EGFR R831H

CI-VAR-00003911Explore in graph →NP_005219.2:p.Arg831HisNM_005228.4:c.2492G>AClinVar 560007 CIViC 1017 rs150036236

Curated evidence

Evidence by cancer (4 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–4 of 4 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Non-Small Cell Carcinoma3
EGFR R831H	Gefitinib	Predictive	B	Supports Sensitivity Response	—	submitted	EID2618 EGFR belongs to a family of receptor tyrosine kinases that includes EGFR/erbB-1, Her2/erbB-2, Her3/erbB-3, and Her4/erbB-4. Ligand binding causes receptor homo- or hetero-dimerization, leading to acti… (full text at CIViC) PMID 20966921 · Pao et al., 2010 · Open in CIViC	civic
EGFR R831H	Gefitinib	Predictive	B	Supports Sensitivity Response	—	submitted	EID2619 EGFR belongs to a family of receptor tyrosine kinases that includes EGFR/erbB-1, Her2/erbB-2, Her3/erbB-3, and Her4/erbB-4. PMID 15870435 · Cappuzzo et al., 2005 · Open in CIViC	civic
EGFR R831H

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
560007	Conflicting classifications of pathogenicity	criteria provided, conflicting classifications	1	Squamous cell lung carcinoma; Lung adenocarcinoma; EGFR-related lung cancer; Hereditary cancer-predisposing syndrome	germline	6	Mar 30, 2025	clinvar

Malignant Neoplasm1
EGFR R831H	Erlotinib	Predictive	D	Supports Sensitivity Response	3	accepted	EID4279 In an in vitro study performed after identification of the mutation in a malignant peritoneal mesothelioma patient, COS-7 cells expressing EGFR R831H demonstrated increased EGFR phosphotyrosine after … (full text at CIViC) PMID 20942962 · Foster et al., 2010 · Open in CIViC	civic