Malignant Male Reproductive System Neoplasm

Malignant Male Reproductive System Neoplasm — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

28 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Count Me In (CMI): The Metastatic Prostate Cancer (MPC) Project CMI-MPCCMI

60 cases with simple somatic mutation data · 63 cases total · Data Release 46.0 · mapped to Malignant Prostate Neoplasm CURATED_BROADER

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Metastatic castration-sensitive prostate cancer (MSK, Clin Cancer Res 2020) prad_mcspc_mskcc_2020MSK

424 cases with simple somatic mutation data · 424 cases total · 2026-04-07 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	129	424	30.4%	cbioportal
2	SPOP	Ssm	53	424	12.5%	cbioportal
3	FOXA1	Ssm	50	424	11.8%	cbioportal
4	PTEN	Ssm	46	424	10.8%	cbioportal
5	APC	Ssm	36	424	8.5%	cbioportal
6	KMT2C	Ssm	34	424	8%	cbioportal
7	KMT2D	Ssm	30	424	7.1%	cbioportal
8	ZFHX3	Ssm	25	387	6.5%	cbioportal
10	CDK12	Ssm	24	424	5.7%	cbioportal
11	PIK3CA	Ssm	24	424	5.7%	cbioportal
9	ATM	Ssm	24	424	5.7%	cbioportal
12	CTNNB1	Ssm	23	424	5.4%	cbioportal
13	BRCA2	Ssm	19	424	4.5%	cbioportal
15	MGA	Ssm	14	387	3.6%	cbioportal
14	SPEN	Ssm	15	424	3.5%	cbioportal
16	NCOR1	Ssm	13	424	3.1%	cbioportal
57	TP53BP1	Ssm	7	233	3%	cbioportal
18	CREBBP	Ssm	12	424	2.8%	cbioportal
17	BRAF	Ssm	12	424	2.8%	cbioportal
19	JAK1	Ssm	12	424	2.8%	cbioportal
21	GRIN2A	Ssm	11	424	2.6%	cbioportal
22	PTPRT	Ssm	11	424	2.6%	cbioportal
20	FAT1	Ssm	11	424	2.6%	cbioportal
28	NF1	Ssm	10	424	2.4%	cbioportal
29	NOTCH1	Ssm	10	424	2.4%	cbioportal
27	KMT2A	Ssm	10	424	2.4%	cbioportal
26	ASXL2	Ssm	10	424	2.4%	cbioportal
25	ASXL1	Ssm	10	424	2.4%	cbioportal
24	ARID1B	Ssm	10	424	2.4%	cbioportal
23	ARID1A	Ssm	10	424	2.4%	cbioportal

Data updated 22 days agoSource updated 2026-04-07

Metastatic Prostate Adenocarcinoma (MCTP, Nature 2012) prad_michMCTP

61 cases with simple somatic mutation data · 121 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	25	61	41%	cbioportal
3	ZFHX3	Ssm	8	61	13.1%	cbioportal
2	TTN	Ssm	8	61	13.1%	cbioportal
4	ABCA13	Ssm	7	61	11.5%	cbioportal
5	RYR3	Ssm	7	61	11.5%	cbioportal
7	DNAH11	Ssm	6	61	9.8%	cbioportal
6	APC	Ssm	6	61	9.8%	cbioportal
8	KMT2D	Ssm	6	61	9.8%	cbioportal
9	MUC16	Ssm	6	61	9.8%	cbioportal
10	PTEN	Ssm	6	61	9.8%	cbioportal
11	RB1	Ssm	6	61	9.8%	cbioportal
14	USH2A	Ssm	5	61	8.2%	cbioportal
12	AR	Ssm	5	61	8.2%	cbioportal
13	CSMD1	Ssm	5	61	8.2%	cbioportal
20	FAT4	Ssm	4	61	6.6%	cbioportal
25	LPAR1	Ssm	4	61	6.6%	cbioportal
24	JARID2	Ssm	4	61	6.6%	cbioportal
37	ZNF646	Ssm	4	61	6.6%	cbioportal
30	RYR1	Ssm	4	61	6.6%	cbioportal
29	PLEC	Ssm	4	61	6.6%	cbioportal
28	NEB	Ssm	4	61	6.6%	cbioportal
27	NAALADL2	Ssm	4	61	6.6%	cbioportal
23	HSPG2	Ssm	4	61	6.6%	cbioportal
22	GRIA1	Ssm	4	61	6.6%	cbioportal
16	ATM	Ssm	4	61	6.6%	cbioportal
17	CDC42EP1	Ssm	4	61	6.6%	cbioportal
18	COL6A3	Ssm	4	61	6.6%	cbioportal
19	DGKB	Ssm	4	61	6.6%	cbioportal
21	FREM2	Ssm	4	61	6.6%	cbioportal
26	MAGI3	Ssm	4	61	6.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Metastatic Prostate Adenocarcinoma (SU2C/PCF Dream Team, PNAS 2019) prad_su2c_2019SU2C/PCF Dream Team

444 cases with simple somatic mutation data · 444 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	163	444	36.7%	cbioportal
2	TTN	Ssm	88	444	19.8%	cbioportal
3	MUC16	Ssm	67	444	15.1%	cbioportal
4	AR	Ssm	61	444	13.7%	cbioportal
5	SYNE1	Ssm	49	444	11%	cbioportal
6	CSMD3	Ssm	43	444	9.7%	cbioportal
7	FOXA1	Ssm	41	444	9.2%	cbioportal
8	KMT2C	Ssm	40	444	9%	cbioportal
9	BRCA2	Ssm	37	444	8.3%	cbioportal
10	KMT2D	Ssm	37	444	8.3%	cbioportal
11	AHNAK2	Ssm	35	444	7.9%	cbioportal
12	HMCN1	Ssm	32	444	7.2%	cbioportal
13	APC	Ssm	31	444	7%	cbioportal
14	USH2A	Ssm	31	444	7%	cbioportal
16	OBSCN	Ssm	29	444	6.5%	cbioportal
15	CACNA1E	Ssm	29	444	6.5%	cbioportal
17	LRP1B	Ssm	28	444	6.3%	cbioportal
19	PTEN	Ssm	28	444	6.3%	cbioportal
20	RYR1	Ssm	28	444	6.3%	cbioportal
18	PLEC	Ssm	28	444	6.3%	cbioportal
21	ATM	Ssm	27	444	6.1%	cbioportal
23	FAT3	Ssm	27	444	6.1%	cbioportal
22	DCHS2	Ssm	27	444	6.1%	cbioportal
25	MUC4	Ssm	26	444	5.9%	cbioportal
26	RYR3	Ssm	26	444	5.9%	cbioportal
24	CDK12	Ssm	26	444	5.9%	cbioportal
29	RYR2	Ssm	25	444	5.6%	cbioportal
30	SPOP	Ssm	25	444	5.6%	cbioportal
27	ABCA13	Ssm	25	444	5.6%	cbioportal
28	MACF1	Ssm	25	444	5.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Metastatic Prostate Cancer (SU2C/PCF Dream Team, Cell 2015) prad_su2c_2015SU2C/PCF Dream Team

