Malignant Anal Neoplasm

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Metric	Scope	Rank / eligible	Δ	Value	Percentile	Confidence	Formula	Generated	Inputs
Age-standardized incidence rate	USA · both sexes · all ages · 2023 · top-level cancers	#19 / 24	=	2.2 per 100,000	21.7	High confidence	ci-asir-v1	Sep 29, 2026	show formula: epidemiology_observations.value WHERE metric = as_incidence_rate (standard_population fixed per scope) sourceId CI-SOURCE-00000012 estimateType observed observationId 150 siteDefinition USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218) inputs hash b755ca35e68b729c8dc63070 Trace lineage (admin)
Age-standardized incidence rate	USA · Female · all ages · 2023 · top-level cancers	#19 / 29	=	2.7 per 100,000	35.7	High confidence	ci-asir-v1	Sep 29, 2026	show formula: epidemiology_observations.value WHERE metric = as_incidence_rate (standard_population fixed per scope) sourceId CI-SOURCE-00000012 estimateType observed observationId 50 siteDefinition USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218) inputs hash 4d01732d23418d0cca033d77 Trace lineage (admin)
Age-standardized incidence rate	USA · Male · all ages · 2023 · top-level cancers	#21 / 27	=	1.5 per 100,000	23.1	High confidence	ci-asir-v1	Sep 29, 2026	show formula: epidemiology_observations.value WHERE metric = as_incidence_rate (standard_population fixed per scope) sourceId CI-SOURCE-00000012 estimateType observed observationId 100 siteDefinition USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218) inputs hash dbeda648a4f2a0068318f6d1 Trace lineage (admin)
Age-standardized mortality rate	USA · both sexes · all ages · 2024 · top-level cancers	#19 / 23	▲ 8	0.4 per 100,000	18.2	High confidence	ci-asmr-v1	Sep 29, 2026	show formula: epidemiology_observations.value WHERE metric = as_mortality_rate (standard_population fixed per scope) sourceId CI-SOURCE-00000012 estimateType observed observationId 306 siteDefinition USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218) inputs hash 075bdb903aa37f48ae5b75b4 Trace lineage (admin)
Age-standardized mortality rate	USA · Female · all ages · 2024 · top-level cancers	#21 / 28	▲ 3	0.4 per 100,000	25.9	High confidence	ci-asmr-v1	Sep 29, 2026	show formula: epidemiology_observations.value WHERE metric = as_mortality_rate (standard_population fixed per scope) sourceId CI-SOURCE-00000012 estimateType observed observationId 202 siteDefinition USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218) inputs hash cd5df15b22c08f77ce10639c Trace lineage (admin)
Age-standardized mortality rate	USA · Male · all ages · 2024 · top-level cancers	#20 / 26	▲ 4	0.3 per 100,000	24	High confidence	ci-asmr-v1	Sep 29, 2026	show formula: epidemiology_observations.value WHERE metric = as_mortality_rate (standard_population fixed per scope) sourceId CI-SOURCE-00000012 estimateType observed observationId 254 siteDefinition USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218) inputs hash 9f37d571bb39dc7855fa4d55 Trace lineage (admin)
Annual deaths	USA · both sexes · all ages · 2024 · top-level cancers	#23 / 31	▲ 4	1,650 count	26.7	High confidence	ci-mortality-count-v1	Sep 29, 2026	show formula: epidemiology_observations.value WHERE metric = mortality_count sourceId CI-SOURCE-00000012 estimateType observed observationId 305 siteDefinition USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218) inputs hash eda90f606aa05f603e206877 Trace lineage (admin)
Annual deaths	USA · Female · all ages · 2024 · top-level cancers	#21 / 28	▲ 3	1,067 count	25.9	High confidence	ci-mortality-count-v1	Sep 29, 2026	show formula: epidemiology_observations.value WHERE metric = mortality_count sourceId CI-SOURCE-00000012 estimateType observed observationId 201 siteDefinition USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218) inputs hash 10479f4404c381a0461a96b6 Trace lineage (admin)
Annual deaths	USA · Male · all ages · 2024 · top-level cancers	#20 / 26	▲ 4	583 count	24	High confidence	ci-mortality-count-v1	Sep 29, 2026	show formula: epidemiology_observations.value WHERE metric = mortality_count sourceId CI-SOURCE-00000012 estimateType observed observationId 253 siteDefinition USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218) inputs hash 0338faa988571e3aeb36ce8d Trace lineage (admin)
Annual new cases	USA · both sexes · all ages · 2023 · top-level cancers	#23 / 32	=	9,334 count	29	High confidence	ci-incidence-count-v1	Sep 29, 2026	show formula: epidemiology_observations.value WHERE metric = incidence_count sourceId CI-SOURCE-00000012 estimateType observed observationId 149 siteDefinition USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218) inputs hash a22c4753e0a7e00ce4e210b1 Trace lineage (admin)
Annual new cases	USA · Female · all ages · 2023 · top-level cancers	#19 / 29	=	6,275 count	35.7	High confidence	ci-incidence-count-v1	Sep 29, 2026	show formula: epidemiology_observations.value WHERE metric = incidence_count sourceId CI-SOURCE-00000012 estimateType observed observationId 49 siteDefinition USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218) inputs hash be481a61ede7e4e6eff7e04e Trace lineage (admin)
Annual new cases	USA · Male · all ages · 2023 · top-level cancers	#21 / 27	=	3,059 count	23.1	High confidence	ci-incidence-count-v1	Sep 29, 2026	show formula: epidemiology_observations.value WHERE metric = incidence_count sourceId CI-SOURCE-00000012 estimateType observed observationId 99 siteDefinition USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218) inputs hash faf268f2311c0e2f45598554 Trace lineage (admin)
Mortality-to-incidence ratio	USA · both sexes · all ages · 2023 · top-level cancers	#24 / 31	=	0.17 ratio	23.3	High confidence	ci-mir-v1	Sep 29, 2026	show formula: mortality_count / incidence_count (same geography, year, sex, source family) deaths 1601 formula mortality_count / incidence_count (same geography, year, sex, source family) incidence 9334 incidenceObservationId 149 mortalityObservationId 303 inputs hash 4850aed222cf5b82949f3250 Trace lineage (admin)
Mortality-to-incidence ratio	USA · Female · all ages · 2023 · top-level cancers	#23 / 28	=	0.16 ratio	18.5	High confidence	ci-mir-v1	Sep 29, 2026	show formula: mortality_count / incidence_count (same geography, year, sex, source family) deaths 1002 formula mortality_count / incidence_count (same geography, year, sex, source family) incidence 6275 incidenceObservationId 49 mortalityObservationId 199 inputs hash 6256cbc77f64879a8ded9826 Trace lineage (admin)
