EGFR D770_N771insNPG

CI-VAR-00000544Explore in graph →CIViC 1569

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Hematopoietic and Lymphoid Cell Neoplasm2
EGFR D770_N771insNPG	Cetuximab	Predictive	D	Supports Sensitivity Response	—	submitted	EID4492 EGFR D770_N771insNPG insertion mutation has been associated with resistance to first generation EGFR tyrosine kinase inhibitors, including erlotinib and gefitinib. In an in vitro study, NIH-3T3 cells … (full text at CIViC) PMID 16187797 · Greulich et al., 2005 · Open in CIViC	civic
EGFR D770_N771insNPG	Erlotinib	Predictive	D	Supports Sensitivity Response	—	submitted	EID4491 EGFR D770_N771insNPG insertion mutation has been associated with resistance to first generation EGFR tyrosine kinase inhibitors, including erlotinib and gefitinib. In an in vitro study, NIH-3T3 cells … (full text at CIViC) PMID 16187797 · Greulich et al., 2005 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Lung Non-Small Cell Carcinoma2
EGFR D770_N771insNPG	Erlotinib	Predictive	D	Supports Resistance	—	submitted	EID4651 In an in vitro study, a Ba/F3 cell line expressing EGFR D770_N771insNPG demonstrated reduced sensitivity to erlotinib treatment (IC50=2.139�M), comparable to Ba/F3 cells expressing EGFR L858R and T790… (full text at CIViC) PMID 24353160 · Yasuda et al., 2013 · Open in CIViC	civic
EGFR D770_N771insNPG	Afatinib + GefitinibSubstitutes	Predictive	D	Does Not Support Sensitivity Response	3	accepted	EID5947 Ba/F3 cells transduced with EGFR D770_N771insNPG were IL3 growth independent, suggesting a driver mutation. Gefitinib growth inhibition IC50 in D770_N771insNPG transduced Ba/F3 cells was 3.356 micro … (full text at CIViC) PMID 24353160 · Yasuda et al., 2013 · Open in CIViC	civic