EGFR E114K

CI-VAR-00000657Explore in graph →NP_005219.2:p.Glu114LysNM_005228.5:c.340G>AClinVar 1059673 CIViC 3464 rs1219568637

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Neoplasm2
EGFR E114K	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9586 The oncogenic potential of somatic EGFR mutations found in colorectal cancer samples were tested. IL-3 independent growth of Ba/F3 cells was achieved when cells were transduced with EGFR E114K. NIH-3T… (full text at CIViC) PMID 31290142 · Kim et al., 2020 · Open in CIViC	civic
EGFR E114K	Cetuximab + PanitumumabSubstitutes	Predictive	D	Supports Sensitivity Response	4	submitted	EID9587 Oncogenic somatic EGFR mutations found in colorectal cancer samples were tested for sensitivity to EGFR inhibitors cetuximab and panitumumab. Ba/F3 cells expressing EGFR E114K showed a dose-dependent … (full text at CIViC) PMID 31290142 · Kim et al., 2020 · Open in CIViC

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
1059673	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	EGFR-related lung cancer; Lung cancer; Inflammatory skin and bowel disease, neonatal, 2; Hereditary cancer-predisposing syndrome	germline	3	Nov 01, 2025	clinvar

Unmapped disease2unmapped disease
EGFR E114K	(functional)	Functional	D	Supports Unaltered Function	2	accepted	EID9584 A functional screen of somatic mutations found in large-scale cancer data sets classified EGFR E114K as neutral, based on growth-factor independent growth in Ba/F3 and MCF10A cells, and consensus amon… (full text at CIViC) PMID 29533785 · Ng et al., 2018 · Open in CIViC	civic
EGFR E114K	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID9585 Ba/F3 cells transfected with EGFR E114K had levels of p-EGFR, p-STAT5, and p-AKT that were similar to known activating mutation L858R and higher than in cells expressing wild-type EGFR. PMID 31290142 · Kim et al., 2020 · Open in CIViC	civic