150 cases with simple somatic mutation data · 150 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4	Ssm	60	150	40%	cbioportal
2	TP53	Ssm	58	150	38.7%	cbioportal
3	TTN	Ssm	41	150	27.3%	cbioportal
4	MUC16	Ssm	35	150	23.3%	cbioportal
5	AR	Ssm	27	150	18%	cbioportal
6	KMT2C	Ssm	23	150	15.3%	cbioportal
7	SYNE1	Ssm	21	150	14%	cbioportal
8	KMT2D	Ssm	18	150	12%	cbioportal
9	FOXA1	Ssm	16	150	10.7%	cbioportal
10	MUC2	Ssm	15	150	10%	cbioportal
14	USH2A	Ssm	14	150	9.3%	cbioportal
11	CSMD3	Ssm	14	150	9.3%	cbioportal
13	PIEZO1	Ssm	14	150	9.3%	cbioportal
12	FAT4	Ssm	14	150	9.3%	cbioportal
16	PLEC	Ssm	13	150	8.7%	cbioportal
15	CSMD1	Ssm	13	150	8.7%	cbioportal
17	APC	Ssm	12	150	8%	cbioportal
18	LRP1B	Ssm	12	150	8%	cbioportal
19	SPOP	Ssm	12	150	8%	cbioportal
23	DNAH3	Ssm	11	150	7.3%	cbioportal
24	HMCN1	Ssm	11	150	7.3%	cbioportal
22	DCHS2	Ssm	11	150	7.3%	cbioportal
21	CNTNAP5	Ssm	11	150	7.3%	cbioportal
25	MUC5B	Ssm	11	150	7.3%	cbioportal
26	OBSCN	Ssm	11	150	7.3%	cbioportal
27	PKHD1L1	Ssm	11	150	7.3%	cbioportal
28	PREX2	Ssm	11	150	7.3%	cbioportal
29	PTEN	Ssm	11	150	7.3%	cbioportal
30	RYR1	Ssm	11	150	7.3%	cbioportal
31	RYR3	Ssm	11	150	7.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Neuroendocrine Prostate Cancer (Multi-Institute, Nat Med 2016) nepc_wcm_2016Multi-Institute

114 cases with simple somatic mutation data · 114 cases total · 2026-01-08 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	27	114	23.7%	cbioportal
2	TTN	Ssm	21	114	18.4%	cbioportal
3	SPOP	Ssm	13	114	11.4%	cbioportal
4	MUC16	Ssm	11	114	9.6%	cbioportal
5	OBSCN	Ssm	10	114	8.8%	cbioportal
10	ZNF208	Ssm	9	114	7.9%	cbioportal
7	HMCN1	Ssm	9	114	7.9%	cbioportal
8	SHANK1	Ssm	9	114	7.9%	cbioportal
9	TMC8	Ssm	9	114	7.9%	cbioportal
11	ZNF626	Ssm	9	114	7.9%	cbioportal
12	ZNF729	Ssm	9	114	7.9%	cbioportal
6	FOXA1	Ssm	9	114	7.9%	cbioportal
20	RB1	Ssm	8	114	7%	cbioportal
13	CPD	Ssm	8	114	7%	cbioportal
21	ZNFX1	Ssm	8	114	7%	cbioportal
16	FSIP2	Ssm	8	114	7%	cbioportal
15	DYNC1H1	Ssm	8	114	7%	cbioportal
17	KMO	Ssm	8	114	7%	cbioportal
18	LTBP1	Ssm	8	114	7%	cbioportal
14	DNAH3	Ssm	8	114	7%	cbioportal
19	METTL24	Ssm	8	114	7%	cbioportal
29	PIWIL2	Ssm	7	114	6.1%	cbioportal
22	ADRM1	Ssm	7	114	6.1%	cbioportal
23	CHRNA3	Ssm	7	114	6.1%	cbioportal
24	COL14A1	Ssm	7	114	6.1%	cbioportal
25	CSMD3	Ssm	7	114	6.1%	cbioportal
26	NBPF3	Ssm	7	114	6.1%	cbioportal
27	NR2E1	Ssm	7	114	6.1%	cbioportal
28	OR9A4	Ssm	7	114	6.1%	cbioportal
30	SLC44A5	Ssm	7	114	6.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-08

Prostate Adenocarcinoma TCGA-PRADTCGA

500 cases with simple somatic mutation data · 500 cases total · Data Release 46.0 · mapped to Prostate Adenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	CCAR2	Ssm	298	500	59.6%	gdc
2	XPO7	Ssm	297	500	59.4%	gdc
4	C8orf58	Ssm	297	500	59.4%	gdc
3	BIN3	Ssm	297	500	59.4%	gdc
9	PPP3CC	Ssm	296	500	59.2%	gdc
8	BMP1	Ssm	296	500	59.2%	gdc
7	PIWIL2	Ssm	296	500	59.2%	gdc
6	RHOBTB2	Ssm	296	500	59.2%	gdc
5	SORBS3	Ssm	296	500	59.2%	gdc
12	PEBP4	Ssm	296	500	59.2%	gdc
11	AC037459.1	Ssm	296	500	59.2%	gdc
10	TNFRSF10C	Ssm	296	500	59.2%	gdc
18	DOK2	Ssm	295	500	59%	gdc
23	TNFRSF10A	Ssm	295	500	59%	gdc
22	PDLIM2	Ssm	295	500	59%	gdc
21	FAM160B2	Ssm	295	500	59%	gdc
20	TNFRSF10D	Ssm	295	500	59%	gdc
19	POLR3D	Ssm	295	500	59%	gdc
14	AC107959.5	Ssm	295	500	59%	gdc
17	DMTN	Ssm	295	500	59%	gdc
16	REEP4	Ssm	295	500	59%	gdc
15	EGR3	Ssm	295	500	59%	gdc
13	HR	Ssm	295	500	59%	gdc
26	NKX3-1	Ssm	294	500	58.8%	gdc
25	TNFRSF10B	Ssm	294	500	58.8%	gdc
24	CHMP7	Ssm	294	500	58.8%	gdc
30	SLC25A37	Ssm	294	500	58.8%	gdc
29	R3HCC1	Ssm	294	500	58.8%	gdc
28	NPM2	Ssm	294	500	58.8%	gdc
27	LGI3	Ssm	294	500	58.8%	gdc

