Thyroid Gland Neoplasm	-30	6.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1649 formula percentile(mortality_count) − percentile(publications_5y) activity 13792 burdenPercentile 30 activityPercentile 60 ranking row 2596923
30	=	Malignant Gastric Neoplasm	-33.3	3.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 11352 formula percentile(mortality_count) − percentile(publications_5y) activity 34783 burdenPercentile 56.7 activityPercentile 90 ranking row 2596924
31	=	Malignant Cervical Neoplasm	-40	0	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 4008 formula percentile(mortality_count) − percentile(publications_5y) activity 26673 burdenPercentile 43.3 activityPercentile 83.3 ranking row 2596925

Data updated 16 hours agoSource updated unknown31 eligible entities · inputs hash d8fce3d6cbaf169941dc5c8f

Methodology

How this table was built

Formula: percentile(mortality_count) − percentile(publications_5y)
Version: ci-research-gap-v1
Scope: USA · both sexes · all ages · 2008 · top-level cancers
Scope key: geo=USA|sex=all|age=all|year=2008|level=top
Eligible entities: 31
Generated: Sep 29, 2026, 06:30 AM UTC
Inputs hash: d8fce3d6cbaf169941dc5c8f
Sources: U.S. Cancer Statistics (USCS) — NPCR/SEER incidence and NVSS mortality pubmed cdc-wonder seer iarc-globocan
Aggregation: none

Eligibility

requires: mortality_count
publications_5y
entityLevel: top

Full methodology · ties share a rank (1, 2, 2, 4) · previous rank refers to the last snapshot of the same scope.

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Burden and lethality metrics depend on registry definitions (site groups, standard population, estimate type). Compare only within one table.