Mortality-to-incidence ratio	USA · Male · all ages · 2023 · top-level cancers	#21 / 26	=	0.2 ratio	20	High confidence	ci-mir-v1	Sep 29, 2026	show formula: mortality_count / incidence_count (same geography, year, sex, source family) deaths 599 formula mortality_count / incidence_count (same geography, year, sex, source family) incidence 3059 incidenceObservationId 99 mortalityObservationId 251 inputs hash 4fbc8d78eb3f4392ae965953 Trace lineage (admin)
Curated clinical evidence items	World · both sexes · all ages · latest · all malignant entities	#392 / 492	=	1 count	20.4	Medium confidence	ci-civic-evidence-v1	Sep 29, 2026	show formula: COUNT(civic_evidence_items) WHERE status = ACCEPTED AND cancer_id IN descendants(cancer) counter evidenceCount computedAt 2026-09-29T06:00:20.557Z inputs hash 00ec4259c26ee135c931f5a6 Trace lineage (admin)
Curated clinical evidence items	World · both sexes · all ages · latest · top-level cancers	#27 / 28	=	1 count	3.7	Medium confidence	ci-civic-evidence-v1	Sep 29, 2026	show formula: COUNT(civic_evidence_items) WHERE status = ACCEPTED AND cancer_id IN descendants(cancer) counter evidenceCount computedAt 2026-09-29T06:00:20.557Z inputs hash bc8c48b7174cc05d41e44bad Trace lineage (admin)
Genes with curated or cohort evidence	World · both sexes · all ages · latest · all malignant entities	#361 / 521	=	1 count	30.8	Medium confidence	ci-genes-v1	Sep 29, 2026	show formula: COUNT(DISTINCT gene) FROM (civic accepted evidence ∪ gdc frequency ≥ 0.05 AND cases_affected ≥ 20) counter geneCount computedAt 2026-09-29T06:00:20.557Z inputs hash dc02edfbbd5b601934401df4 Trace lineage (admin)
Genes with curated or cohort evidence	World · both sexes · all ages · latest · top-level cancers	#28 / 30	=	1 count	6.9	Medium confidence	ci-genes-v1	Sep 29, 2026	show formula: COUNT(DISTINCT gene) FROM (civic accepted evidence ∪ gdc frequency ≥ 0.05 AND cases_affected ≥ 20) counter geneCount computedAt 2026-09-29T06:00:20.557Z inputs hash 310f15666b06921ed2f70861 Trace lineage (admin)
Publications, last 12 months	World · both sexes · all ages · latest · all malignant entities	#202 / 2,294	=	284 count	91.2	Medium confidence	ci-pubs-12m-v1	Sep 29, 2026	show formula: literature_counts.count WHERE window_key = 12m counter publicationCount12m computedAt 2026-09-29T06:00:20.557Z inputs hash 6636ad9f834652e029647409 Trace lineage (admin)
Publications, last 12 months	World · both sexes · all ages · latest · top-level cancers	#27 / 36	=	284 count	25.7	Medium confidence	ci-pubs-12m-v1	Sep 29, 2026	show formula: literature_counts.count WHERE window_key = 12m counter publicationCount12m computedAt 2026-09-29T06:00:20.557Z inputs hash 09e4f7aeda6ce8f572cc37f7 Trace lineage (admin)
Publications, last 5 years	World · both sexes · all ages · latest · all malignant entities	#213 / 2,873	=	1,291 count	92.6	Medium confidence	ci-pubs-5y-v1	Sep 29, 2026	show formula: literature_counts.count WHERE window_key = 5y (query stored per row) counter publicationCount5y computedAt 2026-09-29T06:00:20.557Z inputs hash 531d42217f151c0dd79899a6 Trace lineage (admin)
Publications, last 5 years	World · both sexes · all ages · latest · top-level cancers	#27 / 36	=	1,291 count	25.7	Medium confidence	ci-pubs-5y-v1	Sep 29, 2026	show formula: literature_counts.count WHERE window_key = 5y (query stored per row) counter publicationCount5y computedAt 2026-09-29T06:00:20.557Z inputs hash 8a115533edc694931ad082be Trace lineage (admin)
Publication growth	World · both sexes · all ages · latest · all malignant entities	#83 / 286	=	1.28 ratio	71.2	Medium confidence	ci-pub-growth-v1	Sep 29, 2026	show formula: publications_12m / (publications_5y_prior / 5) formula publications_12m / (publications_5y_prior / 5) publications_12m 284 publications_5y_prior 1113 inputs hash 3385afecab0ace04e61b6db0 Trace lineage (admin)
Publication growth	World · both sexes · all ages · latest · top-level cancers	#3 / 36	=	1.28 ratio	94.3	Medium confidence	ci-pub-growth-v1	Sep 29, 2026	show formula: publications_12m / (publications_5y_prior / 5) formula publications_12m / (publications_5y_prior / 5) publications_12m 284 publications_5y_prior 1113 inputs hash 402d29deeb47adac5c955a64 Trace lineage (admin)
Active clinical trials	World · both sexes · all ages · latest · all malignant entities	#239 / 1,654	=	68 count	85.6	Medium confidence	ci-active-trials-v1	Sep 29, 2026	show formula: COUNT(DISTINCT trial) FROM trial_conditions JOIN clinical_trials WHERE cancer_id IN descendants(cancer) AND study_type = INTERVENTIONAL AND overall_status IN (RECRUITING, NOT_YET_RECRUITING, ENROLLING_BY_INVITATION, ACTIVE_NOT_RECRUITING) counter activeTrialCount computedAt 2026-09-29T06:00:20.557Z inputs hash f2f5ed2084d93bba6dcb810e Trace lineage (admin)
Active clinical trials	World · both sexes · all ages · latest · top-level cancers	#27 / 36	=	68 count	25.7	Medium confidence	ci-active-trials-v1	Sep 29, 2026	show formula: COUNT(DISTINCT trial) FROM trial_conditions JOIN clinical_trials WHERE cancer_id IN descendants(cancer) AND study_type = INTERVENTIONAL AND overall_status IN (RECRUITING, NOT_YET_RECRUITING, ENROLLING_BY_INVITATION, ACTIVE_NOT_RECRUITING) counter activeTrialCount computedAt 2026-09-29T06:00:20.557Z inputs hash 36db18bc2db682c45dedd597 Trace lineage (admin)
Active Phase III trials	World · both sexes · all ages · latest · all malignant entities	#237 / 810	=	7 count	70.8	Medium confidence	ci-phase3-trials-v1	Sep 29, 2026	show formula: COUNT(DISTINCT trial) … active statuses AND PHASE3 = ANY(phases) counter phase3TrialCount computedAt 2026-09-29T06:00:20.557Z inputs hash 56fba75197c8c0044b9e345f Trace lineage (admin)
Active Phase III trials	World · both sexes · all ages · latest · top-level cancers	#27 / 36	=	7 count	25.7	Medium confidence	ci-phase3-trials-v1	Sep 29, 2026	show formula: COUNT(DISTINCT trial) … active statuses AND PHASE3 = ANY(phases) counter phase3TrialCount computedAt 2026-09-29T06:00:20.557Z inputs hash 7e874e202ec3e68f4c4a2534 Trace lineage (admin)
Recruiting clinical trials	World · both sexes · all ages · latest · all malignant entities	#246 / 1,277	=	34 count	80.8	Medium confidence	ci-recruiting-trials-v1	Sep 29, 2026	show formula: COUNT(DISTINCT trial) … overall_status = RECRUITING AND study_type = INTERVENTIONAL counter recruitingTrialCount computedAt 2026-09-29T06:00:20.557Z inputs hash 4352f89d0670b61272a585b3 Trace lineage (admin)
