Ranking · Unmet Need

Research Gap Index

Burden percentile minus research-activity percentile (publications, last 5 years) within the same scope. Positive values flag cancers with high mortality burden but comparatively little literature. Caveat (Phase 1): literature counts are query-based per entity (query stored on each row); they are not aggregated over descendants.

Computedci-research-gap-v1unit: percentile pointshigher = worseAll metrics

Rank	Δ	Cancer	Research Gap Index (percentile points)	Percentile	Confidence	Sources	Why #n?
1	=	Malignant Central Nervous System Neoplasm	+56	100	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 7011 formula percentile(mortality_count) − percentile(publications_5y) activity 298 burdenPercentile 56 activityPercentile 0 ranking row 2592602
2	=	Malignant Esophageal Neoplasm	+24	96	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 9279 formula percentile(mortality_count) − percentile(publications_5y) activity 10921 burdenPercentile 76 activityPercentile 52 ranking row 2592603
3	=	Malignant Kidney Neoplasm	+20	92	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 7249 formula percentile(mortality_count) − percentile(publications_5y) activity 3700 burdenPercentile 60 activityPercentile 40 ranking row 2592605
3	=	Non-Hodgkin Lymphoma	+20	92	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 11812 formula percentile(mortality_count) − percentile(publications_5y) activity 17190 burdenPercentile 84 activityPercentile 64 ranking row 2592604
5	=	Malignant Colon Neoplasm	+16	84	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 23850 formula percentile(mortality_count) − percentile(publications_5y) activity 18406 burdenPercentile 92 activityPercentile 76 ranking row 2592606
6	=	Malignant Laryngeal Neoplasm	+12	80	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3041 formula percentile(mortality_count) − percentile(publications_5y) activity 2031 burdenPercentile 40 activityPercentile 28 ranking row 2592608
6	=	Malignant Nasopharyngeal Neoplasm	+12	80	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 444 formula percentile(mortality_count) − percentile(publications_5y) activity 952 burdenPercentile 24 activityPercentile 12 ranking row 2592609
6	=	Malignant Salivary Gland Neoplasm	+12	80	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 419 formula percentile(mortality_count) − percentile(publications_5y) activity 474 burdenPercentile 16 activityPercentile 4 ranking row 2592607
9	=	Malignant Pancreatic Neoplasm	+8	68	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 14237 formula percentile(mortality_count) − percentile(publications_5y) activity 25767 burdenPercentile 88 activityPercentile 80 ranking row 2592610
10	=	Malignant Liver Neoplasm	+4	64	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 8176 formula percentile(mortality_count) − percentile(publications_5y) activity 17939 burdenPercentile 72 activityPercentile 68 ranking row 2592614
10	=	Malignant Lung Neoplasm	+4	64	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 90410 formula percentile(mortality_count) − percentile(publications_5y) activity 93034 burdenPercentile 100 activityPercentile 96 ranking row 2592612
10	=	Malignant Mesothelioma	+4	64	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1925 formula percentile(mortality_count) − percentile(publications_5y) activity 2145 burdenPercentile 36 activityPercentile 32 ranking row 2592611
10	=	Malignant Prostate Neoplasm	+4	64	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 31078 formula percentile(mortality_count) − percentile(publications_5y) activity 52116 burdenPercentile 96 activityPercentile 92 ranking row 2592615
10	=	Multiple Myeloma	+4	64	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 5321 formula percentile(mortality_count) − percentile(publications_5y) activity 10244 burdenPercentile 52 activityPercentile 48 ranking row 2592613
15	=	Cutaneous Melanoma	0	44	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 4592 formula percentile(mortality_count) − percentile(publications_5y) activity 4407 burdenPercentile 44 activityPercentile 44 ranking row 2592616
15	=	Malignant Hypopharyngeal Neoplasm	0	44	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 287 formula percentile(mortality_count) − percentile(publications_5y) activity 581 burdenPercentile 8 activityPercentile 8 ranking row 2592617
17	=	Hodgkin Lymphoma	-4	36	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 686 formula percentile(mortality_count) − percentile(publications_5y) activity 2178 burdenPercentile 32 activityPercentile 36 ranking row 2592619
17	=	Leukemia	-4	36	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 11803 formula percentile(mortality_count) − percentile(publications_5y) activity 31893 burdenPercentile 80 activityPercentile 84 ranking row 2592618
17	=	Malignant Bladder Neoplasm	-4	36	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 8163 formula percentile(mortality_count) − percentile(publications_5y) activity 18250 burdenPercentile 68 activityPercentile 72 ranking row 2592620
20	=	Malignant Rectal Neoplasm	-8	24	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 4634 formula percentile(mortality_count) − percentile(publications_5y) activity 12506 burdenPercentile 48 activityPercentile 56 ranking row 2592621
21	=	Malignant Penile Neoplasm	-12	20	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 217 formula percentile(mortality_count) − percentile(publications_5y) activity 1025 burdenPercentile 4 activityPercentile 16 ranking row 2592622
21	=	Malignant Testicular Neoplasm	-12	20	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 338 formula percentile(mortality_count) − percentile(publications_5y) activity 1806 burdenPercentile 12 activityPercentile 24 ranking row 2592623
23	=	Malignant Anal Neoplasm	-20	12	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 194 formula percentile(mortality_count) − percentile(publications_5y) activity 1291 burdenPercentile 0 activityPercentile 20 ranking row 2592624
24	=	Malignant Gastric Neoplasm	-24	8	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 7328 formula percentile(mortality_count) − percentile(publications_5y) activity 34783 burdenPercentile 64 activityPercentile 88 ranking row 2592625
25	=	Malignant Thyroid Gland Neoplasm	-32	4	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 550 formula percentile(mortality_count) − percentile(publications_5y) activity 13792 burdenPercentile 28 activityPercentile 60 ranking row 2592626
26	=	Malignant Breast Neoplasm	-80	0	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 428 formula percentile(mortality_count) − percentile(publications_5y) activity 133010 burdenPercentile 20 activityPercentile 100 ranking row 2592627

Data updated 16 hours agoSource updated unknown26 eligible entities · inputs hash ab6060bff41be09f6e526867

Methodology

How this table was built

Formula: percentile(mortality_count) − percentile(publications_5y)
Version: ci-research-gap-v1
Scope: USA · Male · all ages · 2000 · top-level cancers
Scope key: geo=USA|sex=male|age=all|year=2000|level=top
Eligible entities: 26
Generated: Sep 29, 2026, 06:30 AM UTC
Inputs hash: ab6060bff41be09f6e526867
Sources: U.S. Cancer Statistics (USCS) — NPCR/SEER incidence and NVSS mortality pubmed cdc-wonder seer iarc-globocan
Aggregation: none

Eligibility

requires: mortality_count
publications_5y
entityLevel: top

Full methodology · ties share a rank (1, 2, 2, 4) · previous rank refers to the last snapshot of the same scope.

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