EGFR G719S

CI-VAR-00001797Explore in graph →NP_005219.2:p.Gly719SerNM_005228.4:c.2155G>AClinVar 16612 CIViC 134 rs28929495

Curated evidence

Evidence by cancer (11 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–11 of 11 evidence items across 5 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Adenocarcinoma1
EGFR G719S	Erlotinib	Predictive	C	Supports Sensitivity Response	—	submitted	EID4192 In an advanced lung adenocarcinoma patient harboring EGFR G719S mutation, EGFR G719S was reported to be sensitive to erlotinib treatment. The patient was initially treated with standard chemotherapy, … (full text at CIViC) PMID 21841502 · De Pas et al., 2011 · Open in CIViC	civic
Lung Non-Small Cell Carcinoma6
EGFR G719S	Erlotinib	Predictive	C	Supports Sensitivity Response	3	submitted	EID6040 The G719S mutation was found in a 50-year-old female never smoker with advanced adenocarcinoma of the lung. One month after the end of chemotherapy, , she started erlotinib at 150 mg/d. At the first c… (full text at CIViC) PMID 21841502 ·

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Malignant Colorectal Neoplasm2
EGFR G719S	Cetuximab	Predictive	D	Supports Sensitivity Response	4	accepted	EID787 Whole genome sequencing of a case of colon carcinoma revealed a G724S mutation in the EGFR gene. In-vitro, this mutation was shown to be oncogenic and sensitive to Cetuximab, yet relatively insensitiv… (full text at CIViC) PMID 24894453 · Cho et al., 2014 · Open in CIViC	civic
EGFR G719S	Cetuximab + PanitumumabSubstitutes	Predictive	D	Supports Sensitivity Response	3	submitted	EID9660 Oncogenic somatic EGFR mutations found in colorectal cancer samples were tested for sensitivity to EGFR inhibitors cetuximab and panitumumab. Ba/F3 cells expressing EGFR G719S showed a dose-dependent … (full text at CIViC) PMID 31290142 · Kim et al., 2020 · Open in CIViC	civic

Malignant Neoplasm1
EGFR G719S	(oncogenic)	Oncogenic	D	Supports Oncogenicity	2	submitted	EID9651 The oncogenic potential of somatic EGFR mutations found in colorectal cancer samples were tested. IL-3 independent growth of Ba/F3 cells was achieved when cells were transduced with EGFR G719S. NIH-3T… (full text at CIViC) PMID 31290142 · Kim et al., 2020 · Open in CIViC	civic

Unmapped disease1unmapped disease
EGFR G719S	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID9643 Ba/F3 cells transfected with EGFR G719S had levels of p-EGFR, p-STAT5, and p-AKT that were similar to known activating mutation L858R and higher than in cells expressing wild-type EGFR. PMID 31290142 · Kim et al., 2020 · Open in CIViC	civic