Recruiting clinical trials	World · both sexes · all ages · latest · top-level cancers	#28 / 36	=	34 count	22.9	Medium confidence	ci-recruiting-trials-v1	Sep 29, 2026	show formula: COUNT(DISTINCT trial) … overall_status = RECRUITING AND study_type = INTERVENTIONAL counter recruitingTrialCount computedAt 2026-09-29T06:00:20.557Z inputs hash e254423b3e4889483596cf7d Trace lineage (admin)
Recruiting Phase III trials	World · both sexes · all ages · latest · all malignant entities	#281 / 585	=	2 count	52.1	High confidence	ci-phase3-recruiting-v1	Sep 29, 2026	show formula: COUNT(DISTINCT trial) … overall_status = RECRUITING AND PHASE3 = ANY(phases) AND study_type = INTERVENTIONAL asOf 2026-09-29 studyType INTERVENTIONAL aggregation descendants activeTrials 68 activeStatuses RECRUITING NOT_YET_RECRUITING ENROLLING_BY_INVITATION ACTIVE_NOT_RECRUITING formulaVersion ci-trial-intel-v1 phase3Recruiting 2 inputs hash ada23aaf0a7d803bc6e67424 Trace lineage (admin)
Recruiting Phase III trials	World · both sexes · all ages · latest · top-level cancers	#29 / 33	=	2 count	12.5	High confidence	ci-phase3-recruiting-v1	Sep 29, 2026	show formula: COUNT(DISTINCT trial) … overall_status = RECRUITING AND PHASE3 = ANY(phases) AND study_type = INTERVENTIONAL asOf 2026-09-29 studyType INTERVENTIONAL aggregation descendants activeTrials 68 activeStatuses RECRUITING NOT_YET_RECRUITING ENROLLING_BY_INVITATION ACTIVE_NOT_RECRUITING formulaVersion ci-trial-intel-v1 phase3Recruiting 2 inputs hash 284e53e9bc6e51772da0f4e8 Trace lineage (admin)
Sponsor concentration (HHI)	World · both sexes · all ages · latest · all malignant entities	#467 / 615	=	0.023 index (0–1)	24.1	High confidence	ci-sponsor-hhi-v1	Sep 29, 2026	show formula: Σ (active_trials_by_lead_sponsor / active_trials)² over the cancer and its descendants asOf 2026-09-29 studyType INTERVENTIONAL topSponsor National Cancer Institute (NCI) aggregation descendants activeTrials 68 activeStatuses RECRUITING NOT_YET_RECRUITING ENROLLING_BY_INVITATION ACTIVE_NOT_RECRUITING formulaVersion ci-trial-intel-v1 minActiveTrials 10 topSponsorShare
Sponsor concentration (HHI)	World · both sexes · all ages · latest · top-level cancers	#16 / 36	=	0.023 index (0–1)	57.1	High confidence	ci-sponsor-hhi-v1	Sep 29, 2026	show formula: Σ (active_trials_by_lead_sponsor / active_trials)² over the cancer and its descendants asOf 2026-09-29 studyType INTERVENTIONAL topSponsor National Cancer Institute (NCI) aggregation descendants activeTrials 68 activeStatuses RECRUITING NOT_YET_RECRUITING ENROLLING_BY_INVITATION ACTIVE_NOT_RECRUITING formulaVersion ci-trial-intel-v1 minActiveTrials 10 topSponsorShare 0.0882353
Trial termination share	World · both sexes · all ages · latest · all malignant entities	#391 / 454	=	0.27 ratio	13.9	Medium confidence	ci-trial-termination-v1	Sep 29, 2026	show formula: (terminated + withdrawn) / (completed + terminated + withdrawn) WHERE first_posted_date ≥ 2010-01-01 AND study_type = INTERVENTIONAL asOf 2026-09-29 since 2010-01-01 terminal 70 completed 51 studyType INTERVENTIONAL withdrawn 4 terminated 15 aggregation descendants activeStatuses RECRUITING NOT_YET_RECRUITING ENROLLING_BY_INVITATION ACTIVE_NOT_RECRUITING
Trial termination share	World · both sexes · all ages · latest · top-level cancers	#23 / 34	=	0.27 ratio	33.3	Medium confidence	ci-trial-termination-v1	Sep 29, 2026	show formula: (terminated + withdrawn) / (completed + terminated + withdrawn) WHERE first_posted_date ≥ 2010-01-01 AND study_type = INTERVENTIONAL asOf 2026-09-29 since 2010-01-01 terminal 70 completed 51 studyType INTERVENTIONAL withdrawn 4 terminated 15 aggregation descendants activeStatuses RECRUITING NOT_YET_RECRUITING ENROLLING_BY_INVITATION ACTIVE_NOT_RECRUITING
Active trials per 1,000 annual deaths	USA · both sexes · all ages · 2024 · top-level cancers	#20 / 35	=	41.2 per 1,000 deaths	44.1	High confidence	ci-trials-per-deaths-v1	Sep 29, 2026	show formula: active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) deaths 1651 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 68 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9448 componentsFormulaVersion
Active trials per 1,000 annual deaths	USA · Female · all ages · 2024 · top-level cancers	#23 / 32	=	63.7 per 1,000 deaths	29	High confidence	ci-trials-per-deaths-v1	Sep 29, 2026	show formula: active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) deaths 1068 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 68 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9442 componentsFormulaVersion
Active trials per 1,000 annual deaths	USA · Male · all ages · 2024 · top-level cancers	#9 / 30	=	116.6 per 1,000 deaths	72.4	Medium confidence	ci-trials-per-deaths-v1	Sep 29, 2026	show formula: active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) deaths 583 formula active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 activeTrials 68 burdenSourceId CI-SOURCE-00000011 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9445 componentsFormulaVersion
Publications (5 y) per 1,000 annual deaths	USA · both sexes · all ages · 2024 · top-level cancers	#20 / 35	=	782 per 1,000 deaths	44.1	High confidence	ci-pubs-per-deaths-v1	Sep 29, 2026	show formula: publications_5y / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) deaths 1651 formula publications_5y / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 burdenSourceId CI-SOURCE-00000011 publications5y 1291 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9448 componentsFormulaVersion
Publications (5 y) per 1,000 annual deaths	USA · Female · all ages · 2024 · top-level cancers	#24 / 32	=	1,208.8 per 1,000 deaths	25.8	High confidence	ci-pubs-per-deaths-v1	Sep 29, 2026	show formula: publications_5y / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) deaths 1068 formula publications_5y / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 burdenSourceId CI-SOURCE-00000011 publications5y 1291 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9442
