Ranking · Unmet Need

Research Gap Index

Burden percentile minus research-activity percentile (publications, last 5 years) within the same scope. Positive values flag cancers with high mortality burden but comparatively little literature. Caveat (Phase 1): literature counts are query-based per entity (query stored on each row); they are not aggregated over descendants.

Computedci-research-gap-v1unit: percentile pointshigher = worseAll metrics

Rank	Δ	Cancer	Research Gap Index (percentile points)	Percentile	Confidence	Sources	Why #n?
1	=	Malignant Central Nervous System Neoplasm	+70	100	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12765 formula percentile(mortality_count) − percentile(publications_5y) activity 298 burdenPercentile 73.3 activityPercentile 3.3 ranking row 2591630
2	=	Malignant Uterine Corpus Neoplasm	+36.7	96.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3121 formula percentile(mortality_count) − percentile(publications_5y) activity 105 burdenPercentile 36.7 activityPercentile 0 ranking row 2591631
3	=	Malignant Colon Neoplasm	+23.4	93.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 48962 formula percentile(mortality_count) − percentile(publications_5y) activity 18406 burdenPercentile 96.7 activityPercentile 73.3 ranking row 2591632
4	=	Non-Hodgkin Lymphoma	+20	90	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 22802 formula percentile(mortality_count) − percentile(publications_5y) activity 17190 burdenPercentile 83.3 activityPercentile 63.3 ranking row 2591633
5	=	Malignant Kidney Neoplasm	+13.4	86.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 11116 formula percentile(mortality_count) − percentile(publications_5y) activity 3700 burdenPercentile 56.7 activityPercentile 43.3 ranking row 2591634
6	=	Malignant Esophageal Neoplasm	+10	83.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 11917 formula percentile(mortality_count) − percentile(publications_5y) activity 10921 burdenPercentile 63.3 activityPercentile 53.3 ranking row 2591635
6	=	Malignant Pancreatic Neoplasm	+10	83.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 29081 formula percentile(mortality_count) − percentile(publications_5y) activity 25767 burdenPercentile 86.7 activityPercentile 76.7 ranking row 2591636
6	=	Malignant Salivary Gland Neoplasm	+10	83.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 656 formula percentile(mortality_count) − percentile(publications_5y) activity 474 burdenPercentile 20 activityPercentile 10 ranking row 2591637
9	=	Malignant Laryngeal Neoplasm	+6.7	73.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3815 formula percentile(mortality_count) − percentile(publications_5y) activity 2031 burdenPercentile 40 activityPercentile 33.3 ranking row 2591638
10	=	Malignant Vulvar Neoplasm	+6.6	70	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 762 formula percentile(mortality_count) − percentile(publications_5y) activity 870 burdenPercentile 23.3 activityPercentile 16.7 ranking row 2591639
11	=	Malignant Vaginal Neoplasm	+3.3	66.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 403 formula percentile(mortality_count) − percentile(publications_5y) activity 373 burdenPercentile 10 activityPercentile 6.7 ranking row 2591640
12	=	Malignant Lung Neoplasm	+3.3	63.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 152061 formula percentile(mortality_count) − percentile(publications_5y) activity 93034 burdenPercentile 100 activityPercentile 96.7 ranking row 2591641
12	=	Multiple Myeloma	+3.3	63.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 10508 formula percentile(mortality_count) − percentile(publications_5y) activity 10244 burdenPercentile 53.3 activityPercentile 50 ranking row 2591642
14	=	Cutaneous Melanoma	0	56.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 7215 formula percentile(mortality_count) − percentile(publications_5y) activity 4407 burdenPercentile 46.7 activityPercentile 46.7 ranking row 2591643
14	=	Malignant Liver Neoplasm	0	56.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12382 formula percentile(mortality_count) − percentile(publications_5y) activity 17939 burdenPercentile 66.7 activityPercentile 66.7 ranking row 2591644
16	=	Malignant Ovarian Neoplasm	-3.3	50	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 13627 formula percentile(mortality_count) − percentile(publications_5y) activity 25793 burdenPercentile 76.7 activityPercentile 80 ranking row 2591645
