EGFR Fusion

CI-VAR-00001337Explore in graph →CIViC 4242

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Adenocarcinoma2
EGFR L858R AND EGFR T790M AND VOPP1::EGFR Fusion	Osimertinib	Predictive	C	Supports Sensitivity Response	3	submitted	EID12549 A 67 year old female with stage IIIA lung adenocarcinoma had right lobectomy followed by 4 cycles adjuvant chemotherapy with pemetrexed and cisplatin. Next generation sequencing (NGS) found EGFR L858R… (full text at CIViC) PMID 35004270 · Wang et al., 2021 · Open in CIViC	civic
EGFR T790M AND VOPP1::EGFR Fusion	Icotinib	Predictive	C	Supports Resistance	2	accepted	EID10895 A patient was initially diagnosed with stage IIIA lung adenocarcinoma with EGFR L858R and was treated with lobectomy and adjuvant pemetrexed and cisplatin. 20 months later the patient had recurrent di… (full text at CIViC) PMID 35004270 · Wang et al., 2021 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Malignant Neoplasm1
VOPP1::EGFR Fusion	(oncogenic)	Oncogenic	C	Supports Oncogenicity	1	submitted	EID12551 Next generation sequencing was performed on 35023 Chinese cases with 13 different solid tumor types. EGFR Fusions were detected in 106 samples. All EGFR fusions contained the complete tyrosine kinase … (full text at CIViC) PMID 39054543 · Zhang et al., 2024 · Open in CIViC	civic