Publications (5 y) per 1,000 annual deaths	USA · Male · all ages · 2024 · top-level cancers	#9 / 30	=	2,214.4 per 1,000 deaths	72.4	Medium confidence	ci-pubs-per-deaths-v1	Sep 29, 2026	show formula: publications_5y / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) deaths 583 formula publications_5y / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100) thresholds minDeaths 100 minActivity 1 burdenSourceId CI-SOURCE-00000011 publications5y 1291 countersComputedAt 2026-09-29 02:00:20.557824-04 mortalityObservationId 9445 componentsFormulaVersion
Research Gap Index	USA · both sexes · all ages · 2024 · top-level cancers	#15 / 31	▲ 3	0 percentile points	53.3	Medium confidence	ci-research-gap-v1	Sep 29, 2026	show formula: percentile(mortality_count) − percentile(publications_5y) deaths 1650 formula percentile(mortality_count) − percentile(publications_5y) activity 1291 burdenPercentile 26.7 activityPercentile 26.7 inputs hash 223409ea4719a317e41b9bc7 Trace lineage (admin)
Research Gap Index	USA · Female · all ages · 2024 · top-level cancers	#14 / 28	▼ 2	0 percentile points	51.9	Medium confidence	ci-research-gap-v1	Sep 29, 2026	show formula: percentile(mortality_count) − percentile(publications_5y) deaths 1067 formula percentile(mortality_count) − percentile(publications_5y) activity 1291 burdenPercentile 25.9 activityPercentile 25.9 inputs hash 7e5d4f431c856bc70e0ca539 Trace lineage (admin)
Research Gap Index	USA · Male · all ages · 2024 · top-level cancers	#9 / 26	▲ 4	+4 percentile points	68	Medium confidence	ci-research-gap-v1	Sep 29, 2026	show formula: percentile(mortality_count) − percentile(publications_5y) deaths 583 formula percentile(mortality_count) − percentile(publications_5y) activity 1291 burdenPercentile 24 activityPercentile 20 inputs hash 164d63cf992b720eb24f77b4 Trace lineage (admin)
Research Gap Ratio	USA · both sexes · all ages · 2024 · top-level cancers	#16 / 35	=	+0.44 log₂ ratio	55.9	High confidence	ci-research-gap-ratio-v1	Sep 29, 2026	show formula: log2( (deaths / Σ deaths) / (publications_5y / Σ publications_5y) ) over eligible top-level cancers (deaths ≥ 100, publications_5y ≥ 1) deaths 1651 formula log2( (deaths / Σ deaths) / (publications_5y / Σ publications_5y) ) over eligible top-level cancers (deaths ≥ 100, publications_5y ≥ 1) sumDeaths 546737 deathShare 0.00302 thresholds minDeaths 100 minActivity 1 burdenSourceId CI-SOURCE-00000011 publications5y 1291 eligibleEntities
Research Gap Ratio	USA · Female · all ages · 2024 · top-level cancers	#9 / 32	=	+0.76 log₂ ratio	74.2	High confidence	ci-research-gap-ratio-v1	Sep 29, 2026	show formula: log2( (deaths / Σ deaths) / (publications_5y / Σ publications_5y) ) over eligible top-level cancers (deaths ≥ 100, publications_5y ≥ 1) deaths 1068 formula log2( (deaths / Σ deaths) / (publications_5y / Σ publications_5y) ) over eligible top-level cancers (deaths ≥ 100, publications_5y ≥ 1) sumDeaths 256685 deathShare 0.004161 thresholds minDeaths 100 minActivity 1 burdenSourceId CI-SOURCE-00000011 publications5y 1291 eligibleEntities
Research Gap Ratio	USA · Male · all ages · 2024 · top-level cancers	#22 / 30	=	-0.29 log₂ ratio	27.6	Medium confidence	ci-research-gap-ratio-v1	Sep 29, 2026	show formula: log2( (deaths / Σ deaths) / (publications_5y / Σ publications_5y) ) over eligible top-level cancers (deaths ≥ 100, publications_5y ≥ 1) deaths 583 formula log2( (deaths / Σ deaths) / (publications_5y / Σ publications_5y) ) over eligible top-level cancers (deaths ≥ 100, publications_5y ≥ 1) sumDeaths 290052 deathShare 0.00201 thresholds minDeaths 100 minActivity 1 burdenSourceId CI-SOURCE-00000011 publications5y 1291 eligibleEntities
Trial Gap Index	USA · both sexes · all ages · 2024 · top-level cancers	#10 / 31	▲ 4	+3.4 percentile points	70	Medium confidence	ci-trial-gap-v1	Sep 29, 2026	show formula: percentile(mortality_count) − percentile(active_trials) deaths 1650 formula percentile(mortality_count) − percentile(active_trials) activity 68 burdenPercentile 26.7 activityPercentile 23.3 inputs hash 42c083a5afae5a6aa2195f16 Trace lineage (admin)
Trial Gap Index	USA · Female · all ages · 2024 · top-level cancers	#10 / 28	▲ 3	+7.4 percentile points	66.7	Medium confidence	ci-trial-gap-v1	Sep 29, 2026	show formula: percentile(mortality_count) − percentile(active_trials) deaths 1067 formula percentile(mortality_count) − percentile(active_trials) activity 68 burdenPercentile 25.9 activityPercentile 18.5 inputs hash 8bb8392360b97a549e3a1451 Trace lineage (admin)
Trial Gap Index	USA · Male · all ages · 2024 · top-level cancers	#11 / 26	▲ 6	+4 percentile points	60	Medium confidence	ci-trial-gap-v1	Sep 29, 2026	show formula: percentile(mortality_count) − percentile(active_trials) deaths 583 formula percentile(mortality_count) − percentile(active_trials) activity 68 burdenPercentile 24 activityPercentile 20 inputs hash 0d0aad9990c01ec7597b7feb Trace lineage (admin)
Trial Gap Ratio	USA · both sexes · all ages · 2024 · top-level cancers	#16 / 35	=	-0.18 log₂ ratio	55.9	High confidence	ci-trial-gap-ratio-v1	Sep 29, 2026	show formula: log2( (deaths / Σ deaths) / (active_trials / Σ active_trials) ) over eligible top-level cancers (deaths ≥ 100, active_trials ≥ 1) deaths 1651 formula log2( (deaths / Σ deaths) / (active_trials / Σ active_trials) ) over eligible top-level cancers (deaths ≥ 100, active_trials ≥ 1) sumDeaths 546737 deathShare 0.00302 thresholds minDeaths 100 minActivity 1 trialShare 0.003422 activeTrials 68 burdenSourceId
Trial Gap Ratio	USA · Female · all ages · 2024 · top-level cancers	#10 / 32	=	+0.17 log₂ ratio	71	High confidence	ci-trial-gap-ratio-v1	Sep 29, 2026	show formula: log2( (deaths / Σ deaths) / (active_trials / Σ active_trials) ) over eligible top-level cancers (deaths ≥ 100, active_trials ≥ 1) deaths 1068 formula log2( (deaths / Σ deaths) / (active_trials / Σ active_trials) ) over eligible top-level cancers (deaths ≥ 100, active_trials ≥ 1) sumDeaths 256685 deathShare 0.004161 thresholds minDeaths 100 minActivity 1 trialShare 0.003693 activeTrials 68 burdenSourceId
Trial Gap Ratio	USA · Male · all ages · 2024 · top-level cancers	#22 / 30	=	-0.9 log₂ ratio	27.6	Medium confidence	ci-trial-gap-ratio-v1	Sep 29, 2026	show formula: log2( (deaths / Σ deaths) / (active_trials / Σ active_trials) ) over eligible top-level cancers (deaths ≥ 100, active_trials ≥ 1) deaths 583 formula log2( (deaths / Σ deaths) / (active_trials / Σ active_trials) ) over eligible top-level cancers (deaths ≥ 100, active_trials ≥ 1) sumDeaths 290052 deathShare 0.00201 thresholds minDeaths 100 minActivity 1 trialShare 0.003739 activeTrials 68 burdenSourceId

