Ranking · Unmet Need

Research Gap Index

Burden percentile minus research-activity percentile (publications, last 5 years) within the same scope. Positive values flag cancers with high mortality burden but comparatively little literature. Caveat (Phase 1): literature counts are query-based per entity (query stored on each row); they are not aggregated over descendants.

Computedci-research-gap-v1unit: percentile pointshigher = worseAll metrics

Rank	Δ	Cancer	Research Gap Index (percentile points)	Percentile	Confidence	Sources	Why #n?
1	▲1	Malignant Central Nervous System Neoplasm	+66.7	100	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 7759 formula percentile(mortality_count) − percentile(publications_5y) activity 298 burdenPercentile 70.4 activityPercentile 3.7 ranking row 2606281
1	=	Malignant Uterine Corpus Neoplasm	+66.7	100	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 7337 formula percentile(mortality_count) − percentile(publications_5y) activity 105 burdenPercentile 66.7 activityPercentile 0 ranking row 2606282
3	▲2	Malignant Kidney Neoplasm	+14.9	92.6	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 4793 formula percentile(mortality_count) − percentile(publications_5y) activity 3700 burdenPercentile 55.6 activityPercentile 40.7 ranking row 2606284
3	▲4	Multiple Myeloma	+14.9	92.6	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 5431 formula percentile(mortality_count) − percentile(publications_5y) activity 10244 burdenPercentile 63 activityPercentile 48.1 ranking row 2606283
5	▲1	Malignant Colon Neoplasm	+14.8	85.2	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 19458 formula percentile(mortality_count) − percentile(publications_5y) activity 18406 burdenPercentile 88.9 activityPercentile 74.1 ranking row 2606285
6	▲2	Malignant Liver Neoplasm	+14.8	81.5	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 9891 formula percentile(mortality_count) − percentile(publications_5y) activity 17939 burdenPercentile 81.5 activityPercentile 66.7 ranking row 2606287
6	▲2	Malignant Pancreatic Neoplasm	+14.8	81.5	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 22994 formula percentile(mortality_count) − percentile(publications_5y) activity 25767 burdenPercentile 92.6 activityPercentile 77.8 ranking row 2606286
6	▼3	Malignant Vulvar Neoplasm	+14.8	81.5	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1436 formula percentile(mortality_count) − percentile(publications_5y) activity 870 burdenPercentile 33.3 activityPercentile 18.5 ranking row 2606288
9	▲1	Non-Hodgkin Lymphoma	+11.1	70.4	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 8501 formula percentile(mortality_count) − percentile(publications_5y) activity 17190 burdenPercentile 74.1 activityPercentile 63 ranking row 2606289
10	▼6	Malignant Vaginal Neoplasm	+7.4	66.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 441 formula percentile(mortality_count) − percentile(publications_5y) activity 373 burdenPercentile 14.8 activityPercentile 7.4 ranking row 2606290
11	▲5	Malignant Lung Neoplasm	+3.7	63	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 62954 formula percentile(mortality_count) − percentile(publications_5y) activity 93034 burdenPercentile 100 activityPercentile 96.3 ranking row 2606291
11	▲4	Malignant Ovarian Neoplasm	+3.7	63	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 13430 formula percentile(mortality_count) − percentile(publications_5y) activity 25793 burdenPercentile 85.2 activityPercentile 81.5 ranking row 2606292
13	▲1	Malignant Rectal Neoplasm	+3.7	55.6	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 4901 formula percentile(mortality_count) − percentile(publications_5y) activity 12506 burdenPercentile 59.3 activityPercentile 55.6 ranking row 2606293
14	▼2	Malignant Anal Neoplasm	0	51.9	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 970 formula percentile(mortality_count) − percentile(publications_5y) activity 1291 burdenPercentile 25.9 activityPercentile 25.9 ranking row 2606294
15	▼2	Malignant Salivary Gland Neoplasm	-3.7	48.1	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 373 formula percentile(mortality_count) − percentile(publications_5y) activity 474 burdenPercentile 7.4 activityPercentile 11.1 ranking row 2606295