Data updated 23 days agoSource updated Data Release 46.0

Prostate Adenocarcinoma (Broad/Cornell, Cell 2013) prad_broad_2013Broad/Cornell

57 cases with simple somatic mutation data · 82 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4	Ssm	7	57	12.3%	cbioportal
4	TP53	Ssm	6	57	10.5%	cbioportal
2	ATM	Ssm	6	57	10.5%	cbioportal
3	MUC16	Ssm	6	57	10.5%	cbioportal
6	KMT2C	Ssm	5	57	8.8%	cbioportal
5	FOXA1	Ssm	5	57	8.8%	cbioportal
7	MACF1	Ssm	5	57	8.8%	cbioportal
13	ZAN	Ssm	4	57	7%	cbioportal
9	FLG	Ssm	4	57	7%	cbioportal
10	PLCB3	Ssm	4	57	7%	cbioportal
11	SPOP	Ssm	4	57	7%	cbioportal
12	TTN	Ssm	4	57	7%	cbioportal
8	BRINP2	Ssm	4	57	7%	cbioportal
32	POTEF	Ssm	3	57	5.3%	cbioportal
26	FASN	Ssm	3	57	5.3%	cbioportal
25	DYNC2I1	Ssm	3	57	5.3%	cbioportal
24	DMD	Ssm	3	57	5.3%	cbioportal
23	CSMD3	Ssm	3	57	5.3%	cbioportal
22	CS	Ssm	3	57	5.3%	cbioportal
21	CREB3L4	Ssm	3	57	5.3%	cbioportal
20	CLIC6	Ssm	3	57	5.3%	cbioportal
19	CD8B	Ssm	3	57	5.3%	cbioportal
14	ABCC9	Ssm	3	57	5.3%	cbioportal
15	ANK2	Ssm	3	57	5.3%	cbioportal
18	C10ORF90	Ssm	3	57	5.3%	cbioportal
16	APC	Ssm	3	57	5.3%	cbioportal
36	TNXB	Ssm	3	57	5.3%	cbioportal
35	SUZ12	Ssm	3	57	5.3%	cbioportal
34	SIPA1L1	Ssm	3	57	5.3%	cbioportal
33	PRDM9	Ssm	3	57	5.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (Broad/Cornell, Nat Genet 2012) prad_broadBroad/Cornell

112 cases with simple somatic mutation data · 123 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPOP	Ssm	14	112	12.5%	cbioportal
2	TTN	Ssm	11	112	9.8%	cbioportal
4	TP53	Ssm	7	112	6.3%	cbioportal
3	THSD7B	Ssm	7	112	6.3%	cbioportal
9	SPTA1	Ssm	6	112	5.4%	cbioportal
5	FAT4	Ssm	6	112	5.4%	cbioportal
6	HMCN1	Ssm	6	112	5.4%	cbioportal
7	MED12	Ssm	6	112	5.4%	cbioportal
8	SCN11A	Ssm	6	112	5.4%	cbioportal
13	MDN1	Ssm	5	112	4.5%	cbioportal
12	FLG	Ssm	5	112	4.5%	cbioportal
11	FAT1	Ssm	5	112	4.5%	cbioportal
10	ABCA13	Ssm	5	112	4.5%	cbioportal
14	NBAS	Ssm	5	112	4.5%	cbioportal
15	OBSCN	Ssm	5	112	4.5%	cbioportal
16	PTEN	Ssm	5	112	4.5%	cbioportal
17	SYNE3	Ssm	5	112	4.5%	cbioportal
28	LRP1B	Ssm	4	112	3.6%	cbioportal
27	ITPR1	Ssm	4	112	3.6%	cbioportal
26	FRAS1	Ssm	4	112	3.6%	cbioportal
30	MYO18B	Ssm	4	112	3.6%	cbioportal
29	MUC16	Ssm	4	112	3.6%	cbioportal
25	FOXA1	Ssm	4	112	3.6%	cbioportal
24	FNDC1	Ssm	4	112	3.6%	cbioportal
23	FMN2	Ssm	4	112	3.6%	cbioportal
22	DISP3	Ssm	4	112	3.6%	cbioportal
18	CACNA1E	Ssm	4	112	3.6%	cbioportal
19	CD1A	Ssm	4	112	3.6%	cbioportal
20	CTNNA2	Ssm	4	112	3.6%	cbioportal
21	CUX1	Ssm	4	112	3.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (CPC-GENE, Nature 2017) prad_cpcg_2017CPC-GENE

477 cases with simple somatic mutation data · 477 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPOP	Ssm	38	477	8%	cbioportal
2	TTN	Ssm	21	477	4.4%	cbioportal
3	TP53	Ssm	16	477	3.4%	cbioportal
4	MUC16	Ssm	12	477	2.5%	cbioportal
6	MED12	Ssm	11	477	2.3%	cbioportal
5	FOXA1	Ssm	11	477	2.3%	cbioportal
7	C6	Ssm	9	477	1.9%	cbioportal
10	RYR2	Ssm	9	477	1.9%	cbioportal
9	QRICH2	Ssm	9	477	1.9%	cbioportal
8	PRB4	Ssm	9	477	1.9%	cbioportal
12	KMT2C	Ssm	8	477	1.7%	cbioportal
11	ATM	Ssm	8	477	1.7%	cbioportal
15	TPTE	Ssm	7	477	1.5%	cbioportal
14	SYNE1	Ssm	7	477	1.5%	cbioportal
13	PCDH15	Ssm	7	477	1.5%	cbioportal
21	SPTA1	Ssm	6	477	1.3%	cbioportal
18	C9	Ssm	6	477	1.3%	cbioportal
17	AHNAK2	Ssm	6	477	1.3%	cbioportal
16	ADAMTS20	Ssm	6	477	1.3%	cbioportal
19	CSMD3	Ssm	6	477	1.3%	cbioportal
20	FAT3	Ssm	6	477	1.3%	cbioportal
22	ANK2	Ssm	5	477	1%	cbioportal
23	C3	Ssm	5	477	1%	cbioportal
24	C7	Ssm	5	477	1%	cbioportal
25	CFAP65	Ssm	5	477	1%	cbioportal
26	CNTNAP5	Ssm	5	477	1%	cbioportal
27	COL11A1	Ssm	5	477	1%	cbioportal
28	DCAF4L2	Ssm	5	477	1%	cbioportal
29	FAT1	Ssm	5	477	1%	cbioportal
30	FNDC1	Ssm	5	477	1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (Fred Hutchinson CRC, Nat Med 2016) prad_fhcrcFred Hutchinson CRC

