EGFR D761N

CI-VAR-00000529Explore in graph →NP_005219.2:p.Asp761AsnNM_005228.5:c.2281G>AClinVar 376082 CIViC 1013 rs121913418

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Neoplasm2
EGFR D761N	Erlotinib + GefitinibSubstitutes	Predictive	D	Does Not Support Sensitivity Response	2	submitted	EID5820 EGFR D716N was expressed in Ba/F3 cells which do not contain endogenous EGFR, and conferred growth factor independance to the cells. Cells were plated and treated with 1st generation EGFR inhibitors G… (full text at CIViC) PMID 19147750 · Kancha et al., 2009 · Open in CIViC	civic
EGFR D761N	Multikinase Inhibitor AEE788	Predictive	D	Supports Sensitivity Response	3	submitted	EID5821 EGFR D716N was expressed in Ba/F3 cells which do not contain endogenous EGFR, and conferred growth factor independance to the cells. Cells were plated and treated with 1st generation EGFR inhibitors G… (full text at CIViC) PMID 19147750 ·

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
376082	Uncertain significance	criteria provided, multiple submitters, no conflicts	2	EGFR-related lung cancer; Hereditary cancer-predisposing syndrome	germline	2	Aug 28, 2025	clinvar