EGFR G724S

CI-VAR-00001800Explore in graph →NP_005219.2:p.Gly724SerNM_005228.4:c.2170G>AClinVar 376360 CIViC 317 rs1051753269

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm1
EGFR G724S	Cetuximab	Predictive	D	Supports Sensitivity Response	4	accepted	EID786 Whole genome sequencing of a case of colon carcinoma revealed a G724S mutation in the EGFR gene. In-vitro, this mutation was shown to be oncogenic and sensitive to Cetuximab, yet relatively insensitiv… (full text at CIViC) PMID 24894453 · Cho et al., 2014 · Open in CIViC	civic
Malignant Neoplasm1
EGFR G724S	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9652 The oncogenic potential of somatic EGFR mutations found in colorectal cancer samples were tested. IL-3 independent growth of Ba/F3 cells was achieved when cells were transduced with EGFR G724S. NIH-3T… (full text at CIViC) PMID 31290142 ·

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
376360	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	EGFR-related lung cancer; Hereditary cancer-predisposing syndrome; Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype	germline/somatic	4	Jan 14, 2026	clinvar

Unmapped disease2unmapped disease
EGFR G724S	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID9644 Ba/F3 cells transfected with EGFR G724S had levels of p-EGFR, p-STAT5, and p-AKT that were similar to known activating mutation L858R and higher than in cells expressing wild-type EGFR. PMID 31290142 · Kim et al., 2020 · Open in CIViC	civic
EGFR G724S	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID10039 EGFR mutations were selected (L861R, G724S, T725M, L858Q, E746K) using an ensemble machine learning approach to prioritize variants. CHO cells were transfected with EGFR-mutant or WT to functionally c… (full text at CIViC) PMID 24743239 · U et al., 2014 · Open in CIViC	civic