141 cases with simple somatic mutation data · 176 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	57	141	40.4%	cbioportal
5	TTN	Ssm	18	141	12.8%	cbioportal
2	CSMD3	Ssm	18	141	12.8%	cbioportal
4	RNF213	Ssm	18	141	12.8%	cbioportal
3	MUC16	Ssm	18	141	12.8%	cbioportal
6	DCHS2	Ssm	17	141	12.1%	cbioportal
7	OBSCN	Ssm	17	141	12.1%	cbioportal
8	ATM	Ssm	16	141	11.3%	cbioportal
11	RYR2	Ssm	16	141	11.3%	cbioportal
10	LRP1B	Ssm	16	141	11.3%	cbioportal
9	HERC2	Ssm	16	141	11.3%	cbioportal
13	DNAH6	Ssm	15	141	10.6%	cbioportal
12	CDH11	Ssm	15	141	10.6%	cbioportal
15	ZFHX3	Ssm	15	141	10.6%	cbioportal
14	TICRR	Ssm	15	141	10.6%	cbioportal
19	PCDHA6	Ssm	14	141	9.9%	cbioportal
18	KMT2D	Ssm	14	141	9.9%	cbioportal
17	CENPF	Ssm	14	141	9.9%	cbioportal
16	ABCA13	Ssm	14	141	9.9%	cbioportal
21	SPTA1	Ssm	14	141	9.9%	cbioportal
20	PLCG1	Ssm	14	141	9.9%	cbioportal
24	LRRK2	Ssm	13	141	9.2%	cbioportal
22	DNAH1	Ssm	13	141	9.2%	cbioportal
26	SYNE1	Ssm	13	141	9.2%	cbioportal
25	SKIC3	Ssm	13	141	9.2%	cbioportal
23	HECTD1	Ssm	13	141	9.2%	cbioportal
28	C7	Ssm	12	141	8.5%	cbioportal
30	DYNC2H1	Ssm	12	141	8.5%	cbioportal
29	CDH12	Ssm	12	141	8.5%	cbioportal
27	APOBEC3G	Ssm	12	141	8.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (MSK, 2025) prad_msk_2025MSK

120 cases with simple somatic mutation data · 120 cases total · 2026-03-04 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	31	120	25.8%	cbioportal
2	BRCA2	Ssm	22	120	18.3%	cbioportal
3	ZFHX3	Ssm	15	116	12.9%	cbioportal
4	FOXA1	Ssm	14	120	11.7%	cbioportal
5	KMT2C	Ssm	14	120	11.7%	cbioportal
6	CDK12	Ssm	12	120	10%	cbioportal
7	ATM	Ssm	10	120	8.3%	cbioportal
8	KMT2D	Ssm	9	120	7.5%	cbioportal
9	SPOP	Ssm	9	120	7.5%	cbioportal
10	SPEN	Ssm	8	120	6.7%	cbioportal
14	MGA	Ssm	7	116	6%	cbioportal
12	AR	Ssm	7	120	5.8%	cbioportal
11	APC	Ssm	7	120	5.8%	cbioportal
13	BRCA1	Ssm	7	120	5.8%	cbioportal
27	TP53BP1	Ssm	5	90	5.6%	cbioportal
20	PTPRD	Ssm	6	120	5%	cbioportal
15	CTNNB1	Ssm	6	120	5%	cbioportal
16	KMT2A	Ssm	6	120	5%	cbioportal
17	NCOR1	Ssm	6	120	5%	cbioportal
18	PTCH1	Ssm	6	120	5%	cbioportal
19	PTEN	Ssm	6	120	5%	cbioportal
184	GNB1	Ssm	1	22	4.5%	cbioportal
150	ARHGAP35	Ssm	1	22	4.5%	cbioportal
31	CARM1	Ssm	4	90	4.4%	cbioportal
35	ERF	Ssm	4	90	4.4%	cbioportal
21	ANKRD11	Ssm	5	116	4.3%	cbioportal
24	NOTCH2	Ssm	5	120	4.2%	cbioportal
23	MED12	Ssm	5	120	4.2%	cbioportal
26	SMARCA4	Ssm	5	120	4.2%	cbioportal
22	KDM6A	Ssm	5	120	4.2%	cbioportal

Data updated 22 days agoSource updated 2026-03-04

Prostate Adenocarcinoma (MSK, Cancer Cell 2010) prad_mskccMSK

182 cases with simple somatic mutation data · 240 cases total · 2026-02-19 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
66	ROS1	Ssm	2	9	22.2%	cbioportal
69	STAT5B	Ssm	2	9	22.2%	cbioportal
80	EGF	Ssm	1	9	11.1%	cbioportal
115	RAC3	Ssm	1	9	11.1%	cbioportal
119	SRC	Ssm	1	9	11.1%	cbioportal
120	STAT1	Ssm	1	9	11.1%	cbioportal
121	TYK2	Ssm	1	9	11.1%	cbioportal
111	PTK2	Ssm	1	9	11.1%	cbioportal
92	JAK2	Ssm	1	9	11.1%	cbioportal
107	PDGFRB	Ssm	1	9	11.1%	cbioportal
106	NSD1	Ssm	1	9	11.1%	cbioportal
103	MUTYH	Ssm	1	9	11.1%	cbioportal
100	MAPK7	Ssm	1	9	11.1%	cbioportal
97	LCK	Ssm	1	9	11.1%	cbioportal
90	IDH2	Ssm	1	9	11.1%	cbioportal
89	FGF1	Ssm	1	9	11.1%	cbioportal
88	FES	Ssm	1	9	11.1%	cbioportal
85	ETS2	Ssm	1	9	11.1%	cbioportal
81	ELK1	Ssm	1	9	11.1%	cbioportal
110	PRKCZ	Ssm	1	9	11.1%	cbioportal
114	PTPN6	Ssm	1	9	11.1%	cbioportal
78	CASP9	Ssm	1	9	11.1%	cbioportal
75	BLK	Ssm	1	9	11.1%	cbioportal
1	PTPRF	Ssm	9	106	8.5%	cbioportal
2	EP300	Ssm	7	106	6.6%	cbioportal
4	FLT4	Ssm	6	106	5.7%	cbioportal
3	AR	Ssm	6	106	5.7%	cbioportal
11	PTPN14	Ssm	5	106	4.7%	cbioportal
6	AXL	Ssm	5	106	4.7%	cbioportal
7	EPS15	Ssm	5	106	4.7%	cbioportal

