EGFR S492R

CI-VAR-00004078Explore in graph →NP_005219.2:p.Ser492ArgNM_005228.4:c.1476C>AClinVar 376341 CIViC 453 rs1057519860

Curated evidence

Evidence by cancer (9 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–9 of 9 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Malignant Colorectal Neoplasm7
EGFR S492R	Cetuximab	Predictive	C	Supports Resistance	4	accepted	EID717 In-vitro studies found this mutation to confer resistance to cetuximab. 2 of 10 patients studied also harbored EGFR S492R and were resistant to cetuximab therapy. Panitumumab was still active in-vitro… (full text at CIViC) PMID 22270724 · Montagut et al., 2012 · Open in CIViC	civic
EGFR S492R	Cetuximab	Predictive	D	Supports Resistance	4	accepted	EID1080 In this preclinical study of the effects of cetuximab, panitumumab or sym004 on various EGFR mutations in colorectal cancer. The S492R mutation was sensitive to Sym004 and panitumumab treatment but re… (full text at CIViC) PMID 26888827 · Sánchez-Martín et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Malignant Neoplasm1
EGFR S492R	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9647 The oncogenic potential of somatic EGFR mutations found in colorectal cancer samples were tested. IL-3 independent growth of Ba/F3 cells was achieved when cells were transduced with EGFR S492R. NIH-3T… (full text at CIViC) PMID 31290142 · Kim et al., 2020 · Open in CIViC	civic

Unmapped disease1unmapped disease
EGFR S492R	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID9639 Ba/F3 cells transfected with EGFR S492R had levels of p-EGFR, p-STAT5, and p-AKT that were similar to known activating mutation L858R and higher than in cells expressing wild-type EGFR. PMID 31290142 · Kim et al., 2020 · Open in CIViC	civic