Metric

Scope

Rank / eligible

Value

Percentile

Confidence

Formula

Generated

Inputs

Age-standardized incidence rate

USA · both sexes · all ages · 2023 · top-level cancers

#19 / 24

2.2 per 100,000

21.7

High confidence

ci-asir-v1

Sep 29, 2026

show

formula: epidemiology_observations.value WHERE metric = as_incidence_rate (standard_population fixed per scope)

sourceId: CI-SOURCE-00000012
estimateType: observed
observationId: 150
siteDefinition: USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218)

inputs hash b755ca35e68b729c8dc63070

Trace lineage (admin)

Age-standardized incidence rate

USA · Female · all ages · 2023 · top-level cancers

#19 / 29

2.7 per 100,000

35.7

High confidence

ci-asir-v1

Sep 29, 2026

show

formula: epidemiology_observations.value WHERE metric = as_incidence_rate (standard_population fixed per scope)

sourceId: CI-SOURCE-00000012
estimateType: observed
observationId: 50
siteDefinition: USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218)

inputs hash 4d01732d23418d0cca033d77

Trace lineage (admin)

Age-standardized incidence rate

USA · Male · all ages · 2023 · top-level cancers

#21 / 27

1.5 per 100,000

23.1

High confidence

ci-asir-v1

Sep 29, 2026

show

formula: epidemiology_observations.value WHERE metric = as_incidence_rate (standard_population fixed per scope)

sourceId: CI-SOURCE-00000012
estimateType: observed
observationId: 100
siteDefinition: USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218)

inputs hash dbeda648a4f2a0068318f6d1

Trace lineage (admin)

Age-standardized mortality rate

USA · both sexes · all ages · 2024 · top-level cancers

#19 / 23

▲ 8

0.4 per 100,000

18.2

High confidence

ci-asmr-v1

Sep 29, 2026

show

formula: epidemiology_observations.value WHERE metric = as_mortality_rate (standard_population fixed per scope)

sourceId: CI-SOURCE-00000012
estimateType: observed
observationId: 306
siteDefinition: USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218)

inputs hash 075bdb903aa37f48ae5b75b4

Trace lineage (admin)

Age-standardized mortality rate

USA · Female · all ages · 2024 · top-level cancers

#21 / 28

▲ 3

0.4 per 100,000

25.9

High confidence

ci-asmr-v1

Sep 29, 2026

show

formula: epidemiology_observations.value WHERE metric = as_mortality_rate (standard_population fixed per scope)

sourceId: CI-SOURCE-00000012
estimateType: observed
observationId: 202
siteDefinition: USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218)

inputs hash cd5df15b22c08f77ce10639c

Trace lineage (admin)

Age-standardized mortality rate

USA · Male · all ages · 2024 · top-level cancers

#20 / 26

▲ 4

0.3 per 100,000

High confidence

ci-asmr-v1

Sep 29, 2026

show

formula: epidemiology_observations.value WHERE metric = as_mortality_rate (standard_population fixed per scope)

sourceId: CI-SOURCE-00000012
estimateType: observed
observationId: 254
siteDefinition: USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218)

inputs hash 9f37d571bb39dc7855fa4d55

Trace lineage (admin)

Annual deaths

USA · both sexes · all ages · 2024 · top-level cancers

#23 / 31

▲ 4

1,650 count

26.7

High confidence

ci-mortality-count-v1

Sep 29, 2026

show

formula: epidemiology_observations.value WHERE metric = mortality_count

sourceId: CI-SOURCE-00000012
estimateType: observed
observationId: 305
siteDefinition: USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218)

inputs hash eda90f606aa05f603e206877

Trace lineage (admin)

Annual deaths

USA · Female · all ages · 2024 · top-level cancers

#21 / 28

▲ 3

1,067 count

25.9

High confidence

ci-mortality-count-v1

Sep 29, 2026

show

formula: epidemiology_observations.value WHERE metric = mortality_count

sourceId: CI-SOURCE-00000012
estimateType: observed
observationId: 201
siteDefinition: USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218)

inputs hash 10479f4404c381a0461a96b6

Trace lineage (admin)

Annual deaths

USA · Male · all ages · 2024 · top-level cancers

#20 / 26

▲ 4

583 count

High confidence

ci-mortality-count-v1

Sep 29, 2026

show

formula: epidemiology_observations.value WHERE metric = mortality_count

sourceId: CI-SOURCE-00000012
estimateType: observed
observationId: 253
siteDefinition: USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218)

inputs hash 0338faa988571e3aeb36ce8d

Trace lineage (admin)

Annual new cases

USA · both sexes · all ages · 2023 · top-level cancers

#23 / 32

9,334 count

High confidence

ci-incidence-count-v1

Sep 29, 2026

show

formula: epidemiology_observations.value WHERE metric = incidence_count

sourceId: CI-SOURCE-00000012
estimateType: observed
observationId: 149
siteDefinition: USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218)

inputs hash a22c4753e0a7e00ce4e210b1

Trace lineage (admin)

Annual new cases

USA · Female · all ages · 2023 · top-level cancers

#19 / 29

6,275 count

35.7

High confidence

ci-incidence-count-v1

Sep 29, 2026

show

formula: epidemiology_observations.value WHERE metric = incidence_count

sourceId: CI-SOURCE-00000012
estimateType: observed
observationId: 49
siteDefinition: USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218)

inputs hash be481a61ede7e4e6eff7e04e

Trace lineage (admin)

Annual new cases

USA · Male · all ages · 2023 · top-level cancers

#21 / 27

3,059 count

23.1

High confidence

ci-incidence-count-v1

Sep 29, 2026

show

formula: epidemiology_observations.value WHERE metric = incidence_count

sourceId: CI-SOURCE-00000012
estimateType: observed
observationId: 99
siteDefinition: USCS "Anus, Anal Canal and Anorectum" (ICD-10 C21; ICD-O-3 C210-C212, C218)

inputs hash faf268f2311c0e2f45598554

Trace lineage (admin)

Mortality-to-incidence ratio

USA · both sexes · all ages · 2023 · top-level cancers

#24 / 31

0.17 ratio

23.3

High confidence

ci-mir-v1

Sep 29, 2026

show

formula: mortality_count / incidence_count (same geography, year, sex, source family)

deaths: 1601
formula: mortality_count / incidence_count (same geography, year, sex, source family)
incidence: 9334
incidenceObservationId: 149
mortalityObservationId: 303

inputs hash 4850aed222cf5b82949f3250

Trace lineage (admin)

Mortality-to-incidence ratio

USA · Female · all ages · 2023 · top-level cancers

#23 / 28

0.16 ratio

18.5

High confidence

ci-mir-v1

Sep 29, 2026

show

formula: mortality_count / incidence_count (same geography, year, sex, source family)

deaths: 1002
formula: mortality_count / incidence_count (same geography, year, sex, source family)
incidence: 6275
incidenceObservationId: 49
mortalityObservationId: 199

inputs hash 6256cbc77f64879a8ded9826

Trace lineage (admin)

Mortality-to-incidence ratio

USA · Male · all ages · 2023 · top-level cancers

#21 / 26

0.2 ratio

High confidence

ci-mir-v1

Sep 29, 2026

show

formula: mortality_count / incidence_count (same geography, year, sex, source family)

deaths: 599
formula: mortality_count / incidence_count (same geography, year, sex, source family)
incidence: 3059
incidenceObservationId: 99
mortalityObservationId: 251

inputs hash 4fbc8d78eb3f4392ae965953

Trace lineage (admin)

Curated clinical evidence items

World · both sexes · all ages · latest · all malignant entities

#392 / 492

1 count

20.4

Medium confidence

ci-civic-evidence-v1

Sep 29, 2026

show

formula: COUNT(civic_evidence_items) WHERE status = ACCEPTED AND cancer_id IN descendants(cancer)

counter: evidenceCount
computedAt: 2026-09-29T06:00:20.557Z

inputs hash 00ec4259c26ee135c931f5a6

Trace lineage (admin)