Data updated 22 days agoSource updated 2026-02-19

Prostate Adenocarcinoma (MSK, Clin Cancer Res. 2022) prad_pik3r1_msk_2021MSK

1,417 cases with simple somatic mutation data · 1,417 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	411	1,417	29%	cbioportal
2	SPOP	Ssm	200	1,417	14.1%	cbioportal
3	FOXA1	Ssm	197	1,417	13.9%	cbioportal
4	APC	Ssm	124	1,417	8.8%	cbioportal
5	PTEN	Ssm	119	1,417	8.4%	cbioportal
6	KMT2C	Ssm	81	1,417	5.7%	cbioportal
8	ZFHX3	Ssm	75	1,361	5.5%	cbioportal
7	KMT2D	Ssm	76	1,417	5.4%	cbioportal
9	CDK12	Ssm	67	1,417	4.7%	cbioportal
10	CTNNB1	Ssm	61	1,417	4.3%	cbioportal
11	PIK3CA	Ssm	60	1,417	4.2%	cbioportal
12	ATM	Ssm	59	1,417	4.2%	cbioportal
13	BRCA2	Ssm	56	1,417	4%	cbioportal
14	AR	Ssm	53	1,417	3.7%	cbioportal
15	PIK3R1	Ssm	48	1,417	3.4%	cbioportal
16	KDM6A	Ssm	44	1,417	3.1%	cbioportal
17	MGA	Ssm	39	1,361	2.9%	cbioportal
18	RB1	Ssm	36	1,417	2.5%	cbioportal
19	MED12	Ssm	35	1,417	2.5%	cbioportal
20	PTPRD	Ssm	31	1,417	2.2%	cbioportal
21	GRIN2A	Ssm	28	1,417	2%	cbioportal
22	ASXL2	Ssm	27	1,417	1.9%	cbioportal
24	JAK1	Ssm	26	1,417	1.8%	cbioportal
23	EPHB1	Ssm	26	1,417	1.8%	cbioportal
25	SPEN	Ssm	26	1,417	1.8%	cbioportal
27	SF3B1	Ssm	25	1,417	1.8%	cbioportal
26	NCOR1	Ssm	25	1,417	1.8%	cbioportal
28	ARID1A	Ssm	23	1,417	1.6%	cbioportal
29	ASXL1	Ssm	22	1,417	1.6%	cbioportal
30	BRAF	Ssm	22	1,417	1.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (MSK/DFCI, Nature Genetics 2018) prad_p1000MSK/DFCI

1,013 cases with simple somatic mutation data · 1,013 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	189	1,013	18.7%	cbioportal
2	TTN	Ssm	151	1,013	14.9%	cbioportal
3	MUC16	Ssm	113	1,013	11.2%	cbioportal
4	SPOP	Ssm	92	1,013	9.1%	cbioportal
5	SYNE1	Ssm	73	1,013	7.2%	cbioportal
6	FOXA1	Ssm	69	1,013	6.8%	cbioportal
7	KMT2C	Ssm	66	1,013	6.5%	cbioportal
8	KMT2D	Ssm	65	1,013	6.4%	cbioportal
9	CSMD3	Ssm	61	1,013	6%	cbioportal
10	HMCN1	Ssm	55	1,013	5.4%	cbioportal
11	LRP1B	Ssm	54	1,013	5.3%	cbioportal
12	OBSCN	Ssm	53	1,013	5.2%	cbioportal
13	AR	Ssm	48	1,013	4.7%	cbioportal
14	SPTA1	Ssm	47	1,013	4.6%	cbioportal
15	USH2A	Ssm	46	1,013	4.5%	cbioportal
16	RYR1	Ssm	45	1,013	4.4%	cbioportal
18	RYR2	Ssm	44	1,013	4.3%	cbioportal
17	PTEN	Ssm	44	1,013	4.3%	cbioportal
19	ABCA13	Ssm	43	1,013	4.2%	cbioportal
20	FAT3	Ssm	41	1,013	4%	cbioportal
21	ZFHX3	Ssm	41	1,013	4%	cbioportal
22	DCHS2	Ssm	40	1,013	3.9%	cbioportal
23	FAT4	Ssm	39	1,013	3.8%	cbioportal
24	ATM	Ssm	38	1,013	3.8%	cbioportal
26	CSMD1	Ssm	37	1,013	3.7%	cbioportal
25	CACNA1E	Ssm	37	1,013	3.7%	cbioportal
27	DNAH3	Ssm	36	1,013	3.6%	cbioportal
29	MYO15A	Ssm	34	1,013	3.4%	cbioportal
30	XIRP2	Ssm	34	1,013	3.4%	cbioportal
28	MUC4	Ssm	34	1,013	3.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (MSK, Eur Urol 2020) prad_cdk12_mskcc_2020MSK

1,465 cases with simple somatic mutation data · 1,465 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	391	1,465	26.7%	cbioportal
2	FOXA1	Ssm	179	1,465	12.2%	cbioportal
3	SPOP	Ssm	166	1,465	11.3%	cbioportal
4	PTEN	Ssm	97	1,465	6.6%	cbioportal
5	KMT2C	Ssm	89	1,465	6.1%	cbioportal
6	CDK12	Ssm	88	1,465	6%	cbioportal
7	APC	Ssm	86	1,465	5.9%	cbioportal
8	KMT2D	Ssm	74	1,465	5.1%	cbioportal
9	AR	Ssm	56	1,465	3.8%	cbioportal
13	ZFHX3	Ssm	51	1,337	3.8%	cbioportal
10	CTNNB1	Ssm	55	1,465	3.8%	cbioportal
12	PIK3CA	Ssm	52	1,465	3.5%	cbioportal
11	ATM	Ssm	52	1,465	3.5%	cbioportal
14	BRCA2	Ssm	45	1,465	3.1%	cbioportal
15	KDM6A	Ssm	38	1,465	2.6%	cbioportal
16	GRIN2A	Ssm	36	1,465	2.5%	cbioportal
17	MED12	Ssm	31	1,465	2.1%	cbioportal
18	PTPRD	Ssm	30	1,465	2%	cbioportal
19	SPEN	Ssm	28	1,465	1.9%	cbioportal
20	RB1	Ssm	27	1,465	1.8%	cbioportal
24	MGA	Ssm	24	1,337	1.8%	cbioportal
21	BRAF	Ssm	26	1,465	1.8%	cbioportal
48	ERF	Ssm	14	809	1.7%	cbioportal
22	PIK3R1	Ssm	25	1,465	1.7%	cbioportal
23	ASXL1	Ssm	24	1,465	1.6%	cbioportal
25	NCOR1	Ssm	24	1,465	1.6%	cbioportal
27	JAK1	Ssm	23	1,465	1.6%	cbioportal
29	NF1	Ssm	23	1,465	1.6%	cbioportal
26	ARID1A	Ssm	23	1,465	1.6%	cbioportal
28	KMT2A	Ssm	23	1,465	1.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma Organoids (MSK, Cell 2014) prad_mskcc_cheny1_organoids_2014MSK

12 cases with simple somatic mutation data · 12 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	7	12	58.3%	cbioportal
2	TBP	Ssm	6	12	50%	cbioportal
3	LCE4A	Ssm	4	12	33.3%	cbioportal
16	TRIOBP	Ssm	3	12	25%	cbioportal
13	SCN5A	Ssm	3	12	25%	cbioportal
4	ABHD15	Ssm	3	12	25%	cbioportal
5	ATXN1	Ssm	3	12	25%	cbioportal
6	CRACD	Ssm	3	12	25%	cbioportal
7	FOXA1	Ssm	3	12	25%	cbioportal
8	GIT2	Ssm	3	12	25%	cbioportal
9	KIRREL1	Ssm	3	12	25%	cbioportal
10	KRT1	Ssm	3	12	25%	cbioportal
11	KRT72	Ssm	3	12	25%	cbioportal
12	NKX6-2	Ssm	3	12	25%	cbioportal
14	SPATA3	Ssm	3	12	25%	cbioportal
15	SPATA31D1	Ssm	3	12	25%	cbioportal
23	ANK2	Ssm	2	12	16.7%	cbioportal
17	A1BG	Ssm	2	12	16.7%	cbioportal
18	ACTL9	Ssm	2	12	16.7%	cbioportal
19	ADAMTS12	Ssm	2	12	16.7%	cbioportal
20	ADCY1	Ssm	2	12	16.7%	cbioportal
21	AEBP1	Ssm	2	12	16.7%	cbioportal
22	AGO3	Ssm	2	12	16.7%	cbioportal
24	ANO1	Ssm	2	12	16.7%	cbioportal
25	APOL4	Ssm	2	12	16.7%	cbioportal
26	ARGFX	Ssm	2	12	16.7%	cbioportal
27	ARID3B	Ssm	2	12	16.7%	cbioportal
28	ART5	Ssm	2	12	16.7%	cbioportal
29	ASPM	Ssm	2	12	16.7%	cbioportal
30	BLTP3B	Ssm	2	12	16.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (SMMU, Eur Urol 2017) prad_eururol_2017SMMU

