EGFR Exon 27 Deletion

CI-VAR-00001016Explore in graph →CIViC 5329

Curated evidence

Evidence by cancer (2 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–2 of 2 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Glioblastoma1
EGFR Exon 25 Deletion AND EGFR Exon 26 Deletion AND EGFR Exon 27 Deletion	Tyrphostin AG 1478	Predictive	D	Supports Sensitivity Response	2	submitted	EID12685 In glioblastoma models expressing EGFR vIVa (lack of exons 25-27), a C-terminal deletion mutant that shows constitutive basal autophosphorylation and ligand-independent activation of ERK, AKT, and STA… (full text at CIViC) PMID 20676128 · Pines et al., 2010 · Open in CIViC	civic
Unmapped disease1unmapped disease
EGFR Exon 25 Deletion AND EGFR Exon 26 Deletion AND EGFR Exon 27 Deletion	(functional)	Functional	D	Supports Gain Of Function	2	submitted	EID12686 In glioblastoma models expressing EGFR vIVa (lack of exons 25-27), a C-terminal deletion mutant that shows constitutive basal autophosphorylation and ligand-independent activation of ERK, AKT, and STA…

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.