Ranking · Unmet Need

Research Gap Index

Burden percentile minus research-activity percentile (publications, last 5 years) within the same scope. Positive values flag cancers with high mortality burden but comparatively little literature. Caveat (Phase 1): literature counts are query-based per entity (query stored on each row); they are not aggregated over descendants.

Computedci-research-gap-v1unit: percentile pointshigher = worseAll metrics

Rank	Δ	Cancer	Research Gap Index (percentile points)	Percentile	Confidence	Sources	Why #n?
1	=	Malignant Central Nervous System Neoplasm	+66.7	100	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12901 formula percentile(mortality_count) − percentile(publications_5y) activity 298 burdenPercentile 70 activityPercentile 3.3 ranking row 2593970
2	=	Malignant Uterine Corpus Neoplasm	+36.7	96.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3261 formula percentile(mortality_count) − percentile(publications_5y) activity 105 burdenPercentile 36.7 activityPercentile 0 ranking row 2593971
3	=	Malignant Colon Neoplasm	+23.4	93.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 47248 formula percentile(mortality_count) − percentile(publications_5y) activity 18406 burdenPercentile 96.7 activityPercentile 73.3 ranking row 2593972
4	=	Malignant Kidney Neoplasm	+16.7	90	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12286 formula percentile(mortality_count) − percentile(publications_5y) activity 3700 burdenPercentile 60 activityPercentile 43.3 ranking row 2593974
4	=	Non-Hodgkin Lymphoma	+16.7	90	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 21475 formula percentile(mortality_count) − percentile(publications_5y) activity 17190 burdenPercentile 80 activityPercentile 63.3 ranking row 2593973
6	=	Malignant Esophageal Neoplasm	+13.4	83.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12860 formula percentile(mortality_count) − percentile(publications_5y) activity 10921 burdenPercentile 66.7 activityPercentile 53.3 ranking row 2593975
7	=	Malignant Pancreatic Neoplasm	+13.3	80	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 30777 formula percentile(mortality_count) − percentile(publications_5y) activity 25767 burdenPercentile 90 activityPercentile 76.7 ranking row 2593976
8	=	Malignant Liver Neoplasm	+10	76.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 14706 formula percentile(mortality_count) − percentile(publications_5y) activity 17939 burdenPercentile 76.7 activityPercentile 66.7 ranking row 2593978
8	=	Malignant Salivary Gland Neoplasm	+10	76.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 696 formula percentile(mortality_count) − percentile(publications_5y) activity 474 burdenPercentile 20 activityPercentile 10 ranking row 2593977
10	=	Malignant Laryngeal Neoplasm	+6.7	70	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3791 formula percentile(mortality_count) − percentile(publications_5y) activity 2031 burdenPercentile 40 activityPercentile 33.3 ranking row 2593979
11	=	Malignant Vulvar Neoplasm	+6.6	66.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 775 formula percentile(mortality_count) − percentile(publications_5y) activity 870 burdenPercentile 23.3 activityPercentile 16.7 ranking row 2593980
12	=	Malignant Vaginal Neoplasm	+3.3	63.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 391 formula percentile(mortality_count) − percentile(publications_5y) activity 373 burdenPercentile 10 activityPercentile 6.7 ranking row 2593981
13	=	Malignant Lung Neoplasm	+3.3	60	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 157990 formula percentile(mortality_count) − percentile(publications_5y) activity 93034 burdenPercentile 100 activityPercentile 96.7 ranking row 2593982
13	=	Multiple Myeloma	+3.3	60	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 10809 formula percentile(mortality_count) − percentile(publications_5y) activity 10244 burdenPercentile 53.3 activityPercentile 50 ranking row 2593983
15	=	Cutaneous Melanoma	0	53.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 7818 formula percentile(mortality_count) − percentile(publications_5y) activity 4407 burdenPercentile 46.7 activityPercentile 46.7 ranking row 2593984
16	=	Malignant Nasopharyngeal Neoplasm	-3.3	50	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 598 formula percentile(mortality_count) − percentile(publications_5y) activity 952 burdenPercentile 16.7 activityPercentile 20 ranking row 2593985
