EGFR

← targets

Tarloxotinibsmall_molecule

—

INHIBITOR

—

Curated

← targets

TAK-788small_molecule

—

INHIBITOR

—

Curated

← targets

Rociletinibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Rindopepimut

—

VACCINE ANTIGEN

—

Curated

← targets

Pyrotinibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Poziotinibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Panitumumabmonoclonal_antibody

—

INHIBITOR

—

Curated

← targets

Osimertinib Mesylatesmall_molecule

—

INHIBITOR

—

Curated

← targets

Osimertinibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Nimotuzumabmonoclonal_antibody

—

INHIBITOR

—

Curated

← targets

Neratinibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Necitumumabmonoclonal_antibody

—

INHIBITOR

—

Curated

← targets

Naquotinibsmall_molecule

—

INHIBITOR

—

Curated

← targets

Mobocertinibsmall_molecule

—

INHIBITOR

—

Curated

Malignant Neoplasm,Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma+2

EGFR has variant …HAS_VARIANTderived200 of 4,134show all (up to 200)
→ has variant	L858RSNV 48 accepted CIViC evidence items	—	—	Malignant Neoplasm,Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma+2	48	Curated	civic	graph →
→ has variant	T790MSNV 37 accepted CIViC evidence items	—	—	Malignant Neoplasm,Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma+2	37	Curated	civic	graph →
→ has variant	Exon 19 Deletiondeletion 31 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	31	Curated	civic	graph →
→ has variant	Mutationother 17 accepted CIViC evidence items	—	—	Peritoneal Mesothelial Neoplasm,Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma+1	17	Curated	civic	graph →
→ has variant	Amplificationamplification 13 accepted CIViC evidence items	—	—	Glioblastoma,Barrett Adenocarcinoma,Cervical Squamous Cell Carcinoma+2	13	Curated	civic	graph →
→ has variant	Overexpressionexpression 9 accepted CIViC evidence items	—	—	Brain Glioblastoma,Esophageal Squamous Cell Carcinoma,Head and Neck Squamous Cell Carcinoma+1	9	Curated	civic	graph →
→ has variant	Exon 20 Insertioninsertion 7 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	7	Curated	civic	graph →
→ has variant	S768ISNV 6 accepted CIViC evidence items	—	—	Malignant Neoplasm,Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	6	Curated	civic	graph →
→ has variant	VIIIdeletion 6 accepted CIViC evidence items	—	—	Glioblastoma,Head and Neck Squamous Cell Carcinoma,High-Grade Glioma, NOS	6	Curated	civic	graph →
→ has variant	Expressionexpression 5 accepted CIViC evidence items	—	—	Chordoma,Lung Non-Small Cell Carcinoma,Malignant Colorectal Neoplasm	5	Curated	civic	graph →
→ has variant	G719SSNV 4 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Malignant Colorectal Neoplasm	4	Curated	civic	graph →
→ has variant	S492RSNV 4 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	4	Curated	civic	graph →
→ has variant	A763_Y764insFQEAinsertion 3 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	3	Curated	civic	graph →
→ has variant	A767_V769dupASVinsertion 3 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	3	Curated	civic	graph →
→ has variant	E746_A750deldeletion 3 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Minimally Invasive Lung Adenocarcinoma	3	Curated	civic	graph →
→ has variant	G719ASNV 3 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	3	Curated	civic	graph →
→ has variant	L861QSNV 3 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma,High-Grade Glioma, NOS	3	Curated	civic	graph →
→ has variant	C797SSNV 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	2	Curated	civic	graph →
→ has variant	D770delinsGYinsertion 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	2	Curated	civic	graph →
→ has variant	D770_N771insGinsertion 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →
→ has variant	D770_N771insGTinsertion 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	2	Curated	civic	graph →
→ has variant	G465RSNV 2 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has variant	G719 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	2	Curated	civic	graph →
→ has variant	H773_V774insHinsertion 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →
→ has variant	H773_V774insNPHinsertion 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma	2	Curated	civic	graph →
→ has variant	K467TSNV 2 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	2	Curated	civic	graph →
→ has variant	L747_P753delinsSdeletion 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma,Pancreatic Adenocarcinoma	2	Curated	civic	graph →
→ has variant	P772_H773insYNPinsertion 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →
→ has variant	Rare Exon 18-21 Mutation 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →
→ has variant	S768_D770dupinsertion 2 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	2	Curated	civic	graph →
→ has variant	A289VSNV 1 accepted CIViC evidence items	—	—	High-Grade Glioma, NOS	1	Curated	civic	graph →
→ has variant	A767_S768insTLAinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	A864TSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	C775_R776insNPHVCinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	C797YSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	Copy Number Variationstructural 1 accepted CIViC evidence items	—	—	Head and Neck Squamous Cell Carcinoma	1	Curated	civic	graph →
→ has variant	D761YSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	D770delinsASindel 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	D770_N771insDinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	D770_N771insFinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	D770_N771insGDinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	D770_N771insGLinsertion 1 accepted CIViC evidence items	—	—	Lung Adenocarcinoma	1	Curated	civic	graph →
