Ranking · Unmet Need

Research Gap Index

Burden percentile minus research-activity percentile (publications, last 5 years) within the same scope. Positive values flag cancers with high mortality burden but comparatively little literature. Caveat (Phase 1): literature counts are query-based per entity (query stored on each row); they are not aggregated over descendants.

Computedci-research-gap-v1unit: percentile pointshigher = worseAll metrics

Rank	Δ	Cancer	Research Gap Index (percentile points)	Percentile	Confidence	Sources	Why #n?
1	=	Malignant Central Nervous System Neoplasm	+66.7	100	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12830 formula percentile(mortality_count) − percentile(publications_5y) activity 298 burdenPercentile 70 activityPercentile 3.3 ranking row 2593385
2	=	Malignant Uterine Corpus Neoplasm	+36.7	96.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3187 formula percentile(mortality_count) − percentile(publications_5y) activity 105 burdenPercentile 36.7 activityPercentile 0 ranking row 2593386
3	=	Malignant Colon Neoplasm	+23.4	93.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 47987 formula percentile(mortality_count) − percentile(publications_5y) activity 18406 burdenPercentile 96.7 activityPercentile 73.3 ranking row 2593387
4	=	Non-Hodgkin Lymphoma	+20	90	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 21910 formula percentile(mortality_count) − percentile(publications_5y) activity 17190 burdenPercentile 83.3 activityPercentile 63.3 ranking row 2593388
5	=	Malignant Esophageal Neoplasm	+13.4	86.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12700 formula percentile(mortality_count) − percentile(publications_5y) activity 10921 burdenPercentile 66.7 activityPercentile 53.3 ranking row 2593389
5	=	Malignant Kidney Neoplasm	+13.4	86.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12165 formula percentile(mortality_count) − percentile(publications_5y) activity 3700 burdenPercentile 56.7 activityPercentile 43.3 ranking row 2593390
7	=	Malignant Pancreatic Neoplasm	+10	80	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 30263 formula percentile(mortality_count) − percentile(publications_5y) activity 25767 burdenPercentile 86.7 activityPercentile 76.7 ranking row 2593391
7	=	Malignant Salivary Gland Neoplasm	+10	80	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 722 formula percentile(mortality_count) − percentile(publications_5y) activity 474 burdenPercentile 20 activityPercentile 10 ranking row 2593392
9	=	Malignant Laryngeal Neoplasm	+6.7	73.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3722 formula percentile(mortality_count) − percentile(publications_5y) activity 2031 burdenPercentile 40 activityPercentile 33.3 ranking row 2593393
10	=	Malignant Vulvar Neoplasm	+6.6	70	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 794 formula percentile(mortality_count) − percentile(publications_5y) activity 870 burdenPercentile 23.3 activityPercentile 16.7 ranking row 2593394
11	=	Malignant Liver Neoplasm	+6.6	66.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 14047 formula percentile(mortality_count) − percentile(publications_5y) activity 17939 burdenPercentile 73.3 activityPercentile 66.7 ranking row 2593395
12	=	Malignant Lung Neoplasm	+3.3	63.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 157630 formula percentile(mortality_count) − percentile(publications_5y) activity 93034 burdenPercentile 100 activityPercentile 96.7 ranking row 2593396
12	=	Multiple Myeloma	+3.3	63.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 10913 formula percentile(mortality_count) − percentile(publications_5y) activity 10244 burdenPercentile 53.3 activityPercentile 50 ranking row 2593397
14	=	Cutaneous Melanoma	0	56.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 7513 formula percentile(mortality_count) − percentile(publications_5y) activity 4407 burdenPercentile 46.7 activityPercentile 46.7 ranking row 2593398
14	=	Malignant Vaginal Neoplasm	0	56.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 378 formula percentile(mortality_count) − percentile(publications_5y) activity 373 burdenPercentile 6.7 activityPercentile 6.7 ranking row 2593399
16	=	Malignant Ovarian Neoplasm	-3.3	50	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 14682 formula percentile(mortality_count) − percentile(publications_5y) activity 25793 burdenPercentile 76.7 activityPercentile 80 ranking row 2593400
