EGFR G598V

CI-VAR-00001769Explore in graph →NP_001333827.1:p.Gly598ValNM_001346898.2:c.1793G>TClinVar 376210 CIViC 997 rs139236063

Curated evidence

Evidence by cancer (7 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–7 of 7 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Glioblastoma5
EGFR G598V	Afatinib + Erlotinib + OsimertinibSubstitutes	Predictive	D	Supports Sensitivity Response	2	submitted	EID8234 Patient-derived GBM brain tumour stem cells (BTSCs) were used to test the efficacy of EGFR inhibitors in vitro. Afatinib inhibited the growth and sphere-forming ability of BTSCs but not normal astrocy… (full text at CIViC) PMID 32226941 · Jensen et al., 2020 · Open in CIViC	civic
EGFR G598V	Afatinib + PacritinibCombination	Predictive	D	Supports Sensitivity Response	3	submitted	EID8235 Patient-derived GBM brain tumour stem cells (BTSCs) were used to test the efficacy of the EGFR inhibitor afatinib and JAK2 inhibitor pacritinib in vitro. Combination treatment with afatinib and pacrit… (full text at CIViC)

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
376210	-	-	—	Neoplasm; Diffuse pediatric-type high-grade glioma, H3-wildtype and IDH-wildtype; Diffuse midline glioma, H3 K27M-mutant	somatic	2	—	clinvar

Malignant Neoplasm1
EGFR G598V	Erlotinib	Predictive	D	Supports Sensitivity Response	3	accepted	EID10066 In an in vitro study, a Ba/F3 cell line expressing EGFR G598V demonstrated increased sensitivity to erlotinib treatment, compared to Ba/F3 cells expressing EGFR wild-type. Variant function was assesse… (full text at CIViC) PMID 17177598 · Lee et al., 2006 · Open in CIViC	civic

Unmapped disease1unmapped disease
EGFR G598V	(functional)	Functional	D	Supports Gain Of Function	4	submitted	EID10067 In an in vitro study, EGFR ectodomain missense mutants (T263P, A289V, G598V, L861Q) were expressed in human immortalized astrocytes and BaF3 cells. Phosphorylation was measured via immunoblot. All ect… (full text at CIViC) PMID 17177598 · Lee et al., 2006 · Open in CIViC	civic