Variant · Fusion
EGFR e10::e18
CI-VAR-00004937Explore in graph →CIViC 5027
Curated evidence
Evidence by cancer (2 items)
Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 36933012
- Run
- ING-CIVIC-20260908-000001
| Molecular profile | Therapy | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| Glioneuronal Tumor With ATRX Alteration, Kinase Fusion And Anaplastic Features1unmapped disease | ||||||||
| CLIP2::EGFR e10::e18 | (diagnostic) | Diagnostic | C | Supports Positive | 2 | submitted | EID12477A novel group of tumors identified by DNA methylation data based on a separate cluster distinct from all other established CNS tumor types. This study proposed the term glioneuronal tumor with ATRX al… (full text at CIViC) PMID 36933012 · Bogumil et al., 2023 · Open in CIViC | civic |
| Pediatric Glioma1unmapped disease | ||||||||
| Chromothripsis Positive AND CLIP2::EGFR e10::e18 | (oncogenic) | Oncogenic | C | Supports Oncogenicity | 1 | submitted | EID11169Big sequencing study (WGS and RNAseq) performed on 252 high-risk pediatric tumors. One pediatric glioma case was identified with chromothripsis affecting chromosome 7 and likely resulting in formation… | |
ClinVar
Clinical significance (0)
ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.
Data not yet available