EGFR Exon 18 Mutation

CI-VAR-00000999Explore in graph →CIViC 5399

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Non-Small Cell Carcinoma2
EGFR Exon 18 Mutation	Befotertinib	Predictive	D	Supports Sensitivity Response	3	submitted	EID12782 An in vitro study transformed Ba/F3 murine cells (IL-3 dependent lymphocyte model) with one of five uncommon EGFR mutations: Del18 (delE709_T710insD), E709K, G719A, S768I, and L861Q. The response to c… (full text at CIViC) PMID 40940797 · Oiki et al., 2025 · Open in CIViC	civic
EGFR Exon 18 Mutation	Firmonertinib	Predictive	D	Supports Sensitivity Response	3	submitted	EID12781 An in vitro study transformed Ba/F3 murine cells (IL-3 dependent lymphocyte model) with one of five uncommon EGFR mutations: Del18 (delE709_T710insD), E709K, G719A, S768I, and L861Q. The response to c… (full text at CIViC) PMID 40940797 · Oiki et al., 2025 · Open in CIViC

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.