17	=	Leukemia	-3.4	46.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 21608 formula percentile(mortality_count) − percentile(publications_5y) activity 31893 burdenPercentile 83.3 activityPercentile 86.7 ranking row 2593986
17	=	Malignant Mesothelioma	-3.4	46.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 2476 formula percentile(mortality_count) − percentile(publications_5y) activity 2145 burdenPercentile 33.3 activityPercentile 36.7 ranking row 2593987
19	=	Malignant Prostate Neoplasm	-6.6	40	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 29554 formula percentile(mortality_count) − percentile(publications_5y) activity 52116 burdenPercentile 86.7 activityPercentile 93.3 ranking row 2593988
20	=	Malignant Bladder Neoplasm	-6.7	36.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12483 formula percentile(mortality_count) − percentile(publications_5y) activity 18250 burdenPercentile 63.3 activityPercentile 70 ranking row 2593991
20	=	Malignant Breast Neoplasm	-6.7	36.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 41998 formula percentile(mortality_count) − percentile(publications_5y) activity 133010 burdenPercentile 93.3 activityPercentile 100 ranking row 2593989
20	=	Malignant Ovarian Neoplasm	-6.7	36.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 14657 formula percentile(mortality_count) − percentile(publications_5y) activity 25793 burdenPercentile 73.3 activityPercentile 80 ranking row 2593990
20	=	Malignant Rectal Neoplasm	-6.7	36.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 8535 formula percentile(mortality_count) − percentile(publications_5y) activity 12506 burdenPercentile 50 activityPercentile 56.7 ranking row 2593992
24	=	Hodgkin Lymphoma	-10	23.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1347 formula percentile(mortality_count) − percentile(publications_5y) activity 2178 burdenPercentile 30 activityPercentile 40 ranking row 2593993
24	=	Malignant Hypopharyngeal Neoplasm	-10	23.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 318 formula percentile(mortality_count) − percentile(publications_5y) activity 581 burdenPercentile 3.3 activityPercentile 13.3 ranking row 2593994
26	=	Malignant Anal Neoplasm	-13.4	16.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 555 formula percentile(mortality_count) − percentile(publications_5y) activity 1291 burdenPercentile 13.3 activityPercentile 26.7 ranking row 2593995
27	=	Malignant Penile Neoplasm	-23.3	13.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 250 formula percentile(mortality_count) − percentile(publications_5y) activity 1025 burdenPercentile 0 activityPercentile 23.3 ranking row 2593996
27	=	Malignant Testicular Neoplasm	-23.3	13.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 344 formula percentile(mortality_count) − percentile(publications_5y) activity 1806 burdenPercentile 6.7 activityPercentile 30 ranking row 2593997
29	=	Malignant Gastric Neoplasm	-33.3	6.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12110 formula percentile(mortality_count) − percentile(publications_5y) activity 34783 burdenPercentile 56.7 activityPercentile 90 ranking row 2593998
29	=	Malignant Thyroid Gland Neoplasm	-33.3	6.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1312 formula percentile(mortality_count) − percentile(publications_5y) activity 13792 burdenPercentile 26.7 activityPercentile 60 ranking row 2593999
31	=	Malignant Cervical Neoplasm	-40	0	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3919 formula percentile(mortality_count) − percentile(publications_5y) activity 26673 burdenPercentile 43.3 activityPercentile 83.3 ranking row 2594000

Data updated 16 hours agoSource updated unknown31 eligible entities · inputs hash a76ecbc3643a155178afaa55

Methodology

How this table was built

Formula: percentile(mortality_count) − percentile(publications_5y)
Version: ci-research-gap-v1
Scope: USA · both sexes · all ages · 2003 · top-level cancers
Scope key: geo=USA|sex=all|age=all|year=2003|level=top
Eligible entities: 31
Generated: Sep 29, 2026, 06:30 AM UTC
Inputs hash: a76ecbc3643a155178afaa55
Sources: U.S. Cancer Statistics (USCS) — NPCR/SEER incidence and NVSS mortality pubmed cdc-wonder seer iarc-globocan
Aggregation: none

Eligibility

requires: mortality_count
publications_5y
entityLevel: top

Full methodology · ties share a rank (1, 2, 2, 4) · previous rank refers to the last snapshot of the same scope.

Download CSV (with attribution)

Burden and lethality metrics depend on registry definitions (site groups, standard population, estimate type). Compare only within one table.