EGFR G719

CI-VAR-00001791Explore in graph →ClinVar 16612 CIViC 718 rs28929495

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Adenocarcinoma1
EGFR G719	Erlotinib	Predictive	B	Supports Sensitivity Response	2	accepted	EID1780 In a meta-analysis of 7 clinical trials of erlotinib (some vs placebo or other treatment), 10/24 patients with Exon 18 mutations harbored a G719 variant. These variants were associated with improved p… (full text at CIViC) PMID 26773740 · Klughammer et al., 2016 · Open in CIViC	civic
Lung Non-Small Cell Carcinoma3
EGFR G719	Afatinib	Predictive	A	Supports Sensitivity Response	4	submitted	EID11242 In this phase 2 study, 129 patients with NSCLC, including those with less common, non-resistant EGFR mutations such as S768I, L861Q, and/or G719X, were treated with afatinib in two cohorts: 99 with a … (full text at CIViC) PMID 22452895 ·

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
16612	Uncertain significance; drug response	criteria provided, multiple submitters, no conflicts	2	Nonsmall cell lung cancer, response to tyrosine kinase inhibitor in, somatic; Tyrosine kinase inhibitor response; EGFR-related lung cancer; Lung adenocarcinoma; Neoplasm	germline/somatic	5	Feb 10, 2025	clinvar