EGFR L861R

CI-VAR-00002444Explore in graph →NP_005219.2:p.Leu861ArgNM_005228.4:c.2582T>GClinVar 45287 CIViC 1477 rs121913444

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Adenocarcinoma1
EGFR L861R	Crizotinib	Predictive	C	Supports Resistance	—	submitted	EID4300 In a patient with metastatic adenocarcinoma of the lung harboring EGFR L861R mutation, MET D1028H and EGFR amplification, EGFR L861R was associated with acquired resistance to crizotinib monotherapy. … (full text at CIViC) PMID 26845121 · Benderra et al., 2016 · Open in CIViC	civic
Lung Non-Small Cell Carcinoma1
EGFR L861R	Gefitinib	Predictive	C	Supports Sensitivity Response	3	accepted	EID4669 In a study, 1 participant with stage IV lung adenocarcinoma was sequenced at EGFR exons 18 to 21 and was found to have L861R mutation, and was treated with the 1st generation TKI gefitinib. The patien… (full text at CIViC) PMID 21531810 ·

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
45287	Uncertain significance	criteria provided, single submitter	1	Neoplasm	somatic	2	Jun 17, 2013	clinvar

Unmapped disease1unmapped disease
EGFR L861R	(functional)	Functional	D	Supports Gain Of Function	3	submitted	EID10036 EGFR mutations were selected (L861R, G724S, T725M, L858Q, E746K) using an ensemble machine learning approach to prioritize variants. CHO cells were transfected with EGFR-mutant or WT to functionally c… (full text at CIViC) PMID 24743239 · U et al., 2014 · Open in CIViC	civic