Ranking · Unmet Need

Research Gap Index

Burden percentile minus research-activity percentile (publications, last 5 years) within the same scope. Positive values flag cancers with high mortality burden but comparatively little literature. Caveat (Phase 1): literature counts are query-based per entity (query stored on each row); they are not aggregated over descendants.

Computedci-research-gap-v1unit: percentile pointshigher = worseAll metrics

Rank	Δ	Cancer	Research Gap Index (percentile points)	Percentile	Confidence	Sources	Why #n?
1	=	Malignant Central Nervous System Neoplasm	+60	100	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 13152 formula percentile(mortality_count) − percentile(publications_5y) activity 298 burdenPercentile 63.3 activityPercentile 3.3 ranking row 2595140
2	=	Malignant Uterine Corpus Neoplasm	+36.7	96.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3259 formula percentile(mortality_count) − percentile(publications_5y) activity 105 burdenPercentile 36.7 activityPercentile 0 ranking row 2595141
3	=	Malignant Colon Neoplasm	+23.4	93.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 44325 formula percentile(mortality_count) − percentile(publications_5y) activity 18406 burdenPercentile 96.7 activityPercentile 73.3 ranking row 2595142
4	=	Malignant Esophageal Neoplasm	+16.7	90	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 13499 formula percentile(mortality_count) − percentile(publications_5y) activity 10921 burdenPercentile 70 activityPercentile 53.3 ranking row 2595143
4	=	Malignant Kidney Neoplasm	+16.7	90	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12517 formula percentile(mortality_count) − percentile(publications_5y) activity 3700 burdenPercentile 60 activityPercentile 43.3 ranking row 2595145
4	=	Non-Hodgkin Lymphoma	+16.7	90	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 20873 formula percentile(mortality_count) − percentile(publications_5y) activity 17190 burdenPercentile 80 activityPercentile 63.3 ranking row 2595144
7	=	Malignant Pancreatic Neoplasm	+13.3	80	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 32759 formula percentile(mortality_count) − percentile(publications_5y) activity 25767 burdenPercentile 90 activityPercentile 76.7 ranking row 2595146
8	=	Malignant Liver Neoplasm	+10	76.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 16075 formula percentile(mortality_count) − percentile(publications_5y) activity 17939 burdenPercentile 76.7 activityPercentile 66.7 ranking row 2595148
8	=	Malignant Salivary Gland Neoplasm	+10	76.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 701 formula percentile(mortality_count) − percentile(publications_5y) activity 474 burdenPercentile 20 activityPercentile 10 ranking row 2595147
10	=	Malignant Laryngeal Neoplasm	+6.7	70	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3796 formula percentile(mortality_count) − percentile(publications_5y) activity 2031 burdenPercentile 40 activityPercentile 33.3 ranking row 2595149
11	=	Malignant Vulvar Neoplasm	+6.6	66.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 809 formula percentile(mortality_count) − percentile(publications_5y) activity 870 burdenPercentile 23.3 activityPercentile 16.7 ranking row 2595150
12	=	Malignant Vaginal Neoplasm	+3.3	63.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 382 formula percentile(mortality_count) − percentile(publications_5y) activity 373 burdenPercentile 10 activityPercentile 6.7 ranking row 2595151
13	=	Malignant Lung Neoplasm	+3.3	60	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 159217 formula percentile(mortality_count) − percentile(publications_5y) activity 93034 burdenPercentile 100 activityPercentile 96.7 ranking row 2595152
13	=	Multiple Myeloma	+3.3	60	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 10758 formula percentile(mortality_count) − percentile(publications_5y) activity 10244 burdenPercentile 53.3 activityPercentile 50 ranking row 2595153
15	=	Cutaneous Melanoma	0	53.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 8345 formula percentile(mortality_count) − percentile(publications_5y) activity 4407 burdenPercentile 46.7 activityPercentile 46.7 ranking row 2595154
16	=	Malignant Bladder Neoplasm	-3.3	50	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 13253 formula percentile(mortality_count) − percentile(publications_5y) activity 18250 burdenPercentile 66.7 activityPercentile 70 ranking row 2595155