16	=	Malignant Prostate Neoplasm	-3.3	50	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 31728 formula percentile(mortality_count) − percentile(publications_5y) activity 52116 burdenPercentile 90 activityPercentile 93.3 ranking row 2591646
18	=	Malignant Nasopharyngeal Neoplasm	-3.3	43.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 638 formula percentile(mortality_count) − percentile(publications_5y) activity 952 burdenPercentile 16.7 activityPercentile 20 ranking row 2591647
19	=	Malignant Mesothelioma	-3.4	40	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 2343 formula percentile(mortality_count) − percentile(publications_5y) activity 2145 burdenPercentile 33.3 activityPercentile 36.7 ranking row 2591648
20	=	Malignant Hypopharyngeal Neoplasm	-6.6	36.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 385 formula percentile(mortality_count) − percentile(publications_5y) activity 581 burdenPercentile 6.7 activityPercentile 13.3 ranking row 2591649
21	=	Leukemia	-6.7	33.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 21071 formula percentile(mortality_count) − percentile(publications_5y) activity 31893 burdenPercentile 80 activityPercentile 86.7 ranking row 2591650
21	=	Malignant Breast Neoplasm	-6.7	33.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 41528 formula percentile(mortality_count) − percentile(publications_5y) activity 133010 burdenPercentile 93.3 activityPercentile 100 ranking row 2591651
21	=	Malignant Rectal Neoplasm	-6.7	33.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 8260 formula percentile(mortality_count) − percentile(publications_5y) activity 12506 burdenPercentile 50 activityPercentile 56.7 ranking row 2591652
24	=	Hodgkin Lymphoma	-10	23.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1403 formula percentile(mortality_count) − percentile(publications_5y) activity 2178 burdenPercentile 30 activityPercentile 40 ranking row 2591653
24	=	Malignant Bladder Neoplasm	-10	23.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 11910 formula percentile(mortality_count) − percentile(publications_5y) activity 18250 burdenPercentile 60 activityPercentile 70 ranking row 2591654
26	=	Malignant Anal Neoplasm	-13.4	16.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 462 formula percentile(mortality_count) − percentile(publications_5y) activity 1291 burdenPercentile 13.3 activityPercentile 26.7 ranking row 2591655
27	=	Malignant Gastric Neoplasm	-20	13.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12711 formula percentile(mortality_count) − percentile(publications_5y) activity 34783 burdenPercentile 70 activityPercentile 90 ranking row 2591656
28	=	Malignant Penile Neoplasm	-23.3	10	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 202 formula percentile(mortality_count) − percentile(publications_5y) activity 1025 burdenPercentile 0 activityPercentile 23.3 ranking row 2591657
29	=	Malignant Testicular Neoplasm	-26.7	6.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 378 formula percentile(mortality_count) − percentile(publications_5y) activity 1806 burdenPercentile 3.3 activityPercentile 30 ranking row 2591658
30	=	Malignant Thyroid Gland Neoplasm	-33.3	3.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1241 formula percentile(mortality_count) − percentile(publications_5y) activity 13792 burdenPercentile 26.7 activityPercentile 60 ranking row 2591659
31	=	Malignant Cervical Neoplasm	-40	0	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 4204 formula percentile(mortality_count) − percentile(publications_5y) activity 26673 burdenPercentile 43.3 activityPercentile 83.3 ranking row 2591660

Data updated 16 hours agoSource updated unknown31 eligible entities · inputs hash 1abe04f6c43c4bcc4414d29c

Methodology

How this table was built

Formula: percentile(mortality_count) − percentile(publications_5y)
Version: ci-research-gap-v1
Scope: USA · both sexes · all ages · 1999 · top-level cancers
Scope key: geo=USA|sex=all|age=all|year=1999|level=top
Eligible entities: 31
Generated: Sep 29, 2026, 06:30 AM UTC
Inputs hash: 1abe04f6c43c4bcc4414d29c
Sources: U.S. Cancer Statistics (USCS) — NPCR/SEER incidence and NVSS mortality pubmed cdc-wonder seer iarc-globocan
Aggregation: none

Eligibility

requires: mortality_count
publications_5y
entityLevel: top

Full methodology · ties share a rank (1, 2, 2, 4) · previous rank refers to the last snapshot of the same scope.

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Burden and lethality metrics depend on registry definitions (site groups, standard population, estimate type). Compare only within one table.