→ has variant	D770_N771insHinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	D770_N771insNPGinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	D770_N771insSVDinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	D770_N771insTinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	D770_N771insYinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	E114KSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	E734QSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	E746GSNV 1 accepted CIViC evidence items	—	—	Lung Adenocarcinoma	1	Curated	civic	graph →
→ has variant	E746_T751>I 1 accepted CIViC evidence items	—	—	Lung Adenocarcinoma	1	Curated	civic	graph →
→ has variant	E868GSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	EGFRVIII 1 accepted CIViC evidence items	—	—	Glioblastoma	1	Curated	civic	graph →
→ has variant	Exon 18 Overexpressionexpression 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	Exon 19 deldeletion 1 accepted CIViC evidence items	—	—	Lung Adenocarcinoma	1	Curated	civic	graph →
→ has variant	Exon 4 Deletiondeletion_cna 1 accepted CIViC evidence items	—	—	Ovarian Carcinoma	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Lung Adenocarcinoma	1	Curated	civic	graph →
→ has variant	Fusionfusion 1 accepted CIViC evidence items	—	—	Lung Adenocarcinoma	1	Curated	civic	graph →
→ has variant	G598VSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	G719DSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	G724SSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	Gain-of-function 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	H773delinsNPYindel 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	H773delinsPNPYindel 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	H773delinsYNPYindel 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	H773delinsYPNPYindel 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	H773_V774insAHinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	H773_V774insGNPHinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	H773_V774insHPHinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	H773_V774insPHinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	H773_V774insTHinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	K754ESNV 1 accepted CIViC evidence items	—	—	Malignant Lung Neoplasm	1	Curated	civic	graph →
→ has variant	K757RSNV 1 accepted CIViC evidence items	—	—	Lung Adenocarcinoma	1	Curated	civic	graph →
→ has variant	K806ESNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	L747PSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	L747_S752delinsQinsertion 1 accepted CIViC evidence items	—	—	Lung Adenocarcinoma	1	Curated	civic	graph →
→ has variant	L838PSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	L838VSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	L861 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	L861RSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	M766_A767insAIinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	M766_A767insASVinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	N771delinsCHindel 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	N771delinsGFindel 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	N771delinsGYinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	N771delinsRDindel 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	N771delinsSQRGHindel 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	N771dup 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	N771_P772insDNinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	N771_P772insLinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	N771_P772insRHinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	N771_P772insTinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	N771_P772insVDNinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	N826SSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	N826YSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	N842SSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	P753SSNV 1 accepted CIViC evidence items	—	—	Skin Squamous Cell Carcinoma	1	Curated	civic	graph →
→ has variant	P772delinsHRindel 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	P772_H773insDNPinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	P772_H773insPHPinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	P772_H773insQinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	P772_H773insRNPinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	P772_V774insPHVinsertion 1 accepted CIViC evidence items	—	—	Lung Adenocarcinoma	1	Curated	civic	graph →
→ has variant	R108KSNV 1 accepted CIViC evidence items	—	—	High-Grade Glioma, NOS	1	Curated	civic	graph →
→ has variant	R222CSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	R252CSNV 1 accepted CIViC evidence items	—	—	not mapped	1	Curated	civic	graph →
→ has variant	R451CSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	R705KSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	R776CSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	R831HSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	Rare Mutation 1 accepted CIViC evidence items	—	—	Lung Adenocarcinoma	1	Curated	civic	graph →
→ has variant	S645CSNV 1 accepted CIViC evidence items	—	—	Malignant Lung Neoplasm	1	Curated	civic	graph →
→ has variant	S720 1 accepted CIViC evidence items	—	—	Lung Adenocarcinoma	1	Curated	civic	graph →
→ has variant	S768_V769insLDSinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	T263PSNV 1 accepted CIViC evidence items	—	—	High-Grade Glioma, NOS	1	Curated	civic	graph →