65 cases with simple somatic mutation data · 65 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPOP	Ssm	11	65	16.9%	cbioportal
2	KDM6A	Ssm	5	65	7.7%	cbioportal
3	KMT2D	Ssm	4	65	6.2%	cbioportal
8	SEMA5A	Ssm	3	65	4.6%	cbioportal
7	RYR1	Ssm	3	65	4.6%	cbioportal
5	MYH2	Ssm	3	65	4.6%	cbioportal
6	PTEN	Ssm	3	65	4.6%	cbioportal
4	COL22A1	Ssm	3	65	4.6%	cbioportal
9	TP53	Ssm	3	65	4.6%	cbioportal
19	CFAP69	Ssm	2	65	3.1%	cbioportal
12	AKR1A1	Ssm	2	65	3.1%	cbioportal
11	ADCY8	Ssm	2	65	3.1%	cbioportal
10	ADAM2	Ssm	2	65	3.1%	cbioportal
26	CSF1R	Ssm	2	65	3.1%	cbioportal
14	ATM	Ssm	2	65	3.1%	cbioportal
15	BOC	Ssm	2	65	3.1%	cbioportal
16	C2	Ssm	2	65	3.1%	cbioportal
17	CAMTA1	Ssm	2	65	3.1%	cbioportal
18	CDK12	Ssm	2	65	3.1%	cbioportal
13	ALOX5	Ssm	2	65	3.1%	cbioportal
20	CHD6	Ssm	2	65	3.1%	cbioportal
21	CLCNKA	Ssm	2	65	3.1%	cbioportal
22	COL16A1	Ssm	2	65	3.1%	cbioportal
23	COL4A1	Ssm	2	65	3.1%	cbioportal
24	COL4A2	Ssm	2	65	3.1%	cbioportal
25	CPOX	Ssm	2	65	3.1%	cbioportal
27	CSMD1	Ssm	2	65	3.1%	cbioportal
28	CTNNB1	Ssm	2	65	3.1%	cbioportal
29	CUL3	Ssm	2	65	3.1%	cbioportal
30	DNAH10	Ssm	2	65	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (TCGA, Cell 2015) prad_tcga_pubTCGA

333 cases with simple somatic mutation data · 333 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	SPOP	Ssm	37	333	11.1%	cbioportal
2	TTN	Ssm	37	333	11.1%	cbioportal
3	TP53	Ssm	23	333	6.9%	cbioportal
4	MUC16	Ssm	20	333	6%	cbioportal
5	MUC17	Ssm	17	333	5.1%	cbioportal
6	SPTA1	Ssm	15	333	4.5%	cbioportal
7	ATM	Ssm	13	333	3.9%	cbioportal
9	KMT2C	Ssm	13	333	3.9%	cbioportal
8	FOXA1	Ssm	13	333	3.9%	cbioportal
10	AHNAK2	Ssm	12	333	3.6%	cbioportal
12	LRP1B	Ssm	12	333	3.6%	cbioportal
11	CSMD3	Ssm	12	333	3.6%	cbioportal
14	OBSCN	Ssm	11	333	3.3%	cbioportal
13	KMT2D	Ssm	11	333	3.3%	cbioportal
16	FAT3	Ssm	10	333	3%	cbioportal
18	RP1	Ssm	10	333	3%	cbioportal
17	HMCN1	Ssm	10	333	3%	cbioportal
15	AHNAK	Ssm	10	333	3%	cbioportal
22	PTEN	Ssm	9	333	2.7%	cbioportal
19	BRCA2	Ssm	9	333	2.7%	cbioportal
21	FLG2	Ssm	9	333	2.7%	cbioportal
20	DCHS2	Ssm	9	333	2.7%	cbioportal
30	PCDH18	Ssm	8	333	2.4%	cbioportal
23	ADGRB3	Ssm	8	333	2.4%	cbioportal
24	ADGRV1	Ssm	8	333	2.4%	cbioportal
25	BRAF	Ssm	8	333	2.4%	cbioportal
26	CTNNB1	Ssm	8	333	2.4%	cbioportal
27	DNAH9	Ssm	8	333	2.4%	cbioportal
28	FLG	Ssm	8	333	2.4%	cbioportal
29	MACF1	Ssm	8	333	2.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (TCGA, Firehose Legacy) prad_tcgaTCGA

499 cases with simple somatic mutation data · 501 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	FRG1BP	Ssm	97	499	19.4%	cbioportal
2	TTN	Ssm	63	499	12.6%	cbioportal
3	TP53	Ssm	61	499	12.2%	cbioportal
4	SPOP	Ssm	57	499	11.4%	cbioportal
5	MUC16	Ssm	38	499	7.6%	cbioportal
6	MUC17	Ssm	33	499	6.6%	cbioportal
7	KMT2C	Ssm	30	499	6%	cbioportal
8	KMT2D	Ssm	29	499	5.8%	cbioportal
9	FOXA1	Ssm	28	499	5.6%	cbioportal
10	NBPF1	Ssm	27	499	5.4%	cbioportal
11	SYNE1	Ssm	27	499	5.4%	cbioportal
12	SPTA1	Ssm	26	499	5.2%	cbioportal
13	KRTAP4-11	Ssm	24	499	4.8%	cbioportal
14	LRP1B	Ssm	24	499	4.8%	cbioportal
15	NBPF10	Ssm	23	499	4.6%	cbioportal
16	ATM	Ssm	22	499	4.4%	cbioportal
17	CSMD3	Ssm	22	499	4.4%	cbioportal
18	ZAN	Ssm	22	499	4.4%	cbioportal
19	CHEK2	Ssm	21	499	4.2%	cbioportal
20	MUC4	Ssm	21	499	4.2%	cbioportal
21	FAT3	Ssm	19	499	3.8%	cbioportal
22	HMCN1	Ssm	19	499	3.8%	cbioportal
23	RYR1	Ssm	19	499	3.8%	cbioportal
27	USH2A	Ssm	18	499	3.6%	cbioportal
24	CACNA1E	Ssm	18	499	3.6%	cbioportal
25	OBSCN	Ssm	18	499	3.6%	cbioportal
26	RGPD8	Ssm	18	499	3.6%	cbioportal
28	MACF1	Ssm	17	499	3.4%	cbioportal
29	PTEN	Ssm	17	499	3.4%	cbioportal
30	RYR2	Ssm	17	499	3.4%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Prostate Adenocarcinoma (TCGA GDC, 2025) prad_tcga_gdcTCGA GDC

