Ranking · Unmet Need

Research Gap Index

Burden percentile minus research-activity percentile (publications, last 5 years) within the same scope. Positive values flag cancers with high mortality burden but comparatively little literature. Caveat (Phase 1): literature counts are query-based per entity (query stored on each row); they are not aggregated over descendants.

Computedci-research-gap-v1unit: percentile pointshigher = worseAll metrics

Rank	Δ	Cancer	Research Gap Index (percentile points)	Percentile	Confidence	Sources	Why #n?
1	=	Malignant Central Nervous System Neoplasm	+70.4	100	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 5755 formula percentile(mortality_count) − percentile(publications_5y) activity 298 burdenPercentile 74.1 activityPercentile 3.7 ranking row 2594756
2	=	Malignant Uterine Corpus Neoplasm	+44.4	96.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3272 formula percentile(mortality_count) − percentile(publications_5y) activity 105 burdenPercentile 44.4 activityPercentile 0 ranking row 2594757
3	=	Multiple Myeloma	+18.6	92.6	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 5106 formula percentile(mortality_count) − percentile(publications_5y) activity 10244 burdenPercentile 66.7 activityPercentile 48.1 ranking row 2594758
4	=	Malignant Kidney Neoplasm	+18.6	88.9	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 4673 formula percentile(mortality_count) − percentile(publications_5y) activity 3700 burdenPercentile 59.3 activityPercentile 40.7 ranking row 2594759
5	=	Malignant Colon Neoplasm	+18.5	85.2	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 22914 formula percentile(mortality_count) − percentile(publications_5y) activity 18406 burdenPercentile 92.6 activityPercentile 74.1 ranking row 2594761
5	=	Non-Hodgkin Lymphoma	+18.5	85.2	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 9882 formula percentile(mortality_count) − percentile(publications_5y) activity 17190 burdenPercentile 81.5 activityPercentile 63 ranking row 2594760
7	=	Malignant Pancreatic Neoplasm	+11.1	77.8	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 15995 formula percentile(mortality_count) − percentile(publications_5y) activity 25767 burdenPercentile 88.9 activityPercentile 77.8 ranking row 2594762
8	=	Malignant Vulvar Neoplasm	+11.1	74.1	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 806 formula percentile(mortality_count) − percentile(publications_5y) activity 870 burdenPercentile 29.6 activityPercentile 18.5 ranking row 2594763
9	=	Malignant Vaginal Neoplasm	+7.4	70.4	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 416 formula percentile(mortality_count) − percentile(publications_5y) activity 373 burdenPercentile 14.8 activityPercentile 7.4 ranking row 2594764
10	=	Malignant Liver Neoplasm	+3.7	66.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 5489 formula percentile(mortality_count) − percentile(publications_5y) activity 17939 burdenPercentile 70.4 activityPercentile 66.7 ranking row 2594766
10	=	Malignant Lung Neoplasm	+3.7	66.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 68431 formula percentile(mortality_count) − percentile(publications_5y) activity 93034 burdenPercentile 100 activityPercentile 96.3 ranking row 2594765
10	=	Malignant Ovarian Neoplasm	+3.7	66.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 14716 formula percentile(mortality_count) − percentile(publications_5y) activity 25793 burdenPercentile 85.2 activityPercentile 81.5 ranking row 2594767
13	=	Malignant Salivary Gland Neoplasm	-3.7	55.6	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 234 formula percentile(mortality_count) − percentile(publications_5y) activity 474 burdenPercentile 7.4 activityPercentile 11.1 ranking row 2594768
14	=	Malignant Breast Neoplasm	-3.7	51.9	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 40954 formula percentile(mortality_count) − percentile(publications_5y) activity 133010 burdenPercentile 96.3 activityPercentile 100 ranking row 2594769
14	=	Malignant Laryngeal Neoplasm	-3.7	51.9	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 733 formula percentile(mortality_count) − percentile(publications_5y) activity 2031 burdenPercentile 25.9 activityPercentile 29.6 ranking row 2594770