→ has variant	T785ASNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	T847ISNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	V441FSNV 1 accepted CIViC evidence items	—	—	Malignant Colorectal Neoplasm	1	Curated	civic	graph →
→ has variant	V742ASNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	V769_D770insASVinsertion 1 accepted CIViC evidence items	—	—	Lung Adenocarcinoma	1	Curated	civic	graph →
→ has variant	V769_D770insCVinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	V769_D770insGAinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	V769_D770insGVASVinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	V774ASNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	V774_C775insHVinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	V774MSNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	V834ISNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	V851ISNV 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	W731LSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	Wildtypeother 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	Y1092 PHOSPHORYLATION 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	Y764_V765insHHinsertion 1 accepted CIViC evidence items	—	—	Lung Non-Small Cell Carcinoma	1	Curated	civic	graph →
→ has variant	Y801HSNV 1 accepted CIViC evidence items	—	—	Malignant Neoplasm	1	Curated	civic	graph →
→ has variant	3' UTR MUTATION no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A702SSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A750PSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A750TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A839SSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A839TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A840VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A859TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A859VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A864VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A871GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A871TSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	A871VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Alterationother no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	AUTOCRINE ACTIVATION no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	C797GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D761NSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D770_N771insGYinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D770_P772dup no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D830NSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D830YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D837NSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D837YSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	D855GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	dele no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	delL747_P753insS no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	e10::e18fusion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E14 no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E701fsindel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E701fs AND L702fsindel no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E709ASNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E709DSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E709GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E709KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E709QSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E709_T710>Dinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E734KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E746_A750deldeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E746_A750>IP no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E746KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E746_P753>VS no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E746_S752>A no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E746_S752delinsDdeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E746_S752>I no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E746_S752insVinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E746_T751delELREATdeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E746_T751delinsAinsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E746_T751delinsVAdeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E746_T751>IP no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E746_T751>V no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E746VSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E758GSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E865KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E868KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	E884KSNV no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	EGFR ITD no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	exon 1-14 (partial) (vI) no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	exon 14-15 deletion (vII)deletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Exon 18 deletiondeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Exon 18 Mutation no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Exon 19 insertioninsertion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	exon 25-26 deletiondeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	exon 25-27 deletiondeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Exon 25-28 deletiondeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Exon 25 Deletiondeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Exon 26 Deletiondeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →
→ has variant	Exon 27 Deletiondeletion no accepted CIViC evidence item (variant record only)	—	—	not mapped	0	Observed	civic	graph →