491 cases with simple somatic mutation data · 501 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	55	491	11.2%	cbioportal
2	SPOP	Ssm	54	491	11%	cbioportal
3	TTN	Ssm	47	491	9.6%	cbioportal
4	FOXA1	Ssm	29	491	5.9%	cbioportal
5	KMT2D	Ssm	28	491	5.7%	cbioportal
6	MUC16	Ssm	26	491	5.3%	cbioportal
7	SYNE1	Ssm	22	491	4.5%	cbioportal
8	KMT2C	Ssm	21	491	4.3%	cbioportal
9	LRP1B	Ssm	20	491	4.1%	cbioportal
10	SPTA1	Ssm	20	491	4.1%	cbioportal
11	ATM	Ssm	18	491	3.7%	cbioportal
13	RYR2	Ssm	17	491	3.5%	cbioportal
12	CSMD3	Ssm	17	491	3.5%	cbioportal
14	PTEN	Ssm	16	491	3.3%	cbioportal
15	KDM6A	Ssm	15	491	3.1%	cbioportal
17	HMCN1	Ssm	14	491	2.9%	cbioportal
16	CACNA1E	Ssm	14	491	2.9%	cbioportal
18	MUC17	Ssm	14	491	2.9%	cbioportal
19	RP1	Ssm	13	491	2.6%	cbioportal
20	USH2A	Ssm	13	491	2.6%	cbioportal
22	MYO15A	Ssm	12	491	2.4%	cbioportal
21	FAT3	Ssm	12	491	2.4%	cbioportal
23	RYR1	Ssm	12	491	2.4%	cbioportal
24	ABCA13	Ssm	11	491	2.2%	cbioportal
30	ZMYM3	Ssm	11	491	2.2%	cbioportal
29	OBSCN	Ssm	11	491	2.2%	cbioportal
28	MACF1	Ssm	11	491	2.2%	cbioportal
27	CNTNAP5	Ssm	11	491	2.2%	cbioportal
26	APC	Ssm	11	491	2.2%	cbioportal
25	ADGRB3	Ssm	11	491	2.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Adenocarcinoma (TCGA, PanCancer Atlas) prad_tcga_pan_can_atlas_2018TCGA

494 cases with simple somatic mutation data · 494 cases total · 2026-06-04 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	57	494	11.5%	cbioportal
2	SPOP	Ssm	55	494	11.1%	cbioportal
3	TTN	Ssm	54	494	10.9%	cbioportal
4	MUC16	Ssm	31	494	6.3%	cbioportal
5	FOXA1	Ssm	28	494	5.7%	cbioportal
6	KMT2D	Ssm	28	494	5.7%	cbioportal
7	KMT2C	Ssm	25	494	5.1%	cbioportal
8	SPTA1	Ssm	23	494	4.7%	cbioportal
9	SYNE1	Ssm	23	494	4.7%	cbioportal
10	LRP1B	Ssm	22	494	4.5%	cbioportal
11	ATM	Ssm	20	494	4%	cbioportal
12	CSMD3	Ssm	19	494	3.8%	cbioportal
13	FAT3	Ssm	18	494	3.6%	cbioportal
14	PTEN	Ssm	18	494	3.6%	cbioportal
15	RYR2	Ssm	18	494	3.6%	cbioportal
16	HMCN1	Ssm	16	494	3.2%	cbioportal
17	OBSCN	Ssm	16	494	3.2%	cbioportal
18	CACNA1E	Ssm	15	494	3%	cbioportal
19	COL11A1	Ssm	15	494	3%	cbioportal
20	MUC17	Ssm	15	494	3%	cbioportal
21	RYR1	Ssm	15	494	3%	cbioportal
22	USH2A	Ssm	15	494	3%	cbioportal
23	MACF1	Ssm	14	494	2.8%	cbioportal
24	MYO15A	Ssm	14	494	2.8%	cbioportal
25	RP1	Ssm	13	494	2.6%	cbioportal
26	ZFHX3	Ssm	13	494	2.6%	cbioportal
27	ABCA13	Ssm	12	494	2.4%	cbioportal
28	CSMD1	Ssm	12	494	2.4%	cbioportal
29	DCHS2	Ssm	12	494	2.4%	cbioportal
30	DNAH17	Ssm	12	494	2.4%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Prostate Cancer-IDH Driver Mutant Cohort (MSK, 2024) prad_idhmut_msk_2025MSK

99 cases with simple somatic mutation data · 99 cases total · 2026-08-20 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	IDH1	Ssm	29	99	29.3%	cbioportal
2	TP53	Ssm	17	99	17.2%	cbioportal
4	SPOP	Ssm	12	99	12.1%	cbioportal
3	FOXA1	Ssm	12	99	12.1%	cbioportal
6	CTNNB1	Ssm	6	99	6.1%	cbioportal
7	PIK3CA	Ssm	6	99	6.1%	cbioportal
5	BRCA2	Ssm	6	99	6.1%	cbioportal
9	KMT2D	Ssm	5	99	5.1%	cbioportal
8	ATM	Ssm	5	99	5.1%	cbioportal
12	IDH2	Ssm	4	99	4%	cbioportal
13	PTEN	Ssm	4	99	4%	cbioportal
10	APC	Ssm	4	99	4%	cbioportal
11	CDK12	Ssm	4	99	4%	cbioportal
19	MGA	Ssm	3	96	3.1%	cbioportal
22	ZFHX3	Ssm	3	96	3.1%	cbioportal
18	KMT2A	Ssm	3	99	3%	cbioportal
21	TSC2	Ssm	3	99	3%	cbioportal
20	PTPRD	Ssm	3	99	3%	cbioportal
16	JAK1	Ssm	3	99	3%	cbioportal
15	DNMT3B	Ssm	3	99	3%	cbioportal
14	BCOR	Ssm	3	99	3%	cbioportal
17	KDM6A	Ssm	3	99	3%	cbioportal
40	NSD2	Ssm	2	89	2.2%	cbioportal
117	LRP1B	Ssm	1	45	2.2%	cbioportal
51	ACVR1B	Ssm	1	45	2.2%	cbioportal
119	MAP3K7	Ssm	1	45	2.2%	cbioportal
93	FANCL	Ssm	1	45	2.2%	cbioportal
124	MLH3	Ssm	1	45	2.2%	cbioportal
43	POLD1	Ssm	2	96	2.1%	cbioportal
45	SMARCA4	Ssm	2	99	2%	cbioportal