Curated clinical evidence items

World · both sexes · all ages · latest · top-level cancers

#27 / 28

1 count

3.7

Medium confidence

ci-civic-evidence-v1

Sep 29, 2026

show

formula: COUNT(civic_evidence_items) WHERE status = ACCEPTED AND cancer_id IN descendants(cancer)

counter: evidenceCount
computedAt: 2026-09-29T06:00:20.557Z

inputs hash bc8c48b7174cc05d41e44bad

Trace lineage (admin)

Genes with curated or cohort evidence

World · both sexes · all ages · latest · all malignant entities

#361 / 521

1 count

30.8

Medium confidence

ci-genes-v1

Sep 29, 2026

show

formula: COUNT(DISTINCT gene) FROM (civic accepted evidence ∪ gdc frequency ≥ 0.05 AND cases_affected ≥ 20)

counter: geneCount
computedAt: 2026-09-29T06:00:20.557Z

inputs hash dc02edfbbd5b601934401df4

Trace lineage (admin)

Genes with curated or cohort evidence

World · both sexes · all ages · latest · top-level cancers

#28 / 30

1 count

6.9

Medium confidence

ci-genes-v1

Sep 29, 2026

show

formula: COUNT(DISTINCT gene) FROM (civic accepted evidence ∪ gdc frequency ≥ 0.05 AND cases_affected ≥ 20)

counter: geneCount
computedAt: 2026-09-29T06:00:20.557Z

inputs hash 310f15666b06921ed2f70861

Trace lineage (admin)

Publications, last 12 months

World · both sexes · all ages · latest · all malignant entities

#202 / 2,294

284 count

91.2

Medium confidence

ci-pubs-12m-v1

Sep 29, 2026

show

formula: literature_counts.count WHERE window_key = 12m

counter: publicationCount12m
computedAt: 2026-09-29T06:00:20.557Z

inputs hash 6636ad9f834652e029647409

Trace lineage (admin)

Publications, last 12 months

World · both sexes · all ages · latest · top-level cancers

#27 / 36

284 count

25.7

Medium confidence

ci-pubs-12m-v1

Sep 29, 2026

show

formula: literature_counts.count WHERE window_key = 12m

counter: publicationCount12m
computedAt: 2026-09-29T06:00:20.557Z

inputs hash 09e4f7aeda6ce8f572cc37f7

Trace lineage (admin)

Publications, last 5 years

World · both sexes · all ages · latest · all malignant entities

#213 / 2,873

1,291 count

92.6

Medium confidence

ci-pubs-5y-v1

Sep 29, 2026

show

formula: literature_counts.count WHERE window_key = 5y (query stored per row)

counter: publicationCount5y
computedAt: 2026-09-29T06:00:20.557Z

inputs hash 531d42217f151c0dd79899a6

Trace lineage (admin)

Publications, last 5 years

World · both sexes · all ages · latest · top-level cancers

#27 / 36

1,291 count

25.7

Medium confidence

ci-pubs-5y-v1

Sep 29, 2026

show

formula: literature_counts.count WHERE window_key = 5y (query stored per row)

counter: publicationCount5y
computedAt: 2026-09-29T06:00:20.557Z

inputs hash 8a115533edc694931ad082be

Trace lineage (admin)

Publication growth

World · both sexes · all ages · latest · all malignant entities

#83 / 286

1.28 ratio

71.2

Medium confidence

ci-pub-growth-v1

Sep 29, 2026

show

formula: publications_12m / (publications_5y_prior / 5)

formula: publications_12m / (publications_5y_prior / 5)
publications_12m: 284
publications_5y_prior: 1113

inputs hash 3385afecab0ace04e61b6db0

Trace lineage (admin)

Publication growth

World · both sexes · all ages · latest · top-level cancers

#3 / 36

1.28 ratio

94.3

Medium confidence

ci-pub-growth-v1

Sep 29, 2026

show

formula: publications_12m / (publications_5y_prior / 5)

formula: publications_12m / (publications_5y_prior / 5)
publications_12m: 284
publications_5y_prior: 1113

inputs hash 402d29deeb47adac5c955a64

Trace lineage (admin)

Active clinical trials

World · both sexes · all ages · latest · all malignant entities

#239 / 1,654

68 count

85.6

Medium confidence

ci-active-trials-v1

Sep 29, 2026

show

formula: COUNT(DISTINCT trial) FROM trial_conditions JOIN clinical_trials WHERE cancer_id IN descendants(cancer) AND study_type = INTERVENTIONAL AND overall_status IN (RECRUITING, NOT_YET_RECRUITING, ENROLLING_BY_INVITATION, ACTIVE_NOT_RECRUITING)

counter: activeTrialCount
computedAt: 2026-09-29T06:00:20.557Z

inputs hash f2f5ed2084d93bba6dcb810e

Trace lineage (admin)

Active clinical trials

World · both sexes · all ages · latest · top-level cancers

#27 / 36

68 count

25.7

Medium confidence

ci-active-trials-v1

Sep 29, 2026

show

counter: activeTrialCount
computedAt: 2026-09-29T06:00:20.557Z

inputs hash 36db18bc2db682c45dedd597

Trace lineage (admin)

Active Phase III trials

World · both sexes · all ages · latest · all malignant entities

#237 / 810

7 count

70.8

Medium confidence

ci-phase3-trials-v1

Sep 29, 2026

show

formula: COUNT(DISTINCT trial) … active statuses AND PHASE3 = ANY(phases)

counter: phase3TrialCount
computedAt: 2026-09-29T06:00:20.557Z

inputs hash 56fba75197c8c0044b9e345f

Trace lineage (admin)

Active Phase III trials

World · both sexes · all ages · latest · top-level cancers

#27 / 36

7 count

25.7

Medium confidence

ci-phase3-trials-v1

Sep 29, 2026

show

formula: COUNT(DISTINCT trial) … active statuses AND PHASE3 = ANY(phases)

counter: phase3TrialCount
computedAt: 2026-09-29T06:00:20.557Z

inputs hash 7e874e202ec3e68f4c4a2534

Trace lineage (admin)

Recruiting clinical trials

World · both sexes · all ages · latest · all malignant entities

#246 / 1,277

34 count

80.8

Medium confidence

ci-recruiting-trials-v1

Sep 29, 2026

show

formula: COUNT(DISTINCT trial) … overall_status = RECRUITING AND study_type = INTERVENTIONAL

counter: recruitingTrialCount
computedAt: 2026-09-29T06:00:20.557Z

inputs hash 4352f89d0670b61272a585b3

Trace lineage (admin)

Recruiting clinical trials

World · both sexes · all ages · latest · top-level cancers

#28 / 36

34 count

22.9

Medium confidence

ci-recruiting-trials-v1

Sep 29, 2026

show

formula: COUNT(DISTINCT trial) … overall_status = RECRUITING AND study_type = INTERVENTIONAL

counter: recruitingTrialCount
computedAt: 2026-09-29T06:00:20.557Z

inputs hash e254423b3e4889483596cf7d

Trace lineage (admin)

Recruiting Phase III trials

World · both sexes · all ages · latest · all malignant entities

#281 / 585

2 count

52.1

High confidence

ci-phase3-recruiting-v1

Sep 29, 2026

show

formula: COUNT(DISTINCT trial) … overall_status = RECRUITING AND PHASE3 = ANY(phases) AND study_type = INTERVENTIONAL

asOf: 2026-09-29
studyType: INTERVENTIONAL
aggregation: descendants
activeTrials: 68
activeStatuses: RECRUITING
NOT_YET_RECRUITING
ENROLLING_BY_INVITATION
ACTIVE_NOT_RECRUITING
formulaVersion: ci-trial-intel-v1
phase3Recruiting: 2

inputs hash ada23aaf0a7d803bc6e67424

Trace lineage (admin)