EGFR has variant …HAS_VARIANTderived200 of 4,134show all (up to 200)

→ has variant

L858RSNV

48 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma+2

→ has variant

T790MSNV

37 accepted CIViC evidence items

—

Curated

→ has variant

Exon 19 Deletiondeletion

31 accepted CIViC evidence items

—

Curated

Peritoneal Mesothelial Neoplasm,Malignant Lung Neoplasm,Lung Non-Small Cell Carcinoma+1

→ has variant

Mutationother

17 accepted CIViC evidence items

—

Curated

Glioblastoma,Barrett Adenocarcinoma,Cervical Squamous Cell Carcinoma+2

→ has variant

Amplificationamplification

13 accepted CIViC evidence items

—

Curated

Brain Glioblastoma,Esophageal Squamous Cell Carcinoma,Head and Neck Squamous Cell Carcinoma+1

→ has variant

Overexpressionexpression

9 accepted CIViC evidence items

—

Curated

→ has variant

Exon 20 Insertioninsertion

7 accepted CIViC evidence items

—

Curated

Malignant Neoplasm,Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma

→ has variant

S768ISNV

6 accepted CIViC evidence items

—

Curated

Glioblastoma,Head and Neck Squamous Cell Carcinoma,High-Grade Glioma, NOS

→ has variant

VIIIdeletion

6 accepted CIViC evidence items

—

Curated

Chordoma,Lung Non-Small Cell Carcinoma,Malignant Colorectal Neoplasm

→ has variant

Expressionexpression

5 accepted CIViC evidence items

—

Curated

Lung Non-Small Cell Carcinoma,Malignant Colorectal Neoplasm

→ has variant

G719SSNV

4 accepted CIViC evidence items

—

Curated

→ has variant

S492RSNV

4 accepted CIViC evidence items

—

Curated

→ has variant

A763_Y764insFQEAinsertion

3 accepted CIViC evidence items

—

Curated

→ has variant

A767_V769dupASVinsertion

3 accepted CIViC evidence items

—

Curated

Lung Non-Small Cell Carcinoma,Minimally Invasive Lung Adenocarcinoma

→ has variant

E746_A750deldeletion

3 accepted CIViC evidence items

—

Curated

→ has variant

G719ASNV

3 accepted CIViC evidence items

—

Curated

Lung Non-Small Cell Carcinoma,Lung Adenocarcinoma,High-Grade Glioma, NOS

→ has variant

L861QSNV

3 accepted CIViC evidence items

—

Curated

→ has variant

C797SSNV

2 accepted CIViC evidence items

—

Curated

→ has variant

D770delinsGYinsertion

2 accepted CIViC evidence items

—

Curated

→ has variant

D770_N771insGinsertion

2 accepted CIViC evidence items

—

Curated

→ has variant

D770_N771insGTinsertion

2 accepted CIViC evidence items

—

Curated

→ has variant

G465RSNV

2 accepted CIViC evidence items

—

Curated

→ has variant

G719

2 accepted CIViC evidence items

—

Curated

→ has variant

H773_V774insHinsertion

2 accepted CIViC evidence items

—

Curated

→ has variant

H773_V774insNPHinsertion

2 accepted CIViC evidence items

—

Curated

→ has variant

K467TSNV

2 accepted CIViC evidence items

—

Curated

Lung Non-Small Cell Carcinoma,Pancreatic Adenocarcinoma

→ has variant

L747_P753delinsSdeletion

2 accepted CIViC evidence items

—

Curated

→ has variant

P772_H773insYNPinsertion

2 accepted CIViC evidence items

—

Curated

→ has variant

Rare Exon 18-21 Mutation

2 accepted CIViC evidence items

—

Curated

→ has variant

S768_D770dupinsertion

2 accepted CIViC evidence items

—

Curated

→ has variant

A289VSNV

1 accepted CIViC evidence items

—

High-Grade Glioma, NOS

Curated

→ has variant

A767_S768insTLAinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

A864TSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

C775_R776insNPHVCinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

C797YSNV

1 accepted CIViC evidence items

—

Curated

Head and Neck Squamous Cell Carcinoma

→ has variant

Copy Number Variationstructural

1 accepted CIViC evidence items

—

Curated

→ has variant

D761YSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

D770delinsASindel

1 accepted CIViC evidence items

—

Curated

→ has variant

D770_N771insDinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

D770_N771insFinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

D770_N771insGDinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

D770_N771insGLinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

D770_N771insHinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

D770_N771insNPGinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

D770_N771insSVDinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

D770_N771insTinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

D770_N771insYinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

E114KSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

E734QSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

E746GSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

1 accepted CIViC evidence items

—

Curated

→ has variant

E868GSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

1 accepted CIViC evidence items

—

Glioblastoma

Curated

→ has variant

Exon 18 Overexpressionexpression

1 accepted CIViC evidence items

—

Curated

→ has variant

Exon 19 deldeletion

1 accepted CIViC evidence items

—

Curated

→ has variant

Exon 4 Deletiondeletion_cna

1 accepted CIViC evidence items

—

Ovarian Carcinoma

Curated

→ has variant

Fusionfusion

1 accepted CIViC evidence items

—

Curated

→ has variant

Fusionfusion

1 accepted CIViC evidence items

—

Curated

→ has variant

G598VSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

G719DSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

