EGFR P753S

CI-VAR-00003394Explore in graph →NP_005219.2:p.Pro753SerNM_005228.4:c.2257C>TClinVar 376081 CIViC 460 rs121913231

Curated evidence

Evidence by cancer (1 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–1 of 1 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Skin Squamous Cell Carcinoma1
EGFR P753S	Cetuximab + SirolimusCombination	Predictive	C	Supports Sensitivity Response	3	accepted	EID1089 72-year old male patient presents with SCC with a mutation profile consistent with UV exposure. Sequencing revealed a number of abnormalities including P753S mutation in EGFR. Patient began therapy wi… (full text at CIViC) PMID 24934779 · Ganesan et al., 2016 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.