EGFR E709K

CI-VAR-00000815Explore in graph →ClinVar 177646 CIViC 1412

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Non-Small Cell Carcinoma1
EGFR G719A AND EGFR E709K	Erlotinib + GefitinibSubstitutes	Predictive	C	Supports Sensitivity Response	3	submitted	EID6036 Stage IIIB/IV patients with histologically proven NSCLC were enrolled in this study if the tumor cells bore EGFR mutations other than T790M. Patient with E709K and G719A demontrates PR and an early … (full text at CIViC) PMID 25179728 · Chang et al., 2015 · Open in CIViC	civic
Malignant Neoplasm1
EGFR E709K	(oncogenic)	Oncogenic	D	Supports Oncogenicity	3	submitted	EID9650 The oncogenic potential of somatic EGFR mutations found in colorectal cancer samples were tested. IL-3 independent growth of Ba/F3 cells was achieved when cells were transduced with EGFR E709K. NIH-3T…

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

Unmapped disease1unmapped disease
EGFR E709K	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID9642 Ba/F3 cells transfected with EGFR E709K had levels of p-EGFR, p-STAT5, and p-AKT that were similar to known activating mutation L858R and higher than in cells expressing wild-type EGFR. PMID 31290142 · Kim et al., 2020 · Open in CIViC	civic