G724SSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

Gain-of-function

1 accepted CIViC evidence items

—

Curated

→ has variant

H773delinsNPYindel

1 accepted CIViC evidence items

—

Curated

→ has variant

H773delinsPNPYindel

1 accepted CIViC evidence items

—

Curated

→ has variant

H773delinsYNPYindel

1 accepted CIViC evidence items

—

Curated

→ has variant

H773delinsYPNPYindel

1 accepted CIViC evidence items

—

Curated

→ has variant

H773_V774insAHinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

H773_V774insGNPHinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

H773_V774insHPHinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

H773_V774insPHinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

H773_V774insTHinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

K754ESNV

1 accepted CIViC evidence items

—

Malignant Lung Neoplasm

Curated

→ has variant

K757RSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

K806ESNV

1 accepted CIViC evidence items

—

Curated

→ has variant

L747PSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

L747_S752delinsQinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

L838PSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

L838VSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

1 accepted CIViC evidence items

—

Curated

→ has variant

L861RSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

M766_A767insAIinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

M766_A767insASVinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

N771delinsCHindel

1 accepted CIViC evidence items

—

Curated

→ has variant

N771delinsGFindel

1 accepted CIViC evidence items

—

Curated

→ has variant

N771delinsGYinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

N771delinsRDindel

1 accepted CIViC evidence items

—

Curated

→ has variant

N771delinsSQRGHindel

1 accepted CIViC evidence items

—

Curated

→ has variant

N771dup

1 accepted CIViC evidence items

—

Curated

→ has variant

N771_P772insDNinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

N771_P772insLinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

N771_P772insRHinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

N771_P772insTinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

N771_P772insVDNinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

N826SSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

N826YSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

N842SSNV

1 accepted CIViC evidence items

—

Curated

Skin Squamous Cell Carcinoma

→ has variant

P753SSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

P772delinsHRindel

1 accepted CIViC evidence items

—

Curated

→ has variant

P772_H773insDNPinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

P772_H773insPHPinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

P772_H773insQinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

P772_H773insRNPinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

P772_V774insPHVinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

R108KSNV

1 accepted CIViC evidence items

—

High-Grade Glioma, NOS

Curated

→ has variant

R222CSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

R252CSNV

1 accepted CIViC evidence items

—

not mapped

Curated

→ has variant

R451CSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

R705KSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

R776CSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

R831HSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

1 accepted CIViC evidence items

—

Curated

→ has variant

S645CSNV

1 accepted CIViC evidence items

—

Malignant Lung Neoplasm

Curated

→ has variant

S720

1 accepted CIViC evidence items

—

Curated

→ has variant

S768_V769insLDSinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

T263PSNV

1 accepted CIViC evidence items

—

High-Grade Glioma, NOS

Curated

→ has variant

T785ASNV

1 accepted CIViC evidence items

—

Curated

→ has variant

T847ISNV

1 accepted CIViC evidence items

—

Curated

→ has variant

V441FSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

V742ASNV

1 accepted CIViC evidence items

—

Curated

→ has variant

V769_D770insASVinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

V769_D770insCVinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

V769_D770insGAinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

V769_D770insGVASVinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

V774ASNV

1 accepted CIViC evidence items

—

Curated

→ has variant

V774_C775insHVinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

V774MSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

V834ISNV

1 accepted CIViC evidence items

—

Curated

→ has variant

V851ISNV

1 accepted CIViC evidence items

—

Curated

→ has variant

W731LSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

Wildtypeother

1 accepted CIViC evidence items

—

Curated

→ has variant

Y1092 PHOSPHORYLATION

1 accepted CIViC evidence items

—

Curated

→ has variant

Y764_V765insHHinsertion

1 accepted CIViC evidence items

—

Curated

→ has variant

Y801HSNV

1 accepted CIViC evidence items

—

Curated

→ has variant