16	=	Malignant Prostate Neoplasm	-3.3	50	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 30446 formula percentile(mortality_count) − percentile(publications_5y) activity 52116 burdenPercentile 90 activityPercentile 93.3 ranking row 2593401
18	=	Malignant Nasopharyngeal Neoplasm	-3.3	43.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 628 formula percentile(mortality_count) − percentile(publications_5y) activity 952 burdenPercentile 16.7 activityPercentile 20 ranking row 2593402
19	=	Malignant Mesothelioma	-3.4	40	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 2430 formula percentile(mortality_count) − percentile(publications_5y) activity 2145 burdenPercentile 33.3 activityPercentile 36.7 ranking row 2593403
20	=	Leukemia	-6.7	36.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 21581 formula percentile(mortality_count) − percentile(publications_5y) activity 31893 burdenPercentile 80 activityPercentile 86.7 ranking row 2593404
20	=	Malignant Bladder Neoplasm	-6.7	36.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12627 formula percentile(mortality_count) − percentile(publications_5y) activity 18250 burdenPercentile 63.3 activityPercentile 70 ranking row 2593406
20	=	Malignant Breast Neoplasm	-6.7	36.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 41883 formula percentile(mortality_count) − percentile(publications_5y) activity 133010 burdenPercentile 93.3 activityPercentile 100 ranking row 2593405
20	=	Malignant Rectal Neoplasm	-6.7	36.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 8616 formula percentile(mortality_count) − percentile(publications_5y) activity 12506 burdenPercentile 50 activityPercentile 56.7 ranking row 2593407
24	=	Malignant Hypopharyngeal Neoplasm	-10	23.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 323 formula percentile(mortality_count) − percentile(publications_5y) activity 581 burdenPercentile 3.3 activityPercentile 13.3 ranking row 2593408
25	=	Hodgkin Lymphoma	-13.3	20	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1352 formula percentile(mortality_count) − percentile(publications_5y) activity 2178 burdenPercentile 26.7 activityPercentile 40 ranking row 2593409
26	=	Malignant Anal Neoplasm	-13.4	16.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 539 formula percentile(mortality_count) − percentile(publications_5y) activity 1291 burdenPercentile 13.3 activityPercentile 26.7 ranking row 2593410
27	=	Malignant Testicular Neoplasm	-20	13.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 393 formula percentile(mortality_count) − percentile(publications_5y) activity 1806 burdenPercentile 10 activityPercentile 30 ranking row 2593411
28	=	Malignant Penile Neoplasm	-23.3	10	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 209 formula percentile(mortality_count) − percentile(publications_5y) activity 1025 burdenPercentile 0 activityPercentile 23.3 ranking row 2593412
29	=	Malignant Gastric Neoplasm	-30	6.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 12198 formula percentile(mortality_count) − percentile(publications_5y) activity 34783 burdenPercentile 60 activityPercentile 90 ranking row 2593413
29	=	Malignant Thyroid Gland Neoplasm	-30	6.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1367 formula percentile(mortality_count) − percentile(publications_5y) activity 13792 burdenPercentile 30 activityPercentile 60 ranking row 2593414
31	=	Malignant Cervical Neoplasm	-40	0	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3952 formula percentile(mortality_count) − percentile(publications_5y) activity 26673 burdenPercentile 43.3 activityPercentile 83.3 ranking row 2593415

Data updated 16 hours agoSource updated unknown31 eligible entities · inputs hash 2ed3329bf2f2b5826ba632ef

Methodology

How this table was built

Formula: percentile(mortality_count) − percentile(publications_5y)
Version: ci-research-gap-v1
Scope: USA · both sexes · all ages · 2002 · top-level cancers
Scope key: geo=USA|sex=all|age=all|year=2002|level=top
Eligible entities: 31
Generated: Sep 29, 2026, 06:30 AM UTC
Inputs hash: 2ed3329bf2f2b5826ba632ef
Sources: U.S. Cancer Statistics (USCS) — NPCR/SEER incidence and NVSS mortality pubmed cdc-wonder seer iarc-globocan
Aggregation: none

Eligibility

requires: mortality_count
publications_5y
entityLevel: top

Full methodology · ties share a rank (1, 2, 2, 4) · previous rank refers to the last snapshot of the same scope.

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Burden and lethality metrics depend on registry definitions (site groups, standard population, estimate type). Compare only within one table.