17	=	Malignant Nasopharyngeal Neoplasm	-3.3	46.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 615 formula percentile(mortality_count) − percentile(publications_5y) activity 952 burdenPercentile 16.7 activityPercentile 20 ranking row 2595156
18	=	Leukemia	-3.4	43.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 21716 formula percentile(mortality_count) − percentile(publications_5y) activity 31893 burdenPercentile 83.3 activityPercentile 86.7 ranking row 2595157
18	=	Malignant Mesothelioma	-3.4	43.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 2553 formula percentile(mortality_count) − percentile(publications_5y) activity 2145 burdenPercentile 33.3 activityPercentile 36.7 ranking row 2595158
20	=	Malignant Prostate Neoplasm	-6.6	36.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 28905 formula percentile(mortality_count) − percentile(publications_5y) activity 52116 burdenPercentile 86.7 activityPercentile 93.3 ranking row 2595159
21	=	Malignant Breast Neoplasm	-6.7	33.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 41491 formula percentile(mortality_count) − percentile(publications_5y) activity 133010 burdenPercentile 93.3 activityPercentile 100 ranking row 2595160
21	=	Malignant Ovarian Neoplasm	-6.7	33.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 14787 formula percentile(mortality_count) − percentile(publications_5y) activity 25793 burdenPercentile 73.3 activityPercentile 80 ranking row 2595161
21	=	Malignant Rectal Neoplasm	-6.7	33.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 8680 formula percentile(mortality_count) − percentile(publications_5y) activity 12506 burdenPercentile 50 activityPercentile 56.7 ranking row 2595162
24	=	Malignant Hypopharyngeal Neoplasm	-10	23.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 281 formula percentile(mortality_count) − percentile(publications_5y) activity 581 burdenPercentile 3.3 activityPercentile 13.3 ranking row 2595163
25	=	Hodgkin Lymphoma	-13.3	20	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1272 formula percentile(mortality_count) − percentile(publications_5y) activity 2178 burdenPercentile 26.7 activityPercentile 40 ranking row 2595164
26	=	Malignant Anal Neoplasm	-13.4	16.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 583 formula percentile(mortality_count) − percentile(publications_5y) activity 1291 burdenPercentile 13.3 activityPercentile 26.7 ranking row 2595165
27	=	Malignant Penile Neoplasm	-23.3	13.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 217 formula percentile(mortality_count) − percentile(publications_5y) activity 1025 burdenPercentile 0 activityPercentile 23.3 ranking row 2595166
27	=	Malignant Testicular Neoplasm	-23.3	13.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 359 formula percentile(mortality_count) − percentile(publications_5y) activity 1806 burdenPercentile 6.7 activityPercentile 30 ranking row 2595167
29	=	Malignant Thyroid Gland Neoplasm	-30	6.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1462 formula percentile(mortality_count) − percentile(publications_5y) activity 13792 burdenPercentile 30 activityPercentile 60 ranking row 2595168
30	=	Malignant Gastric Neoplasm	-33.3	3.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 11514 formula percentile(mortality_count) − percentile(publications_5y) activity 34783 burdenPercentile 56.7 activityPercentile 90 ranking row 2595169
31	=	Malignant Cervical Neoplasm	-40	0	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3924 formula percentile(mortality_count) − percentile(publications_5y) activity 26673 burdenPercentile 43.3 activityPercentile 83.3 ranking row 2595170

Data updated 16 hours agoSource updated unknown31 eligible entities · inputs hash 373031678ce2e0b266428136

Methodology

How this table was built

Formula: percentile(mortality_count) − percentile(publications_5y)
Version: ci-research-gap-v1
Scope: USA · both sexes · all ages · 2005 · top-level cancers
Scope key: geo=USA|sex=all|age=all|year=2005|level=top
Eligible entities: 31
Generated: Sep 29, 2026, 06:30 AM UTC
Inputs hash: 373031678ce2e0b266428136
Sources: U.S. Cancer Statistics (USCS) — NPCR/SEER incidence and NVSS mortality pubmed cdc-wonder seer iarc-globocan
Aggregation: none

Eligibility

requires: mortality_count
publications_5y
entityLevel: top

Full methodology · ties share a rank (1, 2, 2, 4) · previous rank refers to the last snapshot of the same scope.

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Burden and lethality metrics depend on registry definitions (site groups, standard population, estimate type). Compare only within one table.