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A702SSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A750PSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A750TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A839SSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A839TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A840VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A859TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A859VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A864VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A871GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A871TSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

A871VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Alterationother

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

AUTOCRINE ACTIVATION

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

C797GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D761NSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D770_N771insGYinsertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D770_P772dup

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D830NSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D830YSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D837NSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D837YSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

D855GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

dele

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

delL747_P753insS

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

e10::e18fusion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E14

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E701fsindel

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E701fs AND L702fsindel

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E709ASNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E709DSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E709GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E709KSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E709QSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E709_T710>Dinsertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E734KSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E746_A750deldeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E746_A750>IP

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E746KSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E746_P753>VS

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E746_S752>A

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E746_S752delinsDdeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E746_S752>I

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E746_S752insVinsertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E746_T751delELREATdeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E746_T751delinsAinsertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E746_T751delinsVAdeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E746_T751>IP

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E746_T751>V

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E746VSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E758GSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E865KSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E868KSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

E884KSNV

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

EGFR ITD

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

exon 1-14 (partial) (vI)

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

exon 14-15 deletion (vII)deletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Exon 18 deletiondeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Exon 18 Mutation

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Exon 19 insertioninsertion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

exon 25-26 deletiondeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

exon 25-27 deletiondeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Exon 25-28 deletiondeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Exon 25 Deletiondeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Exon 26 Deletiondeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

→ has variant

Exon 27 Deletiondeletion

no accepted CIViC evidence item (variant record only)

—

not mapped

Observed

EGFR altered in cohorts of …ALTERED_INderived6 of 6
→ altered in cohorts of	Glioblastomasubtype 455 / 601 cases (76 %) · ssm · TCGA-GBM	—	—	Glioblastoma	1	Observed	gdc	graph →
→ altered in cohorts of	Lung Adenocarcinomasubtype 866 / 2,653 cases (33 %) · ssm · luad_mskcc_2023_met_organotropism · largest of 16 cohorts	—	—	Lung Adenocarcinoma	16	Observed	cbioportal	graph →
→ altered in cohorts of	Lung Non-Small Cell Carcinomasubtype 662 / 2,621 cases (25 %) · ssm · nsclc_ctdx_msk_2022 · largest of 5 cohorts	—	—	Lung Non-Small Cell Carcinoma	5	Observed	cbioportal	graph →
→ altered in cohorts of	Diffuse Glioma 146 / 1,004 cases (15 %) · ssm · glioma_mskcc_2019 · largest of 10 cohorts	—	—	Diffuse Glioma	10	Observed	cbioportal	graph →
→ altered in cohorts of	Cutaneous Melanoma 65 / 696 cases (9.3 %) · ssm · mel_mskimpact_2020	—	—	Cutaneous Melanoma	1	Observed	cbioportal	graph →
→ altered in cohorts of	Invasive Breast Carcinoma 27 / 527 cases (5.1 %) · ssm · brca_msk_2025	—	—	Invasive Breast Carcinoma	1	Observed	cbioportal	graph →

EGFR altered in cohorts of …ALTERED_INderived6 of 6

→ altered in cohorts of

Glioblastomasubtype

455 / 601 cases (76 %) · ssm · TCGA-GBM

—

Glioblastoma

Observed

gdc