Recruiting Phase III trials

World · both sexes · all ages · latest · top-level cancers

#29 / 33

2 count

12.5

High confidence

ci-phase3-recruiting-v1

Sep 29, 2026

show

formula: COUNT(DISTINCT trial) … overall_status = RECRUITING AND PHASE3 = ANY(phases) AND study_type = INTERVENTIONAL

asOf: 2026-09-29
studyType: INTERVENTIONAL
aggregation: descendants
activeTrials: 68
activeStatuses: RECRUITING
NOT_YET_RECRUITING
ENROLLING_BY_INVITATION
ACTIVE_NOT_RECRUITING
formulaVersion: ci-trial-intel-v1
phase3Recruiting: 2

inputs hash 284e53e9bc6e51772da0f4e8

Trace lineage (admin)

Sponsor concentration (HHI)

World · both sexes · all ages · latest · all malignant entities

#467 / 615

0.023 index (0–1)

24.1

High confidence

ci-sponsor-hhi-v1

Sep 29, 2026

show

formula: Σ (active_trials_by_lead_sponsor / active_trials)² over the cancer and its descendants

asOf: 2026-09-29
studyType: INTERVENTIONAL
topSponsor: National Cancer Institute (NCI)
aggregation: descendants
activeTrials: 68
activeStatuses: RECRUITING
NOT_YET_RECRUITING
ENROLLING_BY_INVITATION
ACTIVE_NOT_RECRUITING
formulaVersion: ci-trial-intel-v1
minActiveTrials: 10
topSponsorShare

Sponsor concentration (HHI)

World · both sexes · all ages · latest · top-level cancers

#16 / 36

0.023 index (0–1)

57.1

High confidence

ci-sponsor-hhi-v1

Sep 29, 2026

show

formula: Σ (active_trials_by_lead_sponsor / active_trials)² over the cancer and its descendants

asOf: 2026-09-29
studyType: INTERVENTIONAL
topSponsor: National Cancer Institute (NCI)
aggregation: descendants
activeTrials: 68
activeStatuses: RECRUITING
NOT_YET_RECRUITING
ENROLLING_BY_INVITATION
ACTIVE_NOT_RECRUITING
formulaVersion: ci-trial-intel-v1
minActiveTrials: 10
topSponsorShare: 0.0882353

Trial termination share

World · both sexes · all ages · latest · all malignant entities

#391 / 454

0.27 ratio

13.9

Medium confidence

ci-trial-termination-v1

Sep 29, 2026

show

formula: (terminated + withdrawn) / (completed + terminated + withdrawn) WHERE first_posted_date ≥ 2010-01-01 AND study_type = INTERVENTIONAL

asOf: 2026-09-29
since: 2010-01-01
terminal: 70
completed: 51
studyType: INTERVENTIONAL
withdrawn: 4
terminated: 15
aggregation: descendants
activeStatuses: RECRUITING
NOT_YET_RECRUITING
ENROLLING_BY_INVITATION
ACTIVE_NOT_RECRUITING

Trial termination share

World · both sexes · all ages · latest · top-level cancers

#23 / 34

0.27 ratio

33.3

Medium confidence

ci-trial-termination-v1

Sep 29, 2026

show

formula: (terminated + withdrawn) / (completed + terminated + withdrawn) WHERE first_posted_date ≥ 2010-01-01 AND study_type = INTERVENTIONAL

asOf: 2026-09-29
since: 2010-01-01
terminal: 70
completed: 51
studyType: INTERVENTIONAL
withdrawn: 4
terminated: 15
aggregation: descendants
activeStatuses: RECRUITING
NOT_YET_RECRUITING
ENROLLING_BY_INVITATION
ACTIVE_NOT_RECRUITING

Active trials per 1,000 annual deaths

USA · both sexes · all ages · 2024 · top-level cancers

#20 / 35

41.2 per 1,000 deaths

44.1

High confidence

ci-trials-per-deaths-v1

Sep 29, 2026

show

formula: active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100)

deaths

1651

formula

active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100)

thresholds

minDeaths: 100
minActivity: 1

activeTrials

burdenSourceId

CI-SOURCE-00000011

countersComputedAt

2026-09-29 02:00:20.557824-04

mortalityObservationId

9448

componentsFormulaVersion

Active trials per 1,000 annual deaths

USA · Female · all ages · 2024 · top-level cancers

#23 / 32

63.7 per 1,000 deaths

High confidence

ci-trials-per-deaths-v1

Sep 29, 2026

show

formula: active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100)

deaths

1068

formula

active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100)

thresholds

minDeaths: 100
minActivity: 1

activeTrials

burdenSourceId

CI-SOURCE-00000011

countersComputedAt

2026-09-29 02:00:20.557824-04

mortalityObservationId

9442

componentsFormulaVersion

Active trials per 1,000 annual deaths

USA · Male · all ages · 2024 · top-level cancers

#9 / 30

116.6 per 1,000 deaths

72.4

Medium confidence

ci-trials-per-deaths-v1

Sep 29, 2026

show

formula: active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100)

deaths

583

formula

active_trials / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100)

thresholds

minDeaths: 100
minActivity: 1

activeTrials

burdenSourceId

CI-SOURCE-00000011

countersComputedAt

2026-09-29 02:00:20.557824-04

mortalityObservationId

9445

componentsFormulaVersion

Publications (5 y) per 1,000 annual deaths

USA · both sexes · all ages · 2024 · top-level cancers

#20 / 35

782 per 1,000 deaths

44.1

High confidence

ci-pubs-per-deaths-v1

Sep 29, 2026

show

formula: publications_5y / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100)

deaths

1651

formula

publications_5y / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100)

thresholds

minDeaths: 100
minActivity: 1

burdenSourceId

CI-SOURCE-00000011

publications5y

1291

countersComputedAt

2026-09-29 02:00:20.557824-04

mortalityObservationId

9448

componentsFormulaVersion

Publications (5 y) per 1,000 annual deaths

USA · Female · all ages · 2024 · top-level cancers

#24 / 32

1,208.8 per 1,000 deaths

25.8

High confidence

ci-pubs-per-deaths-v1

Sep 29, 2026

show

formula: publications_5y / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100)

deaths

1068

formula

publications_5y / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100)

thresholds

minDeaths: 100
minActivity: 1

burdenSourceId

CI-SOURCE-00000011

publications5y

1291

countersComputedAt

2026-09-29 02:00:20.557824-04

mortalityObservationId

9442

Publications (5 y) per 1,000 annual deaths

USA · Male · all ages · 2024 · top-level cancers

#9 / 30

2,214.4 per 1,000 deaths

72.4

Medium confidence

ci-pubs-per-deaths-v1

Sep 29, 2026

show

formula: publications_5y / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100)

deaths

583

formula

publications_5y / (mortality_count / 1000) (same geography, year, sex, source family; deaths ≥ 100)

thresholds

minDeaths: 100
minActivity: 1

burdenSourceId

CI-SOURCE-00000011

publications5y

1291

countersComputedAt

2026-09-29 02:00:20.557824-04

mortalityObservationId

9445

componentsFormulaVersion

Research Gap Index

USA · both sexes · all ages · 2024 · top-level cancers

#15 / 31

▲ 3

0 percentile points

53.3

Medium confidence

ci-research-gap-v1

Sep 29, 2026

show

formula: percentile(mortality_count) − percentile(publications_5y)

deaths: 1650
formula: percentile(mortality_count) − percentile(publications_5y)
activity: 1291
burdenPercentile: 26.7
activityPercentile: 26.7

inputs hash 223409ea4719a317e41b9bc7

Trace lineage (admin)