16	=	Cutaneous Melanoma	-7.4	44.4	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 2827 formula percentile(mortality_count) − percentile(publications_5y) activity 4407 burdenPercentile 37 activityPercentile 44.4 ranking row 2594771
17	=	Malignant Rectal Neoplasm	-7.5	40.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3785 formula percentile(mortality_count) − percentile(publications_5y) activity 12506 burdenPercentile 48.1 activityPercentile 55.6 ranking row 2594772
18	=	Leukemia	-11.1	37	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 9421 formula percentile(mortality_count) − percentile(publications_5y) activity 31893 burdenPercentile 77.8 activityPercentile 88.9 ranking row 2594773
19	=	Malignant Esophageal Neoplasm	-11.2	33.3	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 2942 formula percentile(mortality_count) − percentile(publications_5y) activity 10921 burdenPercentile 40.7 activityPercentile 51.9 ranking row 2594774
20	=	Malignant Mesothelioma	-14.8	29.6	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 494 formula percentile(mortality_count) − percentile(publications_5y) activity 2145 burdenPercentile 18.5 activityPercentile 33.3 ranking row 2594775
21	=	Malignant Anal Neoplasm	-14.8	25.9	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 349 formula percentile(mortality_count) − percentile(publications_5y) activity 1291 burdenPercentile 11.1 activityPercentile 25.9 ranking row 2594776
22	=	Hodgkin Lymphoma	-14.8	22.2	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 546 formula percentile(mortality_count) − percentile(publications_5y) activity 2178 burdenPercentile 22.2 activityPercentile 37 ranking row 2594777
22	=	Malignant Hypopharyngeal Neoplasm	-14.8	22.2	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 70 formula percentile(mortality_count) − percentile(publications_5y) activity 581 burdenPercentile 0 activityPercentile 14.8 ranking row 2594778
24	=	Malignant Bladder Neoplasm	-14.8	14.8	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 4035 formula percentile(mortality_count) − percentile(publications_5y) activity 18250 burdenPercentile 55.6 activityPercentile 70.4 ranking row 2594779
25	=	Malignant Nasopharyngeal Neoplasm	-18.5	11.1	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 205 formula percentile(mortality_count) − percentile(publications_5y) activity 952 burdenPercentile 3.7 activityPercentile 22.2 ranking row 2594780
26	=	Malignant Thyroid Gland Neoplasm	-26	7.4	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 816 formula percentile(mortality_count) − percentile(publications_5y) activity 13792 burdenPercentile 33.3 activityPercentile 59.3 ranking row 2594781
27	=	Malignant Gastric Neoplasm	-29.6	3.7	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 4901 formula percentile(mortality_count) − percentile(publications_5y) activity 34783 burdenPercentile 63 activityPercentile 92.6 ranking row 2594782
28	=	Malignant Cervical Neoplasm	-33.3	0	Medium confidence	cdc-uscs pubmed cdc-wonder seer iarc-globocan	inputs deaths 3850 formula percentile(mortality_count) − percentile(publications_5y) activity 26673 burdenPercentile 51.9 activityPercentile 85.2 ranking row 2594783

Data updated 16 hours agoSource updated unknown28 eligible entities · inputs hash 6276985148f791cd89607dcd

Methodology

How this table was built

Formula: percentile(mortality_count) − percentile(publications_5y)
Version: ci-research-gap-v1
Scope: USA · Female · all ages · 2004 · top-level cancers
Scope key: geo=USA|sex=female|age=all|year=2004|level=top
Eligible entities: 28
Generated: Sep 29, 2026, 06:30 AM UTC
Inputs hash: 6276985148f791cd89607dcd
Sources: U.S. Cancer Statistics (USCS) — NPCR/SEER incidence and NVSS mortality pubmed cdc-wonder seer iarc-globocan
Aggregation: none

Eligibility

requires: mortality_count
publications_5y
entityLevel: top

Full methodology · ties share a rank (1, 2, 2, 4) · previous rank refers to the last snapshot of the same scope.

Download CSV (with attribution)

Burden and lethality metrics depend on registry definitions (site groups, standard population, estimate type). Compare only within one table.