Data updated 22 days agoSource updated 2026-08-20

Prostate Cancer (MSK, JCO Precis Oncol 2017) prad_mskcc_2017MSK

504 cases with simple somatic mutation data · 504 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	166	504	32.9%	cbioportal
2	FOXA1	Ssm	58	504	11.5%	cbioportal
3	SPOP	Ssm	47	504	9.3%	cbioportal
4	APC	Ssm	40	504	7.9%	cbioportal
5	KMT2C	Ssm	34	504	6.7%	cbioportal
6	PTEN	Ssm	28	504	5.6%	cbioportal
7	CDK12	Ssm	27	504	5.4%	cbioportal
9	KMT2D	Ssm	25	504	5%	cbioportal
8	AR	Ssm	25	504	5%	cbioportal
10	BRCA2	Ssm	24	504	4.8%	cbioportal
11	SPEN	Ssm	21	504	4.2%	cbioportal
12	GRIN2A	Ssm	19	504	3.8%	cbioportal
13	ATM	Ssm	18	504	3.6%	cbioportal
14	CTNNB1	Ssm	17	504	3.4%	cbioportal
15	PIK3CA	Ssm	17	504	3.4%	cbioportal
16	JAK1	Ssm	15	504	3%	cbioportal
27	MGA	Ssm	10	345	2.9%	cbioportal
30	ZFHX3	Ssm	10	345	2.9%	cbioportal
17	FAT1	Ssm	14	504	2.8%	cbioportal
18	RB1	Ssm	14	504	2.8%	cbioportal
20	MED12	Ssm	12	504	2.4%	cbioportal
21	NCOR1	Ssm	12	504	2.4%	cbioportal
19	KMT2A	Ssm	12	504	2.4%	cbioportal
23	KDM6A	Ssm	11	504	2.2%	cbioportal
24	NOTCH1	Ssm	11	504	2.2%	cbioportal
25	PTPRS	Ssm	11	504	2.2%	cbioportal
22	ASXL1	Ssm	11	504	2.2%	cbioportal
29	PIK3R1	Ssm	10	504	2%	cbioportal
28	NSD1	Ssm	10	504	2%	cbioportal
26	BRAF	Ssm	10	504	2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Prostate Cancer (MSK, Science 2022) prad_organoids_msk_2022MSK

47 cases with simple somatic mutation data · 47 cases total · 2026-01-16 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	32	47	68.1%	cbioportal
5	MUC16	Ssm	7	24	29.2%	cbioportal
10	TTN	Ssm	6	24	25%	cbioportal
7	AEBP1	Ssm	6	24	25%	cbioportal
19	MACF1	Ssm	5	24	20.8%	cbioportal
18	LRP1B	Ssm	5	24	20.8%	cbioportal
11	ABHD15	Ssm	5	24	20.8%	cbioportal
14	CDH23	Ssm	5	24	20.8%	cbioportal
16	DNAH2	Ssm	5	24	20.8%	cbioportal
17	HERC1	Ssm	5	24	20.8%	cbioportal
20	MUC5B	Ssm	5	24	20.8%	cbioportal
21	OBSCN	Ssm	5	24	20.8%	cbioportal
26	TRIOBP	Ssm	5	24	20.8%	cbioportal
2	FOXA1	Ssm	8	47	17%	cbioportal
74	SYNE3	Ssm	4	24	16.7%	cbioportal
29	ANK2	Ssm	4	24	16.7%	cbioportal
28	AHNAK	Ssm	4	24	16.7%	cbioportal
71	SPATA31D1	Ssm	4	24	16.7%	cbioportal
66	RNF213	Ssm	4	24	16.7%	cbioportal
68	RYR1	Ssm	4	24	16.7%	cbioportal
69	RYR2	Ssm	4	24	16.7%	cbioportal
70	RYR3	Ssm	4	24	16.7%	cbioportal
52	MUC6	Ssm	4	24	16.7%	cbioportal
75	TRIM67	Ssm	4	24	16.7%	cbioportal
48	ITPRID1	Ssm	4	24	16.7%	cbioportal
49	KCNQ5	Ssm	4	24	16.7%	cbioportal
50	LAMA3	Ssm	4	24	16.7%	cbioportal
51	MCF2L2	Ssm	4	24	16.7%	cbioportal
53	MYO10	Ssm	4	24	16.7%	cbioportal
65	RAPGEF4	Ssm	4	24	16.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Race Differences in Prostate Cancer (MSK, 2021) prad_msk_stopsack_2021MSK

2,069 cases with simple somatic mutation data · 2,069 cases total · 2026-01-13 · mapped to Prostate Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	551	2,069	26.6%	cbioportal
2	FOXA1	Ssm	273	2,069	13.2%	cbioportal
3	SPOP	Ssm	260	2,069	12.6%	cbioportal
4	PTEN	Ssm	155	2,069	7.5%	cbioportal
5	KMT2C	Ssm	140	2,069	6.8%	cbioportal
6	APC	Ssm	138	2,069	6.7%	cbioportal
7	KMT2D	Ssm	133	2,069	6.4%	cbioportal
9	ZFHX3	Ssm	110	1,924	5.7%	cbioportal
8	CDK12	Ssm	118	2,069	5.7%	cbioportal
10	PIK3CA	Ssm	92	2,069	4.4%	cbioportal
11	ATM	Ssm	86	2,069	4.2%	cbioportal
12	AR	Ssm	80	2,069	3.9%	cbioportal
13	CTNNB1	Ssm	78	2,069	3.8%	cbioportal
14	BRCA2	Ssm	74	2,069	3.6%	cbioportal
15	SPEN	Ssm	70	2,069	3.4%	cbioportal
27	ERF	Ssm	47	1,402	3.4%	cbioportal
16	KDM6A	Ssm	69	2,069	3.3%	cbioportal
20	MGA	Ssm	61	1,924	3.2%	cbioportal
17	JAK1	Ssm	64	2,069	3.1%	cbioportal
18	RB1	Ssm	63	2,069	3%	cbioportal
19	GRIN2A	Ssm	61	2,069	2.9%	cbioportal
21	FAT1	Ssm	56	2,069	2.7%	cbioportal
23	MED12	Ssm	52	2,069	2.5%	cbioportal
22	KMT2A	Ssm	52	2,069	2.5%	cbioportal
25	NCOR1	Ssm	50	2,069	2.4%	cbioportal
24	ASXL1	Ssm	50	2,069	2.4%	cbioportal
26	PTPRD	Ssm	49	2,069	2.4%	cbioportal
44	KMT2B	Ssm	32	1,402	2.3%	cbioportal
28	ARID1A	Ssm	43	2,069	2.1%	cbioportal
29	PIK3R1	Ssm	41	2,069	2%	cbioportal

Data updated 22 days agoSource updated 2026-01-13