Research Gap Index

USA · Female · all ages · 2024 · top-level cancers

#14 / 28

▼ 2

0 percentile points

51.9

Medium confidence

ci-research-gap-v1

Sep 29, 2026

show

formula: percentile(mortality_count) − percentile(publications_5y)

deaths: 1067
formula: percentile(mortality_count) − percentile(publications_5y)
activity: 1291
burdenPercentile: 25.9
activityPercentile: 25.9

inputs hash 7e5d4f431c856bc70e0ca539

Trace lineage (admin)

Research Gap Index

USA · Male · all ages · 2024 · top-level cancers

#9 / 26

▲ 4

+4 percentile points

Medium confidence

ci-research-gap-v1

Sep 29, 2026

show

formula: percentile(mortality_count) − percentile(publications_5y)

deaths: 583
formula: percentile(mortality_count) − percentile(publications_5y)
activity: 1291
burdenPercentile: 24
activityPercentile: 20

inputs hash 164d63cf992b720eb24f77b4

Trace lineage (admin)

Research Gap Ratio

USA · both sexes · all ages · 2024 · top-level cancers

#16 / 35

+0.44 log₂ ratio

55.9

High confidence

ci-research-gap-ratio-v1

Sep 29, 2026

show

formula: log2( (deaths / Σ deaths) / (publications_5y / Σ publications_5y) ) over eligible top-level cancers (deaths ≥ 100, publications_5y ≥ 1)

deaths

1651

formula

log2( (deaths / Σ deaths) / (publications_5y / Σ publications_5y) ) over eligible top-level cancers (deaths ≥ 100, publications_5y ≥ 1)

sumDeaths

546737

deathShare

0.00302

thresholds

minDeaths: 100
minActivity: 1

burdenSourceId

CI-SOURCE-00000011

publications5y

1291

eligibleEntities

Research Gap Ratio

USA · Female · all ages · 2024 · top-level cancers

#9 / 32

+0.76 log₂ ratio

74.2

High confidence

ci-research-gap-ratio-v1

Sep 29, 2026

show

formula: log2( (deaths / Σ deaths) / (publications_5y / Σ publications_5y) ) over eligible top-level cancers (deaths ≥ 100, publications_5y ≥ 1)

deaths

1068

formula

log2( (deaths / Σ deaths) / (publications_5y / Σ publications_5y) ) over eligible top-level cancers (deaths ≥ 100, publications_5y ≥ 1)

sumDeaths

256685

deathShare

0.004161

thresholds

minDeaths: 100
minActivity: 1

burdenSourceId

CI-SOURCE-00000011

publications5y

1291

eligibleEntities

Research Gap Ratio

USA · Male · all ages · 2024 · top-level cancers

#22 / 30

-0.29 log₂ ratio

27.6

Medium confidence

ci-research-gap-ratio-v1

Sep 29, 2026

show

formula: log2( (deaths / Σ deaths) / (publications_5y / Σ publications_5y) ) over eligible top-level cancers (deaths ≥ 100, publications_5y ≥ 1)

deaths

583

formula

log2( (deaths / Σ deaths) / (publications_5y / Σ publications_5y) ) over eligible top-level cancers (deaths ≥ 100, publications_5y ≥ 1)

sumDeaths

290052

deathShare

0.00201

thresholds

minDeaths: 100
minActivity: 1

burdenSourceId

CI-SOURCE-00000011

publications5y

1291

eligibleEntities

Trial Gap Index

USA · both sexes · all ages · 2024 · top-level cancers

#10 / 31

▲ 4

+3.4 percentile points

Medium confidence

ci-trial-gap-v1

Sep 29, 2026

show

formula: percentile(mortality_count) − percentile(active_trials)

deaths: 1650
formula: percentile(mortality_count) − percentile(active_trials)
activity: 68
burdenPercentile: 26.7
activityPercentile: 23.3

inputs hash 42c083a5afae5a6aa2195f16

Trace lineage (admin)

Trial Gap Index

USA · Female · all ages · 2024 · top-level cancers

#10 / 28

▲ 3

+7.4 percentile points

66.7

Medium confidence

ci-trial-gap-v1

Sep 29, 2026

show

formula: percentile(mortality_count) − percentile(active_trials)

deaths: 1067
formula: percentile(mortality_count) − percentile(active_trials)
activity: 68
burdenPercentile: 25.9
activityPercentile: 18.5

inputs hash 8bb8392360b97a549e3a1451

Trace lineage (admin)

Trial Gap Index

USA · Male · all ages · 2024 · top-level cancers

#11 / 26

▲ 6

+4 percentile points

Medium confidence

ci-trial-gap-v1

Sep 29, 2026

show

formula: percentile(mortality_count) − percentile(active_trials)

deaths: 583
formula: percentile(mortality_count) − percentile(active_trials)
activity: 68
burdenPercentile: 24
activityPercentile: 20

inputs hash 0d0aad9990c01ec7597b7feb

Trace lineage (admin)

Trial Gap Ratio

USA · both sexes · all ages · 2024 · top-level cancers

#16 / 35

-0.18 log₂ ratio

55.9

High confidence

ci-trial-gap-ratio-v1

Sep 29, 2026

show

formula: log2( (deaths / Σ deaths) / (active_trials / Σ active_trials) ) over eligible top-level cancers (deaths ≥ 100, active_trials ≥ 1)

deaths

1651

formula

log2( (deaths / Σ deaths) / (active_trials / Σ active_trials) ) over eligible top-level cancers (deaths ≥ 100, active_trials ≥ 1)

sumDeaths

546737

deathShare

0.00302

thresholds

minDeaths: 100
minActivity: 1

trialShare

0.003422

activeTrials

burdenSourceId

Trial Gap Ratio

USA · Female · all ages · 2024 · top-level cancers

#10 / 32

+0.17 log₂ ratio

High confidence

ci-trial-gap-ratio-v1

Sep 29, 2026

show

formula: log2( (deaths / Σ deaths) / (active_trials / Σ active_trials) ) over eligible top-level cancers (deaths ≥ 100, active_trials ≥ 1)

deaths

1068

formula

log2( (deaths / Σ deaths) / (active_trials / Σ active_trials) ) over eligible top-level cancers (deaths ≥ 100, active_trials ≥ 1)

sumDeaths

256685

deathShare

0.004161

thresholds

minDeaths: 100
minActivity: 1

trialShare

0.003693

activeTrials

burdenSourceId

Trial Gap Ratio

USA · Male · all ages · 2024 · top-level cancers

#22 / 30

-0.9 log₂ ratio

27.6

Medium confidence

ci-trial-gap-ratio-v1

Sep 29, 2026

show

formula: log2( (deaths / Σ deaths) / (active_trials / Σ active_trials) ) over eligible top-level cancers (deaths ≥ 100, active_trials ≥ 1)

deaths

583

formula

log2( (deaths / Σ deaths) / (active_trials / Σ active_trials) ) over eligible top-level cancers (deaths ≥ 100, active_trials ≥ 1)

sumDeaths

290052

deathShare

0.00201

thresholds

minDeaths: 100
minActivity: 1

trialShare

0.003739

activeTrials

burdenSourceId

Why this rank?

Research gap