16	▲4	Malignant Breast Neoplasm	-3.7	44.4	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 42310 formula percentile(mortality_count) − percentile(publications_5y) activity 133010 burdenPercentile 96.3 activityPercentile 100 ranking row 2606296
17	=	Cutaneous Melanoma	-7.4	40.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 2861 formula percentile(mortality_count) − percentile(publications_5y) activity 4407 burdenPercentile 37 activityPercentile 44.4 ranking row 2606297
18	▼1	Malignant Laryngeal Neoplasm	-7.4	37	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 761 formula percentile(mortality_count) − percentile(publications_5y) activity 2031 burdenPercentile 22.2 activityPercentile 29.6 ranking row 2606298
19	▲2	Leukemia	-11.1	33.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 9810 formula percentile(mortality_count) − percentile(publications_5y) activity 31893 burdenPercentile 77.8 activityPercentile 88.9 ranking row 2606299
20	▲4	Malignant Esophageal Neoplasm	-11.2	29.6	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3185 formula percentile(mortality_count) − percentile(publications_5y) activity 10921 burdenPercentile 40.7 activityPercentile 51.9 ranking row 2606300
21	▲1	Malignant Mesothelioma	-14.8	25.9	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 626 formula percentile(mortality_count) − percentile(publications_5y) activity 2145 burdenPercentile 18.5 activityPercentile 33.3 ranking row 2606301
22	▼5	Malignant Hypopharyngeal Neoplasm	-14.8	22.2	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 105 formula percentile(mortality_count) − percentile(publications_5y) activity 581 burdenPercentile 0 activityPercentile 14.8 ranking row 2606302
23	=	Malignant Nasopharyngeal Neoplasm	-18.5	18.5	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 199 formula percentile(mortality_count) − percentile(publications_5y) activity 952 burdenPercentile 3.7 activityPercentile 22.2 ranking row 2606303
24	▲4	Malignant Bladder Neoplasm	-18.5	14.8	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 4644 formula percentile(mortality_count) − percentile(publications_5y) activity 18250 burdenPercentile 51.9 activityPercentile 70.4 ranking row 2606304
25	▲4	Hodgkin Lymphoma	-25.9	11.1	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 407 formula percentile(mortality_count) − percentile(publications_5y) activity 2178 burdenPercentile 11.1 activityPercentile 37 ranking row 2606305
26	▲8	Malignant Thyroid Gland Neoplasm	-29.7	7.4	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 1154 formula percentile(mortality_count) − percentile(publications_5y) activity 13792 burdenPercentile 29.6 activityPercentile 59.3 ranking row 2606306
27	▲6	Malignant Cervical Neoplasm	-37.1	3.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 4366 formula percentile(mortality_count) − percentile(publications_5y) activity 26673 burdenPercentile 48.1 activityPercentile 85.2 ranking row 2606307
28	▲7	Malignant Gastric Neoplasm	-48.2	0	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 4302 formula percentile(mortality_count) − percentile(publications_5y) activity 34783 burdenPercentile 44.4 activityPercentile 92.6 ranking row 2606308

Data updated 16 hours agoSource updated unknown28 eligible entities · inputs hash 0ad367faf3570a439dc69167

Methodology

How this table was built

Formula: percentile(mortality_count) − percentile(publications_5y)
Version: ci-research-gap-v1
Scope: USA · Female · all ages · 2021 · top-level cancers
Scope key: geo=USA|sex=female|age=all|year=2021|level=top
Eligible entities: 28
Generated: Sep 29, 2026, 06:30 AM UTC
Inputs hash: 0ad367faf3570a439dc69167
Sources: U.S. Cancer Statistics (USCS) — NPCR/SEER incidence and NVSS mortality pubmed cdc-wonder seer iarc-globocan
Aggregation: none

Eligibility

requires: mortality_count
publications_5y
entityLevel: top

Full methodology · ties share a rank (1, 2, 2, 4) · previous rank refers to the last snapshot of the same scope.

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